dbPTM

CUX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CUX1_HUMAN
UniProt AC	P39880
Protein Name	Homeobox protein cut-like 1
Gene Name	CUX1
Organism	Homo sapiens (Human).
Sequence Length	1505
Subcellular Localization	Nucleus.
Protein Description	Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity)..
Protein Sequence	MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPIEWEF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	QVAPLLKSFQGEIDA HHHHHHHHHHHHHHH	23.83	22210691
68	Phosphorylation	QGEIDALSKRSKEAE HHHHHHHHHHHHHHH	27.95	22210691
78	Ubiquitination	SKEAEAAFLNVYKRL HHHHHHHHHHHHHHH	7.03	21890473
78	Ubiquitination	SKEAEAAFLNVYKRL HHHHHHHHHHHHHHH	7.03	21890473
78	Ubiquitination	SKEAEAAFLNVYKRL HHHHHHHHHHHHHHH	7.03	21890473
78	Ubiquitination	SKEAEAAFLNVYKRL HHHHHHHHHHHHHHH	7.03	21890473
83	Ubiquitination	AAFLNVYKRLIDVPD HHHHHHHHHHCCCCC	36.12	21890473
83 (in isoform 1)	Ubiquitination	-	36.12	21890473
83 (in isoform 2)	Ubiquitination	-	36.12	21890473
83 (in isoform 4)	Ubiquitination	-	36.12	21890473
83 (in isoform 5)	Ubiquitination	-	36.12	21890473
87 (in isoform 6)	Ubiquitination	-	50.95	21890473
94 (in isoform 3)	Ubiquitination	-	17.59	21890473
94	Ubiquitination	DVPDPVPALDLGQQL CCCCCCCCCCHHHHH	17.59	21890473
117	Ubiquitination	DIETENQKLRETLEE HHHHHHHHHHHHHHH	62.18	-
175	Acetylation	LQNDFAEKERKLQET HHHHHHHHHHHHHHH	60.43	26051181
199	Phosphorylation	EAEHKVQSLQTALEK HHHHHHHHHHHHHHH	25.98	25849741
201	Ubiquitination	EHKVQSLQTALEKTR HHHHHHHHHHHHHHH	29.94	21890473
201	Ubiquitination	EHKVQSLQTALEKTR HHHHHHHHHHHHHHH	29.94	21890473
201	Ubiquitination	EHKVQSLQTALEKTR HHHHHHHHHHHHHHH	29.94	21890473
201	Ubiquitination	EHKVQSLQTALEKTR HHHHHHHHHHHHHHH	29.94	21890473
206	Ubiquitination	SLQTALEKTRTELFD HHHHHHHHHHHHHHC	44.12	21890473
206 (in isoform 1)	Ubiquitination	-	44.12	21890473
206 (in isoform 2)	Ubiquitination	-	44.12	21890473
206 (in isoform 4)	Ubiquitination	-	44.12	21890473
206 (in isoform 5)	Ubiquitination	-	44.12	21890473
210 (in isoform 6)	Ubiquitination	-	44.12	21890473
217	Ubiquitination	ELFDLKTKYDEETTA HHHCCCCCCCHHHCC	49.47	-
217 (in isoform 3)	Ubiquitination	-	49.47	21890473
217	Ubiquitination	ELFDLKTKYDEETTA HHHCCCCCCCHHHCC	49.47	21890473
234	Phosphorylation	DEIEMIMTDLERANQ HHHHHHHHHHHHHHH	26.89	29514088
263	Phosphorylation	QLSSANHSLQLASQI HHHHHHHHHHHHHHH	20.02	28555341
286	Phosphorylation	AIEVLTRSSLEVELA HHHHHHHCCHHHHHH	33.76	28674419
287	Phosphorylation	IEVLTRSSLEVELAA HHHHHHCCHHHHHHH	25.84	27134283
312	Phosphorylation	DVQRLQASLTKLREN HHHHHHHHHHHHHHC	24.50	23403867
