MYPN_HUMAN - dbPTM
MYPN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYPN_HUMAN
UniProt AC Q86TC9
Protein Name Myopalladin
Gene Name MYPN
Organism Homo sapiens (Human).
Sequence Length 1320
Subcellular Localization Cytoplasm . Nucleus . Cytoplasm, myofibril, sarcomere . Cytoplasm, myofibril, sarcomere, Z line . Bound to sarcomere both at the Z-line periphery and in the central I-band region.
Protein Description Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines..
Protein Sequence MQDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLPDLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationQDDSIEASTSISQLL
CCCHHHHHHHHHHHH
15.1927732954
10PhosphorylationDDSIEASTSISQLLR
CCHHHHHHHHHHHHH
36.8128122231
11PhosphorylationDSIEASTSISQLLRE
CHHHHHHHHHHHHHH
20.1127732954
13PhosphorylationIEASTSISQLLRESY
HHHHHHHHHHHHHHH
17.9727732954
46PhosphorylationSNPCHFGSPSGAAEG
CCCCCCCCCCCCCCC
18.2328348404
48PhosphorylationPCHFGSPSGAAEGGG
CCCCCCCCCCCCCCC
42.6428348404
64PhosphorylationQDDLPDLSAFLSQEE
CCCCCCHHHHHCHHH
25.1028348404
68PhosphorylationPDLSAFLSQEELDES
CCHHHHHCHHHHHHH
29.1428348404
85PhosphorylationLARLAINYDPLEKAD
HHHHHHCCCHHHCCC
16.90-
90UbiquitinationINYDPLEKADETQAR
HCCCHHHCCCHHHHH
69.67-
101PhosphorylationTQARKRLSPDQMKHS
HHHHHHCCHHHHCCC
30.3925159151
108PhosphorylationSPDQMKHSPNLSFEP
CHHHHCCCCCCCCCC
15.2330576142
112PhosphorylationMKHSPNLSFEPNFCQ
HCCCCCCCCCCCCCC
33.9220068231
124PhosphorylationFCQDNPRSPTSSKES
CCCCCCCCCCCCCCC
33.5125159151
126PhosphorylationQDNPRSPTSSKESPQ
CCCCCCCCCCCCCHH
47.0530576142
127PhosphorylationDNPRSPTSSKESPQE
CCCCCCCCCCCCHHH
42.6829116813
128PhosphorylationNPRSPTSSKESPQEA
CCCCCCCCCCCHHHH
42.8130576142
131PhosphorylationSPTSSKESPQEAKRP
CCCCCCCCHHHHCCC
35.3025159151
136UbiquitinationKESPQEAKRPQYCSE
CCCHHHHCCCCCCCH
64.95-
147UbiquitinationYCSETQSKKVFLNKA
CCCHHHCHHHHHHHH
43.04-
163PhosphorylationDFIEELSSLFKSHSS
HHHHHHHHHHHHCCC
50.9124719451
167PhosphorylationELSSLFKSHSSKRIR
HHHHHHHHCCCCCCC
22.67-
196PhosphorylationNKVMQENSSSFSDLS
HHHHHHCCCCCHHHH
26.9721815630
197PhosphorylationKVMQENSSSFSDLSE
HHHHHCCCCCHHHHH
47.1630576142
198PhosphorylationVMQENSSSFSDLSER
HHHHCCCCCHHHHHH
28.7021815630
200PhosphorylationQENSSSFSDLSERRE
HHCCCCCHHHHHHHH
39.3223186163
203PhosphorylationSSSFSDLSERRERSS
CCCCHHHHHHHHHCC
33.7626546556
209PhosphorylationLSERRERSSVPIPIP
HHHHHHHCCCCCCCC
30.8228555341
210PhosphorylationSERRERSSVPIPIPA
HHHHHHCCCCCCCCC
37.8328555341
234UbiquitinationALEQQEAKRREAEQA
