TLE4_HUMAN - dbPTM
TLE4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TLE4_HUMAN
UniProt AC Q04727
Protein Name Transducin-like enhancer protein 4
Gene Name TLE4
Organism Homo sapiens (Human).
Sequence Length 773
Subcellular Localization Nucleus.
Protein Description Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity)..
Protein Sequence MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASIASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MIRDLSKMYPQTR
--CCHHHHHHCCCCC		21.4829978859
9PhosphorylationIRDLSKMYPQTRHPA
CHHHHHHCCCCCCCC		8.9129978859
12PhosphorylationLSKMYPQTRHPAPHQ
HHHHCCCCCCCCCCC		26.8329978859
13MethylationSKMYPQTRHPAPHQP
HHHCCCCCCCCCCCC		28.66115918585
34UbiquitinationTISESCDRIKEEFQF
EECHHHHHHHHHHHH		46.3221890473
36UbiquitinationSESCDRIKEEFQFLQ
CHHHHHHHHHHHHHH		52.6821890473
36 (in isoform 1)Ubiquitination-52.6821890473
36 (in isoform 2)Ubiquitination-52.6821890473
36 (in isoform 3)Ubiquitination-52.6821890473
48UbiquitinationFLQAQYHSLKLECEK
HHHHHHHHHHHHHHH		23.4332015554
50UbiquitinationQAQYHSLKLECEKLA
HHHHHHHHHHHHHHH		45.3032015554
53UbiquitinationYHSLKLECEKLASEK
HHHHHHHHHHHHCCC		8.9533845483
55UbiquitinationSLKLECEKLASEKTE
HHHHHHHHHHCCCHH		62.1033845483
60UbiquitinationCEKLASEKTEMQRHY
HHHHHCCCHHHHHHH		47.49-
75PhosphorylationVMYYEMSYGLNIEMH
HHHHHHHHCCCCCHH		25.0758505
87PhosphorylationEMHKQAEIVKRLNAI
CHHHHHHHHHHHHHH		5.0533259812
89PhosphorylationHKQAEIVKRLNAICA
HHHHHHHHHHHHHHH		57.7532142685
89UbiquitinationHKQAEIVKRLNAICA
HHHHHHHHHHHHHHH		57.75-
171PhosphorylationGSSAGLLALSSALGG
CCHHHHHHHHHHHCC		15.5032142685
181PhosphorylationSALGGQSHLPIKDEK
HHHCCCCCCCCCCCC		27.9533259812
182PhosphorylationALGGQSHLPIKDEKK
HHCCCCCCCCCCCCC		5.9333259812
183PhosphorylationLGGQSHLPIKDEKKH
HCCCCCCCCCCCCCC		26.5932142685
184PhosphorylationGGQSHLPIKDEKKHH
CCCCCCCCCCCCCCC		12.6632142685
185PhosphorylationGQSHLPIKDEKKHHD
CCCCCCCCCCCCCCC		58.8732142685
186PhosphorylationQSHLPIKDEKKHHDN
CCCCCCCCCCCCCCC		73.9232142685
187PhosphorylationSHLPIKDEKKHHDND
CCCCCCCCCCCCCCC		60.0332142685
188PhosphorylationHLPIKDEKKHHDNDH
CCCCCCCCCCCCCCC		68.4933259812
189PhosphorylationLPIKDEKKHHDNDHQ
CCCCCCCCCCCCCCC		44.0932142685
190PhosphorylationPIKDEKKHHDNDHQR
CCCCCCCCCCCCCCC		44.6032142685
191PhosphorylationIKDEKKHHDNDHQRD
CCCCCCCCCCCCCCC		44.4433259812
193PhosphorylationDEKKHHDNDHQRDRD
CCCCCCCCCCCCCHH		44.2832142685
201PhosphorylationDHQRDRDSIKSSSVS
CCCCCHHHHHHCCCC		32.5819664995
204PhosphorylationRDRDSIKSSSVSPSA
CCHHHHHHCCCCCCH		26.6123927012
205PhosphorylationDRDSIKSSSVSPSAS
CHHHHHHCCCCCCHH		29.7423927012
206PhosphorylationRDSIKSSSVSPSASF
HHHHHHCCCCCCHHH		33.4323401153
207PhosphorylationDSIKSSSVSPSASFR
HHHHHCCCCCCHHHC		12.0233259812
208PhosphorylationSIKSSSVSPSASFRG
HHHHCCCCCCHHHCC		18.3219664994