314	Phosphorylation	QRLQASLTKLRENSA HHHHHHHHHHHHCCH	26.07	23403867
322	Phosphorylation	KLRENSASQISQLEQ HHHHCCHHHHHHHHH	28.06	17525332
336	Phosphorylation	QQLSAKNSTLKQLEE HHHHHCCHHHHHHHH	34.12	22210691
337	Phosphorylation	QLSAKNSTLKQLEEK HHHHCCHHHHHHHHH	47.57	22210691
351	Phosphorylation	KLKGQADYEEVKKEL HHCCCCCHHHHHHHH	19.60	28796482
363	Phosphorylation	KELNILKSMEFAPSE HHHHHHHHCCCCCCC	21.79	-
369	Phosphorylation	KSMEFAPSEGAGTQD HHCCCCCCCCCCCCC	45.28	-
374	Phosphorylation	APSEGAGTQDAAKPL CCCCCCCCCCCCCCH	23.81	-
383	Ubiquitination	DAAKPLEVLLLEKNR CCCCCHHHHHHHCCC	6.34	21890473
383 (in isoform 9)	Phosphorylation	-	6.34	-
383	Ubiquitination	DAAKPLEVLLLEKNR CCCCCHHHHHHHCCC	6.34	21890473
383	Ubiquitination	DAAKPLEVLLLEKNR CCCCCHHHHHHHCCC	6.34	21890473
383	Ubiquitination	DAAKPLEVLLLEKNR CCCCCHHHHHHHCCC	6.34	21890473
388	Ubiquitination	LEVLLLEKNRSLQSE HHHHHHHCCCCCCCC	58.59	21890473
388 (in isoform 1)	Ubiquitination	-	58.59	21890473
388 (in isoform 2)	Ubiquitination	-	58.59	21890473
388 (in isoform 4)	Ubiquitination	-	58.59	21890473
388 (in isoform 5)	Ubiquitination	-	58.59	21890473
388 (in isoform 9)	Phosphorylation	-	58.59	-
390 (in isoform 9)	Phosphorylation	-	50.22	-
391	Phosphorylation	LLLEKNRSLQSENAA HHHHCCCCCCCCCHH	39.90	20068231
392 (in isoform 6)	Ubiquitination	-	6.16	21890473
394	Phosphorylation	EKNRSLQSENAALRI HCCCCCCCCCHHHHH	37.80	22210691
397	Ubiquitination	RSLQSENAALRISNS CCCCCCCHHHHHCCC	12.11	21890473
399 (in isoform 3)	Ubiquitination	-	4.67	21890473
402	Phosphorylation	ENAALRISNSDLSGS CCHHHHHCCCCCCCC	24.69	24732914
404	Phosphorylation	AALRISNSDLSGSAR HHHHHCCCCCCCCHH	32.89	24732914
404 (in isoform 9)	Phosphorylation	-	32.89	28555341
407	Phosphorylation	RISNSDLSGSARRKG HHCCCCCCCCHHHCC	35.37	29255136
409	Phosphorylation	SNSDLSGSARRKGKD CCCCCCCCHHHCCCC	18.41	29255136
418 (in isoform 3)	Phosphorylation	-	52.22	24719451
420 (in isoform 3)	Phosphorylation	-	40.03	27251275
425	Phosphorylation	PESRRPGSLPAPPPS CCCCCCCCCCCCCCH	33.59	25159151
432	Phosphorylation	SLPAPPPSQLPRNPG CCCCCCCHHCCCCCC	50.55	23312004
436 (in isoform 3)	Phosphorylation	-	71.25	24719451
437 (in isoform 9)	Phosphorylation	-	47.17	24173317
443 (in isoform 3)	Phosphorylation	-	43.83	24719451
452	Phosphorylation	TNGTHQFSPAGLSQD CCCCCCCCCCCCCCC	13.79	18669648
454 (in isoform 9)	Phosphorylation	-	30.29	-
457 (in isoform 9)	Phosphorylation	-	27.13	-
461 (in isoform 9)	Phosphorylation	-	10.48	-
467	Phosphorylation	FFSSSLASPSLPLAS CCCCCCCCCCCCCCC	21.95	18669648
482	Phosphorylation	TGKFALNSLLQRQLM CCHHHHHHHHHHHHH	31.16	28555341
