XIRP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XIRP1_HUMAN
• UniProt AC: Q702N8
• Protein Name: Xin actin-binding repeat-containing protein 1
• Gene Name: XIRP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1843
• Subcellular Localization: Cell junction . Colocalizes with actin stress fibers.
• Protein Description: Protects actin filaments from depolymerization..
• Protein Sequence: MADTQTQVAPTPTMRMATAEDLPLPPPPALEDLPLPPPKESFSKFHQQRQASELRRLYRHIHPELRKNLAEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWRLDAIGEHERPAAKEPVLCGDVQATSRKFEEGSFANSTDQEPTRPQPGGGDVRAARWLFETKPLDELTGQAKELEATVREPAASGDVQGTRMLFETRPLDRLGSRPSLQEQSPLELRSEIQELKGDVKKTVKLFQTEPLCAIQDAEGAIHEVKAACREEIQSNAVRSARWLFETRPLDAINQDPSQVRVIRGISLEEGARPDVSATRWIFETQPLDAIREILVDEKDFQPSPDLIPPGPDVQQQQHLFETRALDTLKGDEEAGAEAPPKEEVVPGDVRSTLWLFETKPLDAFRDKVQVGHLQRVDPQDGEGHLSSDSSSALPFSQSAPQRDELKGDVKTFKNLFETLPLDSIGQGEVLAHGSPSREEGTDSAGQAQGIGSPVYAMQDSKGRLHALTSVSREQIVGGDVQGYRWMFETQPLDQLGRSPSTIDVVRGITRQEVVAGDVGTARWLFETQPLEMIHQREQQERQKEEGKSQGDPQPEAPPKGDVQTIRWLFETCPMSELAEKQGSEVTDPTAKAEAQSCTWMFKPQPVDRPVGSREQHLQVSQVPAGERQTDRHVFETEPLQASGRPCGRRPVRYCSRVEIPSGQVSRQKEVFQALEAGKKEEQEPRVIAGSIPAGSVHKFTWLFENCPMGSLAAESIQGGNLLEEQPMSPSGNRMQESQETAAEGTLRTLHATPGILHHGGILMEARGPGELCLAKYVLSGTGQGHPYIRKEELVSGELPRIICQVLRRPDVDQQGLLVQEDPTGQLQLKPLRLPTPGSSGNIEDMDPELQQLLACGLGTSVARTGLVMQETEQGLVALTAYSLQPRLTSKASERSSVQLLASCIDKGDLSGLHSLRWEPPADPSPVPASEGAQSLHPTESIIHVPPLDPSMGMGHLRASGATPCPPQAIGKAVPLAGEAAAPAQLQNTEKQEDSHSGQKGMAVLGKSEGATTTPPGPGAPDLLAAMQSLRMATAEAQSLHQQVLNKHKQGPTPTATSNPIQDGLRKAGATQSNIRPGGGSDPRIPAAPRKVSREEQALPRGLPGGWVTIQDGIYTAHPVRTFDPPGGVQLSQREPQSRHRETALSVQAPRPLQGGPGQSTGPGREEPGGCTQMAWGPPGKAMAEVCPGGLQAAETTLKTAPLGRHILASGPQAAGASPHPHNAFVPPPPTLPAAVTGPDFPAGAHRAEDSIQQASEPLKDPLLHSHSSPAGQRTPGGSQTKTPKLDPTMPPKKKPQLPPKPAHLTQSHPPQRLPKPLPLSPSFSSEVGQREHQRGERDTAIPQPAKVPTTVDQGHIPLARCPSGHSQPSLQHGLSTTAPRPTKNQATGSNAQSSEPPKLNALNHDPTSPQWGPGPSGEQPMEGSHQGAPESPDSLQRNQKELQGLLNQVQALEKEAASSVDVQALRRLFEAVPQLGGAAPQAPAAHQKPEASVEQAFGELTRVSTEVAQLKEQTLARLLDIEEAVHKALSSMSSLQPEASARGHFQGPPKDHSAHKISVTVSSSARPSGSGQEVGGQTAVKNQAKVECHTEAQSQVKIRNHTEARGHTASTAPSTRRQETSREYLCPPRVLPSSRDSPSSPTFISIQSATRKPLETPSFKGNPDVSVKSTQLAQDIGQALLHQKGVQDKTGKKDITQCSVQPEPAPPSASPLPRGWQKSVLELQTGPGSSQHYGAMRTVTEQYEEVDQFGNTVLMSSTTVTEQAEPPRNPGSHLGLHASPLLRQFLHSPAGFSSDLTEAETVQVSCSYSQPAAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	TQTQVAPTPTMRMAT CCCCCCCCCCCCCCC	22.96	27732954
