TNNI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNI1_HUMAN
• UniProt AC: P19237
• Protein Name: Troponin I, slow skeletal muscle
• Gene Name: TNNI1
• Organism: Homo sapiens (Human).
• Sequence Length: 187
• Protein Description: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity..
• Protein Sequence: MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMDLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGDWRKNVEAMSGMEGRKKMFDAAKSPTSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MPEVERKPK ------CCCCCCCCC	55.10	-
13	Phosphorylation	RKPKITASRKLLLKS CCCCCCHHHHHHHHH	22.69	26437602
19	Acetylation	ASRKLLLKSLMLAKA HHHHHHHHHHHHHHH	41.32	133983
25	Acetylation	LKSLMLAKAKECWEQ HHHHHHHHHHHHHHH	56.90	133987
44	Phosphorylation	REAEKVRYLAERIPT HHHHHHHHHHHHCCC	17.16	26437602
51	Phosphorylation	YLAERIPTLQTRGLS HHHHHCCCHHHCCCC	29.18	26437602
58	Phosphorylation	TLQTRGLSLSALQDL CHHHCCCCHHHHHHH	24.09	19764811
60	Phosphorylation	QTRGLSLSALQDLCR HHCCCCHHHHHHHHH	24.45	19764811
91	Phosphorylation	EAKCLHNTREIKDLK HHHHCCCCHHHHHHH	20.94	26437602
119	Phosphorylation	PLRRVRVSADAMLRA CCHHHHHCHHHHHHH	15.18	26437602
130	Phosphorylation	MLRALLGSKHKVSMD HHHHHHCCCCCCCCH	31.40	26437602
135	Phosphorylation	LGSKHKVSMDLRANL HCCCCCCCCHHHHHH	16.04	26437602
169	Phosphorylation	RKNVEAMSGMEGRKK HHCHHHHCCCCHHHH	41.87	26437602
183	Phosphorylation	KMFDAAKSPTSQ--- HHHHHHHCCCCC---	28.78	19764811
185	Phosphorylation	FDAAKSPTSQ----- HHHHHCCCCC-----	47.02	19764811
186	Phosphorylation	DAAKSPTSQ------ HHHHCCCCC------	36.96	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM63	Q969Q1	PMID:19240029

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CC85B_HUMAN	CCDC85B	physical	16189514
TNNC1_HUMAN	TNNC1	physical	15542288
TNNT2_HUMAN	TNNT2	physical	15542288
PNMA1_HUMAN	PNMA1	physical	25416956
MYH3_HUMAN	MYH3	physical	26344197
MYH6_HUMAN	MYH6	physical	26344197
MYH7_HUMAN	MYH7	physical	26344197
TPM1_HUMAN	TPM1	physical	26344197
TPM2_HUMAN	TPM2	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.