491	Phosphorylation	LQRQLMQSFYSKAMQ HHHHHHHHHHHHHHH	16.52	28555341
509 (in isoform 4)	Ubiquitination	-	31.28	21890473
510 (in isoform 9)	Phosphorylation	-	20.25	30108239
511 (in isoform 9)	Phosphorylation	-	21.71	27251275
513 (in isoform 6)	Ubiquitination	-	25.01	21890473
516 (in isoform 9)	Phosphorylation	-	24.76	30108239
518 (in isoform 9)	Phosphorylation	-	23.34	27251275
521 (in isoform 9)	Phosphorylation	-	29.53	27251275
524 (in isoform 9)	Methylation	-	45.12	-
529 (in isoform 9)	Phosphorylation	-	8.29	25884760
537 (in isoform 9)	Phosphorylation	-	51.15	26657352
538 (in isoform 9)	Phosphorylation	-	55.38	25159151
540 (in isoform 9)	Phosphorylation	-	36.65	30108239
561	Ubiquitination	AEIARQVKEQLIKHN HHHHHHHHHHHHHCC	31.25	-
567 (in isoform 9)	Phosphorylation	-	24.93	21964256
577	Ubiquitination	GQRIFGHYVLGLSQG HHHHHHHHHHCCCCC	9.57	21890473
577	Ubiquitination	GQRIFGHYVLGLSQG HHHHHHHHHHCCCCC	9.57	21890473
577	Ubiquitination	GQRIFGHYVLGLSQG HHHHHHHHHHCCCCC	9.57	21890473
577	Ubiquitination	GQRIFGHYVLGLSQG HHHHHHHHHHCCCCC	9.57	21890473
585	Phosphorylation	VLGLSQGSVSEILAR HHCCCCCCHHHHHCC	18.16	-
586	Ubiquitination	LGLSQGSVSEILARP HCCCCCCHHHHHCCC	8.33	21890473
586	Ubiquitination	LGLSQGSVSEILARP HCCCCCCHHHHHCCC	8.33	21890473
586	Ubiquitination	LGLSQGSVSEILARP HCCCCCCHHHHHCCC	8.33	21890473
586	Ubiquitination	LGLSQGSVSEILARP HCCCCCCHHHHHCCC	8.33	21890473
591	Ubiquitination	GSVSEILARPKPWNK CCHHHHHCCCCCCCC	31.24	21890473
600	Phosphorylation	PKPWNKLTVRGKEPF CCCCCCCCCCCCCCH	15.12	-
600	Ubiquitination	PKPWNKLTVRGKEPF CCCCCCCCCCCCCCH	15.12	21890473
604	Acetylation	NKLTVRGKEPFHKMK CCCCCCCCCCHHHHH	52.21	18585823
611	Ubiquitination	KEPFHKMKQFLSDEQ CCCHHHHHHHCCHHH	42.58	2189047
611 (in isoform 1)	Ubiquitination	-	42.58	21890473
611 (in isoform 2)	Ubiquitination	-	42.58	21890473
611 (in isoform 5)	Ubiquitination	-	42.58	21890473
622 (in isoform 3)	Ubiquitination	-	9.35	21890473
637	Phosphorylation	QRENPGQSLNRLFQE CCCCCCHHHHHHHHH	33.26	28555341
647	Ubiquitination	RLFQEVPKRRNGSEG HHHHHCCCCCCCCCC	69.99	-
652	Phosphorylation	VPKRRNGSEGNITTR CCCCCCCCCCCCEEE	45.97	28555341
657	Phosphorylation	NGSEGNITTRIRASE CCCCCCCEEEEEECC	17.64	28102081
658	Phosphorylation	GSEGNITTRIRASET CCCCCCEEEEEECCC	21.94	28102081
663	Phosphorylation	ITTRIRASETGSDEA CEEEEEECCCCCHHH	26.33	30576142
663 (in isoform 3)	Phosphorylation	-	26.33	24719451
665	Phosphorylation	TRIRASETGSDEAIK EEEEECCCCCHHHHH	39.22	30576142
667	Phosphorylation	IRASETGSDEAIKSI EEECCCCCHHHHHHH	39.43	30576142
672	Ubiquitination	TGSDEAIKSILEQAK CCCHHHHHHHHHHHH	38.19	-
