dbPTM

MYPN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYPN_HUMAN
UniProt AC	Q86TC9
Protein Name	Myopalladin
Gene Name	MYPN
Organism	Homo sapiens (Human).
Sequence Length	1320
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasm, myofibril, sarcomere . Cytoplasm, myofibril, sarcomere, Z line . Bound to sarcomere both at the Z-line periphery and in the central I-band region.
Protein Description	Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines..
Protein Sequence	MQDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLPDLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	QDDSIEASTSISQLL CCCHHHHHHHHHHHH	15.19	27732954
10	Phosphorylation	DDSIEASTSISQLLR CCHHHHHHHHHHHHH	36.81	28122231
11	Phosphorylation	DSIEASTSISQLLRE CHHHHHHHHHHHHHH	20.11	27732954
13	Phosphorylation	IEASTSISQLLRESY HHHHHHHHHHHHHHH	17.97	27732954
46	Phosphorylation	SNPCHFGSPSGAAEG CCCCCCCCCCCCCCC	18.23	28348404
48	Phosphorylation	PCHFGSPSGAAEGGG CCCCCCCCCCCCCCC	42.64	28348404
64	Phosphorylation	QDDLPDLSAFLSQEE CCCCCCHHHHHCHHH	25.10	28348404
68	Phosphorylation	PDLSAFLSQEELDES CCHHHHHCHHHHHHH	29.14	28348404
85	Phosphorylation	LARLAINYDPLEKAD HHHHHHCCCHHHCCC	16.90	-
90	Ubiquitination	INYDPLEKADETQAR HCCCHHHCCCHHHHH	69.67	-
101	Phosphorylation	TQARKRLSPDQMKHS HHHHHHCCHHHHCCC	30.39	25159151
108	Phosphorylation	SPDQMKHSPNLSFEP CHHHHCCCCCCCCCC	15.23	30576142
112	Phosphorylation	MKHSPNLSFEPNFCQ HCCCCCCCCCCCCCC	33.92	20068231
124	Phosphorylation	FCQDNPRSPTSSKES CCCCCCCCCCCCCCC	33.51	25159151
126	Phosphorylation	QDNPRSPTSSKESPQ CCCCCCCCCCCCCHH	47.05	30576142
127	Phosphorylation	DNPRSPTSSKESPQE CCCCCCCCCCCCHHH	42.68	29116813
128	Phosphorylation	NPRSPTSSKESPQEA CCCCCCCCCCCHHHH	42.81	30576142
131	Phosphorylation	SPTSSKESPQEAKRP CCCCCCCCHHHHCCC	35.30	25159151
136	Ubiquitination	KESPQEAKRPQYCSE CCCHHHHCCCCCCCH	64.95	-
147	Ubiquitination	YCSETQSKKVFLNKA CCCHHHCHHHHHHHH	43.04	-
163	Phosphorylation	DFIEELSSLFKSHSS HHHHHHHHHHHHCCC	50.91	24719451
167	Phosphorylation	ELSSLFKSHSSKRIR HHHHHHHHCCCCCCC	22.67	-
196	Phosphorylation	NKVMQENSSSFSDLS HHHHHHCCCCCHHHH	26.97	21815630
197	Phosphorylation	KVMQENSSSFSDLSE HHHHHCCCCCHHHHH	47.16	30576142
198	Phosphorylation	VMQENSSSFSDLSER HHHHCCCCCHHHHHH	28.70	21815630
200	Phosphorylation	QENSSSFSDLSERRE HHCCCCCHHHHHHHH	39.32	23186163
203	Phosphorylation	SSSFSDLSERRERSS CCCCHHHHHHHHHCC	33.76	26546556
209	Phosphorylation	LSERRERSSVPIPIP HHHHHHHCCCCCCCC	30.82	28555341
210	Phosphorylation	SERRERSSVPIPIPA HHHHHHCCCCCCCCC	37.83	28555341
234	Ubiquitination	ALEQQEAKRREAEQA HHHHHHHHHHHHHHH	51.76	-
