dbPTM

PSMD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PSMD3_HUMAN
UniProt AC	O43242
Protein Name	26S proteasome non-ATPase regulatory subunit 3
Gene Name	PSMD3
Organism	Homo sapiens (Human).
Sequence Length	534
Subcellular Localization
Protein Description	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
Protein Sequence	MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Sumoylation	------MKQEGSARR ------CCCCCCCCC	57.99	-
2	Acetylation	------MKQEGSARR ------CCCCCCCCC	57.99	25953088
2	Sumoylation	------MKQEGSARR ------CCCCCCCCC	57.99	-
6	Phosphorylation	--MKQEGSARRRGAD --CCCCCCCCCCCCC	20.18	26074081
14	Acetylation	ARRRGADKAKPPPGG CCCCCCCCCCCCCCC	58.75	23954790
14	Ubiquitination	ARRRGADKAKPPPGG CCCCCCCCCCCCCCC	58.75	22817900
16	Acetylation	RRGADKAKPPPGGGE CCCCCCCCCCCCCCC	64.89	23236377
16	Ubiquitination	RRGADKAKPPPGGGE CCCCCCCCCCCCCCC	64.89	21906983
38	Sumoylation	APQDVEMKEEAATGG CCCCCCCHHHHHCCC	38.61	25114211
38	Ubiquitination	APQDVEMKEEAATGG CCCCCCCHHHHHCCC	38.61	21906983
43	Phosphorylation	EMKEEAATGGGSTGE CCHHHHHCCCCCCCC	43.33	29255136
47	Phosphorylation	EAATGGGSTGEADGK HHHCCCCCCCCCCHH	36.19	23401153
48	Phosphorylation	AATGGGSTGEADGKT HHCCCCCCCCCCHHH	42.17	29255136
54	Ubiquitination	STGEADGKTAAAAAE CCCCCCHHHHHHHHH	35.22	21890473
54	Acetylation	STGEADGKTAAAAAE CCCCCCHHHHHHHHH	35.22	26051181
54	Ubiquitination	STGEADGKTAAAAAE CCCCCCHHHHHHHHH	35.22	21906983
56	Ubiquitination	GEADGKTAAAAAEHS CCCCHHHHHHHHHHH	9.89	-
63	Phosphorylation	AAAAAEHSQRELDTV HHHHHHHHHHHHCCC	23.57	28258704
69	Phosphorylation	HSQRELDTVTLEDIK HHHHHHCCCCHHHHH	28.19	25338102
71	Ubiquitination	QRELDTVTLEDIKEH HHHHCCCCHHHHHHH	26.90	-
76	Ubiquitination	TVTLEDIKEHVKQLE CCCHHHHHHHHHHHH	54.83	21890473
76	2-Hydroxyisobutyrylation	TVTLEDIKEHVKQLE CCCHHHHHHHHHHHH	54.83	-
76	Acetylation	TVTLEDIKEHVKQLE CCCHHHHHHHHHHHH	54.83	23236377
76	Ubiquitination	TVTLEDIKEHVKQLE CCCHHHHHHHHHHHH	54.83	21906983
80	2-Hydroxyisobutyrylation	EDIKEHVKQLEKAVS HHHHHHHHHHHHHHC	51.58	-
80	Ubiquitination	EDIKEHVKQLEKAVS HHHHHHHHHHHHHHC	51.58	22817900
84	2-Hydroxyisobutyrylation	EHVKQLEKAVSGKEP HHHHHHHHHHCCCCC	63.78	-
84	Acetylation	EHVKQLEKAVSGKEP HHHHHHHHHHCCCCC	63.78	25953088
84	Ubiquitination	EHVKQLEKAVSGKEP HHHHHHHHHHCCCCC	63.78	33845483
85	Ubiquitination	HVKQLEKAVSGKEPR HHHHHHHHHCCCCCH	7.42	-
89	Ubiquitination	LEKAVSGKEPRFVLR HHHHHCCCCCHHHHH	57.97	-
104	O-linked_Glycosylation	ALRMLPSTSRRLNHY HHHCCCCCCHHHCHH	25.06	30379171
105	O-linked_Glycosylation	LRMLPSTSRRLNHYV HHCCCCCCHHHCHHH	21.53	30379171
105	Phosphorylation	LRMLPSTSRRLNHYV HHCCCCCCHHHCHHH	21.53	-
115	Ubiquitination	LNHYVLYKAVQGFFT HCHHHHHHHHHCCCC	37.61	16196087
123	Phosphorylation	AVQGFFTSNNATRDF HHHCCCCCCCCCCCC	23.95	26437602