209PhosphorylationIKSSSVSPSASFRGA
HHHCCCCCCHHHCCH		31.5832142685
210PhosphorylationKSSSVSPSASFRGAE
HHCCCCCCHHHCCHH		29.1023927012
211PhosphorylationSSSVSPSASFRGAEK
HCCCCCCHHHCCHHH		18.9732142685
212AcetylationSSVSPSASFRGAEKH
CCCCCCHHHCCHHHH		21.58-
212AcetylationSSVSPSASFRGAEKH
CCCCCCHHHCCHHHH		21.5819608861
212O-linked_GlycosylationSSVSPSASFRGAEKH
CCCCCCHHHCCHHHH		21.5830059200
212PhosphorylationSSVSPSASFRGAEKH
CCCCCCHHHCCHHHH		21.5823927012
221PhosphorylationRGAEKHRNSADYSSE
CCHHHHCCCCCCCCH		41.0733259812
222PhosphorylationGAEKHRNSADYSSES
CHHHHCCCCCCCCHH		23.6026657352
223PhosphorylationAEKHRNSADYSSESK
HHHHCCCCCCCCHHH		24.2632142685
225PhosphorylationKHRNSADYSSESKKQ
HHCCCCCCCCHHHHH		17.5130301811
226PhosphorylationHRNSADYSSESKKQK
HCCCCCCCCHHHHHH		28.3330622161
227PhosphorylationRNSADYSSESKKQKT
CCCCCCCCHHHHHHC		39.3930622161
230AcetylationADYSSESKKQKTEEK
CCCCCHHHHHHCHHH		55.9925953088
237AcetylationKKQKTEEKEIAARYD
HHHHCHHHHHHHHCC		48.4619608861
243PhosphorylationEKEIAARYDSDGEKS
HHHHHHHCCCCCCCC		18.3120363803
245PhosphorylationEIAARYDSDGEKSDD
HHHHHCCCCCCCCCC		38.2825693802
249UbiquitinationRYDSDGEKSDDNLVV
HCCCCCCCCCCCEEE		65.7922053931
250PhosphorylationYDSDGEKSDDNLVVD
CCCCCCCCCCCEEEE		45.9920164059
256AcetylationKSDDNLVVDVSNEDP
CCCCCEEEECCCCCC		7.29-
256AcetylationKSDDNLVVDVSNEDP
CCCCCEEEECCCCCC		7.2919608861
259PhosphorylationDNLVVDVSNEDPSSP
CCEEEECCCCCCCCC		30.0020363803
264PhosphorylationDVSNEDPSSPRGSPA
ECCCCCCCCCCCCCC		66.3517081983
265PhosphorylationVSNEDPSSPRGSPAH
CCCCCCCCCCCCCCC		24.8119413330
266PhosphorylationSNEDPSSPRGSPAHS
CCCCCCCCCCCCCCC		49.3332142685
267PhosphorylationNEDPSSPRGSPAHSP
CCCCCCCCCCCCCCC		61.2332142685
268PhosphorylationEDPSSPRGSPAHSPR
CCCCCCCCCCCCCCC		41.1732142685
269PhosphorylationDPSSPRGSPAHSPRE
CCCCCCCCCCCCCCC		21.8617081983
271PhosphorylationSSPRGSPAHSPRENG
CCCCCCCCCCCCCCC		19.9332142685
272PhosphorylationSPRGSPAHSPRENGL
CCCCCCCCCCCCCCC		41.5432142685
273PhosphorylationPRGSPAHSPRENGLD
CCCCCCCCCCCCCCC		27.9720363803
275PhosphorylationGSPAHSPRENGLDKT
CCCCCCCCCCCCCHH		53.6932142685
281AcetylationPRENGLDKTRLLKKD
CCCCCCCHHHHCCCC		40.3619608861
282PhosphorylationRENGLDKTRLLKKDA
CCCCCCHHHHCCCCC		26.64-
283AcetylationENGLDKTRLLKKDAP
CCCCCHHHHCCCCCC		43.70-
290PhosphorylationRLLKKDAPISPASIA
HHCCCCCCCCHHHHH		37.4132142685
291PhosphorylationLLKKDAPISPASIAS
HCCCCCCCCHHHHHC		9.1532142685
292PhosphorylationLKKDAPISPASIASS
CCCCCCCCHHHHHCC		17.2229255136
293PhosphorylationKKDAPISPASIASSS
CCCCCCCHHHHHCCC		30.6532142685
295O-linked_GlycosylationDAPISPASIASSSST
CCCCCHHHHHCCCCC		23.2830059200
295PhosphorylationDAPISPASIASSSST
CCCCCHHHHHCCCCC		23.2825554490
298PhosphorylationISPASIASSSSTPSS
CCHHHHHCCCCCCCC		29.1419413330
299PhosphorylationSPASIASSSSTPSSK
CHHHHHCCCCCCCCC		21.2025022875