243	Phosphorylation	REAEQAASEAAGGDT HHHHHHHHHHCCCCC	30.68	30576142
250	Phosphorylation	SEAAGGDTTPGSSPS HHHCCCCCCCCCCCH	37.86	25159151
251	Phosphorylation	EAAGGDTTPGSSPSS HHCCCCCCCCCCCHH	30.32	25159151
254	Phosphorylation	GGDTTPGSSPSSLYY CCCCCCCCCCHHHCC	40.03	25159151
255	Phosphorylation	GDTTPGSSPSSLYYE CCCCCCCCCHHHCCC	34.41	25159151
257	Phosphorylation	TTPGSSPSSLYYEEP CCCCCCCHHHCCCCC	34.62	25159151
258	Phosphorylation	TPGSSPSSLYYEEPL CCCCCCHHHCCCCCC	24.63	25159151
260	Phosphorylation	GSSPSSLYYEEPLGQ CCCCHHHCCCCCCCC	15.69	30576142
261	Phosphorylation	SSPSSLYYEEPLGQP CCCHHHCCCCCCCCC	21.07	18669648
385	Phosphorylation	IQKPNEVSSPPTTSA CCCCCCCCCCCCCCC	30.83	24732914
386	Phosphorylation	QKPNEVSSPPTTSAV CCCCCCCCCCCCCCC	39.82	24732914
389	Phosphorylation	NEVSSPPTTSAVIPP CCCCCCCCCCCCCCC	36.45	24732914
390	O-linked_Glycosylation	EVSSPPTTSAVIPPA CCCCCCCCCCCCCCC	22.06	30379171
390	Phosphorylation	EVSSPPTTSAVIPPA CCCCCCCCCCCCCCC	22.06	24732914
391	Phosphorylation	VSSPPTTSAVIPPAV CCCCCCCCCCCCCCC	24.02	24732914
412	Phosphorylation	VAQPRVATIQQCQSP HCCCCEEEHHHCCCC	19.23	24732914
418	Phosphorylation	ATIQQCQSPTNYLQG EEHHHCCCCCCCCCC	41.12	25159151
420	Phosphorylation	IQQCQSPTNYLQGLD HHHCCCCCCCCCCCC	41.56	24732914
422	Phosphorylation	QCQSPTNYLQGLDGK HCCCCCCCCCCCCCC	11.68	24732914
478	Phosphorylation	EGTLIEDSPDFRILQ CCCCCCCCCCCCHHC	17.36	21815630
539	Phosphorylation	VRGNEDLSNNGSLHS ECCCCCCCCCCCCCC	40.34	20068231
543	Phosphorylation	EDLSNNGSLHSANST CCCCCCCCCCCCCCC	25.65	30576142
546	Phosphorylation	SNNGSLHSANSTTNL CCCCCCCCCCCCCCC	34.14	20068231
549	Phosphorylation	GSLHSANSTTNLAAI CCCCCCCCCCCCEEE	36.00	20068231
550	Phosphorylation	SLHSANSTTNLAAIE CCCCCCCCCCCEEEC	21.36	20068231
551	Phosphorylation	LHSANSTTNLAAIEP CCCCCCCCCCEEECC	28.23	20068231
561	Phosphorylation	AAIEPQPSPPHSEPP EEECCCCCCCCCCCC	45.90	30576142
565	Phosphorylation	PQPSPPHSEPPSVEQ CCCCCCCCCCCCCCC	58.53	30576142
569	Phosphorylation	PPHSEPPSVEQPPKP CCCCCCCCCCCCCCC	49.34	20068231
590	Phosphorylation	VNHNEPRSSSRIGLR ECCCCCCCCCCEEEE	43.30	28555341
592	Phosphorylation	HNEPRSSSRIGLRVH CCCCCCCCCEEEEEE	29.21	18669648
609	Phosphorylation	LPEDDKGSEASSEAG CCCCCCCCCCCCCCC	35.41	20873877
612	Phosphorylation	DDKGSEASSEAGVVT CCCCCCCCCCCCEEE	25.35	20873877
613	Phosphorylation	DKGSEASSEAGVVTT CCCCCCCCCCCEEEC	38.21	20873877
619	Phosphorylation	SSEAGVVTTRQTRPD CCCCCEEECCCCCCC	17.54	24144214
620	Phosphorylation	SEAGVVTTRQTRPDS CCCCEEECCCCCCCC	14.79	24144214
627	Phosphorylation	TRQTRPDSFQERFNG CCCCCCCCHHHHHCC	31.35	30576142