HHHHHHHHHHHHHHH
51.76-
243PhosphorylationREAEQAASEAAGGDT
HHHHHHHHHHCCCCC
30.6830576142
250PhosphorylationSEAAGGDTTPGSSPS
HHHCCCCCCCCCCCH
37.8625159151
251PhosphorylationEAAGGDTTPGSSPSS
HHCCCCCCCCCCCHH
30.3225159151
254PhosphorylationGGDTTPGSSPSSLYY
CCCCCCCCCCHHHCC
40.0325159151
255PhosphorylationGDTTPGSSPSSLYYE
CCCCCCCCCHHHCCC
34.4125159151
257PhosphorylationTTPGSSPSSLYYEEP
CCCCCCCHHHCCCCC
34.6225159151
258PhosphorylationTPGSSPSSLYYEEPL
CCCCCCHHHCCCCCC
24.6325159151
260PhosphorylationGSSPSSLYYEEPLGQ
CCCCHHHCCCCCCCC
15.6930576142
261PhosphorylationSSPSSLYYEEPLGQP
CCCHHHCCCCCCCCC
21.0718669648
385PhosphorylationIQKPNEVSSPPTTSA
CCCCCCCCCCCCCCC
30.8324732914
386PhosphorylationQKPNEVSSPPTTSAV
CCCCCCCCCCCCCCC
39.8224732914
389PhosphorylationNEVSSPPTTSAVIPP
CCCCCCCCCCCCCCC
36.4524732914
390O-linked_GlycosylationEVSSPPTTSAVIPPA
CCCCCCCCCCCCCCC
22.0630379171
390PhosphorylationEVSSPPTTSAVIPPA
CCCCCCCCCCCCCCC
22.0624732914
391PhosphorylationVSSPPTTSAVIPPAV
CCCCCCCCCCCCCCC
24.0224732914
412PhosphorylationVAQPRVATIQQCQSP
HCCCCEEEHHHCCCC
19.2324732914
418PhosphorylationATIQQCQSPTNYLQG
EEHHHCCCCCCCCCC
41.1225159151
420PhosphorylationIQQCQSPTNYLQGLD
HHHCCCCCCCCCCCC
41.5624732914
422PhosphorylationQCQSPTNYLQGLDGK
HCCCCCCCCCCCCCC
11.6824732914
478PhosphorylationEGTLIEDSPDFRILQ
CCCCCCCCCCCCHHC
17.3621815630
539PhosphorylationVRGNEDLSNNGSLHS
ECCCCCCCCCCCCCC
40.3420068231
543PhosphorylationEDLSNNGSLHSANST
CCCCCCCCCCCCCCC
25.6530576142
546PhosphorylationSNNGSLHSANSTTNL
CCCCCCCCCCCCCCC
34.1420068231
549PhosphorylationGSLHSANSTTNLAAI
CCCCCCCCCCCCEEE
36.0020068231
550PhosphorylationSLHSANSTTNLAAIE
CCCCCCCCCCCEEEC
21.3620068231
551PhosphorylationLHSANSTTNLAAIEP
CCCCCCCCCCEEECC
28.2320068231
561PhosphorylationAAIEPQPSPPHSEPP
EEECCCCCCCCCCCC
45.9030576142
565PhosphorylationPQPSPPHSEPPSVEQ
CCCCCCCCCCCCCCC
58.5330576142
569PhosphorylationPPHSEPPSVEQPPKP
CCCCCCCCCCCCCCC
49.3420068231
590PhosphorylationVNHNEPRSSSRIGLR
ECCCCCCCCCCEEEE
43.3028555341
592PhosphorylationHNEPRSSSRIGLRVH
CCCCCCCCCEEEEEE
29.2118669648
609PhosphorylationLPEDDKGSEASSEAG
CCCCCCCCCCCCCCC
35.4120873877
612PhosphorylationDDKGSEASSEAGVVT
CCCCCCCCCCCCEEE
25.3520873877
613PhosphorylationDKGSEASSEAGVVTT
CCCCCCCCCCCEEEC
38.2120873877
619PhosphorylationSSEAGVVTTRQTRPD
CCCCCEEECCCCCCC
17.5424144214
620PhosphorylationSEAGVVTTRQTRPDS
CCCCEEECCCCCCCC
14.7924144214
627PhosphorylationTRQTRPDSFQERFNG
CCCCCCCCHHHHHCC
31.3530576142
639PhosphorylationFNGQATKTPEPSSPV
HCCCCCCCCCCCCCC
