PAX5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAX5_HUMAN
• UniProt AC: Q02548
• Protein Name: Paired box protein Pax-5
• Gene Name: PAX5
• Organism: Homo sapiens (Human).
• Sequence Length: 391
• Subcellular Localization: Nucleus.
• Protein Description: May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene..
• Protein Sequence: MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MDLEKNYPTPRT ---CCCCCCCCCCCC	69.91	21357426
7	Phosphorylation	-MDLEKNYPTPRTSR -CCCCCCCCCCCCCC	21.39	22817900
9	Phosphorylation	DLEKNYPTPRTSRTG CCCCCCCCCCCCCCC	18.29	24719451
15	Phosphorylation	PTPRTSRTGHGGVNQ CCCCCCCCCCCCCCC	33.04	24719451
67	Acetylation	VSHGCVSKILGRYYE HHCHHHHHHHCCHHC	22.89	21357426
73	Phosphorylation	SKILGRYYETGSIKP HHHHCCHHCCCCCCC	12.97	18083107
79	Acetylation	YYETGSIKPGVIGGS HHCCCCCCCCCCCCC	37.10	21357426
87	Acetylation	PGVIGGSKPKVATPK CCCCCCCCCCCCCHH	52.73	21357426
89	Acetylation	VIGGSKPKVATPKVV CCCCCCCCCCCHHHH	48.52	21357426
92	Phosphorylation	GSKPKVATPKVVEKI CCCCCCCCHHHHHHH	26.99	20860994
94	Acetylation	KPKVATPKVVEKIAE CCCCCCHHHHHHHHH	55.33	21357426
98	Acetylation	ATPKVVEKIAEYKRQ CCHHHHHHHHHHHHH	35.29	21357426
102	Phosphorylation	VVEKIAEYKRQNPTM HHHHHHHHHHHCCCC	11.49	-
103	Acetylation	VEKIAEYKRQNPTMF HHHHHHHHHHCCCCH	38.73	21357426
133	Phosphorylation	NDTVPSVSSINRIIR CCCCCCHHHHHHHHH	29.82	-
168	Phosphorylation	TGSVTQVSSVSTDSA CCCEEEEEEEECCCC	18.40	-
179	Phosphorylation	TDSAGSSYSISGILG CCCCCCEEEEEEEEC	16.24	-
180	Phosphorylation	DSAGSSYSISGILGI CCCCCEEEEEEEECC	16.54	-
206	Phosphorylation	RDEGIQESPVPNGHS CCCCCCCCCCCCCCC	18.15	26714015
230	Phosphorylation	QMRGDLFTQQQLEVL HHCCCCCHHHHHHHH	32.53	28857561
283	Phosphorylation	DMKANLASPTPADIG HHHHHCCCCCCCCCC	32.26	28348404
285	Phosphorylation	KANLASPTPADIGSS HHHCCCCCCCCCCCC	28.72	28348404
291	Phosphorylation	PTPADIGSSVPGPQS CCCCCCCCCCCCCCC	28.61	26714015
292	Phosphorylation	TPADIGSSVPGPQSY CCCCCCCCCCCCCCC	27.41	26714015
298	Phosphorylation	SSVPGPQSYPIVTGR CCCCCCCCCCEEECC	35.69	26714015
299	Phosphorylation	SVPGPQSYPIVTGRD CCCCCCCCCEEECCC	7.54	-
377	Methylation	YYYSAAARGAAPPAA CHHHHHHCCCCCCCH	30.47	115386157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAX5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAX5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAX5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TLE4_HUMAN	TLE4	physical	10811620
DAXX_HUMAN	DAXX	physical	11799127
RUNX1_HUMAN	RUNX1	physical	10455134
EP300_HUMAN	EP300	physical	21357426
TBP_HUMAN	TBP	physical	10197586
RB_HUMAN	RB1	physical	10197586

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• : Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9
• : 18)(p13
• : q11.2) with ZNF521. Translocation t(9
• : 3)(p13
• : p14.1) with FOXP1. Translocation t(9
• : 12)(p13
• : p13) with ETV6.
• 613065:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.