dbPTM

FLNC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FLNC_HUMAN
UniProt AC	Q14315
Protein Name	Filamin-C
Gene Name	FLNC
Organism	Homo sapiens (Human).
Sequence Length	2725
Subcellular Localization	Cytoplasm . Membrane Peripheral membrane protein . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a mino
Protein Description	Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers..
Protein Sequence	MMNNSGYSDAGLGLGDETDEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPAMEGPHTVHVAFAGAPITRSPFPVHVSEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGVQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKIKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACDPLPHEEEPSEVPQLRQPYAPPRPGARPTHWATEEPVVPVEPMESMLRPFNLVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVKVP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MMNNSGYSDAGL ---CCCCCCCCCCCC	33.82	22199227
7	Phosphorylation	-MMNNSGYSDAGLGL -CCCCCCCCCCCCCC	11.82	22777824
8	Phosphorylation	MMNNSGYSDAGLGLG CCCCCCCCCCCCCCC	25.22	22777824
18	Phosphorylation	GLGLGDETDEMPSTE CCCCCCCCCCCCCCH	41.84	27732954
24	Phosphorylation	ETDEMPSTEKDLAED CCCCCCCCHHHHHHC	40.98	26657352
35	Acetylation	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH	38.65	7668573
35	Methylation	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH	38.65	-
35	Ubiquitination	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH	38.65	-
36	Ubiquitination	AEDAPWKKIQQNTFT HHCCCHHHHHHHHHH	41.71	-
41	Phosphorylation	WKKIQQNTFTRWCNE HHHHHHHHHHHHHHH	23.26	23403867
43	Phosphorylation	KIQQNTFTRWCNEHL HHHHHHHHHHHHHHH	22.63	23186163
58	Phosphorylation	KCVGKRLTDLQRDLS HHHHHHHHHHHHHHH	38.40	26437602
78	Phosphorylation	IALLEVLSQKRMYRK HHHHHHHHHHCHHHH	38.54	-
80	Ubiquitination	LLEVLSQKRMYRKFH HHHHHHHHCHHHHHC	35.44	-
101	Phosphorylation	QMKLENVSVALEFLE HHEEECHHHHHHHHH	17.16	27174698
113	Acetylation	FLEREHIKLVSIDSK HHHHCCEEEEEECCH	44.75	23236377
113	Malonylation	FLEREHIKLVSIDSK HHHHCCEEEEEECCH	44.75	26320211
116	Phosphorylation	REHIKLVSIDSKAIV HCCEEEEEECCHHHH	30.99	27499020
120	Malonylation	KLVSIDSKAIVDGNL EEEEECCHHHHCCCH	38.08	26320211
162	Acetylation	DARKQTPKQRLLGWI HHHHHCHHHHHHHHH	51.98	7427313
189	Ubiquitination	NRDWQDGKALGALVD CCCCCCCCHHHHHHC	49.04	-
270	Phosphorylation	KPGAPVRSKQLNPKK CCCCCCCCCCCCCCC	25.61	26437602
335	Phosphorylation	PNNDKDRTYAVSYVP CCCCCCCEEEEEECC	26.43	26437602
339	Phosphorylation	KDRTYAVSYVPKVAG CCCEEEEEECCCCCC	16.55	26437602
362	Phosphorylation	AGQNIERSPFEVNVG CCCCCCCCCCEEECC	22.58	26437602
379	Phosphorylation	LGDANKVSARGPGLE CCCCCCCCCCCCCCC	17.54	26437602
397	Phosphorylation	NVANKPTYFDIYTAG CCCCCCCEEEEEECC	14.05	-
401	Phosphorylation	KPTYFDIYTAGAGTG CCCEEEEEECCCCCC	7.74	-
423	Phosphorylation	DPQGRRDTVEVALED CCCCCCCEEEEEEEE	19.43	26657352
462	Phosphorylation	AGAPITRSPFPVHVS ECCCCCCCCCCCCHH	23.42	26437602
469	Phosphorylation	SPFPVHVSEACNPNA CCCCCCHHHCCCCCC	12.47	23312004