639	Phosphorylation	FNGQATKTPEPSSPV HCCCCCCCCCCCCCC	28.64	21712546
643	Phosphorylation	ATKTPEPSSPVKEPP CCCCCCCCCCCCCCC	45.68	22167270
644	Phosphorylation	TKTPEPSSPVKEPPP CCCCCCCCCCCCCCC	44.41	22167270
660	Phosphorylation	LAKPKLDSTQLQQLH CCCCCCCHHHHHHHH	28.61	20068231
661	Phosphorylation	AKPKLDSTQLQQLHN CCCCCCHHHHHHHHH	32.72	20068231
683	Phosphorylation	QLQNPPPSSPKEFPF CCCCCCCCCCCCCCC	66.11	22167270
684	Phosphorylation	LQNPPPSSPKEFPFS CCCCCCCCCCCCCCE	45.85	22167270
697	Phosphorylation	FSMTVLNSNAPPAVT CEEEEECCCCCCCEE	30.15	29507054
704	O-linked_Glycosylation	SNAPPAVTTSSKQVK CCCCCCEECCCCCCC	24.06	30379171
704	Phosphorylation	SNAPPAVTTSSKQVK CCCCCCEECCCCCCC	24.06	30206219
705	Phosphorylation	NAPPAVTTSSKQVKA CCCCCEECCCCCCCC	25.14	30206219
706	Phosphorylation	APPAVTTSSKQVKAP CCCCEECCCCCCCCC	26.60	30206219
707	Phosphorylation	PPAVTTSSKQVKAPS CCCEECCCCCCCCCC	25.64	30206219
711	Ubiquitination	TTSSKQVKAPSSQTF ECCCCCCCCCCCCCC	52.68	-
714	O-linked_Glycosylation	SKQVKAPSSQTFSLA CCCCCCCCCCCCCCC	39.68	30379171
714	Phosphorylation	SKQVKAPSSQTFSLA CCCCCCCCCCCCCCC	39.68	22210691
715	O-linked_Glycosylation	KQVKAPSSQTFSLAR CCCCCCCCCCCCCCC	31.98	30379171
715	Phosphorylation	KQVKAPSSQTFSLAR CCCCCCCCCCCCCCC	31.98	22210691
719	Phosphorylation	APSSQTFSLARPKYF CCCCCCCCCCCCCEE	25.22	22964224
725	Phosphorylation	FSLARPKYFFPSTNT CCCCCCCEECCCCCC	17.09	22210691
749	Phosphorylation	SPVFTLSSTPQTIQR CCCEECCCCCHHHHH	47.41	22210691
750	Phosphorylation	PVFTLSSTPQTIQRT CCEECCCCCHHHHHC	18.95	22210691
757	Phosphorylation	TPQTIQRTVSKESLL CCHHHHHCCCCHHHE	16.86	26699800
759	Phosphorylation	QTIQRTVSKESLLVS HHHHHCCCCHHHEEE	30.05	22167270
760	Ubiquitination	TIQRTVSKESLLVSH HHHHCCCCHHHEEEC	47.16	-
762	Phosphorylation	QRTVSKESLLVSHPS HHCCCCHHHEEECCC	30.64	26699800
766	Phosphorylation	SKESLLVSHPSVQTK CCHHHEEECCCCCCC	29.65	26699800
769	Phosphorylation	SLLVSHPSVQTKSPG HHEEECCCCCCCCCC	22.79	26437602
813	Phosphorylation	QFQPRCVSPIPVSPT CCCCCEECCCCCCCC	22.27	16964243
818	Phosphorylation	CVSPIPVSPTSRIQN EECCCCCCCCCCCCC	19.67	16964243
820	Phosphorylation	SPIPVSPTSRIQNPV CCCCCCCCCCCCCHH	24.11	22199227
821	Phosphorylation	PIPVSPTSRIQNPVA CCCCCCCCCCCCHHH	30.67	22199227
865	Phosphorylation	QGLAKKNTKSPQPVN CCCCCCCCCCCCCCC	41.60	26462736
867	Phosphorylation	LAKKNTKSPQPVNDD CCCCCCCCCCCCCCC	27.08	25159151
879	Phosphorylation	NDDNIRETKNAVIRD CCCCHHHHHHHHHHH	21.54	24505115
880	Ubiquitination	DDNIRETKNAVIRDL CCCHHHHHHHHHHHH	37.85	-
890	Ubiquitination	VIRDLGKKITFSDVR HHHHHCCCCCHHHCC	45.22	-
892	Phosphorylation	RDLGKKITFSDVRPN HHHCCCCCHHHCCCC	26.43	20860994