673	Phosphorylation	GSDEAIKSILEQAKR CCHHHHHHHHHHHHH	26.71	28555341
679	Ubiquitination	KSILEQAKRELQVQK HHHHHHHHHHHCCCC	46.21	-
686	Ubiquitination	KRELQVQKTAEPAQP HHHHCCCCCCCCCCC	51.34	-
694	Phosphorylation	TAEPAQPSSASGSGN CCCCCCCCCCCCCCC	26.84	24114839
695	Phosphorylation	AEPAQPSSASGSGNS CCCCCCCCCCCCCCH	32.89	24114839
699	Phosphorylation	QPSSASGSGNSDDAI CCCCCCCCCCHHHHH	32.10	24114839
708	Phosphorylation	NSDDAIRSILQQARR CHHHHHHHHHHHHHH	22.87	28555341
717	Sulfoxidation	LQQARREMEAQQAAL HHHHHHHHHHHHHHH	4.99	21406390
729	Ubiquitination	AALDPALKQAPLSQS HHHCHHHHHCCCCHH	46.66	-
734	O-linked_Glycosylation	ALKQAPLSQSDITIL HHHHCCCCHHCCEEE	26.95	30059200
734	Phosphorylation	ALKQAPLSQSDITIL HHHHCCCCHHCCEEE	26.95	22817901
736	Phosphorylation	KQAPLSQSDITILTP HHCCCCHHCCEEECH	27.83	27251275
739	Phosphorylation	PLSQSDITILTPKLL CCCHHCCEEECHHHH	18.22	29978859
742	Phosphorylation	QSDITILTPKLLSTS HHCCEEECHHHHCCC	17.96	29978859
747	Phosphorylation	ILTPKLLSTSPMPTV EECHHHHCCCCCCCC	36.96	24732914
747 (in isoform 3)	Phosphorylation	-	36.96	27251275
748	Phosphorylation	LTPKLLSTSPMPTVS ECHHHHCCCCCCCCC	36.50	24732914
749	Phosphorylation	TPKLLSTSPMPTVSS CHHHHCCCCCCCCCC	18.80	28102081
753	Phosphorylation	LSTSPMPTVSSYPPL HCCCCCCCCCCCCCE	27.11	24732914
753 (in isoform 3)	Phosphorylation	-	27.11	24719451
755	Phosphorylation	TSPMPTVSSYPPLAI CCCCCCCCCCCCEEE	27.00	24732914
756	Phosphorylation	SPMPTVSSYPPLAIS CCCCCCCCCCCEEEE	37.00	24732914
757	Phosphorylation	PMPTVSSYPPLAISL CCCCCCCCCCEEEEE	11.02	24732914
758 (in isoform 3)	Phosphorylation	-	21.26	27251275
760 (in isoform 3)	Phosphorylation	-	5.97	24719451
763	Phosphorylation	SYPPLAISLKKPSAA CCCCEEEEECCCCCC	28.64	24732914
767 (in isoform 3)	Phosphorylation	-	27.84	21406692
768	Phosphorylation	AISLKKPSAAPEAGA EEEECCCCCCCCCCC	46.04	-
785	Sumoylation	LPNPPALKKEAQDAP CCCCHHHHHHHHCCC	51.15	28112733
811	Sumoylation	QGVLRQVKNEVGRSG HHHHHHHHHHHCCCC	38.77	-
811	Sumoylation	QGVLRQVKNEVGRSG HHHHHHHHHHHCCCC	38.77	28112733
817	Phosphorylation	VKNEVGRSGAWKDHW HHHHHCCCCCCCCHH	27.25	21857030
842	Sumoylation	AASSEEAKAEETGGG CCCHHHHHHHHHCCC	60.66	28112733
850	Acetylation	AEETGGGKEKGSGGS HHHHCCCCCCCCCCC	60.57	23749302
868	Phosphorylation	SQPRAERSQLQGPSS CCCHHHHHHCCCCCC	27.09	28555341
874	Phosphorylation	RSQLQGPSSSEYWKE HHHCCCCCCHHHHHH	54.01	25159151
875	Phosphorylation	SQLQGPSSSEYWKEW HHCCCCCCHHHHHHC	30.26	25627689
876	Phosphorylation	QLQGPSSSEYWKEWP HCCCCCCHHHHHHCC	38.76	25627689
884	Phosphorylation	EYWKEWPSAESPYSQ HHHHHCCCCCCCCCC	45.82	30576142
887	Phosphorylation	KEWPSAESPYSQSSE HHCCCCCCCCCCCCC	28.93	25159151