480	Phosphorylation	NPNACRASGRGLQPK CCCCCCCCCCCCCCC	15.07	26437602
498	Ubiquitination	VKEVADFKVFTKGAG EEEEEEEEEEECCCC	36.67	-
501	Phosphorylation	VADFKVFTKGAGSGE EEEEEEEECCCCCCE	31.40	-
502	Malonylation	ADFKVFTKGAGSGEL EEEEEEECCCCCCEE	34.99	26320211
502	Ubiquitination	ADFKVFTKGAGSGEL EEEEEEECCCCCCEE	34.99	-
506	Phosphorylation	VFTKGAGSGELKVTV EEECCCCCCEEEEEE	28.67	26437602
510	Malonylation	GAGSGELKVTVKGPK CCCCCEEEEEEECCC	31.40	26320211
512	Phosphorylation	GSGELKVTVKGPKGT CCCEEEEEEECCCCC	18.21	26437602
519	Phosphorylation	TVKGPKGTEEPVKVR EEECCCCCCCCEEEE	43.21	26437602
535	Glutathionylation	AGDGVFECEYYPVVP CCCCEEEEEEEEEEC	2.50	22555962
545	Phosphorylation	YPVVPGKYVVTITWG EEEECCEEEEEEEEC	13.18	-
559	Phosphorylation	GGYAIPRSPFEVQVS CCEECCCCCCEEEEC	28.69	26657352
566	Phosphorylation	SPFEVQVSPEAGVQK CCCEEEECCCCCCCE	10.42	26437602
621	Acetylation	AKIECDDKGDGSCDV CEEEECCCCCCCCEE	45.72	-
625	Phosphorylation	CDDKGDGSCDVRYWP ECCCCCCCCEEEEEC	16.34	28270605
712	Glutathionylation	YAQDADGCPIDIKVI EEECCCCCEEEEEEE	2.48	22555962
729	Phosphorylation	GDGTFRCSYVPTKPI CCCEEEEEECCCCCC	25.55	26437602
733	Phosphorylation	FRCSYVPTKPIKHTI EEEEECCCCCCCEEE	39.13	26437602
734	Acetylation	RCSYVPTKPIKHTII EEEECCCCCCCEEEE	38.38	23236377
752	Phosphorylation	GGVNVPKSPFRVNVG CCCCCCCCCCEEECC	24.17	29523821
762	Phosphorylation	RVNVGEGSHPERVKV EEECCCCCCCCEEEE	31.41	26437602
770	Phosphorylation	HPERVKVYGPGVEKT CCCEEEEECCCCCCC	16.34	17192257
776	Acetylation	VYGPGVEKTGLKANE EECCCCCCCCCCCCC	45.55	23236377
776	Malonylation	VYGPGVEKTGLKANE EECCCCCCCCCCCCC	45.55	26320211
776	Ubiquitination	VYGPGVEKTGLKANE EECCCCCCCCCCCCC	45.55	-
828	Phosphorylation	IIKNDNDTFTVKYTP EEECCCCCEEEEECC	27.71	26657352
832	Acetylation	DNDTFTVKYTPPGAG CCCCEEEEECCCCCC	40.11	23236377
833	Phosphorylation	NDTFTVKYTPPGAGR CCCEEEEECCCCCCE	21.83	24719451
834	Phosphorylation	DTFTVKYTPPGAGRY CCEEEEECCCCCCEE	19.79	24719451
868	Phosphorylation	VDPSHDASKVKAEGP ECCCCCHHHCCCCCC	44.00	26437602
880	Phosphorylation	EGPGLNRTGVEVGKP CCCCCCCCCCCCCCC	44.50	26437602
886	Malonylation	RTGVEVGKPTHFTVL CCCCCCCCCCEEEEE	52.50	26320211
886	Methylation	RTGVEVGKPTHFTVL CCCCCCCCCCEEEEE	52.50	-
895	Malonylation	THFTVLTKGAGKAKL CEEEEEECCCCCEEE	42.47	26320211
895	Ubiquitination	THFTVLTKGAGKAKL CEEEEEECCCCCEEE	42.47	-
909	Phosphorylation	LDVQFAGTAKGEVVR EEEEECCCCCCEEEE	23.05	28464451
926	Phosphorylation	EIIDNHDYSYTVKYT EEECCCCCEEEEEEE	8.95	26437602
927	Phosphorylation	IIDNHDYSYTVKYTA EECCCCCEEEEEEEE	22.01	-
954	Phosphorylation	GGDPVPKSPFVVNVA CCCCCCCCCEEEEEC	19.94	26657352
968	Acetylation	APPLDLSKIKVQGLN CCCCCHHHCEEECCC	54.57	23236377
970	Malonylation	PLDLSKIKVQGLNSK CCCHHHCEEECCCCE	32.04	26320211
976	Phosphorylation	IKVQGLNSKVAVGQE CEEECCCCEEECCCC	33.28	26437602
1002	Methylation	GQGQLDVRMTSPSRR CCCCEEEEECCCCCC	23.48	-
1004	Phosphorylation	GQLDVRMTSPSRRPI CCEEEEECCCCCCCC	27.24	23186163
1005	Phosphorylation	QLDVRMTSPSRRPIP CEEEEECCCCCCCCC	16.13	23917254
