dbPTM

ACTN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACTN2_HUMAN
UniProt AC	P35609
Protein Name	Alpha-actinin-2
Gene Name	ACTN2
Organism	Homo sapiens (Human).
Sequence Length	894
Subcellular Localization	Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
Protein Description	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein..
Protein Sequence	MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Ubiquitination	LLDPAWEKQQRKTFT CCCHHHHHHHHHHHH	40.82	-
38	Ubiquitination	LLDPAWEKQQRKTFT CCCHHHHHHHHHHHH	40.82	-
42	Ubiquitination	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	21890473
42	Ubiquitination	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	21890473
42	Ubiquitination	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	21890473
43	Phosphorylation	WEKQQRKTFTAWCNS HHHHHHHHHHHHHHH	28.54	26437602
45	Phosphorylation	KQQRKTFTAWCNSHL HHHHHHHHHHHHHHH	25.20	26437602
50	Phosphorylation	TFTAWCNSHLRKAGT HHHHHHHHHHHHHCH	22.29	26437602
54	Ubiquitination	WCNSHLRKAGTQIEN HHHHHHHHHCHHHHC	58.49	-
57	Phosphorylation	SHLRKAGTQIENIEE HHHHHHCHHHHCHHH	31.10	16097034
80	Phosphorylation	MLLLEVISGERLPKP HHHHHHHCCCCCCCC	39.51	-
83	Methylation	LEVISGERLPKPDRG HHHHCCCCCCCCCCC	60.87	-
86	Methylation	ISGERLPKPDRGKMR HCCCCCCCCCCCCCC	65.23	-
106	Phosphorylation	NVNKALDYIASKGVK CHHHHHHHHHHCCCE	10.15	20068231
109	Phosphorylation	KALDYIASKGVKLVS HHHHHHHHCCCEEEE	22.00	26437602
116	Phosphorylation	SKGVKLVSIGAEEIV HCCCEEEEECCHHEE	26.24	27251275
130	Phosphorylation	VDGNVKMTLGMIWTI ECCCCHHHHHHHHHH	17.91	-
147	Phosphorylation	RFAIQDISVEETSAK HHHHHCCCCCCCCHH	31.59	19664994
151	Phosphorylation	QDISVEETSAKEGLL HCCCCCCCCHHHCCH	22.07	23927012
152	Phosphorylation	DISVEETSAKEGLLL CCCCCCCCHHHCCHH	40.39	23927012
161	S-palmitoylation	KEGLLLWCQRKTAPY HHCCHHHHHCCCCCC	2.57	29575903
178	Phosphorylation	VNIQNFHTSWKDGLG CCCCCCCCCCCCCHH	31.95	26437602
179	Phosphorylation	NIQNFHTSWKDGLGL CCCCCCCCCCCCHHH	24.45	26437602
181	Acetylation	QNFHTSWKDGLGLCA CCCCCCCCCCHHHHH	41.51	30586715
200	Phosphorylation	HRPDLIDYSKLNKDD HCCCCCCHHHCCCCC	10.74	3832141
201	Phosphorylation	RPDLIDYSKLNKDDP CCCCCCHHHCCCCCC	27.24	26437602
237	Phosphorylation	DAEDIVNTPKPDERA CHHHHHCCCCCCHHH	23.07	19764811
250	Phosphorylation	RAIMTYVSCFYHAFA HHHHHHHHHHHHHHC	6.52	-
253	Phosphorylation	MTYVSCFYHAFAGAE HHHHHHHHHHHCCHH	9.14	-
268	Methylation	QAETAANRICKVLAV HHHHHHHHHHHHHHH	30.84	-
291	Phosphorylation	EEYERLASELLEWIR HHHHHHHHHHHHHHH	33.11	73403065
300	Phosphorylation	LLEWIRRTIPWLENR HHHHHHHHCHHHHCC	22.88	26437602
308	Phosphorylation	IPWLENRTPEKTMQA CHHHHCCCHHHHHHH	47.59	26437602
312	Phosphorylation	ENRTPEKTMQAMQKK HCCCHHHHHHHHHHH	16.92	26437602
