FEZ2_HUMAN - dbPTM
FEZ2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FEZ2_HUMAN
UniProt AC Q9UHY8
Protein Name Fasciculation and elongation protein zeta-2
Gene Name FEZ2
Organism Homo sapiens (Human).
Sequence Length 353
Subcellular Localization
Protein Description Involved in axonal outgrowth and fasciculation..
Protein Sequence MAADGDWQDFYEFQEPARSLLDQENCNASPEPGAEAGAEAGGGADGFPAPACSLEEKLSLCFRPSDPGAEPPRTAVRPITERSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGVSDSLLFDTSDDEELREQLDMHSIIVSCVNDEPLFTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSTGSYEERVKRLSVSELNEILEEIETAIKEYSEELVQQLALRDELEFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNERSHMPGTYLTTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSLLTDYILKVLCPT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationDGDWQDFYEFQEPAR
CCCHHHHHHCHHHHH		24.9125106551
11 (in isoform 2)Phosphorylation-24.9127642862
29PhosphorylationDQENCNASPEPGAEA
CHHCCCCCCCCCHHC		18.7928348404
29 (in isoform 2)Phosphorylation-18.7927251275
53PhosphorylationGFPAPACSLEEKLSL
CCCCCCCCHHHHHHH		40.7028102081
65PhosphorylationLSLCFRPSDPGAEPP
HHHCCCCCCCCCCCC		52.7825159151
107UbiquitinationNVMPVDWKSSHTRTL
CCCCCCCCCCCCCEE		37.3021963094
108PhosphorylationVMPVDWKSSHTRTLH
CCCCCCCCCCCCEEE		24.09-
109PhosphorylationMPVDWKSSHTRTLHL
CCCCCCCCCCCEEEE		25.75-
111PhosphorylationVDWKSSHTRTLHLLT
CCCCCCCCCEEEEEE		27.57-
118PhosphorylationTRTLHLLTLNLSEKG
CCEEEEEEEECCCCC		21.69-
122PhosphorylationHLLTLNLSEKGVSDS
EEEEEECCCCCCCCC		35.8723898821
122 (in isoform 2)Phosphorylation-35.8727251275
129PhosphorylationSEKGVSDSLLFDTSD
CCCCCCCCCEECCCC		21.3328060719
134PhosphorylationSDSLLFDTSDDEELR
CCCCEECCCCHHHHH		27.0723663014
134 (in isoform 2)Phosphorylation-27.0724719451
135 (in isoform 2)Phosphorylation-44.9327251275
135PhosphorylationDSLLFDTSDDEELRE
CCCEECCCCHHHHHH		44.9319664994
176PhosphorylationIEEMMQESPDPEDDE
HHHHHHHCCCCCCCC		20.0824275569
192PhosphorylationPTQSDRLSMLSQEIQ
CCHHHHHHHHHHHHH		20.6920873877
195PhosphorylationSDRLSMLSQEIQTLK
HHHHHHHHHHHHHHH		19.6825159151
195 (in isoform 2)Phosphorylation-19.6824719451
200PhosphorylationMLSQEIQTLKRSSTG
HHHHHHHHHHHCCCC		39.6525850435
200O-linked_GlycosylationMLSQEIQTLKRSSTG
HHHHHHHHHHHCCCC		39.6530379171
202UbiquitinationSQEIQTLKRSSTGSY
HHHHHHHHHCCCCCH		54.3329967540
204PhosphorylationEIQTLKRSSTGSYEE
HHHHHHHCCCCCHHH		30.5725159151
205PhosphorylationIQTLKRSSTGSYEER
HHHHHHCCCCCHHHH		40.6025159151
205 (in isoform 2)Phosphorylation-40.6024719451
206PhosphorylationQTLKRSSTGSYEERV
HHHHHCCCCCHHHHH		31.2423663014
208 (in isoform 2)Phosphorylation-29.4727251275
208PhosphorylationLKRSSTGSYEERVKR
HHHCCCCCHHHHHHH		29.4723663014
209PhosphorylationKRSSTGSYEERVKRL
HHCCCCCHHHHHHHC		24.1323663014
217 (in isoform 2)Phosphorylation-27.8527251275
217PhosphorylationEERVKRLSVSELNEI
HHHHHHCCHHHHHHH		27.8528450419
219PhosphorylationRVKRLSVSELNEILE
HHHHCCHHHHHHHHH		32.7528192239
230PhosphorylationEILEEIETAIKEYSE
HHHHHHHHHHHHHHH		39.0720071362
252UbiquitinationLRDELEFEKEVKNSF
HHCHHHHHHHHHHHH		38.6421963094
301PhosphorylationERSHMPGTYLTTVIP
CCCCCCCCEEEEEEE		14.9719835603
304PhosphorylationHMPGTYLTTVIPYEK
CCCCCEEEEEEECCH		14.4919835603
305PhosphorylationMPGTYLTTVIPYEKK
CCCCEEEEEEECCHH		17.53-
309PhosphorylationYLTTVIPYEKKNGPP
EEEEEEECCHHCCCC		29.2919835603
326UbiquitinationEDLQILTKILRAMKE
HHHHHHHHHHHHHHH		35.9821963094
335PhosphorylationLRAMKEDSEKVPSLL
HHHHHHCHHCCCHHH		40.17-
337UbiquitinationAMKEDSEKVPSLLTD
HHHHCHHCCCHHHHH		64.5029967540
340PhosphorylationEDSEKVPSLLTDYIL
HCHHCCCHHHHHHHH		38.7124400094
343PhosphorylationEKVPSLLTDYILKVL
HCCCHHHHHHHHHHH		31.8624400094
345PhosphorylationVPSLLTDYILKVLCP
CCHHHHHHHHHHHCC		11.6924400094
353UbiquitinationILKVLCPT-------
HHHHHCCC-------		50.6921963094
364Ubiquitination------------------
------------------		29967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FEZ2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FEZ2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FEZ2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KPCZ_HUMANPRKCZphysical
14697253
RAI14_HUMANRAI14physical
16484223
ZN251_HUMANZNF251physical
16484223
SMC3_HUMANSMC3physical
16484223
PDCD7_HUMANPDCD7physical
16484223
SP30L_HUMANSAP30Lphysical
16484223
CLAP2_HUMANCLASP2physical
16484223
KIBRA_HUMANWWC1physical
16484223
NC2A_HUMANDRAP1physical
16484223
RB3GP_HUMANRAB3GAP1physical
16484223
SCOC_HUMANSCOCphysical
16484223
BRD1_HUMANBRD1physical
16484223
TLK2_HUMANTLK2physical
16484223
CP059_HUMANC16orf59physical
16484223
TBC25_HUMANTBC1D25physical
16484223
IMA1_HUMANKPNA2physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FEZ2_HUMAN

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Related Literatures of Post-Translational Modification

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