1007	Phosphorylation	DVRMTSPSRRPIPCK EEEECCCCCCCCCCE	40.46	23186163
1014	Acetylation	SRRPIPCKLEPGGGA CCCCCCCEECCCCCC	51.00	23236377
1014	Malonylation	SRRPIPCKLEPGGGA CCCCCCCEECCCCCC	51.00	26320211
1014	Ubiquitination	SRRPIPCKLEPGGGA CCCCCCCEECCCCCC	51.00	-
1028	Phosphorylation	AEAQAVRYMPPEEGP CCEEEEEECCCCCCC	13.84	23532336
1029	Sulfoxidation	EAQAVRYMPPEEGPY CEEEEEECCCCCCCE	2.90	30846556
1042	Phosphorylation	PYKVDITYDGHPVPG CEEEEEEECCEECCC	21.91	22199227
1050	Phosphorylation	DGHPVPGSPFAVEGV CCEECCCCCEEEEEE	15.69	26657352
1068	Phosphorylation	DPSKVCAYGPGLKGG CHHHCEECCCCCCCC	20.80	23917254
1073	Ubiquitination	CAYGPGLKGGLVGTP EECCCCCCCCCCCCC	57.77	-
1079	Phosphorylation	LKGGLVGTPAPFSID CCCCCCCCCCCCEEE	14.59	26657352
1084	Phosphorylation	VGTPAPFSIDTKGAG CCCCCCCEEECCCCC	20.63	30266825
1087	Phosphorylation	PAPFSIDTKGAGTGG CCCCEEECCCCCCCC	29.70	25867546
1103	S-nitrosocysteine	GLTVEGPCEAKIECQ CCEEECCCEEEEEEE	13.44	-
1103	Glutathionylation	GLTVEGPCEAKIECQ CCEEECCCEEEEEEE	13.44	22555962
1103	S-nitrosylation	GLTVEGPCEAKIECQ CCEEECCCEEEEEEE	13.44	20140087
1156	Phosphorylation	IRPVFDPSKVRASGP EEECCCHHHCCCCCC	45.70	26437602
1161	Phosphorylation	DPSKVRASGPGLERG CHHHCCCCCCCCCCC	34.65	22817900
1237	Malonylation	YGGHPVPKFPTRVHV ECCEECCCCCCEEEE	65.30	32601280
1240	Phosphorylation	HPVPKFPTRVHVQPA EECCCCCCEEEEECC	48.75	23312004
1250	Phosphorylation	HVQPAVDTSGVKVSG EEECCCCCCCCEEEC	22.30	29514088
1251	Phosphorylation	VQPAVDTSGVKVSGP EECCCCCCCCEEECC	36.81	26699800
1256	Phosphorylation	DTSGVKVSGPGVEPH CCCCCEEECCCCCCC	33.29	26437602
1279	Phosphorylation	EFTVDARSLTATGGN EEEEECCEEEECCCC	31.62	26657352
1281	Phosphorylation	TVDARSLTATGGNHV EEECCEEEECCCCEE	24.34	23312004
1283	Phosphorylation	DARSLTATGGNHVTA ECCEEEECCCCEEEE	40.15	26437602
1289	Phosphorylation	ATGGNHVTARVLNPS ECCCCEEEEEEECCC	10.95	26437602
1296	Phosphorylation	TARVLNPSGAKTDTY EEEEECCCCCCCCEE	50.76	26437602
1299	Acetylation	VLNPSGAKTDTYVTD EECCCCCCCCEEEEE	50.92	23236377
1299	Malonylation	VLNPSGAKTDTYVTD EECCCCCCCCEEEEE	50.92	26320211
1299	Ubiquitination	VLNPSGAKTDTYVTD EECCCCCCCCEEEEE	50.92	-
1300	Phosphorylation	LNPSGAKTDTYVTDN ECCCCCCCCEEEEEC	32.80	23403867
1302	Phosphorylation	PSGAKTDTYVTDNGD CCCCCCCEEEEECCC	25.73	23403867
1303	Phosphorylation	SGAKTDTYVTDNGDG CCCCCCEEEEECCCC	12.26	22817900
1305	Phosphorylation	AKTDTYVTDNGDGTY CCCCEEEEECCCCEE	17.21	23403867
1311	Phosphorylation	VTDNGDGTYRVQYTA EEECCCCEEEEEEEE	16.94	23403867
1312	Phosphorylation	TDNGDGTYRVQYTAY EECCCCEEEEEEEEE	17.83	23403867
1337	Acetylation	YDEVAVPKSPFRVGV ECCCCCCCCCCCEEC	65.25	30588827
1338	Phosphorylation	DEVAVPKSPFRVGVT CCCCCCCCCCCEECC	24.17	24961811
1348	S-nitrosylation	RVGVTEGCDPTRVRA CEECCCCCCCCCEEE	4.63	2212679
1367	Acetylation	LEGGLVNKANRFTVE CCCCCCCCCCCEEEE	39.29	22424773
1367	Malonylation	LEGGLVNKANRFTVE CCCCCCCCCCCEEEE	39.29	26320211
1367	Ubiquitination	LEGGLVNKANRFTVE CCCCCCCCCCCEEEE	39.29	-
1391	Phosphorylation	GLAIEGPSEAKMSCK EEEEECCCCCCCCCC	62.13	22210691
