UniProt ID | MYPN_HUMAN | |
---|---|---|
UniProt AC | Q86TC9 | |
Protein Name | Myopalladin | |
Gene Name | MYPN | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1320 | |
Subcellular Localization | Cytoplasm . Nucleus . Cytoplasm, myofibril, sarcomere . Cytoplasm, myofibril, sarcomere, Z line . Bound to sarcomere both at the Z-line periphery and in the central I-band region. | |
Protein Description | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.. | |
Protein Sequence | MQDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLPDLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
9 | Phosphorylation | QDDSIEASTSISQLL CCCHHHHHHHHHHHH | 15.19 | 27732954 | |
10 | Phosphorylation | DDSIEASTSISQLLR CCHHHHHHHHHHHHH | 36.81 | 28122231 | |
11 | Phosphorylation | DSIEASTSISQLLRE CHHHHHHHHHHHHHH | 20.11 | 27732954 | |
13 | Phosphorylation | IEASTSISQLLRESY HHHHHHHHHHHHHHH | 17.97 | 27732954 | |
46 | Phosphorylation | SNPCHFGSPSGAAEG CCCCCCCCCCCCCCC | 18.23 | 28348404 | |
48 | Phosphorylation | PCHFGSPSGAAEGGG CCCCCCCCCCCCCCC | 42.64 | 28348404 | |
64 | Phosphorylation | QDDLPDLSAFLSQEE CCCCCCHHHHHCHHH | 25.10 | 28348404 | |
68 | Phosphorylation | PDLSAFLSQEELDES CCHHHHHCHHHHHHH | 29.14 | 28348404 | |
85 | Phosphorylation | LARLAINYDPLEKAD HHHHHHCCCHHHCCC | 16.90 | - | |
90 | Ubiquitination | INYDPLEKADETQAR HCCCHHHCCCHHHHH | 69.67 | - | |
101 | Phosphorylation | TQARKRLSPDQMKHS HHHHHHCCHHHHCCC | 30.39 | 25159151 | |
108 | Phosphorylation | SPDQMKHSPNLSFEP CHHHHCCCCCCCCCC | 15.23 | 30576142 | |
112 | Phosphorylation | MKHSPNLSFEPNFCQ HCCCCCCCCCCCCCC | 33.92 | 20068231 | |
124 | Phosphorylation | FCQDNPRSPTSSKES CCCCCCCCCCCCCCC | 33.51 | 25159151 | |
126 | Phosphorylation | QDNPRSPTSSKESPQ CCCCCCCCCCCCCHH | 47.05 | 30576142 | |
127 | Phosphorylation | DNPRSPTSSKESPQE CCCCCCCCCCCCHHH | 42.68 | 29116813 | |
128 | Phosphorylation | NPRSPTSSKESPQEA CCCCCCCCCCCHHHH | 42.81 | 30576142 | |
131 | Phosphorylation | SPTSSKESPQEAKRP CCCCCCCCHHHHCCC | 35.30 | 25159151 | |
136 | Ubiquitination | KESPQEAKRPQYCSE CCCHHHHCCCCCCCH | 64.95 | - | |
147 | Ubiquitination | YCSETQSKKVFLNKA CCCHHHCHHHHHHHH | 43.04 | - | |
163 | Phosphorylation | DFIEELSSLFKSHSS HHHHHHHHHHHHCCC | 50.91 | 24719451 | |
167 | Phosphorylation | ELSSLFKSHSSKRIR HHHHHHHHCCCCCCC | 22.67 | - | |
196 | Phosphorylation | NKVMQENSSSFSDLS HHHHHHCCCCCHHHH | 26.97 | 21815630 | |
197 | Phosphorylation | KVMQENSSSFSDLSE HHHHHCCCCCHHHHH | 47.16 | 30576142 | |
198 | Phosphorylation | VMQENSSSFSDLSER HHHHCCCCCHHHHHH | 28.70 | 21815630 | |
200 | Phosphorylation | QENSSSFSDLSERRE HHCCCCCHHHHHHHH | 39.32 | 23186163 | |
203 | Phosphorylation | SSSFSDLSERRERSS CCCCHHHHHHHHHCC | 33.76 | 26546556 | |
209 | Phosphorylation | LSERRERSSVPIPIP HHHHHHHCCCCCCCC | 30.82 | 28555341 | |
210 | Phosphorylation | SERRERSSVPIPIPA HHHHHHCCCCCCCCC | 37.83 | 28555341 | |
234 | Ubiquitination | ALEQQEAKRREAEQA HHHHHHHHHHHHHHH | 51.76 | - | |