131	Ubiquitination	NNATRDFLLPFLEEP CCCCCCCHHHHHCCC	7.51	-
135	Ubiquitination	RDFLLPFLEEPMDTE CCCHHHHHCCCCCCC	7.42	-
139	Sulfoxidation	LPFLEEPMDTEADLQ HHHHCCCCCCCCCCC	12.93	30846556
158	Ubiquitination	TGKAASTPLLPEVEA CCCCCCCCCHHHHHH	29.42	-
186	Acetylation	KRYKEAQKISDDLMQ HHHHHHHHHCHHHHH	51.75	25953088
186	Malonylation	KRYKEAQKISDDLMQ HHHHHHHHHCHHHHH	51.75	26320211
186	Ubiquitination	KRYKEAQKISDDLMQ HHHHHHHHHCHHHHH	51.75	29967540
192	Sulfoxidation	QKISDDLMQKISTQN HHHCHHHHHHHHHCH	4.99	21406390
194	Ubiquitination	ISDDLMQKISTQNRR HCHHHHHHHHHCHHH	25.34	21906983
209	2-Hydroxyisobutyrylation	ALDLVAAKCYYYHAR HHHHHHHHHHHHHHH	17.03	-
209	Ubiquitination	ALDLVAAKCYYYHAR HHHHHHHHHHHHHHH	17.03	33845483
218	Phosphorylation	YYYHARVYEFLDKLD HHHHHHHHHHHHHHH	8.73	28152594
223	Ubiquitination	RVYEFLDKLDVVRSF HHHHHHHHHHHHHHH	49.05	21890473
223	Acetylation	RVYEFLDKLDVVRSF HHHHHHHHHHHHHHH	49.05	25953088
223	Ubiquitination	RVYEFLDKLDVVRSF HHHHHHHHHHHHHHH	49.05	23000965
236	Ubiquitination	SFLHARLRTATLRHD HHHHHHHHHCCCCCC	19.43	-
258	Phosphorylation	LNLLLRNYLHYSLYD HHHHHHHHHCHHHHH	6.60	28152594
261	Phosphorylation	LLRNYLHYSLYDQAE HHHHHHCHHHHHHHH	9.58	29496907
264	Phosphorylation	NYLHYSLYDQAEKLV HHHCHHHHHHHHHHH	10.48	22817900
266	Ubiquitination	LHYSLYDQAEKLVSK HCHHHHHHHHHHHHC	37.55	-
269	Ubiquitination	SLYDQAEKLVSKSVF HHHHHHHHHHHCCCC	58.15	21890473
269	Ubiquitination	SLYDQAEKLVSKSVF HHHHHHHHHHHCCCC	58.15	23000965
273	Ubiquitination	QAEKLVSKSVFPEQA HHHHHHHCCCCHHHC	43.06	21890473
273	Ubiquitination	QAEKLVSKSVFPEQA HHHHHHHCCCCHHHC	43.06	23000965
287	Ubiquitination	ANNNEWARYLYYTGR CCCCHHHHHHHHHCC	24.06	-
288	Phosphorylation	NNNEWARYLYYTGRI CCCHHHHHHHHHCCC	7.42	29496907
290	Phosphorylation	NEWARYLYYTGRIKA CHHHHHHHHHCCCEE	7.05	22817900
291	Phosphorylation	EWARYLYYTGRIKAI HHHHHHHHHCCCEEE	10.50	29496907
296	2-Hydroxyisobutyrylation	LYYTGRIKAIQLEYS HHHHCCCEEEEEHHH	37.77	-
296	Acetylation	LYYTGRIKAIQLEYS HHHHCCCEEEEEHHH	37.77	27452117
296	Ubiquitination	LYYTGRIKAIQLEYS HHHHCCCEEEEEHHH	37.77	23000965
302	Ubiquitination	IKAIQLEYSEARRTM CEEEEEHHHHHHHHH	22.02	-
302	Phosphorylation	IKAIQLEYSEARRTM CEEEEEHHHHHHHHH	22.02	22817900
303	Phosphorylation	KAIQLEYSEARRTMT EEEEEHHHHHHHHHH	18.53	21815630
308	Phosphorylation	EYSEARRTMTNALRK HHHHHHHHHHHHHHH	23.85	23403867
310	Phosphorylation	SEARRTMTNALRKAP HHHHHHHHHHHHHCC	19.41	23403867
315	Ubiquitination	TMTNALRKAPQHTAV HHHHHHHHCCCCCCC	66.33	29967540
317	Acetylation	TNALRKAPQHTAVGF HHHHHHCCCCCCCCH	29.53	-
317	Ubiquitination	TNALRKAPQHTAVGF HHHHHHCCCCCCCCH	29.53	-
320	Phosphorylation	LRKAPQHTAVGFKQT HHHCCCCCCCCHHHH	20.14	23403867
323	Ubiquitination	APQHTAVGFKQTVHK CCCCCCCCHHHHHHH	22.90	-