1396	Phosphorylation	GPSEAKMSCKDNKDG CCCCCCCCCCCCCCC	19.80	26437602
1413	Phosphorylation	TVEYIPFTPGDYDVN EEEEECCCCCCEEEE	22.47	26657352
1438	Acetylation	SPFRVPVKDVVDPGK CCCCCCCCCCCCCCC	38.44	23236377
1438	Malonylation	SPFRVPVKDVVDPGK CCCCCCCCCCCCCCC	38.44	26320211
1445	Malonylation	KDVVDPGKVKCSGPG CCCCCCCCEECCCCC	43.86	26320211
1447	Malonylation	VVDPGKVKCSGPGLG CCCCCCEECCCCCCC	26.60	26320211
1449	Phosphorylation	DPGKVKCSGPGLGAG CCCCEECCCCCCCCC	42.16	26437602
1464	Phosphorylation	VRARVPQTFTVDCSQ CEEECCCEEEEEHHH	18.40	26437602
1466	Phosphorylation	ARVPQTFTVDCSQAG EECCCEEEEEHHHCC	20.87	30631047
1506	Phosphorylation	GTHTVHYTPATDGPY CCEEEEEECCCCCCE	7.50	26437602
1519	Phosphorylation	PYTVAVKYADQEVPR CEEEEEEECCCCCCC	14.60	26657352
1527	Phosphorylation	ADQEVPRSPFKIKVL CCCCCCCCCCEEEEE	28.72	30266825
1532	Ubiquitination	PRSPFKIKVLPAHDA CCCCCEEEEEECCCH	38.01	-
1540	Phosphorylation	VLPAHDASKVRASGP EEECCCHHHCCCCCC	37.43	26437602
1545	Phosphorylation	DASKVRASGPGLNAS CHHHCCCCCCCCCCC	34.65	26437602
1552	Phosphorylation	SGPGLNASGIPASLP CCCCCCCCCCCCCCC	35.86	25002506
1557	Phosphorylation	NASGIPASLPVEFTI CCCCCCCCCCEEEEE	28.05	25002506
1602	Phosphorylation	DGTYTVSYLPDMSGR CCEEEEEECCCCCCC	20.23	-
1623	Phosphorylation	YGGDEIPYSPFRIHA ECCEECCCCCEEEEE	34.34	26657352
1624	Phosphorylation	GGDEIPYSPFRIHAL CCEECCCCCEEEEEE	16.53	26699800
1633	Phosphorylation	FRIHALPTGDASKCL EEEEEECCCCCCCEE	48.85	30266825
1637	Phosphorylation	ALPTGDASKCLVTVS EECCCCCCCEEEEEE	28.74	26437602
1728	Phosphorylation	GGEHIPNSPFHVLAC CCEECCCCCEEEEEE	24.48	26657352
1745	Phosphorylation	LPHEEEPSEVPQLRQ CCCCCCCCCCCCCCC	55.28	26699800
1754	Phosphorylation	VPQLRQPYAPPRPGA CCCCCCCCCCCCCCC	24.33	23917254
1799	Phosphorylation	AVQKGELTGEVRMPS EEECCCCEEEEECCC	27.30	26699800
1809	Phosphorylation	VRMPSGKTARPNITD EECCCCCCCCCCCCC	31.27	29396449
1815	Phosphorylation	KTARPNITDNKDGTI CCCCCCCCCCCCCCE	39.91	26437602
1818	Acetylation	RPNITDNKDGTITVR CCCCCCCCCCCEEEE	61.41	23236377
1818	Malonylation	RPNITDNKDGTITVR CCCCCCCCCCCEEEE	61.41	26320211
1821	Phosphorylation	ITDNKDGTITVRYAP CCCCCCCCEEEEECC	24.49	-
1823	Phosphorylation	DNKDGTITVRYAPTE CCCCCCEEEEECCCC	9.96	-
1826	Phosphorylation	DGTITVRYAPTEKGL CCCEEEEECCCCCCC	16.76	29978859
1829	Phosphorylation	ITVRYAPTEKGLHQM EEEEECCCCCCCCCC	42.00	29978859
1831	Acetylation	VRYAPTEKGLHQMGI EEECCCCCCCCCCEE	70.06	23236377
1831	Malonylation	VRYAPTEKGLHQMGI EEECCCCCCCCCCEE	70.06	26320211
1836	Sulfoxidation	TEKGLHQMGIKYDGN CCCCCCCCEEEECCC	4.11	30846556
1848	Phosphorylation	DGNHIPGSPLQFYVD CCCCCCCCCEEEEHH	19.65	26657352
1865	Phosphorylation	NSRHVSAYGPGLSHG HCCCCEECCCCCCCC	19.15	23917254
1893	Phosphorylation	DAGEGGLSLAVEGPS CCCCCCEEEEEECCC	19.98	26437602
1900	Phosphorylation	SLAVEGPSKAEITCK EEEEECCCCCEEEEE	56.19	23911959
1913	Phosphorylation	CKDNKDGTCTVSYLP EECCCCCEEEEEECC	18.35	25002506
1915	Phosphorylation	DNKDGTCTVSYLPTA CCCCCEEEEEECCCC	16.60	25002506
