TELT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TELT_HUMAN
• UniProt AC: O15273
• Protein Name: Telethonin
• Gene Name: TCAP
• Organism: Homo sapiens (Human).
• Sequence Length: 167
• Subcellular Localization: Cytoplasm, myofibril, sarcomere .
• Protein Description: Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk..
• Protein Sequence: MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	EWKDLTLSTRPEEGC HHHHCCEECCCCCCC	19.69	24719451
39	Phosphorylation	TRPEEGCSLHEEDTQ CCCCCCCCCCHHHHH	43.55	19764811
102	Phosphorylation	TPAKMGATKEEREDT CCHHCCCCHHHHCCC	33.01	-
109	Phosphorylation	TKEEREDTPIQLQEL CHHHHCCCCCHHHHH	19.96	26437602
147	Phosphorylation	LPPVVPVSKPGALRR CCCCCCCCCCHHHHH	27.36	-
155	Phosphorylation	KPGALRRSLSRSMSQ CCHHHHHHHHHHHHH	25.02	29978859
157	Phosphorylation	GALRRSLSRSMSQEA HHHHHHHHHHHHHHH	24.45	29978859
159	Phosphorylation	LRRSLSRSMSQEAQR HHHHHHHHHHHHHHH	21.29	26437602
161	Phosphorylation	RSLSRSMSQEAQRG- HHHHHHHHHHHHHC-	26.56	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
157	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
157	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
157	S	Phosphorylation	Kinase	TTN	Q8WZ42	GPS
161	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
161	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TELT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TELT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TITIN_HUMAN	TTN	physical	9817758
ANKR2_HUMAN	ANKRD2	physical	15136035
MYOZ1_HUMAN	MYOZ1	physical	10984498
TITIN_HUMAN	TTN	physical	9645487
MDM2_HUMAN	MDM2	physical	16678796
SIVA_HUMAN	SIVA1	physical	18849585
LHX4_HUMAN	LHX4	physical	21516116
CBX5_HUMAN	CBX5	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
CHIP_HUMAN	STUB1	physical	28514442
HSP74_HUMAN	HSPA4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 607487: Cardiomyopathy, familial hypertrophic 25 (CMH25)
• 601954: Limb-girdle muscular dystrophy 2G (LGMD2G)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.