SCOC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCOC_HUMAN
• UniProt AC: Q9UIL1
• Protein Name: Short coiled-coil protein
• Gene Name: SCOC
• Organism: Homo sapiens (Human).
• Sequence Length: 159
• Subcellular Localization: Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus, trans-Golgi network . Cytoplasm, cytosol .
• Protein Description: Positive regulator of amino acid starvation-induced autophagy..
• Protein Sequence: MRRRVFSSQDWRASGWDGMGFFSRRTFCGRSGRSCRGQLVQVSRPEVSAGSLLLPAPQAEDHSSRILYPRPKSLLPKMMNADMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDAVKEENLKLKSENQVLGQYIENLMSASSVFQTTDTKSKRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	WDGMGFFSRRTFCGR CCCCCEEECCEECCC	20.70	24670416
64	Ubiquitination	PQAEDHSSRILYPRP CCCCCCCCCCCCCCH	21.66	32015554
73	Phosphorylation	ILYPRPKSLLPKMMN CCCCCHHHHHHHHHC	37.51	-
84	Ubiquitination	KMMNADMDAVDAENQ HHHCCCCCCCCHHHH	43.94	33845483
85	Ubiquitination	MMNADMDAVDAENQV HHCCCCCCCCHHHHH	8.41	33845483
87 (in isoform 4)	Phosphorylation	-	50.30	-
90	Ubiquitination	MDAVDAENQVELEEK CCCCCHHHHHHHHHH	53.57	32015554
91	Ubiquitination	DAVDAENQVELEEKT CCCCHHHHHHHHHHH	22.90	32015554
92	Ubiquitination	AVDAENQVELEEKTR CCCHHHHHHHHHHHH	15.90	32015554
110	Phosphorylation	QVLELQHTLEDLSAR HHHHHHHHHHHHHHH	20.91	21118733
117	Ubiquitination	TLEDLSARVDAVKEE HHHHHHHHHHHHHHH	24.39	32015554
118	Ubiquitination	LEDLSARVDAVKEEN HHHHHHHHHHHHHHH	5.76	32015554
121	Ubiquitination	LSARVDAVKEENLKL HHHHHHHHHHHHCCC	7.49	33845483
122	2-Hydroxyisobutyrylation	SARVDAVKEENLKLK HHHHHHHHHHHCCCC	62.12	-
122	Ubiquitination	SARVDAVKEENLKLK HHHHHHHHHHHCCCC	62.12	-
127	Ubiquitination	AVKEENLKLKSENQV HHHHHHCCCCHHHHH	66.50	-
128	Ubiquitination	VKEENLKLKSENQVL HHHHHCCCCHHHHHH	9.22	32015554
129	Ubiquitination	KEENLKLKSENQVLG HHHHCCCCHHHHHHH	54.88	-
144	Phosphorylation	QYIENLMSASSVFQT HHHHHHHHHHHHCCC	28.32	29083192
146	Phosphorylation	IENLMSASSVFQTTD HHHHHHHHHHCCCCC	21.52	29083192
147	Phosphorylation	ENLMSASSVFQTTDT HHHHHHHHHCCCCCC	27.02	29083192
151	Phosphorylation	SASSVFQTTDTKSKR HHHHHCCCCCCCCCC	18.38	29083192
152	Phosphorylation	ASSVFQTTDTKSKRK HHHHCCCCCCCCCCC	30.78	29083192
154	Ubiquitination	SVFQTTDTKSKRK-- HHCCCCCCCCCCC--	34.82	32015554
154	Phosphorylation	SVFQTTDTKSKRK-- HHCCCCCCCCCCC--	34.82	29083192
156	Phosphorylation	FQTTDTKSKRK---- CCCCCCCCCCC----	39.52	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCOC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCOC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCOC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956
EURL_HUMAN	C21orf91	physical	28514442
FEZ2_HUMAN	FEZ2	physical	28514442
TBC30_HUMAN	TBC1D30	physical	28514442
HTR5A_HUMAN	HEATR5A	physical	28514442
SAS6_HUMAN	SASS6	physical	28514442
GCC1_HUMAN	GCC1	physical	28514442
NRBF2_HUMAN	NRBF2	physical	28514442
LUZP1_HUMAN	LUZP1	physical	28514442
A16L1_HUMAN	ATG16L1	physical	28514442
C8AP2_HUMAN	CASP8AP2	physical	28514442
CTIP_HUMAN	RBBP8	physical	28514442
BL1S2_HUMAN	BLOC1S2	physical	28514442
NUMA1_HUMAN	NUMA1	physical	28514442
CCHCR_HUMAN	CCHCR1	physical	28514442
PAWR_HUMAN	PAWR	physical	28514442
SNAPN_HUMAN	SNAPIN	physical	28514442
DACH1_HUMAN	DACH1	physical	28514442
SSNA1_HUMAN	SSNA1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.