1917	Phosphorylation	KDGTCTVSYLPTAPG CCCEEEEEECCCCCC	11.64	25002506
1918	Phosphorylation	DGTCTVSYLPTAPGD CCEEEEEECCCCCCC	16.62	25002506
1921	Phosphorylation	CTVSYLPTAPGDYSI EEEEECCCCCCCEEE	42.78	25002506
1926	Phosphorylation	LPTAPGDYSIIVRFD CCCCCCCEEEEEEEC	14.00	25002506
1927	Phosphorylation	PTAPGDYSIIVRFDD CCCCCCEEEEEEECC	15.58	25002506
1935	Acetylation	IIVRFDDKHIPGSPF EEEEECCCCCCCCCE	45.32	23236377
1940	Phosphorylation	DDKHIPGSPFTAKIT CCCCCCCCCEEEEEC	16.10	25002506
1943	Phosphorylation	HIPGSPFTAKITGDD CCCCCCEEEEECCCC	30.35	25002506
1947	Phosphorylation	SPFTAKITGDDSMRT CCEEEEECCCCCCCC	33.57	28787133
1954	Phosphorylation	TGDDSMRTSQLNVGT CCCCCCCCEEECCCC	16.51	26437602
1955	Phosphorylation	GDDSMRTSQLNVGTS CCCCCCCEEECCCCC	23.47	28787133
1962	Phosphorylation	SQLNVGTSTDVSLKI EEECCCCCCCEEEEE	19.38	26437602
1963	Phosphorylation	QLNVGTSTDVSLKIT EECCCCCCCEEEEEC	40.01	28787133
1970	Phosphorylation	TDVSLKITESDLSQL CCEEEEECHHHHHHH	28.05	26699800
1972	Phosphorylation	VSLKITESDLSQLTA EEEEECHHHHHHHEE	34.89	26657352
1975	Phosphorylation	KITESDLSQLTASIR EECHHHHHHHEEEEE	28.30	26699800
1978	Phosphorylation	ESDLSQLTASIRAPS HHHHHHHEEEEECCC	15.66	26437602
1980	Phosphorylation	DLSQLTASIRAPSGN HHHHHEEEEECCCCC	13.84	-
1985	Phosphorylation	TASIRAPSGNEEPCL EEEEECCCCCCCCCH	53.95	26437602
1994	Acetylation	NEEPCLLKRLPNRHI CCCCCHHHCCCCCCE	38.65	18527217
1994	Ubiquitination	NEEPCLLKRLPNRHI CCCCCHHHCCCCCCE	38.65	-
2004	Phosphorylation	PNRHIGISFTPKEVG CCCCEEEEECCHHHC	20.18	23312004
2006	Phosphorylation	RHIGISFTPKEVGEH CCEEEEECCHHHCCE	27.02	26437602
2016	Phosphorylation	EVGEHVVSVRKSGKH HHCCEEEEEECCCCC	18.34	20068231
2025	Phosphorylation	RKSGKHVTNSPFKIL ECCCCCCCCCCCEEE	29.69	30266825
2027	Phosphorylation	SGKHVTNSPFKILVG CCCCCCCCCCEEEEC	23.50	30266825
2030	Acetylation	HVTNSPFKILVGPSE CCCCCCCEEEECHHH	38.22	23236377
2030	Malonylation	HVTNSPFKILVGPSE CCCCCCCEEEECHHH	38.22	26320211
2030	Ubiquitination	HVTNSPFKILVGPSE CCCCCCCEEEECHHH	38.22	-
2042	Phosphorylation	PSEIGDASKVRVWGK HHHCCCHHEEEEEEC	36.10	26437602
2043	Malonylation	SEIGDASKVRVWGKG HHCCCHHEEEEEECC	35.46	26320211
2071	Phosphorylation	VDTRNAGYGGLGLSI EECCCCCCCCCEEEE	12.95	25003641
2077	Phosphorylation	GYGGLGLSIEGPSKV CCCCCEEEEECCCEE	19.45	26437602
2122	Phosphorylation	ADKHVPGSPFTVKVT CCCCCCCCCEEEEEE	15.69	26699800
2125	Phosphorylation	HVPGSPFTVKVTGEG CCCCCCEEEEEECCC	23.85	26699800
2127	Ubiquitination	PGSPFTVKVTGEGRM CCCCEEEEEECCCCC	30.90	-
2129	Phosphorylation	SPFTVKVTGEGRMKE CCEEEEEECCCCCCH	24.65	26437602
2137	Phosphorylation	GEGRMKESITRRRQA CCCCCCHHHHCCCCC	24.60	26437602
2139	Phosphorylation	GRMKESITRRRQAPS CCCCHHHHCCCCCCC	27.66	24719451
2146	Phosphorylation	TRRRQAPSIATIGST HCCCCCCCEEEECCC	28.06	26657352
2149	Phosphorylation	RQAPSIATIGSTCDL CCCCCEEEECCCCCE	24.97	26657352
2152	Phosphorylation	PSIATIGSTCDLNLK CCEEEECCCCCEEEE	23.24	26437602
2153	Phosphorylation	SIATIGSTCDLNLKI CEEEECCCCCEEEEC	12.58	26657352