13	Phosphorylation	TQVAPTPTMRMATAE CCCCCCCCCCCCCCC	21.64	27732954
18	Phosphorylation	TPTMRMATAEDLPLP CCCCCCCCCCCCCCC	22.64	24719451
41	Phosphorylation	PLPPPKESFSKFHQQ CCCCCHHHHHHHHHH	40.73	24719451
52	Phosphorylation	FHQQRQASELRRLYR HHHHHHHHHHHHHHH	28.91	26437602
87	Phosphorylation	VLGSEEPTEGDVQCM HHCCCCCCCCCHHHH	56.74	22468782
134	Phosphorylation	SRKFEEGSFANSTDQ CCCCCCCCCCCCCCC	25.19	22673903
138	Phosphorylation	EEGSFANSTDQEPTR CCCCCCCCCCCCCCC	29.90	26437602
139	Phosphorylation	EGSFANSTDQEPTRP CCCCCCCCCCCCCCC	41.32	22673903
144	Phosphorylation	NSTDQEPTRPQPGGG CCCCCCCCCCCCCCC	54.98	22673903
205	Phosphorylation	RPLDRLGSRPSLQEQ CCCCCCCCCCCHHHC	45.68	30266825
208	Phosphorylation	DRLGSRPSLQEQSPL CCCCCCCCHHHCCCH	41.39	30266825
213	Phosphorylation	RPSLQEQSPLELRSE CCCHHHCCCHHHHHH	30.60	30266825
268	Phosphorylation	IQSNAVRSARWLFET HHHHHHHHHHHHHHC	18.65	20166139
275	Phosphorylation	SARWLFETRPLDAIN HHHHHHHCCCCCCCC	30.19	28555341
286	Phosphorylation	DAINQDPSQVRVIRG CCCCCCHHHCEEEEE	49.99	28555341
295	Phosphorylation	VRVIRGISLEEGARP CEEEEEECCCCCCCC	32.33	30266825
332	Phosphorylation	DEKDFQPSPDLIPPG CCCCCCCCCCCCCCC	21.91	-
351	Phosphorylation	QQQHLFETRALDTLK HHHHHHHHHHHHHCC	17.57	24043423
418	Phosphorylation	EGHLSSDSSSALPFS CCCCCCCCCCCCCCC	28.30	26437602
452	Phosphorylation	FETLPLDSIGQGEVL HHHCCCCCCCCCCEE	35.98	30301811
463	Phosphorylation	GEVLAHGSPSREEGT CCEEECCCCCCCCCC	15.16	30301811
465	Phosphorylation	VLAHGSPSREEGTDS EEECCCCCCCCCCCC	54.76	30301811
470	Phosphorylation	SPSREEGTDSAGQAQ CCCCCCCCCCHHHCC	30.02	27251275
472	Phosphorylation	SREEGTDSAGQAQGI CCCCCCCCHHHCCCC	33.85	27251275
481	Phosphorylation	GQAQGIGSPVYAMQD HHCCCCCCCEEEEEC	14.85	30266825
484	Phosphorylation	QGIGSPVYAMQDSKG CCCCCCEEEEECCCC	10.35	30266825
497	Phosphorylation	KGRLHALTSVSREQI CCCEEEEEECCHHHH	28.06	23911959
498	Phosphorylation	GRLHALTSVSREQIV CCEEEEEECCHHHHC	20.95	26437602
527	Phosphorylation	PLDQLGRSPSTIDVV CHHHCCCCCHHHHHH	22.77	26437602
529	Phosphorylation	DQLGRSPSTIDVVRG HHCCCCCHHHHHHCC	38.96	30266825
530	Phosphorylation	QLGRSPSTIDVVRGI HCCCCCHHHHHHCCC	25.28	30266825
549	Phosphorylation	VVAGDVGTARWLFET EECCCCCHHHHHHCC	16.94	28290473
625	Phosphorylation	TAKAEAQSCTWMFKP HHHHHHHHCCEEECC	22.14	29978859
627	Phosphorylation	KAEAQSCTWMFKPQP HHHHHHCCEEECCCC	25.80	29978859
641	Phosphorylation	PVDRPVGSREQHLQV CCCCCCCCHHHCEEE	32.64	29978859
682	Phosphorylation	CGRRPVRYCSRVEIP CCCCCCCEEEEEEEC	8.60	26437602