243 | Phosphorylation | REAEQAASEAAGGDT HHHHHHHHHHCCCCC | 30.68 | 30576142 | |
250 | Phosphorylation | SEAAGGDTTPGSSPS HHHCCCCCCCCCCCH | 37.86 | 25159151 | |
251 | Phosphorylation | EAAGGDTTPGSSPSS HHCCCCCCCCCCCHH | 30.32 | 25159151 | |
254 | Phosphorylation | GGDTTPGSSPSSLYY CCCCCCCCCCHHHCC | 40.03 | 25159151 | |
255 | Phosphorylation | GDTTPGSSPSSLYYE CCCCCCCCCHHHCCC | 34.41 | 25159151 | |
257 | Phosphorylation | TTPGSSPSSLYYEEP CCCCCCCHHHCCCCC | 34.62 | 25159151 | |
258 | Phosphorylation | TPGSSPSSLYYEEPL CCCCCCHHHCCCCCC | 24.63 | 25159151 | |
260 | Phosphorylation | GSSPSSLYYEEPLGQ CCCCHHHCCCCCCCC | 15.69 | 30576142 | |
261 | Phosphorylation | SSPSSLYYEEPLGQP CCCHHHCCCCCCCCC | 21.07 | 18669648 | |
385 | Phosphorylation | IQKPNEVSSPPTTSA CCCCCCCCCCCCCCC | 30.83 | 24732914 | |
386 | Phosphorylation | QKPNEVSSPPTTSAV CCCCCCCCCCCCCCC | 39.82 | 24732914 | |
389 | Phosphorylation | NEVSSPPTTSAVIPP CCCCCCCCCCCCCCC | 36.45 | 24732914 | |
390 | O-linked_Glycosylation | EVSSPPTTSAVIPPA CCCCCCCCCCCCCCC | 22.06 | 30379171 | |
390 | Phosphorylation | EVSSPPTTSAVIPPA CCCCCCCCCCCCCCC | 22.06 | 24732914 | |
391 | Phosphorylation | VSSPPTTSAVIPPAV CCCCCCCCCCCCCCC | 24.02 | 24732914 | |
412 | Phosphorylation | VAQPRVATIQQCQSP HCCCCEEEHHHCCCC | 19.23 | 24732914 | |
418 | Phosphorylation | ATIQQCQSPTNYLQG EEHHHCCCCCCCCCC | 41.12 | 25159151 | |
420 | Phosphorylation | IQQCQSPTNYLQGLD HHHCCCCCCCCCCCC | 41.56 | 24732914 | |
422 | Phosphorylation | QCQSPTNYLQGLDGK HCCCCCCCCCCCCCC | 11.68 | 24732914 | |
478 | Phosphorylation | EGTLIEDSPDFRILQ CCCCCCCCCCCCHHC | 17.36 | 21815630 | |
539 | Phosphorylation | VRGNEDLSNNGSLHS ECCCCCCCCCCCCCC | 40.34 | 20068231 | |
543 | Phosphorylation | EDLSNNGSLHSANST CCCCCCCCCCCCCCC | 25.65 | 30576142 | |
546 | Phosphorylation | SNNGSLHSANSTTNL CCCCCCCCCCCCCCC | 34.14 | 20068231 | |
549 | Phosphorylation | GSLHSANSTTNLAAI CCCCCCCCCCCCEEE | 36.00 | 20068231 | |
550 | Phosphorylation | SLHSANSTTNLAAIE CCCCCCCCCCCEEEC | 21.36 | 20068231 | |
551 | Phosphorylation | LHSANSTTNLAAIEP CCCCCCCCCCEEECC | 28.23 | 20068231 | |
561 | Phosphorylation | AAIEPQPSPPHSEPP EEECCCCCCCCCCCC | 45.90 | 30576142 | |
565 | Phosphorylation | PQPSPPHSEPPSVEQ CCCCCCCCCCCCCCC | 58.53 | 30576142 | |
569 | Phosphorylation | PPHSEPPSVEQPPKP CCCCCCCCCCCCCCC | 49.34 | 20068231 | |
590 | Phosphorylation | VNHNEPRSSSRIGLR ECCCCCCCCCCEEEE | 43.30 | 28555341 | |
592 | Phosphorylation | HNEPRSSSRIGLRVH CCCCCCCCCEEEEEE | 29.21 | 18669648 | |
609 | Phosphorylation | LPEDDKGSEASSEAG CCCCCCCCCCCCCCC | 35.41 | 20873877 | |
612 | Phosphorylation | DDKGSEASSEAGVVT CCCCCCCCCCCCEEE | 25.35 | 20873877 | |
613 | Phosphorylation | DKGSEASSEAGVVTT CCCCCCCCCCCEEEC | 38.21 | 20873877 | |
619 | Phosphorylation | SSEAGVVTTRQTRPD CCCCCEEECCCCCCC | 17.54 | 24144214 | |
620 | Phosphorylation | SEAGVVTTRQTRPDS CCCCEEECCCCCCCC | 14.79 | 24144214 | |
627 | Phosphorylation | TRQTRPDSFQERFNG CCCCCCCCHHHHHCC | 31.35 | 30576142 | |
