| UniProt ID | TNNI2_HUMAN | |
|---|---|---|
| UniProt AC | P48788 | |
| Protein Name | Troponin I, fast skeletal muscle | |
| Gene Name | TNNI2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 182 | |
| Subcellular Localization | ||
| Protein Description | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.. | |
| Protein Sequence | MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MGDEEKRNR ------CCHHHHHHH | 51.54 | - | |
| 7 | Dimethylation | -MGDEEKRNRAITAR -CCHHHHHHHHHHHH | 40.94 | - | |
| 7 | Methylation | -MGDEEKRNRAITAR -CCHHHHHHHHHHHH | 40.94 | 24376801 | |
| 12 | Phosphorylation | EKRNRAITARRQHLK HHHHHHHHHHHHHHH | 17.08 | 4369265 | |
| 14 | Methylation | RNRAITARRQHLKSV HHHHHHHHHHHHHHH | 30.09 | 24376809 | |
| 14 | Dimethylation | RNRAITARRQHLKSV HHHHHHHHHHHHHHH | 30.09 | - | |
| 20 | Phosphorylation | ARRQHLKSVMLQIAA HHHHHHHHHHHHHHH | 21.08 | 4369265 | |
| 57 | Phosphorylation | PPLHIPGSMSEVQEL CCCCCCCCHHHHHHH | 17.49 | 26437602 | |
| 59 | Phosphorylation | LHIPGSMSEVQELCK CCCCCCHHHHHHHHH | 35.99 | 26437602 | |
| 80 | Phosphorylation | DAAEEEKYDMEVRVQ CHHHHHHHCHHHHHH | 24.65 | - | |
| 90 | Phosphorylation | EVRVQKTSKELEDMN HHHHHHHHHHHHHHH | 31.03 | 21659604 | |
| 118 | Phosphorylation | PLRRVRMSADAMLKA CHHHHHHCHHHHHHH | 16.66 | 4369265 | |
| 124 | Acetylation | MSADAMLKALLGSKH HCHHHHHHHHHCCCC | 24.73 | 20167786 | |
| 129 | Phosphorylation | MLKALLGSKHKVCMD HHHHHHCCCCHHHHH | 31.40 | 26437602 | |
| 169 | Phosphorylation | RKNIEEKSGMEGRKK HHHHHHHHCCCHHHH | 46.80 | 29449344 | |
| 180 | Phosphorylation | GRKKMFESES----- HHHHHHHCCC----- | 31.69 | 24719451 | |
| 182 | Phosphorylation | KKMFESES------- HHHHHCCC------- | 55.59 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TNNI2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TNNI2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TNNI2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NUCB2_HUMAN | NUCB2 | physical | 28514442 | |
| RFTN2_HUMAN | RFTN2 | physical | 28514442 | |
| KLH21_HUMAN | KLHL21 | physical | 28514442 | |
| TLE4_HUMAN | TLE4 | physical | 28514442 | |
| TLE1_HUMAN | TLE1 | physical | 28514442 | |
| SIR1_HUMAN | SIRT1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 601680 | Arthrogryposis, distal, 2B (DA2B) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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