684	Phosphorylation	RRPVRYCSRVEIPSG CCCCCEEEEEEECCC	30.35	30266825
690	Phosphorylation	CSRVEIPSGQVSRQK EEEEEECCCCCHHHH	47.74	23312004
694	Phosphorylation	EIPSGQVSRQKEVFQ EECCCCCHHHHHHHH	22.55	23312004
724	Phosphorylation	AGSIPAGSVHKFTWL EEECCCCCCCEEEEE	24.13	26437602
757	Phosphorylation	LLEEQPMSPSGNRMQ CCCCCCCCCCCCCCH	23.69	27251275
808	Phosphorylation	CLAKYVLSGTGQGHP EEEEHHHHCCCCCCC	25.02	27251275
810	Phosphorylation	AKYVLSGTGQGHPYI EEHHHHCCCCCCCCC	23.97	27251275
925	Phosphorylation	SKASERSSVQLLASC CCCCCCHHHHHHHHH	21.80	26437602
931	Phosphorylation	SSVQLLASCIDKGDL HHHHHHHHHCCCCCC	16.15	-
1036	Phosphorylation	GMAVLGKSEGATTTP CEEEEECCCCCCCCC	39.19	28674151
1040	Phosphorylation	LGKSEGATTTPPGPG EECCCCCCCCCCCCC	41.90	24719451
1041	Phosphorylation	GKSEGATTTPPGPGA ECCCCCCCCCCCCCH	36.45	28674151
1042	Phosphorylation	KSEGATTTPPGPGAP CCCCCCCCCCCCCHH	24.11	28674151
1057	Phosphorylation	DLLAAMQSLRMATAE HHHHHHHHHHHHHHH	12.59	28674151
1109	Phosphorylation	NIRPGGGSDPRIPAA CCCCCCCCCCCCCCC	47.95	27251275
1121	Phosphorylation	PAAPRKVSREEQALP CCCCCCCCHHHHCCC	36.69	23312004
1174	O-linked_Glycosylation	RHRETALSVQAPRPL CCCCCEEEEECCCCC	15.10	31637018
1296	Phosphorylation	DPLLHSHSSPAGQRT CCCCCCCCCCCCCCC	40.82	-
1311	Phosphorylation	PGGSQTKTPKLDPTM CCCCCCCCCCCCCCC	29.10	-
1317	Phosphorylation	KTPKLDPTMPPKKKP CCCCCCCCCCCCCCC	41.81	-
1349	Phosphorylation	LPKPLPLSPSFSSEV CCCCCCCCCCCCCHH	19.29	30266825
1351	Phosphorylation	KPLPLSPSFSSEVGQ CCCCCCCCCCCHHHH	34.09	26437602
1353	Phosphorylation	LPLSPSFSSEVGQRE CCCCCCCCCHHHHHH	29.90	30266825
1392	Phosphorylation	IPLARCPSGHSQPSL CCCCCCCCCCCCCCC	53.41	26437602
1395	Phosphorylation	ARCPSGHSQPSLQHG CCCCCCCCCCCCCCC	47.51	28348404
1398	Phosphorylation	PSGHSQPSLQHGLST CCCCCCCCCCCCCCC	32.78	26437602
1404	Phosphorylation	PSLQHGLSTTAPRPT CCCCCCCCCCCCCCC	28.45	26437602
1427	Ubiquitination	AQSSEPPKLNALNHD CCCCCCCCCCCCCCC	66.15	-
1436	Phosphorylation	NALNHDPTSPQWGPG CCCCCCCCCCCCCCC	60.13	27251275
1437	Phosphorylation	ALNHDPTSPQWGPGP CCCCCCCCCCCCCCC	22.08	30266825
1445	Phosphorylation	PQWGPGPSGEQPMEG CCCCCCCCCCCCCCC	61.96	30266825
1453	Phosphorylation	GEQPMEGSHQGAPES CCCCCCCCCCCCCCC	10.18	30266825
1460	Phosphorylation	SHQGAPESPDSLQRN CCCCCCCCHHHHHHH	32.71	30266825
1463	Phosphorylation	GAPESPDSLQRNQKE CCCCCHHHHHHHHHH	29.77	30266825
1487	Phosphorylation	ALEKEAASSVDVQAL HHHHHHHCCCCHHHH	37.63	25262027