889	Phosphorylation	WPSAESPYSQSSELS CCCCCCCCCCCCCCC	28.73	26074081
889 (in isoform 3)	Phosphorylation	-	28.73	27642862
890	Phosphorylation	PSAESPYSQSSELSL CCCCCCCCCCCCCCC	27.28	26074081
892	Phosphorylation	AESPYSQSSELSLTG CCCCCCCCCCCCCCC	21.60	26074081
893	Phosphorylation	ESPYSQSSELSLTGA CCCCCCCCCCCCCCC	34.61	26074081
896	Phosphorylation	YSQSSELSLTGASRS CCCCCCCCCCCCCCC	21.60	26074081
898	Phosphorylation	QSSELSLTGASRSET CCCCCCCCCCCCCCC	27.59	26074081
898 (in isoform 3)	Phosphorylation	-	27.59	27251275
901	Phosphorylation	ELSLTGASRSETPQN CCCCCCCCCCCCCCC	37.37	25159151
903	Phosphorylation	SLTGASRSETPQNSP CCCCCCCCCCCCCCC	43.24	26074081
905	Phosphorylation	TGASRSETPQNSPLP CCCCCCCCCCCCCCC	31.27	28302921
909	Phosphorylation	RSETPQNSPLPSSPI CCCCCCCCCCCCCCC	23.67	25850435
913	Phosphorylation	PQNSPLPSSPIVPMS CCCCCCCCCCCCCCC	57.33	29507054
914	Phosphorylation	QNSPLPSSPIVPMSK CCCCCCCCCCCCCCC	19.39	26657352
920	Phosphorylation	SSPIVPMSKPTKPSV CCCCCCCCCCCCCCC	29.43	26657352
923	Phosphorylation	IVPMSKPTKPSVPPL CCCCCCCCCCCCCCC	60.36	26074081
926	Phosphorylation	MSKPTKPSVPPLTPE CCCCCCCCCCCCCHH	49.14	26074081
931	Phosphorylation	KPSVPPLTPEQYEVY CCCCCCCCHHHEEEE	30.47	26074081
935	Phosphorylation	PPLTPEQYEVYMYQE CCCCHHHEEEEEEEE	13.00	26074081
937 (in isoform 3)	Phosphorylation	-	2.57	27251275
974	Phosphorylation	GEKVLGLSQGSVSDM CCHHHCCCCCCHHHH	30.60	25850435
977	Phosphorylation	VLGLSQGSVSDMLSR HHCCCCCCHHHHHCC	15.71	25850435
979	Phosphorylation	GLSQGSVSDMLSRPK CCCCCCHHHHHCCCC	20.99	20068231
983	Phosphorylation	GSVSDMLSRPKPWSK CCHHHHHCCCCCHHH	39.64	20068231
990	Ubiquitination	SRPKPWSKLTQKGRE CCCCCHHHHCCCCCC	52.24	-
1049	Phosphorylation	SSESTPKTSASCSPA CCCCCCCCCCCCCCC	30.63	27732954
1050	Phosphorylation	SESTPKTSASCSPAP CCCCCCCCCCCCCCC	25.06	27732954
1052	Phosphorylation	STPKTSASCSPAPES CCCCCCCCCCCCCCC	18.20	27732954
1054	Phosphorylation	PKTSASCSPAPESPM CCCCCCCCCCCCCCC	22.92	25849741
1059	Phosphorylation	SCSPAPESPMSSSES CCCCCCCCCCCCCHH	25.50	25159151
1062	Phosphorylation	PAPESPMSSSESVKS CCCCCCCCCCHHHHH	33.81	27732954
1063	Phosphorylation	APESPMSSSESVKSL CCCCCCCCCHHHHHH	31.69	27732954
1064	Phosphorylation	PESPMSSSESVKSLT CCCCCCCCHHHHHHH	26.95	27732954
1065 (in isoform 3)	Phosphorylation	-	62.59	27251275
1066	Phosphorylation	SPMSSSESVKSLTEL CCCCCCHHHHHHHHH	36.47	27251275
1069	Phosphorylation	SSSESVKSLTELVQQ CCCHHHHHHHHHHHC	38.07	30266825
1070 (in isoform 3)	Phosphorylation	-	3.41	24719451
1071	Phosphorylation	SESVKSLTELVQQPC CHHHHHHHHHHHCCC	34.07	30266825
1074 (in isoform 3)	Phosphorylation	-	3.96	27251275
