TBC30_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBC30_HUMAN
• UniProt AC: Q9Y2I9
• Protein Name: TBC1 domain family member 30
• Gene Name: TBC1D30
• Organism: Homo sapiens (Human).
• Sequence Length: 924
• Subcellular Localization: Cell membrane ; Peripheral membrane protein .
• Protein Description: GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro..
• Protein Sequence: MDVLPTGGGRPGLRTELEFRGGGGEARLESQEEETIPAAPPAPRLRGAAERPRRSRDTWDGDEDTEPGEACGGRTSRTASLVSGLLNELYSCTEEEEAAGGGRGAEGRRRRRDSLDSSTEASGSDVVLGGRSGAGDSRVLQELQERPSQRHQMLYLRQKDANELKTILRELKYRIGIQSAKLLRHLKQKDRLLHKVQRNCDIVTACLQAVSQKRRVDTKLKFTLEPSLGQNGFQQWYDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATVKPTSVSGRHSKARDSDEENDPDDEDAVVNAVGCLGPFSGFLAPELQKYQKQIKEPNEEQSLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQVHQVYIRADKGPVTSILPSQVNSSPVINHLLLGKKMKMTNRAAKNAVIHIPGHTGGKISPVPYEDLKTKLNSPWRTHIRVHKKNMPRTKSHPGCGDTVGLIDEQNEASKTNGLGAAEAFPSGCTATAGREGSSPEGSTRRTIEGQSPEPVFGDADVDVSAVQAKLGALELNQRDAAAETELRVHPPCQRHCPEPPSAPEENKATSKAPQGSNSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPTVHFPQMSRSFSKPGGGNSGTKKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26 (in isoform 3)	Phosphorylation	-	25.32	-
26	Phosphorylation	FRGGGGEARLESQEE ECCCCCCCCCCCCCC	25.32	-
26 (in isoform 2)	Phosphorylation	-	25.32	-
29	Phosphorylation	GGGEARLESQEEETI CCCCCCCCCCCCCCC	44.84	-
29 (in isoform 3)	Phosphorylation	-	44.84	-
29 (in isoform 2)	Phosphorylation	-	44.84	-
30	Phosphorylation	GGEARLESQEEETIP CCCCCCCCCCCCCCC	47.70	27499020
41 (in isoform 3)	Phosphorylation	-	50.61	-
41 (in isoform 2)	Phosphorylation	-	50.61	-
41	Phosphorylation	ETIPAAPPAPRLRGA CCCCCCCCCCCCCCC	50.61	-
48 (in isoform 3)	Phosphorylation	-	10.34	-
48 (in isoform 2)	Phosphorylation	-	10.34	-
48	Phosphorylation	PAPRLRGAAERPRRS CCCCCCCCCCCCCCC	10.34	-
55 (in isoform 3)	Phosphorylation	-	35.47	-
55	Phosphorylation	AAERPRRSRDTWDGD CCCCCCCCCCCCCCC	35.47	17081983
55 (in isoform 2)	Phosphorylation	-	35.47	-
65	Phosphorylation	TWDGDEDTEPGEACG CCCCCCCCCCCCCCC	41.87	28102081
75	Phosphorylation	GEACGGRTSRTASLV CCCCCCCCHHHHHHH	26.32	23898821
76	Phosphorylation	EACGGRTSRTASLVS CCCCCCCHHHHHHHH	26.69	23898821
78	Phosphorylation	CGGRTSRTASLVSGL CCCCCHHHHHHHHHH	21.99	30278072
80	Phosphorylation	GRTSRTASLVSGLLN CCCHHHHHHHHHHHH	28.79	26657352
83	Phosphorylation	SRTASLVSGLLNELY HHHHHHHHHHHHHHH	29.08	22964224
85	Phosphorylation	TASLVSGLLNELYSC HHHHHHHHHHHHHCC	3.46	24719451
90	Phosphorylation	SGLLNELYSCTEEEE HHHHHHHHCCCHHHH	8.77	27642862
91	Phosphorylation	GLLNELYSCTEEEEA HHHHHHHCCCHHHHH	27.47	28102081
