MYOZ2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYOZ2_HUMAN
• UniProt AC: Q9NPC6
• Protein Name: Myozenin-2
• Gene Name: MYOZ2 {ECO:0000312|HGNC:HGNC:1330}
• Organism: Homo sapiens (Human).
• Sequence Length: 264
• Subcellular Localization: Cytoplasm, myofibril, sarcomere, Z line. Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle..
• Protein Description: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis..
• Protein Sequence: MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLSHNTMMKQ -----CCCHHHHHHH	17.25	29759185
6	Phosphorylation	--MLSHNTMMKQRKQ --CCCHHHHHHHHHH	17.14	29759185
37	Phosphorylation	MDLGKKVSIPRDIML CCCCCCCCCCHHHHH	35.44	24719451
51	Phosphorylation	LEELSHLSNRGARLF HHHHHHHCHHHHHHH	21.03	21712546
53	Methylation	ELSHLSNRGARLFKM HHHHHCHHHHHHHHH	36.45	-
69	Phosphorylation	QRRSDKYTFENFQYQ HHCCCCCEECCCEEE	30.16	-
75	Phosphorylation	YTFENFQYQSRAQIN CEECCCEEECHHHCC	12.34	-
77	Phosphorylation	FENFQYQSRAQINHS ECCCEEECHHHCCHH	25.34	-
101	Phosphorylation	GSNLEGGSQQAPLTP CCCCCCCCCCCCCCC	29.94	-
107	Phosphorylation	GSQQAPLTPPNTPDP CCCCCCCCCCCCCCC	35.32	19764811
111	Phosphorylation	APLTPPNTPDPRSPP CCCCCCCCCCCCCCC	34.54	19764811
116	Phosphorylation	PNTPDPRSPPNPDNI CCCCCCCCCCCCCCC	50.53	26437602
127	Phosphorylation	PDNIAPGYSGPLKEI CCCCCCCCCCCHHHC	14.92	22673903
182	Phosphorylation	GKAELPDYRSFNRVA CCCCCCCCCCCCCCC	13.25	20049867
190	Phosphorylation	RSFNRVATPFGGFEK CCCCCCCCCCCCCHH	19.12	26437602
235	Phosphorylation	GRRSFNRTPKGWISE CCCCCCCCCCCCCCC	30.38	-
253	Phosphorylation	IVITTEPTDDTTVPE EEEECCCCCCCCCCC	40.03	22673903
256	Phosphorylation	TTEPTDDTTVPESED ECCCCCCCCCCCCCC	32.29	22673903
257	Phosphorylation	TEPTDDTTVPESEDL CCCCCCCCCCCCCCC	40.85	22673903
261	Phosphorylation	DDTTVPESEDL---- CCCCCCCCCCC----	30.27	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYOZ2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYOZ2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYOZ2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TELT_HUMAN	TCAP	physical	11842093
FLNC_HUMAN	FLNC	physical	11842093
ACTN4_HUMAN	ACTN4	physical	19447967

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.