TNNC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNC1_HUMAN
• UniProt AC: P63316
• Protein Name: Troponin C, slow skeletal and cardiac muscles
• Gene Name: TNNC1
• Organism: Homo sapiens (Human).
• Sequence Length: 161
• Protein Description: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments..
• Protein Sequence: MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDDIYKAA -------CHHHHHHH	10.62	3951483
5	Phosphorylation	---MDDIYKAAVEQL ---CHHHHHHHHHHH	11.11	24043423
6	Acetylation	--MDDIYKAAVEQLT --CHHHHHHHHHHHC	30.15	30593029
13	Phosphorylation	KAAVEQLTEEQKNEF HHHHHHHCHHHHHHH	36.85	24043423
17	Ubiquitination	EQLTEEQKNEFKAAF HHHCHHHHHHHHHHH	62.82	-
21	Acetylation	EEQKNEFKAAFDIFV HHHHHHHHHHHHEEH	32.40	30593023
92	Ubiquitination	MKDDSKGKSEEELSD HHCCCCCCCHHHHHH	59.43	-
98	Phosphorylation	GKSEEELSDLFRMFD CCCHHHHHHHHHHHH	35.23	-
106	Ubiquitination	DLFRMFDKNADGYID HHHHHHHCCCCCCCC	42.65	-
111	Phosphorylation	FDKNADGYIDLDELK HHCCCCCCCCHHHHH	7.57	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNNC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNNT1_HUMAN	TNNT1	physical	9448267
TNNI3_HUMAN	TNNI3	physical	12939162
TNNI3_HUMAN	TNNI3	physical	12060657
TNNI3_HUMAN	TNNI3	physical	12122471
TNNI1_HUMAN	TNNI1	physical	12044157
TNNI2_HUMAN	TNNI2	physical	7103951
TRI63_HUMAN	TRIM63	physical	15601779
CNN1_HUMAN	CNN1	physical	2455687
TNNI3_HUMAN	TNNI3	physical	7957210
TNNI1_HUMAN	TNNI1	physical	18092822
TNNT2_HUMAN	TNNT2	physical	15542288
UBE2C_HUMAN	UBE2C	physical	21988832
TNNI1_HUMAN	TNNI1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 611879: Cardiomyopathy, dilated 1Z (CMD1Z)
• 613243: Cardiomyopathy, familial hypertrophic 13 (CMH13)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01244: Bepridil
• DB01375: Dihydroxyaluminium
• DB01023: Felodipine
• DB00922: Levosimendan
• DB00831: Trifluoperazine