UniProt ID | PPM1B_HUMAN | |
---|---|---|
UniProt AC | O75688 | |
Protein Name | Protein phosphatase 1B | |
Gene Name | PPM1B | |
Organism | Homo sapiens (Human). | |
Sequence Length | 479 | |
Subcellular Localization |
Cytoplasm, cytosol . Membrane Lipid-anchor . Weakly associates at the membrane and N-myristoylation mediates the membrane localization. |
|
Protein Description | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.. | |
Protein Sequence | MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRLAKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Myristoylation | ------MGAFLDKPK ------CCCCCCCCC | 25.65 | 25255805 | |
12 | Ubiquitination | LDKPKTEKHNAHGAG CCCCCCCCCCCCCCC | 47.60 | - | |
27 | Ubiquitination | NGLRYGLSSMQGWRV CCHHHCHHHCCCEEE | 21.28 | 33845483 | |
39 | Ubiquitination | WRVEMEDAHTAVVGI EEEEECCCCEEEECC | 6.66 | 32015554 | |
89 | Phosphorylation | NEDFRAAGKSGSALE CHHHHHCCCCCCCEE | 24.55 | 32645325 | |
90 | Ubiquitination | EDFRAAGKSGSALEL HHHHHCCCCCCCEEE | 47.09 | 33845483 | |
91 | Phosphorylation | DFRAAGKSGSALELS HHHHCCCCCCCEEEE | 36.74 | 27251275 | |
93 | Phosphorylation | RAAGKSGSALELSVE HHCCCCCCCEEEEHH | 36.45 | 27251275 | |
103 | Ubiquitination | ELSVENVKNGIRTGF EEEHHHHHCCCCCCC | 62.12 | 29967540 | |
104 | Ubiquitination | LSVENVKNGIRTGFL EEHHHHHCCCCCCCC | 47.01 | 23000965 | |
112 | Ubiquitination | GIRTGFLKIDEYMRN CCCCCCCHHHHHHHC | 45.94 | 23000965 | |
116 | Phosphorylation | GFLKIDEYMRNFSDL CCCHHHHHHHCHHHH | 9.53 | 30576142 | |
121 | Phosphorylation | DEYMRNFSDLRNGMD HHHHHCHHHHHCCCC | 39.01 | 30576142 | |
135 | Ubiquitination | DRSGSTAVGVMISPK CCCCCCEEEEEECCC | 6.34 | 23503661 | |
140 | Phosphorylation | TAVGVMISPKHIYFI CEEEEEECCCEEEEE | 15.14 | 24719451 | |
163 | S-nitrosylation | LYRNGQVCFSTQDHK EEECCEEEEECCCCC | 1.39 | 22178444 | |
172 | S-nitrosylation | STQDHKPCNPREKER ECCCCCCCCHHHHHH | 15.15 | 22178444 | |
186 | Phosphorylation | RIQNAGGSVMIQRVN HHHHCCCCEEEEEEC | 13.95 | 28857561 | |
188 | Sulfoxidation | QNAGGSVMIQRVNGS HHCCCCEEEEEECCC | 2.01 | 21406390 | |
195 | Phosphorylation | MIQRVNGSLAVSRAL EEEEECCCCHHHHHH | 14.14 | 26699800 | |
199 | Phosphorylation | VNGSLAVSRALGDYD ECCCCHHHHHHCCCC | 13.26 | 21406692 | |
208 | Ubiquitination | ALGDYDYKCVDGKGP HHCCCCCEECCCCCC | 25.53 | 33845483 | |
265 | Phosphorylation | VKSRLEVSDDLENVC HHHHHCCCHHHHHHH | 18.94 | - | |
289 | Phosphorylation | KGSRDNMSIVLVCFS CCCCCCEEEEEEEEC | 18.79 | 30243723 | |
296 | Phosphorylation | SIVLVCFSNAPKVSD EEEEEEECCCCCCCH | 27.27 | 30243723 | |
302 | Phosphorylation | FSNAPKVSDEAVKKD ECCCCCCCHHHHHHH | 35.54 | 30243723 | |
308 | 2-Hydroxyisobutyrylation | VSDEAVKKDSELDKH CCHHHHHHHHHHHHH | 60.94 | - | |
314 | Ubiquitination | KKDSELDKHLESRVE HHHHHHHHHHHHHHH | 63.81 | 33845483 | |
326 (in isoform 1) | Ubiquitination | - | 46.51 | 22053931 | |
326 (in isoform 2) | Ubiquitination | - | 46.51 | 21906983 | |
326 | Ubiquitination | RVEEIMEKSGEEGMP HHHHHHHHHCCCCCC | 46.51 | 21906983 | |
343 | Phosphorylation | AHVMRILSAENIPNL HHHHHHHCCCCCCCC | 31.03 | 27251275 | |
367 | Phosphorylation | RNVIEAVYSRLNPHR HHHHHHHHHHHCCCC | 8.63 | 29978859 | |
368 | Phosphorylation | NVIEAVYSRLNPHRE HHHHHHHHHHCCCCC | 24.56 | 29978859 | |
376 | Phosphorylation | RLNPHRESDGASDEA HHCCCCCCCCCCHHH | 41.10 | 29255136 | |
376 (in isoform 2) | Phosphorylation | - | 41.10 | 28450419 | |
380 | Phosphorylation | HRESDGASDEAEESG CCCCCCCCHHHHHHC | 41.32 | 29255136 | |
386 | Phosphorylation | ASDEAEESGSQGKLV CCHHHHHHCCHHHHH | 34.94 | 10934208 | |
388 | Phosphorylation | DEAEESGSQGKLVEA HHHHHHCCHHHHHHH | 45.07 | 27542207 | |
391 | Ubiquitination | EESGSQGKLVEALRQ HHHCCHHHHHHHHHH | 41.54 | 23000965 | |
391 (in isoform 1) | Ubiquitination | - | 41.54 | 22053931 | |
399 | Ubiquitination | LVEALRQMRINHRGN HHHHHHHHCCCCCCC | 3.62 | 23000965 | |
418 | Phosphorylation | LEEMLTSYRLAKVEG HHHHHHHHHHHHCCC | 12.38 | - | |
422 | Ubiquitination | LTSYRLAKVEGEESP HHHHHHHHCCCCCCC | 45.47 | 23503661 | |
430 | Ubiquitination | VEGEESPAEPAATAT CCCCCCCCCCCCCCC | 44.69 | 23503661 | |
465 | Phosphorylation | SGLAELDSSNEDAGT CCCEECCCCCCCCCC | 47.92 | 22468782 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
195 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PPM1B_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PPM1B_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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