dbPTM

C8AP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	C8AP2_HUMAN
UniProt AC	Q9UKL3
Protein Name	CASP8-associated protein 2
Gene Name	CASP8AP2 {ECO:0000312\|HGNC:HGNC:1510}
Organism	Homo sapiens (Human).
Sequence Length	1982
Subcellular Localization	Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Exported from the nucleus to the mitochondria upon FAS activation.
Protein Description	Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase..
Protein Sequence	MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDNSVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDLAVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSMMPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQTQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLPNTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDLTQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTESPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSKCR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAADDDNGD ------CCCCCCCCC	30.79	20068231
18	Phosphorylation	TSLFDVFSASPLKNN CCHHHEEECCCCCCC	27.90	25850435
20	Phosphorylation	LFDVFSASPLKNNDE HHHEEECCCCCCCCC	29.57	28355574
29	Phosphorylation	LKNNDEGSLDIYAGL CCCCCCCCEEEEEEC	22.33	30576142
33	Phosphorylation	DEGSLDIYAGLDSAV CCCCEEEEEECHHHH	8.35	26074081
38	Phosphorylation	DIYAGLDSAVSDSAS EEEEECHHHHCCCCC	35.30	27251275
58	Phosphorylation	SRNCLDLYEEILTEE CCHHHHHHHHHHCCC	15.93	27642862
63	O-linked_Glycosylation	DLYEEILTEEGTAKE HHHHHHHCCCCCCCE	37.34	30379171
67	Phosphorylation	EILTEEGTAKEATYN HHHCCCCCCCEEECH	37.52	-
72	O-linked_Glycosylation	EGTAKEATYNDLQVE CCCCCEEECHHHHHH	24.77	30379171
92	Ubiquitination	LQMKELMKKFKEIQT HHHHHHHHHHHHHHH	68.62	21906983
93	Ubiquitination	QMKELMKKFKEIQTQ HHHHHHHHHHHHHHH	47.94	21906983
112	Ubiquitination	INENQSLKKNISALI CCCCHHHHHHHHHHH	49.36	30230243
166	Phosphorylation	VKTKDLKSRSPHLDD CCHHHHHCCCCCHHH	45.33	30576142
168	Phosphorylation	TKDLKSRSPHLDDCS HHHHHCCCCCHHHCC	24.62	30576142
175	Phosphorylation	SPHLDDCSKTDHRAK CCCHHHCCCCCHHHH	45.65	26074081
186	O-linked_Glycosylation	HRAKSDVSKDVHHST HHHHHHHCCCCCCCC	28.29	30379171
192	Phosphorylation	VSKDVHHSTSLPNLE HCCCCCCCCCCCCHH	12.57	23186163
193	Phosphorylation	SKDVHHSTSLPNLEK CCCCCCCCCCCCHHH	29.90	23186163
194	Phosphorylation	KDVHHSTSLPNLEKE CCCCCCCCCCCHHHC	44.86	28450419
210	Phosphorylation	KPHSDKRSTSHLPTS CCCCCCCCCCCCCCC	39.75	20068231
211	Phosphorylation	PHSDKRSTSHLPTSV CCCCCCCCCCCCCCH	24.97	20068231
212	Phosphorylation	HSDKRSTSHLPTSVE CCCCCCCCCCCCCHH	25.03	20068231
216	Phosphorylation	RSTSHLPTSVEKHCT CCCCCCCCCHHHHCC	52.33	28985074
217	Phosphorylation	STSHLPTSVEKHCTN CCCCCCCCHHHHCCC	26.75	20068231
232	Phosphorylation	GVWSRSHYQVGEGSS CCCCCCCEECCCCCC	13.21	27642862
239	Phosphorylation	YQVGEGSSNEDSRRG EECCCCCCCCCCCCC	55.91	28985074
253	Phosphorylation	GRKDIRHSQFNRGTE CCHHHCHHHHHCCCH	26.98	28555341
298	Phosphorylation	YGKGEPKTESKSSKF CCCCCCCCCCCCCCC	57.09	20860994
306	Methylation	ESKSSKFKSNSDSDY CCCCCCCCCCCCCCC	53.08	-
435	Phosphorylation	FQDGRCPSSLSNSRT CCCCCCCCHHCCCCC	47.76	29052541
436	Phosphorylation	QDGRCPSSLSNSRTH CCCCCCCHHCCCCCC	22.43	29052541
438	Phosphorylation	GRCPSSLSNSRTHKN CCCCCHHCCCCCCCC	34.41	29052541
460	Phosphorylation	AMHQWENTPLKAERH HHHHHCCCCHHHHHH	20.62	25850435
509	Phosphorylation	KETKKTTTDLKKQNE CCCCCCCCCHHHHCC	44.56	-
521	Acetylation	QNEPKTDKGEVLDNG HCCCCCCCCCCCCCC	63.30	25953088
555	Acetylation	ETKNKDLKLSFMKKL CCCCCCHHHHHHHHH	52.82	25953088