894	Phosphorylation	LGKKITFSDVRPNQQ HCCCCCHHHCCCCCC	26.92	28555341
906	Phosphorylation	NQQEYKISSFEQRLM CCCEEECCHHHHHHH	25.48	23186163
907	Phosphorylation	QQEYKISSFEQRLMN CCEEECCHHHHHHHH	35.95	21815630
923	Phosphorylation	IEFRLERTPVDESDD HCHHEECCCCCCCCC	20.49	30175587
928	Phosphorylation	ERTPVDESDDEIQHD ECCCCCCCCCCCCCC	45.99	22167270
939	Phosphorylation	IQHDEIPTGKCIAPI CCCCCCCCCCCCHHH	55.74	24732914
941	Ubiquitination	HDEIPTGKCIAPIFD CCCCCCCCCCHHHHH	25.58	-
960	Phosphorylation	HFRVTEGSPVTFTCK CEEECCCCCEEEEEE	15.23	25159151
1001	Phosphorylation	MRREGDGTCSLHIES CCCCCCCCCEEEEEE	12.03	20068231
1003	Phosphorylation	REGDGTCSLHIESTT CCCCCCCEEEEEEEC	23.87	20068231
1017	Phosphorylation	TSDDDGNYTIMAANP CCCCCCCEEEEECCC	11.81	20068231
1018	Phosphorylation	SDDDGNYTIMAANPQ CCCCCCEEEEECCCC	14.31	20068231
1038	Phosphorylation	SGHLMVQSLPIRSRL CCEEEEECCCCHHHC	25.38	24719451
1043	Phosphorylation	VQSLPIRSRLTSAGQ EECCCCHHHCCCCCC	32.15	-
1047	Phosphorylation	PIRSRLTSAGQSHRG CCHHHCCCCCCCHHC	34.69	30576142
1051	Phosphorylation	RLTSAGQSHRGRSRV HCCCCCCCHHCCCCH	17.77	26437602
1145	Ubiquitination	QRDAGTYKCIATNKT HHCCCEEEEEEECCC	21.00	-
1170	Ubiquitination	VVAKEVKKAPVILEK HHHHHHHCCHHHHHH	64.20	-
1207	Ubiquitination	PPVFYWKKDNETIPC CCEEEEECCCCCCCC	52.19	-
1284	Phosphorylation	VRPSGSRYGSLTSKG CCCCCCCCCCCCCCC	16.86	22210691
1286	Phosphorylation	PSGSRYGSLTSKGLD CCCCCCCCCCCCCCC	21.38	22210691
1288	Phosphorylation	GSRYGSLTSKGLDIF CCCCCCCCCCCCCHH	30.04	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MYPN_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MYPN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYPN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTN2_HUMAN	ACTN2	physical	11309420
ACTN3_HUMAN	ACTN3	physical	11309420
NEBL_HUMAN	NEBL	physical	11309420
TITIN_HUMAN	TTN	physical	14583192
ANKR1_HUMAN	ANKRD1	physical	14583192
ANR23_HUMAN	ANKRD23	physical	14583192
ANKR1_HUMAN	ANKRD1	physical	11309420
NEBU_HUMAN	NEB	physical	11309420
MTA2_HUMAN	MTA2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615248	Cardiomyopathy, dilated 1KK (CMD1KK)
615248	Cardiomyopathy, familial hypertrophic 22 (CMH22)
615248	Cardiomyopathy, familial restrictive 4 (RCM4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYPN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-251; SER-255; SER-759;SER-813; SER-818; SER-867 AND SER-928, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101 AND SER-928, ANDMASS SPECTROMETRY.	18691976 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-813 AND SER-818, ANDMASS SPECTROMETRY.	16964243 [Abstract]