93	Phosphorylation	LNELYSCTEEEEAAG HHHHHCCCHHHHHCC	40.26	28102081
114	Phosphorylation	GRRRRRDSLDSSTEA HHHHCHHCCCCCCCC	32.06	29255136
117	Phosphorylation	RRRDSLDSSTEASGS HCHHCCCCCCCCCCC	44.44	30278072
118	Phosphorylation	RRDSLDSSTEASGSD CHHCCCCCCCCCCCC	29.90	30278072
119	Phosphorylation	RDSLDSSTEASGSDV HHCCCCCCCCCCCCE	39.25	30278072
122	Phosphorylation	LDSSTEASGSDVVLG CCCCCCCCCCCEEEC	32.37	25849741
124	Phosphorylation	SSTEASGSDVVLGGR CCCCCCCCCEEECCC	25.41	22210691
227	Phosphorylation	LKFTLEPSLGQNGFQ EEEECCCHHCCCHHH	35.44	-
247	Phosphorylation	LKAVARLSTGIPKEW HHHHHHHHCCCCHHH	21.02	23898821
248	Phosphorylation	KAVARLSTGIPKEWR HHHHHHHCCCCHHHH	43.66	24719451
281	Phosphorylation	WDKTMRFTFNERSNP CCCCCEEEECCCCCC	18.39	-
292	Phosphorylation	RSNPDDDSMGIQIVK CCCCCCCCCHHHHHH	26.38	-
307	Phosphorylation	DLHRTGCSSYCGQEA HHHHHCCCCCCCCHH	26.20	30631047
308	Phosphorylation	LHRTGCSSYCGQEAE HHHHCCCCCCCCHHH	28.63	30631047
366	Phosphorylation	ALKIMIYLIDKVLPE HHHHHHHHHHHHCCH	2.56	-
367	Phosphorylation	LKIMIYLIDKVLPES HHHHHHHHHHHCCHH	2.43	-
368	Phosphorylation	KIMIYLIDKVLPESY HHHHHHHHHHCCHHH	32.20	-
392	Phosphorylation	VDMAVFRDLLRMKLP CCHHHHHHHHHCHHH	38.29	27251275
425	Phosphorylation	GGYEPPLTNVFTMQW CCCCCCCCHHHHHHH	34.80	-
435	Phosphorylation	FTMQWFLTLFATCLP HHHHHHHHHHHHHCC	15.45	-
447	Phosphorylation	CLPNQTVLKIWDSVF HCCCCHHHHHHHEEE	3.65	24719451
504	Phosphorylation	LENDLLQSHELMQTV HHHHHHHHHHHHHHH	20.92	-
514	Phosphorylation	LMQTVYSMAPFPFPQ HHHHHHHHCCCCCHH	2.77	24719451
515	Phosphorylation	MQTVYSMAPFPFPQL HHHHHHHCCCCCHHH	9.17	27251275
529	Phosphorylation	LAELREKYTYNITPF HHHHHHHCCCCCCCC	15.09	-
530	Phosphorylation	AELREKYTYNITPFP HHHHHHCCCCCCCCC	22.59	-
531	Phosphorylation	ELREKYTYNITPFPA HHHHHCCCCCCCCCC	11.07	-
534	Phosphorylation	EKYTYNITPFPATVK HHCCCCCCCCCCCCC	18.42	22468782
543	Phosphorylation	FPATVKPTSVSGRHS CCCCCCCCCCCCCCC	35.72	22468782
544	Phosphorylation	PATVKPTSVSGRHSK CCCCCCCCCCCCCCC	23.86	22468782
545	Phosphorylation	ATVKPTSVSGRHSKA CCCCCCCCCCCCCCC	8.49	27251275
546	Phosphorylation	TVKPTSVSGRHSKAR CCCCCCCCCCCCCCC	29.85	22496350
550	Phosphorylation	TSVSGRHSKARDSDE CCCCCCCCCCCCCCC	27.01	24719451
555	Phosphorylation	RHSKARDSDEENDPD CCCCCCCCCCCCCCC	41.17	26657352
558	Methylation	KARDSDEENDPDDED CCCCCCCCCCCCHHH	72.43	-
560	Methylation	RDSDEENDPDDEDAV CCCCCCCCCCHHHHH	51.81	-
563	Phosphorylation	DEENDPDDEDAVVNA CCCCCCCHHHHHHHH	62.15	24719451
581	Phosphorylation	LGPFSGFLAPELQKY CCCCCCCCHHHHHHH	9.91	24719451
610	Phosphorylation	SNNIAELSPGAINSC HCCCHHCCHHHHHHH	16.88	22617229