639 | Phosphorylation | FNGQATKTPEPSSPV HCCCCCCCCCCCCCC | 28.64 | 21712546 | |
643 | Phosphorylation | ATKTPEPSSPVKEPP CCCCCCCCCCCCCCC | 45.68 | 22167270 | |
644 | Phosphorylation | TKTPEPSSPVKEPPP CCCCCCCCCCCCCCC | 44.41 | 22167270 | |
660 | Phosphorylation | LAKPKLDSTQLQQLH CCCCCCCHHHHHHHH | 28.61 | 20068231 | |
661 | Phosphorylation | AKPKLDSTQLQQLHN CCCCCCHHHHHHHHH | 32.72 | 20068231 | |
683 | Phosphorylation | QLQNPPPSSPKEFPF CCCCCCCCCCCCCCC | 66.11 | 22167270 | |
684 | Phosphorylation | LQNPPPSSPKEFPFS CCCCCCCCCCCCCCE | 45.85 | 22167270 | |
697 | Phosphorylation | FSMTVLNSNAPPAVT CEEEEECCCCCCCEE | 30.15 | 29507054 | |
704 | O-linked_Glycosylation | SNAPPAVTTSSKQVK CCCCCCEECCCCCCC | 24.06 | 30379171 | |
704 | Phosphorylation | SNAPPAVTTSSKQVK CCCCCCEECCCCCCC | 24.06 | 30206219 | |
705 | Phosphorylation | NAPPAVTTSSKQVKA CCCCCEECCCCCCCC | 25.14 | 30206219 | |
706 | Phosphorylation | APPAVTTSSKQVKAP CCCCEECCCCCCCCC | 26.60 | 30206219 | |
707 | Phosphorylation | PPAVTTSSKQVKAPS CCCEECCCCCCCCCC | 25.64 | 30206219 | |
711 | Ubiquitination | TTSSKQVKAPSSQTF ECCCCCCCCCCCCCC | 52.68 | - | |
714 | O-linked_Glycosylation | SKQVKAPSSQTFSLA CCCCCCCCCCCCCCC | 39.68 | 30379171 | |
714 | Phosphorylation | SKQVKAPSSQTFSLA CCCCCCCCCCCCCCC | 39.68 | 22210691 | |
715 | O-linked_Glycosylation | KQVKAPSSQTFSLAR CCCCCCCCCCCCCCC | 31.98 | 30379171 | |
715 | Phosphorylation | KQVKAPSSQTFSLAR CCCCCCCCCCCCCCC | 31.98 | 22210691 | |
719 | Phosphorylation | APSSQTFSLARPKYF CCCCCCCCCCCCCEE | 25.22 | 22964224 | |
725 | Phosphorylation | FSLARPKYFFPSTNT CCCCCCCEECCCCCC | 17.09 | 22210691 | |
749 | Phosphorylation | SPVFTLSSTPQTIQR CCCEECCCCCHHHHH | 47.41 | 22210691 | |
750 | Phosphorylation | PVFTLSSTPQTIQRT CCEECCCCCHHHHHC | 18.95 | 22210691 | |
757 | Phosphorylation | TPQTIQRTVSKESLL CCHHHHHCCCCHHHE | 16.86 | 26699800 | |
759 | Phosphorylation | QTIQRTVSKESLLVS HHHHHCCCCHHHEEE | 30.05 | 22167270 | |
760 | Ubiquitination | TIQRTVSKESLLVSH HHHHCCCCHHHEEEC | 47.16 | - | |
762 | Phosphorylation | QRTVSKESLLVSHPS HHCCCCHHHEEECCC | 30.64 | 26699800 | |
766 | Phosphorylation | SKESLLVSHPSVQTK CCHHHEEECCCCCCC | 29.65 | 26699800 | |
769 | Phosphorylation | SLLVSHPSVQTKSPG HHEEECCCCCCCCCC | 22.79 | 26437602 | |
813 | Phosphorylation | QFQPRCVSPIPVSPT CCCCCEECCCCCCCC | 22.27 | 16964243 | |
818 | Phosphorylation | CVSPIPVSPTSRIQN EECCCCCCCCCCCCC | 19.67 | 16964243 | |
820 | Phosphorylation | SPIPVSPTSRIQNPV CCCCCCCCCCCCCHH | 24.11 | 22199227 | |
821 | Phosphorylation | PIPVSPTSRIQNPVA CCCCCCCCCCCCHHH | 30.67 | 22199227 | |
865 | Phosphorylation | QGLAKKNTKSPQPVN CCCCCCCCCCCCCCC | 41.60 | 26462736 | |
867 | Phosphorylation | LAKKNTKSPQPVNDD CCCCCCCCCCCCCCC | 27.08 | 25159151 | |
879 | Phosphorylation | NDDNIRETKNAVIRD CCCCHHHHHHHHHHH | 21.54 | 24505115 | |
880 | Ubiquitination | DDNIRETKNAVIRDL CCCHHHHHHHHHHHH | 37.85 | - | |
890 | Ubiquitination | VIRDLGKKITFSDVR HHHHHCCCCCHHHCC | 45.22 | - | |
892 | Phosphorylation | RDLGKKITFSDVRPN HHHCCCCCHHHCCCC | 26.43 | 20860994 | |