325	2-Hydroxyisobutyrylation	QHTAVGFKQTVHKLL CCCCCCHHHHHHHHH	38.85	-
325	Ubiquitination	QHTAVGFKQTVHKLL CCCCCCHHHHHHHHH	38.85	16196087
352	Phosphorylation	RLQFRQPSLKRSLMP HHHCCCHHHHHHHHH	37.88	24719451
356	Phosphorylation	RQPSLKRSLMPYFLL CCHHHHHHHHHHHHH	27.68	28787133
358	Sulfoxidation	PSLKRSLMPYFLLTQ HHHHHHHHHHHHHHH	2.39	28183972
360	Phosphorylation	LKRSLMPYFLLTQAV HHHHHHHHHHHHHHH	7.90	29496907
364	Phosphorylation	LMPYFLLTQAVRTGN HHHHHHHHHHHHHCC	19.34	20860994
374	Ubiquitination	VRTGNLAKFNQVLDQ HHHCCHHHHHHHHHH	48.27	21890473
374	Acetylation	VRTGNLAKFNQVLDQ HHHCCHHHHHHHHHH	48.27	27452117
374	Ubiquitination	VRTGNLAKFNQVLDQ HHHCCHHHHHHHHHH	48.27	27667366
385	Ubiquitination	VLDQFGEKFQADGTY HHHHHHHHHCCCCEE	43.06	16196087
392	Phosphorylation	KFQADGTYTLIIRLR HHCCCCEEEEEEEEC	12.70	-
393	Phosphorylation	FQADGTYTLIIRLRH HCCCCEEEEEEEECC	16.00	-
404	Ubiquitination	RLRHNVIKTGVRMIS EECCHHHHHCCEEEE	34.64	-
405	Phosphorylation	LRHNVIKTGVRMISL ECCHHHHHCCEEEEE	29.77	21712546
409	Sulfoxidation	VIKTGVRMISLSYSR HHHHCCEEEEECCCC	1.96	30846556
411	Phosphorylation	KTGVRMISLSYSRIS HHCCEEEEECCCCCC	11.26	30622161
413	Phosphorylation	GVRMISLSYSRISLA CCEEEEECCCCCCHH	17.80	26356563
414	Phosphorylation	VRMISLSYSRISLAD CEEEEECCCCCCHHH	13.78	26356563
415	Phosphorylation	RMISLSYSRISLADI EEEEECCCCCCHHHH	21.55	30622161
418	Phosphorylation	SLSYSRISLADIAQK EECCCCCCHHHHHHH	19.18	26356563
425	Ubiquitination	SLADIAQKLQLDSPE CHHHHHHHHCCCCHH	29.22	21906983
430	Phosphorylation	AQKLQLDSPEDAEFI HHHHCCCCHHHHHHH	38.49	25159151
440	Ubiquitination	DAEFIVAKAIRDGVI HHHHHHHHHHHCCCE	33.19	21890473
440	Ubiquitination	DAEFIVAKAIRDGVI HHHHHHHHHHHCCCE	33.19	21906983
450	Phosphorylation	RDGVIEASINHEKGY HCCCEEEEECCCCCC	15.90	23312004
455	Acetylation	EASINHEKGYVQSKE EEEECCCCCCCCCHH	48.25	23236377
455	Malonylation	EASINHEKGYVQSKE EEEECCCCCCCCCHH	48.25	26320211
455	Ubiquitination	EASINHEKGYVQSKE EEEECCCCCCCCCHH	48.25	21963094
457	Phosphorylation	SINHEKGYVQSKEMI EECCCCCCCCCHHHE	13.34	29496907
461	Ubiquitination	EKGYVQSKEMIDIYS CCCCCCCHHHEEECC	33.92	21890473
461	Ubiquitination	EKGYVQSKEMIDIYS CCCCCCCHHHEEECC	33.92	21963094
463	Sulfoxidation	GYVQSKEMIDIYSTR CCCCCHHHEEECCCC	3.71	30846556
467	Phosphorylation	SKEMIDIYSTREPQL CHHHEEECCCCCCCH	10.55	28674419
468	Phosphorylation	KEMIDIYSTREPQLA HHHEEECCCCCCCHH	22.71	29978859
469	Phosphorylation	EMIDIYSTREPQLAF HHEEECCCCCCCHHH	23.29	29978859
481	Phosphorylation	LAFHQRISFCLDIHN HHHHHHHHHHHHHCC	16.46	27251275
490	Phosphorylation	CLDIHNMSVKAMRFP HHHHCCCCEEEECCC	26.28	24719451
492	Ubiquitination	DIHNMSVKAMRFPPK HHCCCCEEEECCCCC	29.20	21963094
499	Ubiquitination	KAMRFPPKSYNKDLE EEECCCCCCCCCCHH	66.85	29967540
500	Phosphorylation	AMRFPPKSYNKDLES EECCCCCCCCCCHHH	39.45	28152594