326	Phosphorylation	KLEDFRDYRRKHKPP HHHHHHHHHHHCCCC	14.20	28152594
338	Ubiquitination	KPPKVQEKCQLEINF CCCHHHHHEEEEEEC	15.36	21890473
338	Ubiquitination	KPPKVQEKCQLEINF CCCHHHHHEEEEEEC	15.36	-
339	S-palmitoylation	PPKVQEKCQLEINFN CCHHHHHEEEEEECC	5.70	29575903
347	Phosphorylation	QLEINFNTLQTKLRI EEEEECCCHHHHHHH	18.99	26657352
350	Phosphorylation	INFNTLQTKLRISNR EECCCHHHHHHHCCC	34.85	21712546
355	Phosphorylation	LQTKLRISNRPAFMP HHHHHHHCCCCCCCC	21.98	26657352
361	Sulfoxidation	ISNRPAFMPSEGKMV HCCCCCCCCCCCCCH	3.76	21406390
363	Phosphorylation	NRPAFMPSEGKMVSD CCCCCCCCCCCCHHH	47.39	26437602
385	Phosphorylation	LEQAEKGYEEWLLNE HHHHHHHHHHHHHHH	23.03	110744103
405	Ubiquitination	RLEHLAEKFRQKAST HHHHHHHHHHHHHHH	39.99	-
409	Ubiquitination	LAEKFRQKASTHETW HHHHHHHHHHHHHHH	39.80	-
411	Phosphorylation	EKFRQKASTHETWAY HHHHHHHHHHHHHHH	37.01	26437602
412	Phosphorylation	KFRQKASTHETWAYG HHHHHHHHHHHHHHC	28.70	26437602
415	Phosphorylation	QKASTHETWAYGKEQ HHHHHHHHHHHCHHH	14.06	26437602
418	Phosphorylation	STHETWAYGKEQILL HHHHHHHHCHHHEEE	21.94	26437602
420	Ubiquitination	HETWAYGKEQILLQK HHHHHHCHHHEEECC	33.50	-
427	Ubiquitination	KEQILLQKDYESASL HHHEEECCCHHHCCH	63.35	-
431	Phosphorylation	LLQKDYESASLTEVR EECCCHHHCCHHHHH	19.54	19764811
431	O-linked_Glycosylation	LLQKDYESASLTEVR EECCCHHHCCHHHHH	19.54	30379171
433	Phosphorylation	QKDYESASLTEVRAL CCCHHHCCHHHHHHH	45.14	19764811
435	Phosphorylation	DYESASLTEVRALLR CHHHCCHHHHHHHHH	29.91	19764811
435	O-linked_Glycosylation	DYESASLTEVRALLR CHHHCCHHHHHHHHH	29.91	30379171
443	Ubiquitination	EVRALLRKHEAFESD HHHHHHHHHHHHHHH	45.85	-
443	Acetylation	EVRALLRKHEAFESD HHHHHHHHHHHHHHH	45.85	-
449	Phosphorylation	RKHEAFESDLAAHQD HHHHHHHHHHHHCHH	31.32	26657352
495	Phosphorylation	DQWDRLGTLTQKRRE HHHHHHHHHHHHHHH	31.09	20068231
497	Phosphorylation	WDRLGTLTQKRREAL HHHHHHHHHHHHHHH	31.70	26437602
499	Acetylation	RLGTLTQKRREALER HHHHHHHHHHHHHHH	48.46	30586709
523	Acetylation	QLHLEFAKRAAPFNN HHHHHHHHHCCCCCH	48.14	30586721
574	Phosphorylation	EADGERQSIMAIQNE CCCCCHHHHHHHHHH	22.13	26437602
588	Phosphorylation	EVEKVIQSYNIRISS HHHHHHHHCCCEECC	14.71	26437602
589	Phosphorylation	VEKVIQSYNIRISSS HHHHHHHCCCEECCC	9.76	24426439
594	Phosphorylation	QSYNIRISSSNPYST HHCCCEECCCCCCCC	20.19	19764811
595	Phosphorylation	SYNIRISSSNPYSTV HCCCEECCCCCCCCC	31.59	20873877
596	Phosphorylation	YNIRISSSNPYSTVT CCCEECCCCCCCCCC	34.73	20873877
599	Phosphorylation	RISSSNPYSTVTMDE EECCCCCCCCCCHHH	22.64	20873877
600	Phosphorylation	ISSSNPYSTVTMDEL ECCCCCCCCCCHHHH	20.05	22673903
601	Phosphorylation	SSSNPYSTVTMDELR CCCCCCCCCCHHHHH	17.72	22673903
603	Phosphorylation	SNPYSTVTMDELRTK CCCCCCCCHHHHHHH	20.99	25332170