1488	Phosphorylation	LEKEAASSVDVQALR HHHHHHCCCCHHHHH	20.01	25262027
1619	Phosphorylation	QAKVECHTEAQSQVK CCEEEEECHHHHCEE	44.68	-
1623	Phosphorylation	ECHTEAQSQVKIRNH EEECHHHHCEEECCC	43.94	-
1631	Phosphorylation	QVKIRNHTEARGHTA CEEECCCCHHCCCCC	34.58	30576142
1640	Phosphorylation	ARGHTASTAPSTRRQ HCCCCCCCCCCCCCC	39.87	30576142
1650	Phosphorylation	STRRQETSREYLCPP CCCCCCCCCHHCCCC	23.51	-
1653	Phosphorylation	RQETSREYLCPPRVL CCCCCCHHCCCCCCC	16.70	-
1662	Phosphorylation	CPPRVLPSSRDSPSS CCCCCCCCCCCCCCC	33.57	22673903
1663	Phosphorylation	PPRVLPSSRDSPSSP CCCCCCCCCCCCCCC	37.86	22673903
1666	Phosphorylation	VLPSSRDSPSSPTFI CCCCCCCCCCCCCEE	26.10	26437602
1668	Phosphorylation	PSSRDSPSSPTFISI CCCCCCCCCCCEEEE	53.56	22673903
1669	Phosphorylation	SSRDSPSSPTFISIQ CCCCCCCCCCEEEEE	31.20	19764811
1671	Phosphorylation	RDSPSSPTFISIQSA CCCCCCCCEEEEECC	35.23	22673903
1674	Phosphorylation	PSSPTFISIQSATRK CCCCCEEEEECCCCC	15.47	22673903
1677	Phosphorylation	PTFISIQSATRKPLE CCEEEEECCCCCCCC	29.91	22673903
1679	Phosphorylation	FISIQSATRKPLETP EEEEECCCCCCCCCC	44.46	22673903
1699	Phosphorylation	PDVSVKSTQLAQDIG CCCCCCHHHHHHHHH	23.14	19413330
1739	Phosphorylation	EPAPPSASPLPRGWQ CCCCCCCCCCCCCCC	31.16	24719451
1808	Phosphorylation	SHLGLHASPLLRQFL CCCCCCCHHHHHHHH	12.82	24719451
1817	Phosphorylation	LLRQFLHSPAGFSSD HHHHHHCCCCCCCCC	20.70	24043423
1822	Phosphorylation	LHSPAGFSSDLTEAE HCCCCCCCCCCCCCE	23.25	24043423
1823	Phosphorylation	HSPAGFSSDLTEAET CCCCCCCCCCCCCEE	34.09	24043423
1826	Phosphorylation	AGFSSDLTEAETVQV CCCCCCCCCCEEEEE	37.83	24043423
1830	Phosphorylation	SDLTEAETVQVSCSY CCCCCCEEEEEEEEC	24.24	24043423
1834	Phosphorylation	EAETVQVSCSYSQPA CCEEEEEEEECCCCC	4.73	24043423
1836	Phosphorylation	ETVQVSCSYSQPAAQ EEEEEEEECCCCCCC	21.95	24043423
1837	Phosphorylation	TVQVSCSYSQPAAQ- EEEEEEECCCCCCC-	18.69	24043423
1838	Phosphorylation	VQVSCSYSQPAAQ-- EEEEEECCCCCCC--	17.25	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XIRP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XIRP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XIRP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEBU_HUMAN	NEB	physical	23985323
NEBL_HUMAN	NEBL	physical	23985323
FLNC_HUMAN	FLNC	physical	23115302
ACTS_CHICK	ACTA1	physical	15454575
VASP_HUMAN	VASP	physical	16631741
ENAH_HUMAN	ENAH	physical	16631741
EVL_HUMAN	EVL	physical	16631741

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.