MYOZ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYOZ1_HUMAN
• UniProt AC: Q9NP98
• Protein Name: Myozenin-1
• Gene Name: MYOZ1 {ECO:0000312|HGNC:HGNC:13752}
• Organism: Homo sapiens (Human).
• Sequence Length: 299
• Subcellular Localization: Nucleus. Cell projection, pseudopodium. Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
• Protein Description: Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis..
• Protein Sequence: MPLSGTPAPNKKRKSSKLIMELTGGGQESSGLNLGKKISVPRDVMLEELSLLTNRGSKMFKLRQMRVEKFIYENHPDVFSDSSMDHFQKFLPTVGGQLGTAGQGFSYSKSNGRGGSQAGGSGSAGQYGSDQQHHLGSGSGAGGTGGPAGQAGRGGAAGTAGVGETGSGDQAGGEGKHITVFKTYISPWERAMGVDPQQKMELGIDLLAYGAKAELPKYKSFNRTAMPYGGYEKASKRMTFQMPKFDLGPLLSEPLVLYNQNLSNRPSFNRTPIPWLSSGEPVDYNVDIGIPLDGETEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	APNKKRKSSKLIMEL CCCCCCCCCCEEEEC	36.42	19764811
16	Phosphorylation	PNKKRKSSKLIMELT CCCCCCCCCEEEECC	34.22	19764811
23	Phosphorylation	SKLIMELTGGGQESS CCEEEECCCCCCCCC	22.07	19764811
29	Phosphorylation	LTGGGQESSGLNLGK CCCCCCCCCCCCCCC	23.09	-
30	Phosphorylation	TGGGQESSGLNLGKK CCCCCCCCCCCCCCC	46.69	-
39	Phosphorylation	LNLGKKISVPRDVML CCCCCCCCCCHHHHH	34.64	24719451
72	Phosphorylation	MRVEKFIYENHPDVF HHHHHHHHHCCCCCC	17.51	22673903
80	Phosphorylation	ENHPDVFSDSSMDHF HCCCCCCCCCCHHHH	36.11	24719451
82	Phosphorylation	HPDVFSDSSMDHFQK CCCCCCCCCHHHHHH	26.77	24719451
83	Phosphorylation	PDVFSDSSMDHFQKF CCCCCCCCHHHHHHH	32.97	26437602
93	Phosphorylation	HFQKFLPTVGGQLGT HHHHHHHCCCCCCCC	33.65	-
116	Phosphorylation	KSNGRGGSQAGGSGS CCCCCCCCCCCCCCC	21.49	26437602
121	Phosphorylation	GGSQAGGSGSAGQYG CCCCCCCCCCCCCCC	28.76	26437602
123	Phosphorylation	SQAGGSGSAGQYGSD CCCCCCCCCCCCCCC	30.81	26437602
127	Phosphorylation	GSGSAGQYGSDQQHH CCCCCCCCCCCCCCC	20.06	-
129	Phosphorylation	GSAGQYGSDQQHHLG CCCCCCCCCCCCCCC	27.58	26437602
139	Phosphorylation	QHHLGSGSGAGGTGG CCCCCCCCCCCCCCC	27.45	19764811
159	Phosphorylation	GRGGAAGTAGVGETG CCCCCCCCCCCCCCC	18.60	19764811
165	Phosphorylation	GTAGVGETGSGDQAG CCCCCCCCCCCCCCC	30.62	19764811
167	Phosphorylation	AGVGETGSGDQAGGE CCCCCCCCCCCCCCC	46.76	19764811
218	Phosphorylation	AKAELPKYKSFNRTA HCCCCCCCCCCCCCC	15.21	-
224	Phosphorylation	KYKSFNRTAMPYGGY CCCCCCCCCCCCCCC	28.54	25219547
228	Phosphorylation	FNRTAMPYGGYEKAS CCCCCCCCCCCHHHC	15.31	25219547
231	Phosphorylation	TAMPYGGYEKASKRM CCCCCCCCHHHCCCE	15.19	25219547
239	Phosphorylation	EKASKRMTFQMPKFD HHHCCCEEEECCCCC	18.10	26437602
252	Phosphorylation	FDLGPLLSEPLVLYN CCCHHHHCCCEEEEC	44.87	28348404
258	Phosphorylation	LSEPLVLYNQNLSNR HCCCEEEECCCCCCC	13.76	19690332
263	Phosphorylation	VLYNQNLSNRPSFNR EEECCCCCCCCCCCC	38.04	28348404
267	Phosphorylation	QNLSNRPSFNRTPIP CCCCCCCCCCCCCCC	31.73	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYOZ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYOZ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYOZ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TELT_HUMAN	TCAP	physical	11842093
FLNC_HUMAN	FLNC	physical	11842093
ACTN2_HUMAN	ACTN2	physical	10984498
TRI63_HUMAN	TRIM63	physical	20149877
A4_HUMAN	APP	physical	21832049
BRCA1_HUMAN	BRCA1	physical	25184681

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.