501	Phosphorylation	MRFPPKSYNKDLESA ECCCCCCCCCCHHHH	32.15	28152594
503	Ubiquitination	FPPKSYNKDLESAEE CCCCCCCCCHHHHHH	56.29	27667366
507	Phosphorylation	SYNKDLESAEERRER CCCCCHHHHHHHHHH	48.56	21815630
523	Methylation	QQDLEFAKEMAEDDD HHHHHHHHHHHHCCC	54.03	115975889
523	Ubiquitination	QQDLEFAKEMAEDDD HHHHHHHHHHHHCCC	54.03	29967540
532	Phosphorylation	MAEDDDDSFP----- HHHCCCCCCC-----	46.54	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
6	S	Phosphorylation	Kinase	CK2A1	P68400	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PSMD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PSMD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEM1_HUMAN	SHFM1	physical	18775730
PSMD7_HUMAN	PSMD7	physical	18775730
PSMD6_HUMAN	PSMD6	physical	18775730
PSMD8_HUMAN	PSMD8	physical	18775730
PSDE_HUMAN	PSMD14	physical	18775730
PSD12_HUMAN	PSMD12	physical	18775730
BRCA2_HUMAN	BRCA2	physical	17563742
PSMD6_HUMAN	PSMD6	physical	22939629
PSMD4_HUMAN	PSMD4	physical	22939629
PSMD8_HUMAN	PSMD8	physical	22939629
SGT1_HUMAN	SUGT1	physical	22939629
ADRM1_HUMAN	ADRM1	physical	22863883
PRS4_HUMAN	PSMC1	physical	22863883
PRS8_HUMAN	PSMC5	physical	22863883
SEM1_HUMAN	SHFM1	physical	25416956
ZBT43_HUMAN	ZBTB43	physical	25416956
CEP44_HUMAN	CEP44	physical	25416956
ADRM1_HUMAN	ADRM1	physical	26344197
CCAR2_HUMAN	CCAR2	physical	26344197
G3P_HUMAN	GAPDH	physical	26344197
GFPT1_HUMAN	GFPT1	physical	26344197
HEAT1_HUMAN	HEATR1	physical	26344197
ECM29_HUMAN	KIAA0368	physical	26344197
MCFD2_HUMAN	MCFD2	physical	26344197
MTCH1_HUMAN	MTCH1	physical	26344197
NAA15_HUMAN	NAA15	physical	26344197
NAA16_HUMAN	NAA16	physical	26344197
PPIL4_HUMAN	PPIL4	physical	26344197
PSA1_HUMAN	PSMA1	physical	26344197
PSA5_HUMAN	PSMA5	physical	26344197
PSB4_HUMAN	PSMB4	physical	26344197
PSB6_HUMAN	PSMB6	physical	26344197
PSB8_HUMAN	PSMB8	physical	26344197
PRS7_HUMAN	PSMC2	physical	26344197
PRS6A_HUMAN	PSMC3	physical	26344197
PRS6B_HUMAN	PSMC4	physical	26344197
PSD11_HUMAN	PSMD11	physical	26344197
PSD12_HUMAN	PSMD12	physical	26344197
PSD13_HUMAN	PSMD13	physical	26344197
PSDE_HUMAN	PSMD14	physical	26344197
PSMD2_HUMAN	PSMD2	physical	26344197
PSMD5_HUMAN	PSMD5	physical	26344197
PSMD6_HUMAN	PSMD6	physical	26344197
PSMD7_HUMAN	PSMD7	physical	26344197
PSMD9_HUMAN	PSMD9	physical	26344197
SNF8_HUMAN	SNF8	physical	26344197
SPRE_HUMAN	SPR	physical	26344197
STML2_HUMAN	STOML2	physical	26344197
TMOD3_HUMAN	TMOD3	physical	26344197
PLCG2_HUMAN	PLCG2	physical	25814554
TM14B_HUMAN	TMEM14B	physical	21516116
LBR_HUMAN	LBR	physical	28031328

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PSMD3_HUMAN

Related Literatures of Post-Translational Modification