609	Phosphorylation	VTMDELRTKWDKVKQ CCHHHHHHHHHHHHH	49.46	26437602
624	Phosphorylation	LVPIRDQSLQEELAR HCCCCCHHHHHHHHH	35.99	26437602
681	Phosphorylation	QMNQLKQYEHNIINY HHHHHHHHHHHHHHH	19.98	26437602
688	Phosphorylation	YEHNIINYKNNIDKL HHHHHHHHHCCHHHC	12.51	26437602
713	Phosphorylation	LVFDNKHTNYTMEHI HCCCCCCCCCCHHHH	31.37	28152594
715	Phosphorylation	FDNKHTNYTMEHIRV CCCCCCCCCHHHHHH	14.49	28152594
716	Phosphorylation	DNKHTNYTMEHIRVG CCCCCCCCHHHHHHH	20.39	26437602
734	Phosphorylation	LLTTIARTINEVETQ HHHHHHHHHHHHHHH	21.09	26437602
744	Phosphorylation	EVETQILTRDAKGIT HHHHHHHCCCCCCCC	28.29	26437602
748	Ubiquitination	QILTRDAKGITQEQM HHHCCCCCCCCHHHH	55.95	-
751	Phosphorylation	TRDAKGITQEQMNEF CCCCCCCCHHHHHHH	34.42	26437602
761	Phosphorylation	QMNEFRASFNHFDRR HHHHHHHHHCHHHHH	23.48	26437602
840	Phosphorylation	ASFRILASDKPYILA HHHHHHHCCCCEEEH	42.60	19764811
844	Phosphorylation	ILASDKPYILAEELR HHHCCCCEEEHHHHH	17.82	38017421
861	Phosphorylation	LPPDQAQYCIKRMPA CCCCHHHHHHHHCCC	10.12	46158725
892	Phosphorylation	SSALYGESDL----- HHHHHCCCCC-----	39.59	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXL22	Q6P050	PMID:22972877

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACTN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACTN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG1_HUMAN	DLG1	physical	12860415
TBA1A_MOUSE	Tuba1a	physical	16169070
KCNA5_HUMAN	KCNA5	physical	10812072
NMDE2_HUMAN	GRIN2B	physical	9009191
ADA12_HUMAN	ADAM12	physical	10788519
MYOZ1_HUMAN	MYOZ1	physical	10984498
TENN_HUMAN	TNN	physical	9817758
MYPN_HUMAN	MYPN	physical	11309420
PDLI1_HUMAN	PDLIM1	physical	10861853
ACTN3_HUMAN	ACTN3	physical	9675099
KCNA5_HUMAN	KCNA5	physical	11389904
ACTN4_HUMAN	ACTN4	physical	22939629
RL35_HUMAN	RPL35	physical	21988832
ZN446_HUMAN	ZNF446	physical	21988832
ACTN2_HUMAN	ACTN2	physical	25416956
MOS_HUMAN	MOS	physical	25416956
SNAI1_HUMAN	SNAI1	physical	25416956
SP100_HUMAN	SP100	physical	25416956
PDLI3_HUMAN	PDLIM3	physical	25416956
MYOZ2_HUMAN	MYOZ2	physical	25416956
MILK2_HUMAN	MICALL2	physical	25416956
BRM1L_HUMAN	BRMS1L	physical	25416956
SAXO1_HUMAN	FAM154A	physical	25416956
RTP5_HUMAN	RTP5	physical	25416956
TNNI1_HUMAN	TNNI1	physical	26344197
TPM1_HUMAN	TPM1	physical	26344197
TPM2_HUMAN	TPM2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612158	Cardiomyopathy, familial hypertrophic 23, with or without left ventricular non-compaction (CMH23)
612158	Cardiomyopathy, dilated 1AA, with or without left ventricular non-compaction (CMD1AA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACTN2_HUMAN

Related Literatures of Post-Translational Modification