300PhosphorylationPASIASSSSTPSSKS
HHHHHCCCCCCCCCC		35.4225022875
301PhosphorylationASIASSSSTPSSKSK
HHHHCCCCCCCCCCC		46.4125022875
302PhosphorylationSIASSSSTPSSKSKE
HHHCCCCCCCCCCCC		29.1925022875
304PhosphorylationASSSSTPSSKSKELS
HCCCCCCCCCCCCCC		50.9525022875
305PhosphorylationSSSSTPSSKSKELSL
CCCCCCCCCCCCCCC		42.0027690223
305 (in isoform 3)Phosphorylation-42.0019413330
306AcetylationSSSTPSSKSKELSLN
CCCCCCCCCCCCCCC		70.6425953088
308AcetylationSTPSSKSKELSLNEK
CCCCCCCCCCCCCCC		67.4223749302
316PhosphorylationELSLNEKSTTPVSKS
CCCCCCCCCCCCCCC		31.1925002506
317PhosphorylationLSLNEKSTTPVSKSN
CCCCCCCCCCCCCCC		46.3025002506
318O-linked_GlycosylationSLNEKSTTPVSKSNT
CCCCCCCCCCCCCCC		28.8730059200
318PhosphorylationSLNEKSTTPVSKSNT
CCCCCCCCCCCCCCC		28.8718669648
321O-linked_GlycosylationEKSTTPVSKSNTPTP
CCCCCCCCCCCCCCC		31.4130059200
321PhosphorylationEKSTTPVSKSNTPTP
CCCCCCCCCCCCCCC		31.4118669648
322AcetylationKSTTPVSKSNTPTPR
CCCCCCCCCCCCCCC		48.2119820931
323PhosphorylationSTTPVSKSNTPTPRT
CCCCCCCCCCCCCCC		38.1322199227
325PhosphorylationTPVSKSNTPTPRTDA
CCCCCCCCCCCCCCC		35.3121955146
327PhosphorylationVSKSNTPTPRTDAPT
CCCCCCCCCCCCCCC		24.3022199227
330O-linked_GlycosylationSNTPTPRTDAPTPGS
CCCCCCCCCCCCCCC		37.4030059200
330PhosphorylationSNTPTPRTDAPTPGS
CCCCCCCCCCCCCCC		37.4027080861
334O-linked_GlycosylationTPRTDAPTPGSNSTP
CCCCCCCCCCCCCCC		41.8430059200
334PhosphorylationTPRTDAPTPGSNSTP
CCCCCCCCCCCCCCC		41.8427080861
337PhosphorylationTDAPTPGSNSTPGLR
CCCCCCCCCCCCCCC		28.8927080861
339PhosphorylationAPTPGSNSTPGLRPV
CCCCCCCCCCCCCCC		37.3627080861
340O-linked_GlycosylationPTPGSNSTPGLRPVP
CCCCCCCCCCCCCCC		26.1530059200
340PhosphorylationPTPGSNSTPGLRPVP
CCCCCCCCCCCCCCC		26.1527080861
350 (in isoform 3)Phosphorylation-36.4718669648
353 (in isoform 3)Phosphorylation-9.3918669648
358PhosphorylationPGVDPLASSLRTPMA
CCCCCCHHHCCCCCC		37.2727080861
359O-linked_GlycosylationGVDPLASSLRTPMAV
CCCCCHHHCCCCCCC		19.1030059200
359PhosphorylationGVDPLASSLRTPMAV
CCCCCHHHCCCCCCC		19.1027080861
370PhosphorylationPMAVPCPYPTPFGIV
CCCCCCCCCCCCCCC		26.8425332170
386UbiquitinationHAGMNGELTSPGAAY
CCCCCCCCCCCCHHH		6.4422053931
388PhosphorylationGMNGELTSPGAAYAG
CCCCCCCCCCHHHHC		33.6825332170
413UbiquitinationAAAAAAAAAAYGRSP
HHHHHHHHHHHCCCC		6.4622053931
419PhosphorylationAAAAYGRSPVVGFDP
HHHHHCCCCCCCCCC		20.0628555341
429UbiquitinationVGFDPHHHMRVPAIP
CCCCCCCCCCCCCCC		11.6022053931
431MethylationFDPHHHMRVPAIPPN
CCCCCCCCCCCCCCC		27.23115918589
431UbiquitinationFDPHHHMRVPAIPPN
CCCCCCCCCCCCCCC		27.2322053931
438UbiquitinationRVPAIPPNLTGIPGG
CCCCCCCCCCCCCCC		44.9022053931
456UbiquitinationYSFHVSADGQMQPVP
EEEEECCCCCEEECC		40.1122053931
463UbiquitinationDGQMQPVPFPPDALI
CCCEEECCCCCCCCC		42.5921890473
481UbiquitinationIPRHARQINTLNHGE
CCCCCCCCCCCCCCE		3.3822053931
