SP30L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SP30L_HUMAN
• UniProt AC: Q9HAJ7
• Protein Name: Histone deacetylase complex subunit SAP30L
• Gene Name: SAP30L
• Organism: Homo sapiens (Human).
• Sequence Length: 183
• Subcellular Localization: Isoform 1: Nucleus, nucleolus .; Isoform 2: Nucleus, nucleolus .; Isoform 3: Nucleus, nucleolus .
• Protein Description: Isoform 1: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. [PubMed: 16820529]
• Protein Sequence: MNGFSTEEDSREGPPAAPAAAAPGYGQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDTDIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKSEGGKQLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNGFSTEE -------CCCCCCHH	11.32	22814378
5	Phosphorylation	---MNGFSTEEDSRE ---CCCCCCHHHCCC	35.99	25159151
46	Phosphorylation	VRPAGNASFSKRVQK EEECCCCCHHHHHHH	33.77	24719451
54	Phosphorylation	FSKRVQKSISQKKLK HHHHHHHHHCCCCCC	15.47	30631047
56	Phosphorylation	KRVQKSISQKKLKLD HHHHHHHCCCCCCCC	42.93	30631047
67	Phosphorylation	LKLDIDKSVRHLYIC CCCCCCHHHCEEEEC	22.19	24260401
78	Methylation	LYICDFHKNFIQSVR EEECHHHHHHHHHHH	54.25	-
92	Phosphorylation	RNKRKRKTSDDGGDS HHHCCCCCCCCCCCC	41.23	30266825
93	Phosphorylation	NKRKRKTSDDGGDSP HHCCCCCCCCCCCCC	36.42	30266825
99	Phosphorylation	TSDDGGDSPEHDTDI CCCCCCCCCCCCCCC	35.15	30266825
104	Phosphorylation	GDSPEHDTDIPEVDL CCCCCCCCCCCCCCE	37.42	30266825
118	Phosphorylation	LFQLQVNTLRRYKRH EEHHHHHHHHHHHHH	23.84	20068231
130	Phosphorylation	KRHYKLQTRPGFNKA HHHHCCCCCCCCCHH	49.63	24719451
144	Phosphorylation	AQLAETVSRHFRNIP HHHHHHHHHHHHCCC	27.70	24719451
157	Phosphorylation	IPVNEKETLAYFIYM CCCCCHHHHHHHHHH	27.96	29759185
163	Phosphorylation	ETLAYFIYMVKSNKS HHHHHHHHHHHCCCH	5.97	29759185
167	Phosphorylation	YFIYMVKSNKSRLDQ HHHHHHHCCCHHHHH	37.77	29759185
170	Phosphorylation	YMVKSNKSRLDQKSE HHHHCCCHHHHHCCC	42.18	24719451
176	Phosphorylation	KSRLDQKSEGGKQLE CHHHHHCCCCCCCCC	35.52	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SP30L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SP30L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SP30L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_HUMAN	SIN3A	physical	16820529
SP30L_HUMAN	SAP30L	physical	16820529
HDAC1_HUMAN	HDAC1	physical	16820529
HDAC2_HUMAN	HDAC2	physical	16820529
HDAC3_HUMAN	HDAC3	physical	16820529
SIN3A_HUMAN	SIN3A	physical	18070604

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-99, AND MASSSPECTROMETRY.
PubMed: 18669648

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-104, AND MASSSPECTROMETRY.
PubMed: 19690332