28.6421712546
643PhosphorylationATKTPEPSSPVKEPP
CCCCCCCCCCCCCCC
45.6822167270
644PhosphorylationTKTPEPSSPVKEPPP
CCCCCCCCCCCCCCC
44.4122167270
660PhosphorylationLAKPKLDSTQLQQLH
CCCCCCCHHHHHHHH
28.6120068231
661PhosphorylationAKPKLDSTQLQQLHN
CCCCCCHHHHHHHHH
32.7220068231
683PhosphorylationQLQNPPPSSPKEFPF
CCCCCCCCCCCCCCC
66.1122167270
684PhosphorylationLQNPPPSSPKEFPFS
CCCCCCCCCCCCCCE
45.8522167270
697PhosphorylationFSMTVLNSNAPPAVT
CEEEEECCCCCCCEE
30.1529507054
704O-linked_GlycosylationSNAPPAVTTSSKQVK
CCCCCCEECCCCCCC
24.0630379171
704PhosphorylationSNAPPAVTTSSKQVK
CCCCCCEECCCCCCC
24.0630206219
705PhosphorylationNAPPAVTTSSKQVKA
CCCCCEECCCCCCCC
25.1430206219
706PhosphorylationAPPAVTTSSKQVKAP
CCCCEECCCCCCCCC
26.6030206219
707PhosphorylationPPAVTTSSKQVKAPS
CCCEECCCCCCCCCC
25.6430206219
711UbiquitinationTTSSKQVKAPSSQTF
ECCCCCCCCCCCCCC
52.68-
714O-linked_GlycosylationSKQVKAPSSQTFSLA
CCCCCCCCCCCCCCC
39.6830379171
714PhosphorylationSKQVKAPSSQTFSLA
CCCCCCCCCCCCCCC
39.6822210691
715O-linked_GlycosylationKQVKAPSSQTFSLAR
CCCCCCCCCCCCCCC
31.9830379171
715PhosphorylationKQVKAPSSQTFSLAR
CCCCCCCCCCCCCCC
31.9822210691
719PhosphorylationAPSSQTFSLARPKYF
CCCCCCCCCCCCCEE
25.2222964224
725PhosphorylationFSLARPKYFFPSTNT
CCCCCCCEECCCCCC
17.0922210691
749PhosphorylationSPVFTLSSTPQTIQR
CCCEECCCCCHHHHH
47.4122210691
750PhosphorylationPVFTLSSTPQTIQRT
CCEECCCCCHHHHHC
18.9522210691
757PhosphorylationTPQTIQRTVSKESLL
CCHHHHHCCCCHHHE
16.8626699800
759PhosphorylationQTIQRTVSKESLLVS
HHHHHCCCCHHHEEE
30.0522167270
760UbiquitinationTIQRTVSKESLLVSH
HHHHCCCCHHHEEEC
47.16-
762PhosphorylationQRTVSKESLLVSHPS
HHCCCCHHHEEECCC
30.6426699800
766PhosphorylationSKESLLVSHPSVQTK
CCHHHEEECCCCCCC
29.6526699800
769PhosphorylationSLLVSHPSVQTKSPG
HHEEECCCCCCCCCC
22.7926437602
813PhosphorylationQFQPRCVSPIPVSPT
CCCCCEECCCCCCCC
22.2716964243
818PhosphorylationCVSPIPVSPTSRIQN
EECCCCCCCCCCCCC
19.6716964243
820PhosphorylationSPIPVSPTSRIQNPV
CCCCCCCCCCCCCHH
24.1122199227
821PhosphorylationPIPVSPTSRIQNPVA
CCCCCCCCCCCCHHH
30.6722199227
865PhosphorylationQGLAKKNTKSPQPVN
CCCCCCCCCCCCCCC
41.6026462736
867PhosphorylationLAKKNTKSPQPVNDD
CCCCCCCCCCCCCCC
27.0825159151
879PhosphorylationNDDNIRETKNAVIRD
CCCCHHHHHHHHHHH
21.5424505115
880UbiquitinationDDNIRETKNAVIRDL
CCCHHHHHHHHHHHH
37.85-
890UbiquitinationVIRDLGKKITFSDVR
HHHHHCCCCCHHHCC
45.22-
892PhosphorylationRDLGKKITFSDVRPN
HHHCCCCCHHHCCCC
26.4320860994
894PhosphorylationLGKKITFSDVRPNQQ
HCCCCCHHHCCCCCC
26.9228555341