482UbiquitinationPRHARQINTLNHGEV
CCCCCCCCCCCCCEE		30.1222053931
483UbiquitinationRHARQINTLNHGEVV
CCCCCCCCCCCCEEE		30.4822053931
484UbiquitinationHARQINTLNHGEVVC
CCCCCCCCCCCEEEE		3.7322053931
486UbiquitinationRQINTLNHGEVVCAV
CCCCCCCCCEEEEEE		36.5822053931
487UbiquitinationQINTLNHGEVVCAVT
CCCCCCCCEEEEEEE		28.4622053931
490UbiquitinationTLNHGEVVCAVTISN
CCCCCEEEEEEEECC		1.1922053931
492UbiquitinationNHGEVVCAVTISNPT
CCCEEEEEEEECCCC		7.0022053931
498UbiquitinationCAVTISNPTRHVYTG
EEEEECCCCCEEEEC		24.8222053931
505UbiquitinationPTRHVYTGGKGCVKV
CCCEEEECCCCEEEE		20.3722053931
506UbiquitinationTRHVYTGGKGCVKVW
CCEEEECCCCEEEEE		18.5122053931
507UbiquitinationRHVYTGGKGCVKVWD
CEEEECCCCEEEEEE		50.9422053931
508UbiquitinationHVYTGGKGCVKVWDI
EEEECCCCEEEEEEC		25.4022053931
519UbiquitinationVWDISHPGNKSPVSQ
EEECCCCCCCCCCHH		49.0922053931
520UbiquitinationWDISHPGNKSPVSQL
EECCCCCCCCCCHHH		46.1922053931
522PhosphorylationISHPGNKSPVSQLDC
CCCCCCCCCCHHHHH		34.2428348404
523UbiquitinationSHPGNKSPVSQLDCL
CCCCCCCCCHHHHHC		31.2422053931
532UbiquitinationSQLDCLNRDNYIRSC
HHHHHCCCCCCHHHE		22.1722053931
533UbiquitinationQLDCLNRDNYIRSCR
HHHHCCCCCCHHHEE		51.7322053931
537UbiquitinationLNRDNYIRSCRLLPD
CCCCCCHHHEEECCC		21.2422053931
538UbiquitinationNRDNYIRSCRLLPDG
CCCCCHHHEEECCCC		8.2722053931
539UbiquitinationRDNYIRSCRLLPDGR
CCCCHHHEEECCCCC		2.2622053931
540UbiquitinationDNYIRSCRLLPDGRT
CCCHHHEEECCCCCE		40.2722053931
543UbiquitinationIRSCRLLPDGRTLIV
HHHEEECCCCCEEEE		46.7522053931
544UbiquitinationRSCRLLPDGRTLIVG
HHEEECCCCCEEEEC		60.2122053931
549UbiquitinationLPDGRTLIVGGEAST
CCCCCEEEECCEEEE		2.4022053931
550UbiquitinationPDGRTLIVGGEASTL
CCCCEEEECCEEEEE		10.1622053931
563UbiquitinationTLSIWDLAAPTPRIK
EEEHHHHCCCCCCCE		14.6622053931
564UbiquitinationLSIWDLAAPTPRIKA
EEHHHHCCCCCCCEE		18.7922053931
565UbiquitinationSIWDLAAPTPRIKAE
EHHHHCCCCCCCEEE		37.0122053931
574UbiquitinationPRIKAELTSSAPACY
CCCEEEECCCCCCEE		16.4922053931
577UbiquitinationKAELTSSAPACYALA
EEEECCCCCCEEEEE		8.7622053931
578UbiquitinationAELTSSAPACYALAI
EEECCCCCCEEEEEE		25.4722053931
581UbiquitinationTSSAPACYALAISPD
CCCCCCEEEEEECCC		13.5222053931
585UbiquitinationPACYALAISPDSKVC
CCEEEEEECCCCCEE		6.8022053931
591UbiquitinationAISPDSKVCFSCCSD
EECCCCCEEEEECCC		4.6322053931
600UbiquitinationFSCCSDGNIAVWDLH
EEECCCCCEEEEECC		24.8421890473
604UbiquitinationSDGNIAVWDLHNQTL
CCCCEEEEECCCHHH		8.0722053931
606UbiquitinationGNIAVWDLHNQTLVR
CCEEEEECCCHHHHH		2.1022053931
619PhosphorylationVRQFQGHTDGASCID
HHHHCCCCCCCEEEE		42.8424114839
619UbiquitinationVRQFQGHTDGASCID
HHHHCCCCCCCEEEE		42.8432015554
623PhosphorylationQGHTDGASCIDISND
CCCCCCCEEEEECCC		19.6924114839
627UbiquitinationDGASCIDISNDGTKL
CCCEEEEECCCCCEE		1.7821890473
628PhosphorylationGASCIDISNDGTKLW
CCEEEEECCCCCEEE		25.7224114839