2167	Sulfoxidation	IPGNWFQMVSAQERL CCCCHHHHEEHHHHH	1.55	30846556
2177	Phosphorylation	AQERLTRTFTRSSHT HHHHHHCCCCCCCCC	24.91	26437602
2179	Phosphorylation	ERLTRTFTRSSHTYT HHHHCCCCCCCCCEE	29.09	28555341
2181	Phosphorylation	LTRTFTRSSHTYTRT HHCCCCCCCCCEEEE	24.34	26657352
2182	Phosphorylation	TRTFTRSSHTYTRTE HCCCCCCCCCEEEEE	19.29	26699800
2184	Phosphorylation	TFTRSSHTYTRTERT CCCCCCCCEEEEEEE	28.65	26699800
2186	Phosphorylation	TRSSHTYTRTERTEI CCCCCCEEEEEEEEE	32.07	26437602
2188	Phosphorylation	SSHTYTRTERTEISK CCCCEEEEEEEEEEE	23.24	26437602
2191	Phosphorylation	TYTRTERTEISKTRG CEEEEEEEEEEECCC	31.29	26437602
2233	Phosphorylation	LGRERLGSFGSITRQ HCCCCCCCCCCCCCC	30.90	19664994
2236	Phosphorylation	ERLGSFGSITRQQEG CCCCCCCCCCCCCCC	20.83	19664994
2238	Phosphorylation	LGSFGSITRQQEGEA CCCCCCCCCCCCCCC	24.91	30266825
2250	Sulfoxidation	GEASSQDMTAQVTSP CCCCCCCCEEEEECC	2.31	30846556
2256	Phosphorylation	DMTAQVTSPSGKVEA CCEEEEECCCCCEEE	20.43	26657352
2272	Phosphorylation	EIVEGEDSAYSVRFV EEEECCCCCEEEEEE	25.46	26699800
2274	Phosphorylation	VEGEDSAYSVRFVPQ EECCCCCEEEEEECH	16.20	23403867
2275	Phosphorylation	EGEDSAYSVRFVPQE ECCCCCEEEEEECHH	13.41	26699800
2283	Sulfoxidation	VRFVPQEMGPHTVAV EEEECHHHCCCEEEE	9.48	30846556
2283 (in isoform 2)	Ubiquitination	-	9.48	21890473
2291	Acetylation	GPHTVAVKYRGQHVP CCCEEEEEECCCCCC	21.35	23236377
2291	Malonylation	GPHTVAVKYRGQHVP CCCEEEEEECCCCCC	21.35	26320211
2291	Ubiquitination	GPHTVAVKYRGQHVP CCCEEEEEECCCCCC	21.35	-
2293	Methylation	HTVAVKYRGQHVPGS CEEEEEECCCCCCCC	32.36	-
2300	Phosphorylation	RGQHVPGSPFQFTVG CCCCCCCCCCEEEEE	19.23	26657352
2305	Phosphorylation	PGSPFQFTVGPLGEG CCCCCEEEEECCCCC	17.48	28857561
2316	Methylation	LGEGGAHKVRAGGTG CCCCCCCEECCCCCC	32.65	-
2316	Ubiquitination	LGEGGAHKVRAGGTG CCCCCCCEECCCCCC	32.65	21890473
2316 (in isoform 1)	Ubiquitination	-	32.65	21890473
2336	Phosphorylation	AGVPAEFSIWTREAG CCCCEEEEEEECCCC	14.55	23917254
2348	Phosphorylation	EAGAGGLSIAVEGPS CCCCCCEEEEEECCC	16.27	23403867
2368	Phosphorylation	FEDRKDGSCGVSYVV EEECCCCCCEEEEEE	20.17	21406692
2372	Phosphorylation	KDGSCGVSYVVQEPG CCCCCEEEEEEECCC	9.48	21406692
2373	Phosphorylation	DGSCGVSYVVQEPGD CCCCEEEEEEECCCC	11.39	21406692
2381	Phosphorylation	VVQEPGDYEVSIKFN EEECCCCEEEEEEEC	24.93	21406692
2384	Phosphorylation	EPGDYEVSIKFNDEH CCCCEEEEEEECCCC	14.23	21406692
2395	Phosphorylation	NDEHIPDSPFVVPVA CCCCCCCCCEEEEEE	18.19	26657352
2412	Phosphorylation	SDDARRLTVTSLQET CHHHHHEEEEEHHHH	21.67	30266825
2414	Phosphorylation	DARRLTVTSLQETGL HHHHEEEEEHHHHCC	20.63	30266825
2415	Phosphorylation	ARRLTVTSLQETGLK HHHEEEEEHHHHCCC	24.58	30266825
2419	Phosphorylation	TVTSLQETGLKVNQP EEEEHHHHCCCCCCC	34.55	21406692
2428	Phosphorylation	LKVNQPASFAVQLNG CCCCCCCEEEEECCC	22.03	26437602
2446	Phosphorylation	VIDARVHTPSGAVEE EEEEEEECCCCCCEE	19.12	26657352
2448	Phosphorylation	DARVHTPSGAVEECY EEEEECCCCCCEEEE	40.31	26657352
2455	Phosphorylation	SGAVEECYVSELDSD CCCCEEEEEEECCCC	15.41	23312004