617	Phosphorylation	SPGAINSCRSEYHAA CHHHHHHHHHHHHHH	4.86	27251275
637	Phosphorylation	MERMTTDINALKRQY HHHHHHHHHHHHHHH	2.82	24719451
659	Phosphorylation	QQQVHQVYIRADKGP HHHCEEEEEECCCCC	4.33	27067055
677	Phosphorylation	ILPSQVNSSPVINHL CCCCCCCCCHHHHHH	36.84	25159151
678	Phosphorylation	LPSQVNSSPVINHLL CCCCCCCCHHHHHHH	20.27	28348404
698	Acetylation	KMTNRAAKNAVIHIP CCCCHHHHHCEEECC	44.44	19810451
708	Phosphorylation	VIHIPGHTGGKISPV EEECCCCCCCCCCCC	54.25	27050516
713	Phosphorylation	GHTGGKISPVPYEDL CCCCCCCCCCCHHHH	24.27	25849741
717	Phosphorylation	GKISPVPYEDLKTKL CCCCCCCHHHHHHHC	23.47	27642862
721	Methylation	PVPYEDLKTKLNSPW CCCHHHHHHHCCCCH	56.80	115980147
723	Methylation	PYEDLKTKLNSPWRT CHHHHHHHCCCCHHH	44.05	115980153
726	Phosphorylation	DLKTKLNSPWRTHIR HHHHHCCCCHHHEEE	35.95	24719451
730	Phosphorylation	KLNSPWRTHIRVHKK HCCCCHHHEEEHHHC	20.13	-
742	Phosphorylation	HKKNMPRTKSHPGCG HHCCCCCCCCCCCCC	30.91	29978859
744	Phosphorylation	KNMPRTKSHPGCGDT CCCCCCCCCCCCCCC	34.01	26657352
745	Phosphorylation	NMPRTKSHPGCGDTV CCCCCCCCCCCCCCC	25.07	-
747	Phosphorylation	PRTKSHPGCGDTVGL CCCCCCCCCCCCCCH	23.71	24719451
749	Phosphorylation	TKSHPGCGDTVGLID CCCCCCCCCCCCHHH	39.27	-
751	Phosphorylation	SHPGCGDTVGLIDEQ CCCCCCCCCCHHHCC	11.19	29978859
778	Phosphorylation	EAFPSGCTATAGREG HHCCCCCEECCCCCC	30.48	28102081
780	Phosphorylation	FPSGCTATAGREGSS CCCCCEECCCCCCCC	16.11	28102081
786	Phosphorylation	ATAGREGSSPEGSTR ECCCCCCCCCCCCCC	37.66	25849741
787	Phosphorylation	TAGREGSSPEGSTRR CCCCCCCCCCCCCCC	37.52	24300666
791	Phosphorylation	EGSSPEGSTRRTIEG CCCCCCCCCCCCCCC	19.65	28102081
792	Phosphorylation	GSSPEGSTRRTIEGQ CCCCCCCCCCCCCCC	34.72	28102081
795	Phosphorylation	PEGSTRRTIEGQSPE CCCCCCCCCCCCCCC	21.79	23403867
800	Phosphorylation	RRTIEGQSPEPVFGD CCCCCCCCCCCCCCC	41.93	30278072
813	Phosphorylation	GDADVDVSAVQAKLG CCCCCCHHHHHHHHC	20.47	23403867
893	Phosphorylation	TARNLGLYGPTERTP CHHHCCCCCCCCCCC	21.18	25159151
908	Phosphorylation	TVHFPQMSRSFSKPG CCCCCCCCCCCCCCC	21.37	21406692
910	Phosphorylation	HFPQMSRSFSKPGGG CCCCCCCCCCCCCCC	26.94	20363803
912	Phosphorylation	PQMSRSFSKPGGGNS CCCCCCCCCCCCCCC	38.91	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBC30_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBC30_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBC30_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX3_HUMAN	STX3	physical	26553929
MYO5B_HUMAN	MYO5B	physical	26553929
SYTL4_HUMAN	SYTL4	physical	26553929
EXOC6_HUMAN	EXOC6	physical	26553929

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.