632PhosphorylationIDISNDGTKLWTGGL
EEECCCCCEEECCCC		26.3124114839
643UbiquitinationTGGLDNTVRSWDLRE
CCCCCCCCEEECCCC		5.9821890473
644MethylationGGLDNTVRSWDLREG
CCCCCCCEEECCCCC		29.96-
645UbiquitinationGLDNTVRSWDLREGR
CCCCCCEEECCCCCC		22.1721890473
646UbiquitinationLDNTVRSWDLREGRQ
CCCCCEEECCCCCCC		9.7032015554
652UbiquitinationSWDLREGRQLQQHDF
EECCCCCCCCCCCCC		29.3221890473
652 (in isoform 2)Ubiquitination-29.3221890473
662UbiquitinationQQHDFTSQIFSLGYC
CCCCCCHHEEEECCC		37.3732015554
664UbiquitinationHDFTSQIFSLGYCPT
CCCCHHEEEECCCCC		3.7032015554
670UbiquitinationIFSLGYCPTGEWLAV
EEEECCCCCCCEEEE		34.6521890473
671UbiquitinationFSLGYCPTGEWLAVG
EEECCCCCCCEEEEE		44.1432015554
695PhosphorylationHVTKPDKYQLHLHES
EECCCCCEEEEEECH		24.5626699800
695UbiquitinationHVTKPDKYQLHLHES
EECCCCCEEEEEECH		24.5621890473
696UbiquitinationVTKPDKYQLHLHESC
ECCCCCEEEEEECHH		28.3121890473
697UbiquitinationTKPDKYQLHLHESCV
CCCCCEEEEEECHHH		4.1621890473
698UbiquitinationKPDKYQLHLHESCVL
CCCCEEEEEECHHHH		15.0421890473
700UbiquitinationDKYQLHLHESCVLSL
CCEEEEEECHHHHEE		17.7421890473
701UbiquitinationKYQLHLHESCVLSLK
CEEEEEECHHHHEEE		52.7921890473
702PhosphorylationYQLHLHESCVLSLKF
EEEEEECHHHHEEEE		9.9726699800
704UbiquitinationLHLHESCVLSLKFAH
EEEECHHHHEEEECC		5.9121890473
706PhosphorylationLHESCVLSLKFAHCG
EECHHHHEEEECCCC		14.7626699800
706UbiquitinationLHESCVLSLKFAHCG
EECHHHHEEEECCCC		14.7621890473
712UbiquitinationLSLKFAHCGKWFVST
HEEEECCCCCEEEEC		5.5621890473
714UbiquitinationLKFAHCGKWFVSTGK
EEECCCCCEEEECCC		42.7432015554
715UbiquitinationKFAHCGKWFVSTGKD
EECCCCCEEEECCCC		5.5532015554
716UbiquitinationFAHCGKWFVSTGKDN
ECCCCCEEEECCCCH		3.3832015554
717UbiquitinationAHCGKWFVSTGKDNL
CCCCCEEEECCCCHH		4.9432015554
719UbiquitinationCGKWFVSTGKDNLLN
CCCEEEECCCCHHHH		42.8421890473
720UbiquitinationGKWFVSTGKDNLLNA
CCEEEECCCCHHHHH		28.0121890473
721AcetylationKWFVSTGKDNLLNAW
CEEEECCCCHHHHHH		43.4630770635
721UbiquitinationKWFVSTGKDNLLNAW
CEEEECCCCHHHHHH		43.4622053931
721 (in isoform 1)Ubiquitination-43.4621890473
722UbiquitinationWFVSTGKDNLLNAWR
EEEECCCCHHHHHHC		52.9721890473
723UbiquitinationFVSTGKDNLLNAWRT
EEECCCCHHHHHHCC		50.3332015554
733UbiquitinationNAWRTPYGASIFQSK
HHHCCCCCCCHHCCC		17.6621890473
734UbiquitinationAWRTPYGASIFQSKE
HHCCCCCCCHHCCCC		8.1321890473
737UbiquitinationTPYGASIFQSKESSS
CCCCCCHHCCCCCCC		6.5921890473
738UbiquitinationPYGASIFQSKESSSV
CCCCCHHCCCCCCCC		52.5032015554
739UbiquitinationYGASIFQSKESSSVL
CCCCHHCCCCCCCCE		27.8632015554
740UbiquitinationGASIFQSKESSSVLS
CCCHHCCCCCCCCEE		51.3232015554
741UbiquitinationASIFQSKESSSVLSC
CCHHCCCCCCCCEEE		62.1932015554
742PhosphorylationSIFQSKESSSVLSCD
CHHCCCCCCCCEEEE		31.48-
746UbiquitinationSKESSSVLSCDISVD
CCCCCCCEEEEEEEC		4.5721890473
747UbiquitinationKESSSVLSCDISVDD