894 | Phosphorylation | LGKKITFSDVRPNQQ HCCCCCHHHCCCCCC | 26.92 | 28555341 | |
906 | Phosphorylation | NQQEYKISSFEQRLM CCCEEECCHHHHHHH | 25.48 | 23186163 | |
907 | Phosphorylation | QQEYKISSFEQRLMN CCEEECCHHHHHHHH | 35.95 | 21815630 | |
923 | Phosphorylation | IEFRLERTPVDESDD HCHHEECCCCCCCCC | 20.49 | 30175587 | |
928 | Phosphorylation | ERTPVDESDDEIQHD ECCCCCCCCCCCCCC | 45.99 | 22167270 | |
939 | Phosphorylation | IQHDEIPTGKCIAPI CCCCCCCCCCCCHHH | 55.74 | 24732914 | |
941 | Ubiquitination | HDEIPTGKCIAPIFD CCCCCCCCCCHHHHH | 25.58 | - | |
960 | Phosphorylation | HFRVTEGSPVTFTCK CEEECCCCCEEEEEE | 15.23 | 25159151 | |
1001 | Phosphorylation | MRREGDGTCSLHIES CCCCCCCCCEEEEEE | 12.03 | 20068231 | |
1003 | Phosphorylation | REGDGTCSLHIESTT CCCCCCCEEEEEEEC | 23.87 | 20068231 | |
1017 | Phosphorylation | TSDDDGNYTIMAANP CCCCCCCEEEEECCC | 11.81 | 20068231 | |
1018 | Phosphorylation | SDDDGNYTIMAANPQ CCCCCCEEEEECCCC | 14.31 | 20068231 | |
1038 | Phosphorylation | SGHLMVQSLPIRSRL CCEEEEECCCCHHHC | 25.38 | 24719451 | |
1043 | Phosphorylation | VQSLPIRSRLTSAGQ EECCCCHHHCCCCCC | 32.15 | - | |
1047 | Phosphorylation | PIRSRLTSAGQSHRG CCHHHCCCCCCCHHC | 34.69 | 30576142 | |
1051 | Phosphorylation | RLTSAGQSHRGRSRV HCCCCCCCHHCCCCH | 17.77 | 26437602 | |
1145 | Ubiquitination | QRDAGTYKCIATNKT HHCCCEEEEEEECCC | 21.00 | - | |
1170 | Ubiquitination | VVAKEVKKAPVILEK HHHHHHHCCHHHHHH | 64.20 | - | |
1207 | Ubiquitination | PPVFYWKKDNETIPC CCEEEEECCCCCCCC | 52.19 | - | |
1284 | Phosphorylation | VRPSGSRYGSLTSKG CCCCCCCCCCCCCCC | 16.86 | 22210691 | |
1286 | Phosphorylation | PSGSRYGSLTSKGLD CCCCCCCCCCCCCCC | 21.38 | 22210691 | |
1288 | Phosphorylation | GSRYGSLTSKGLDIF CCCCCCCCCCCCCHH | 30.04 | 29083192 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MYPN_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MYPN_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MYPN_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ACTN2_HUMAN | ACTN2 | physical | 11309420 | |
ACTN3_HUMAN | ACTN3 | physical | 11309420 | |
NEBL_HUMAN | NEBL | physical | 11309420 | |
TITIN_HUMAN | TTN | physical | 14583192 | |
ANKR1_HUMAN | ANKRD1 | physical | 14583192 | |
ANR23_HUMAN | ANKRD23 | physical | 14583192 | |
ANKR1_HUMAN | ANKRD1 | physical | 11309420 | |
NEBU_HUMAN | NEB | physical | 11309420 | |
MTA2_HUMAN | MTA2 | physical | 26344197 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
615248 | Cardiomyopathy, dilated 1KK (CMD1KK) | |||||
615248 | Cardiomyopathy, familial hypertrophic 22 (CMH22) | |||||
615248 | Cardiomyopathy, familial restrictive 4 (RCM4) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-251; SER-255; SER-759;SER-813; SER-818; SER-867 AND SER-928, AND MASS SPECTROMETRY. | |
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101 AND SER-928, ANDMASS SPECTROMETRY. | |
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-813 AND SER-818, ANDMASS SPECTROMETRY. |