906PhosphorylationNQQEYKISSFEQRLM
CCCEEECCHHHHHHH
25.4823186163
907PhosphorylationQQEYKISSFEQRLMN
CCEEECCHHHHHHHH
35.9521815630
923PhosphorylationIEFRLERTPVDESDD
HCHHEECCCCCCCCC
20.4930175587
928PhosphorylationERTPVDESDDEIQHD
ECCCCCCCCCCCCCC
45.9922167270
939PhosphorylationIQHDEIPTGKCIAPI
CCCCCCCCCCCCHHH
55.7424732914
941UbiquitinationHDEIPTGKCIAPIFD
CCCCCCCCCCHHHHH
25.58-
960PhosphorylationHFRVTEGSPVTFTCK
CEEECCCCCEEEEEE
15.2325159151
1001PhosphorylationMRREGDGTCSLHIES
CCCCCCCCCEEEEEE
12.0320068231
1003PhosphorylationREGDGTCSLHIESTT
CCCCCCCEEEEEEEC
23.8720068231
1017PhosphorylationTSDDDGNYTIMAANP
CCCCCCCEEEEECCC
11.8120068231
1018PhosphorylationSDDDGNYTIMAANPQ
CCCCCCEEEEECCCC
14.3120068231
1038PhosphorylationSGHLMVQSLPIRSRL
CCEEEEECCCCHHHC
25.3824719451
1043PhosphorylationVQSLPIRSRLTSAGQ
EECCCCHHHCCCCCC
32.15-
1047PhosphorylationPIRSRLTSAGQSHRG
CCHHHCCCCCCCHHC
34.6930576142
1051PhosphorylationRLTSAGQSHRGRSRV
HCCCCCCCHHCCCCH
17.7726437602
1145UbiquitinationQRDAGTYKCIATNKT
HHCCCEEEEEEECCC
21.00-
1170UbiquitinationVVAKEVKKAPVILEK
HHHHHHHCCHHHHHH
64.20-
1207UbiquitinationPPVFYWKKDNETIPC
CCEEEEECCCCCCCC
52.19-
1284PhosphorylationVRPSGSRYGSLTSKG
CCCCCCCCCCCCCCC
16.8622210691
1286PhosphorylationPSGSRYGSLTSKGLD
CCCCCCCCCCCCCCC
21.3822210691
1288PhosphorylationGSRYGSLTSKGLDIF
CCCCCCCCCCCCCHH
30.0429083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYPN_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYPN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYPN_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACTN2_HUMANACTN2physical
11309420
ACTN3_HUMANACTN3physical
11309420
NEBL_HUMANNEBLphysical
11309420
TITIN_HUMANTTNphysical
14583192
ANKR1_HUMANANKRD1physical
14583192
ANR23_HUMANANKRD23physical
14583192
ANKR1_HUMANANKRD1physical
11309420
NEBU_HUMANNEBphysical
11309420
MTA2_HUMANMTA2physical
26344197

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615248Cardiomyopathy, dilated 1KK (CMD1KK)
615248Cardiomyopathy, familial hypertrophic 22 (CMH22)
615248Cardiomyopathy, familial restrictive 4 (RCM4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYPN_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-251; SER-255; SER-759;SER-813; SER-818; SER-867 AND SER-928, AND MASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101 AND SER-928, ANDMASS SPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-813 AND SER-818, ANDMASS SPECTROMETRY.

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