CCCCCCEEEEEEECC		13.9521890473
751UbiquitinationSVLSCDISVDDKYIV
CCEEEEEEECCCEEE		13.2721890473
752UbiquitinationVLSCDISVDDKYIVT
CEEEEEEECCCEEEE		12.9421890473
753UbiquitinationLSCDISVDDKYIVTG
EEEEEEECCCEEEEC		39.6321890473
753 (in isoform 3)Ubiquitination-39.6321890473
754UbiquitinationSCDISVDDKYIVTGS
EEEEEECCCEEEECC		43.4321890473
757UbiquitinationISVDDKYIVTGSGDK
EEECCCEEEECCCCC		2.4921890473
758UbiquitinationSVDDKYIVTGSGDKK
EECCCEEEECCCCCE		4.5021890473
763UbiquitinationYIVTGSGDKKATVYE
EEEECCCCCEEEEEE		51.4821890473
764UbiquitinationIVTGSGDKKATVYEV
EEECCCCCEEEEEEE		48.0821890473
765SumoylationVTGSGDKKATVYEVI
EECCCCCEEEEEEEC		54.77-
765SumoylationVTGSGDKKATVYEVI
EECCCCCEEEEEEEC		54.77-
772UbiquitinationKATVYEVIY------
EEEEEEECC------		1.9532015554
777UbiquitinationEVIY-----------
EECC-----------		21890473
778UbiquitinationVIY------------
ECC------------		21890473
779UbiquitinationIY-------------
CC-------------		21890473
788Ubiquitination----------------------
----------------------		21890473
791Ubiquitination-------------------------
-------------------------		21890473
792Ubiquitination--------------------------
--------------------------		21890473
795Ubiquitination-----------------------------
-----------------------------		21890473
799Ubiquitination---------------------------------
---------------------------------		21890473
805Ubiquitination---------------------------------------
---------------------------------------		21890473
818Ubiquitination----------------------------------------------------
----------------------------------------------------		21890473
820Ubiquitination------------------------------------------------------
------------------------------------------------------		21890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseXIAPP98170
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TLE4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TLE4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PAX5_HUMANPAX5physical
10811620
HDAC1_HUMANHDAC1physical
11266540
PAX5_HUMANPAX5physical
12153506
CUX1_HUMANCUX1physical
19332113
CASP_HUMANCUX1physical
19332113
ANM5_HUMANPRMT5physical
22169276
PPM1B_HUMANPPM1Bphysical
22169276
MEP50_HUMANWDR77physical
22169276
PO2F2_HUMANPOU2F2physical
16103132
AES_HUMANAESphysical
28514442
TLE1_HUMANTLE1physical
28514442
TLE2_HUMANTLE2physical
28514442
ZMY19_HUMANZMYND19physical
28514442
ARMC8_HUMANARMC8physical
28514442
MKLN1_HUMANMKLN1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TLE4_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-237 AND LYS-281, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206; SER-208; TYR-243;SER-245; SER-265; SER-292 AND SER-305, AND MASS SPECTROMETRY.

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