2457	Phosphorylation	AVEECYVSELDSDKH CCEEEEEEECCCCCC	13.13	23312004
2461	Phosphorylation	CYVSELDSDKHTIRF EEEEECCCCCCEEEE	62.27	26437602
2463	Malonylation	VSELDSDKHTIRFIP EEECCCCCCEEEEEE	46.75	26320211
2490	O-linked_Glycosylation	NGAHIPGSPFKIRVG CCEECCCCCEEEEEC	23.08	30379171
2490	Phosphorylation	NGAHIPGSPFKIRVG CCEECCCCCEEEEEC	23.08	22199227
2493	Acetylation	HIPGSPFKIRVGEQS ECCCCCEEEEECCCC	32.74	30588821
2566	Sulfoxidation	HVVTYTPMAPGNYLI EEEEEECCCCCCEEE	5.61	30846556
2577	Phosphorylation	NYLIAIKYGGPQHIV CEEEEEEECCCCCEE	22.62	-
2586	Phosphorylation	GPQHIVGSPFKAKVT CCCCEECCCCCCEEC	19.10	22199227
2589	Malonylation	HIVGSPFKAKVTGPR CEECCCCCCEECCCC	51.16	26320211
2593	Phosphorylation	SPFKAKVTGPRLSGG CCCCCEECCCCCCCC	40.54	26699800
2598	Phosphorylation	KVTGPRLSGGHSLHE EECCCCCCCCCCCCC	43.97	30266825
2602	Phosphorylation	PRLSGGHSLHETSTV CCCCCCCCCCCCCEE	34.39	30266825
2606	Phosphorylation	GGHSLHETSTVLVET CCCCCCCCCEEEEEE	20.96	30266825
2607	Phosphorylation	GHSLHETSTVLVETV CCCCCCCCEEEEEEE	17.34	29523821
2608	Phosphorylation	HSLHETSTVLVETVT CCCCCCCEEEEEEEC	25.86	22617229
2613	Phosphorylation	TSTVLVETVTKSSSS CCEEEEEEECCCCCC	26.46	23312004
2615	Phosphorylation	TVLVETVTKSSSSRG EEEEEEECCCCCCCC	32.40	-
2617	Phosphorylation	LVETVTKSSSSRGSS EEEEECCCCCCCCCC	26.53	23403867
2618	Phosphorylation	VETVTKSSSSRGSSY EEEECCCCCCCCCCC	33.61	23403867
2619	Phosphorylation	ETVTKSSSSRGSSYS EEECCCCCCCCCCCC	31.01	23403867
2620	Phosphorylation	TVTKSSSSRGSSYSS EECCCCCCCCCCCCC	42.48	23403867
2623	Phosphorylation	KSSSSRGSSYSSIPK CCCCCCCCCCCCCCC	25.62	30266825
2624	Phosphorylation	SSSSRGSSYSSIPKF CCCCCCCCCCCCCCC	31.68	23911959
2625	Phosphorylation	SSSRGSSYSSIPKFS CCCCCCCCCCCCCCC	14.24	30266825
2626	Phosphorylation	SSRGSSYSSIPKFSS CCCCCCCCCCCCCCC	24.60	30266825
2627	Phosphorylation	SRGSSYSSIPKFSSD CCCCCCCCCCCCCCC	34.38	30266825
2630	Acetylation	SSYSSIPKFSSDASK CCCCCCCCCCCCCHH	57.09	23236377
2630	Ubiquitination	SSYSSIPKFSSDASK CCCCCCCCCCCCCHH	57.09	-
2632	Phosphorylation	YSSIPKFSSDASKVV CCCCCCCCCCCHHCE	33.17	22199227
2633	Phosphorylation	SSIPKFSSDASKVVT CCCCCCCCCCHHCEE	40.09	22199227
2636	Phosphorylation	PKFSSDASKVVTRGP CCCCCCCHHCEECCC	30.85	26699800
2637	Malonylation	KFSSDASKVVTRGPG CCCCCCHHCEECCCC	42.31	26320211
2646	Phosphorylation	VTRGPGLSQAFVGQK EECCCCCCCHHCCCC	25.94	26437602
2653	Malonylation	SQAFVGQKNSFTVDC CCHHCCCCCEEEEEC	48.94	26320211
2653	Ubiquitination	SQAFVGQKNSFTVDC CCHHCCCCCEEEEEC	48.94	-
2655	Phosphorylation	AFVGQKNSFTVDCSK HHCCCCCEEEEECHH	29.36	26657352
2657	Phosphorylation	VGQKNSFTVDCSKAG CCCCCEEEEECHHCC	18.43	29632367
2661	Phosphorylation	NSFTVDCSKAGTNMM CEEEEECHHCCCCEE	22.52	29632367
2665	Phosphorylation	VDCSKAGTNMMMVGV EECHHCCCCEEEEEE	25.46	29632367
2667	Sulfoxidation	CSKAGTNMMMVGVHG CHHCCCCEEEEEECC	1.52	30846556
2668	Sulfoxidation	SKAGTNMMMVGVHGP HHCCCCEEEEEECCC	1.82	30846556
2669	Sulfoxidation	KAGTNMMMVGVHGPK HCCCCEEEEEECCCC	1.33	30846556
