dbPTM

ANKR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANKR1_HUMAN
UniProt AC	Q15327
Protein Name	Ankyrin repeat domain-containing protein 1
Gene Name	ANKRD1
Organism	Homo sapiens (Human).
Sequence Length	319
Subcellular Localization	Nucleus .
Protein Description	May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells..
Protein Sequence	MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	QLKKRKKYRKTKVPV HHHHHHCCCCCCCCC	22.00	26657352
102	Phosphorylation	KRKKYRKTKVPVVKE HHHCCCCCCCCCCCC	28.42	26657352
274	Phosphorylation	MIRLLIMYGADLNIK HHHHHHHHCCCCCCC	11.36	25884760
310	Phosphorylation	FDSLRENSYKTSRIA HHHHHHHCCCCCCCC	24.21	-
311	Phosphorylation	DSLRENSYKTSRIAT HHHHHHCCCCCCCCC	29.84	23612710

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ANKR1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANKR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANKR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYPN_HUMAN	MYPN	physical	14583192
TITIN_HUMAN	TTN	physical	14583192
UBE2O_HUMAN	UBE2O	physical	26186194

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANKR1_HUMAN

Related Literatures of Post-Translational Modification