1080 (in isoform 3)	Phosphorylation	-	43.71	27251275
1084	Phosphorylation	PCPPIEASKDSKPPE CCCCCCCCCCCCCCC	24.97	30266825
1087	Phosphorylation	PIEASKDSKPPEPSD CCCCCCCCCCCCCCC	51.29	26074081
1093	Phosphorylation	DSKPPEPSDPPASDS CCCCCCCCCCCCCCC	62.17	26074081
1098	Phosphorylation	EPSDPPASDSQPTTP CCCCCCCCCCCCCCC	43.50	26074081
1100	Phosphorylation	SDPPASDSQPTTPLP CCCCCCCCCCCCCCC	35.25	26074081
1103	Phosphorylation	PASDSQPTTPLPLSG CCCCCCCCCCCCCCC	33.15	26074081
1104	Phosphorylation	ASDSQPTTPLPLSGH CCCCCCCCCCCCCCC	29.52	28387310
1109	Phosphorylation	PTTPLPLSGHSALSI CCCCCCCCCCCCCCH	32.30	27251275
1111 (in isoform 3)	Phosphorylation	-	13.41	27251275
1112	Phosphorylation	PLPLSGHSALSIQEL CCCCCCCCCCCHHHH	34.14	27251275
1114 (in isoform 3)	Phosphorylation	-	5.34	27251275
1115	Phosphorylation	LSGHSALSIQELVAM CCCCCCCCHHHHHHH	23.18	27251275
1126 (in isoform 3)	Phosphorylation	-	7.28	27251275
1157	Phosphorylation	GETILGLTQGSVSDL CHHHHCCCCCCHHHH	29.14	-
1215	Phosphorylation	AYMKRRHSSVSDSQP HHHHHCCCCCCCCCC	30.53	23401153
1216	Phosphorylation	YMKRRHSSVSDSQPC HHHHCCCCCCCCCCC	21.37	23927012
1218	Phosphorylation	KRRHSSVSDSQPCEP HHCCCCCCCCCCCCC	33.23	17525332
1220	Phosphorylation	RHSSVSDSQPCEPPS CCCCCCCCCCCCCCC	28.63	23927012
1226 (in isoform 3)	Phosphorylation	-	21.25	27251275
1227	Phosphorylation	SQPCEPPSVGTEYSQ CCCCCCCCCCCCCCC	43.84	23401153
1227 (in isoform 3)	Phosphorylation	-	43.84	24719451
1229 (in isoform 3)	Phosphorylation	-	19.71	27251275
1230	Phosphorylation	CEPPSVGTEYSQGAS CCCCCCCCCCCCCCC	29.60	23401153
1232	Phosphorylation	PPSVGTEYSQGASPQ CCCCCCCCCCCCCCC	13.21	17525332
1233	Phosphorylation	PSVGTEYSQGASPQP CCCCCCCCCCCCCCC	18.86	17525332
1237	Phosphorylation	TEYSQGASPQPQHQL CCCCCCCCCCCHHHC	30.78	23927012
1248 (in isoform 3)	Phosphorylation	-	39.80	27251275
1256	Ubiquitination	VVLAPEEKEALKRAY EEECHHHHHHHHHHH	46.77	-
1263	Phosphorylation	KEALKRAYQQKPYPS HHHHHHHHHCCCCCC	18.60	23927012
1268	Phosphorylation	RAYQQKPYPSPKTIE HHHHCCCCCCCCCHH	24.31	30266825
1270	Phosphorylation	YQQKPYPSPKTIEDL HHCCCCCCCCCHHHH	32.93	30266825
1281 (in isoform 3)	Phosphorylation	-	7.62	24719451
1284	Sumoylation	LATQLNLKTSTVINW HHHHHCCCHHHHHHH	39.08	28112733
1312	Phosphorylation	IEEIQAGSQGQAGAS HHHHHCCCCCCCCCC	33.87	17525332
1319	Phosphorylation	SQGQAGASDSPSARS CCCCCCCCCCCCCCC	37.39	30266825
1321	Phosphorylation	GQAGASDSPSARSGR CCCCCCCCCCCCCCC	20.47	30266825
1323	Phosphorylation	AGASDSPSARSGRAA CCCCCCCCCCCCCCC	40.02	30266825
1332	Phosphorylation	RSGRAAPSSEGDSCD CCCCCCCCCCCCCCC	35.97	23401153
1332 (in isoform 3)	Phosphorylation	-	35.97	24719451