2676	Malonylation	MVGVHGPKTPCEEVY EEEECCCCCCCEEEE	70.46	26320211
2677	Phosphorylation	VGVHGPKTPCEEVYV EEECCCCCCCEEEEE	35.98	29632367
2683	Phosphorylation	KTPCEEVYVKHMGNR CCCCEEEEEEECCCE	13.68	29632367
2685	Acetylation	PCEEVYVKHMGNRVY CCEEEEEEECCCEEE	15.36	21466224
2685	Malonylation	PCEEVYVKHMGNRVY CCEEEEEEECCCEEE	15.36	26320211
2692	Phosphorylation	KHMGNRVYNVTYTVK EECCCEEEEEEEEEE	10.73	28270605
2695	Phosphorylation	GNRVYNVTYTVKEKG CCEEEEEEEEEEECC	15.16	28270605
2696	Phosphorylation	NRVYNVTYTVKEKGD CEEEEEEEEEEECCC	12.78	28270605
2697	Phosphorylation	RVYNVTYTVKEKGDY EEEEEEEEEEECCCE	18.75	28270605
2699	Acetylation	YNVTYTVKEKGDYIL EEEEEEEEECCCEEE	46.00	23236377
2699	Malonylation	YNVTYTVKEKGDYIL EEEEEEEEECCCEEE	46.00	26320211
2699	Succinylation	YNVTYTVKEKGDYIL EEEEEEEEECCCEEE	46.00	23954790
2701	Malonylation	VTYTVKEKGDYILIV EEEEEEECCCEEEEE	51.90	26320211
2704	Phosphorylation	TVKEKGDYILIVKWG EEEECCCEEEEEEEC	13.29	-
2714	Phosphorylation	IVKWGDESVPGSPFK EEEECCCCCCCCCCE	38.05	30266825
2718	Phosphorylation	GDESVPGSPFKVKVP CCCCCCCCCCEEECC	22.54	25351925

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2233	S	Phosphorylation	Kinase	AKT1	P31749	PSP
2233	S	Phosphorylation	Kinase	AKT2	P31751	PSP
2246	S	Phosphorylation	Kinase	AKT1	P31749	GPS
2623	S	Phosphorylation	Kinase	PKCA	P17252	PSP
2624	S	Phosphorylation	Kinase	PKCA	P17252	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FBXL22	Q6P050	PMID:24658274

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FLNC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FLNC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MP2K4_HUMAN	MAP2K4	physical	9006895
MYOZ1_HUMAN	MYOZ1	physical	11171996
MYOZ1_HUMAN	MYOZ1	physical	10984498
SGCD_HUMAN	SGCD	physical	10629222
SGCG_HUMAN	SGCG	physical	10629222
TRI54_HUMAN	TRIM54	physical	17360532
NU133_HUMAN	NUP133	physical	22939629
S30BP_HUMAN	SAP30BP	physical	22939629
SRSF9_HUMAN	SRSF9	physical	22939629
SF3A3_HUMAN	SF3A3	physical	22939629
KS6A2_HUMAN	RPS6KA2	physical	21988832
ANR28_HUMAN	ANKRD28	physical	22863883
AP3S1_HUMAN	AP3S1	physical	22863883
BIG2_HUMAN	ARFGEF2	physical	22863883
IKKB_HUMAN	IKBKB	physical	22863883
NUP88_HUMAN	NUP88	physical	22863883
PSD12_HUMAN	PSMD12	physical	22863883
PSD13_HUMAN	PSMD13	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
TXNL1_HUMAN	TXNL1	physical	22863883
SYNP2_HUMAN	SYNPO2	physical	20554076
XIRP1_HUMAN	XIRP1	physical	16631741

Drug and Disease Associations

Kegg Disease
H00595	Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myot
OMIM Disease
609524	Myopathy, myofibrillar, 5 (MFM5)
614065	Myopathy, distal, 4 (MPD4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FLNC_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2233, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1161, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-770, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2683, AND MASSSPECTROMETRY.	18083107 [Abstract]