1333	Phosphorylation	SGRAAPSSEGDSCDG CCCCCCCCCCCCCCC	44.53	21712546
1337	Phosphorylation	APSSEGDSCDGVEAT CCCCCCCCCCCCCCC	25.60	21712546
1344	Phosphorylation	SCDGVEATEGPGSAD CCCCCCCCCCCCCCC	28.15	20873877
1344 (in isoform 3)	Phosphorylation	-	28.15	27251275
1348 (in isoform 3)	Phosphorylation	-	46.45	27251275
1349	Phosphorylation	EATEGPGSADTEEPK CCCCCCCCCCCCCCC	26.55	25850435
1352	Phosphorylation	EGPGSADTEEPKSQG CCCCCCCCCCCCCCC	41.80	25850435
1357	Phosphorylation	ADTEEPKSQGEAERE CCCCCCCCCCCHHCC	54.88	25850435
1373	Phosphorylation	VPRPAEQTEPPPSGT CCCCHHHCCCCCCCC	41.80	30266825
1378	Phosphorylation	EQTEPPPSGTPGPDD HHCCCCCCCCCCCCC	62.16	30266825
1380	Phosphorylation	TEPPPSGTPGPDDAR CCCCCCCCCCCCCCC	29.43	30266825
1404	Phosphorylation	EGPGPLPSPASATAT CCCCCCCCCCCCCCC	40.56	-
1454	Phosphorylation	SSAPRRPSSLQSLFG CCCCCCCCHHHHHHC	41.70	28176443
1455	Phosphorylation	SAPRRPSSLQSLFGL CCCCCCCHHHHHHCC	32.86	25463755
1458	Phosphorylation	RRPSSLQSLFGLPEA CCCCHHHHHHCCCHH	30.84	28176443
1465 (in isoform 3)	Phosphorylation	-	14.84	24719451
1486	Phosphorylation	KKAANLNSIIHRLEK HHHHHHHHHHHHHHH	26.53	23401153
1496	Phosphorylation	HRLEKAASREEPIEW HHHHHHHCCCCCCCC	45.12	28355574
1507 (in isoform 3)	Phosphorylation	-		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1215	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1215	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
1215	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
1237	S	Phosphorylation	Kinase	CDK1	P06493	PhosphoELM
1237	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1270	S	Phosphorylation	Kinase	CDK1	P06493	PhosphoELM
1270	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1357	S	Phosphorylation	Kinase	ATR	Q13535	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CUX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CUX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BIN1_HUMAN	BIN1	physical	16169070
RNZ2_HUMAN	ELAC2	physical	16169070
RECQ5_HUMAN	RECQL5	physical	16169070
CDK7_HUMAN	CDK7	physical	11584018
CCNA1_HUMAN	CCNA1	physical	11584018
SATB1_HUMAN	SATB1	physical	10373541
TLE4_HUMAN	TLE4	physical	19332113
EHMT2_HUMAN	EHMT2	physical	15269344

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CUX1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1496, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054 AND SER-1059, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1496, AND MASSSPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-322; SER-1218; TYR-1232;SER-1233 AND SER-1312, AND MASS SPECTROMETRY.	17525332 [Abstract]