565	Phosphorylation	FMKKLNLTLSPAKKQ HHHHHCCCCCHHHCC	24.90	30266825
567	Phosphorylation	KKLNLTLSPAKKQPV HHHCCCCCHHHCCCC	19.99	23401153
570	Acetylation	NLTLSPAKKQPVSQD CCCCCHHHCCCCCCC	56.15	25953088
575	Phosphorylation	PAKKQPVSQDNQHKI HHHCCCCCCCCCCCC	38.20	-
583	Phosphorylation	QDNQHKITDIPKSSG CCCCCCCCCCCCCCC	32.45	-
649	Phosphorylation	TEPRIGISETNKEDE CCCCCCCCCCCCCCC	32.91	23186163
651	Phosphorylation	PRIGISETNKEDENS CCCCCCCCCCCCCCC	44.81	23186163
658	Phosphorylation	TNKEDENSLLVRSVD CCCCCCCCEEEEECC	22.49	21815630
719	Phosphorylation	VVMDVLQTDVSQNFG HHHHHHCCCHHHHCC	33.92	27251275
722	Phosphorylation	DVLQTDVSQNFGLEL HHHCCCHHHHCCCEE	23.40	27251275
731	Phosphorylation	NFGLELDTKRNDNSD HCCCEEECCCCCCCC	44.52	-
739	Phosphorylation	KRNDNSDYCGISEGM CCCCCCCCCCCCCCC	7.75	18083107
779	Phosphorylation	DILPIMLSEDNNPKF CCCCEEECCCCCCCC	26.06	22468782
793	Phosphorylation	FEPSVIVTPLVESKS CCCCEEEEECCCCCC	10.36	21815630
798	Phosphorylation	IVTPLVESKSCHLEP EEEECCCCCCCCCCC	23.53	26074081
800	Phosphorylation	TPLVESKSCHLEPCL EECCCCCCCCCCCCC	18.95	25159151
811	Phosphorylation	EPCLPKETLDSSLQQ CCCCCHHHHCCHHHH	41.83	30266825
814	Phosphorylation	LPKETLDSSLQQTEL CCHHHHCCHHHHHHH	35.74	30266825
815	Phosphorylation	PKETLDSSLQQTELM CHHHHCCHHHHHHHH	29.84	30266825
819	Phosphorylation	LDSSLQQTELMDHRM HCCHHHHHHHHHHHC	20.37	30266825
828	Phosphorylation	LMDHRMATGETNSVY HHHHHCCCCCCCCEE	26.63	26471730
831	Phosphorylation	HRMATGETNSVYHDD HHCCCCCCCCEEECC	33.85	26471730
833	Phosphorylation	MATGETNSVYHDDDN CCCCCCCCEEECCCC	31.32	26471730
835	Phosphorylation	TGETNSVYHDDDNSV CCCCCCEEECCCCCE	10.19	25921289
841	Phosphorylation	VYHDDDNSVLSIDLN EEECCCCCEEEEECC	31.28	25921289
844	Phosphorylation	DDDNSVLSIDLNHLR CCCCCEEEEECCCCC	16.35	25921289
858	Phosphorylation	RPIPEAISPLNSPVR CCCCHHHCCCCCCCC	30.31	25850435
862	Phosphorylation	EAISPLNSPVRPVAK HHHCCCCCCCCHHHH	32.24	25850435
875	Phosphorylation	AKVLRNESPPQVPVY HHHHCCCCCCCCCCC	45.49	23401153
882	Phosphorylation	SPPQVPVYNNSHKDV CCCCCCCCCCCCCCE	11.53	30266825
885	Phosphorylation	QVPVYNNSHKDVFLP CCCCCCCCCCCEECC	28.42	26074081
894	Phosphorylation	KDVFLPNSAHSTSKS CCEECCCCCCCCCCC	25.97	28787133
897	Phosphorylation	FLPNSAHSTSKSQSD ECCCCCCCCCCCHHH	33.81	28787133
901	Phosphorylation	SAHSTSKSQSDLNKE CCCCCCCCHHHCCHH	34.38	28787133
911	Acetylation	DLNKENQKPIYKSDK HCCHHCCCCCCCCCC	44.99	23749302
918	Ubiquitination	KPIYKSDKCTEADTC CCCCCCCCCCCCCCC	50.58	-
926	Ubiquitination	CTEADTCKNSPLDEL CCCCCCCCCCCCHHH	63.65	-
928	Phosphorylation	EADTCKNSPLDELEE CCCCCCCCCCHHHHC	16.60	25159151
940	Phosphorylation	LEEGEIRSDSETSKP HHCCCCCCCCCCCCC	51.67	23401153
942	Phosphorylation	EGEIRSDSETSKPQE CCCCCCCCCCCCCHH	43.98	23401153
944	Phosphorylation	EIRSDSETSKPQESF CCCCCCCCCCCHHHH	46.10	29255136
945	Phosphorylation	IRSDSETSKPQESFE CCCCCCCCCCHHHHH	37.98	29255136
950	Phosphorylation	ETSKPQESFEKNSKR CCCCCHHHHHHHHCC	33.20	22199227
960	Phosphorylation	KNSKRRVSADVRKSK HHHCCCCCCHHHHCC	19.55	24719451
996	Acetylation	RIHQTNNKWNKRPDK EEEECCCCCCCCCCC	54.97	25953088
1003	Acetylation	KWNKRPDKSSRSSKT CCCCCCCCCCCCCCC	53.68	19815739
1009	Acetylation	DKSSRSSKTEKKDKV CCCCCCCCCHHHHHH	63.05	19815749
1009	Ubiquitination	DKSSRSSKTEKKDKV CCCCCCCCCHHHHHH	63.05	22817900
1012	Ubiquitination	SRSSKTEKKDKVMST CCCCCCHHHHHHCCH	72.07	22817900
1013	Ubiquitination	RSSKTEKKDKVMSTS CCCCCHHHHHHCCHH	57.45	21906983
1015	Ubiquitination	SKTEKKDKVMSTSSL CCCHHHHHHCCHHHH	49.03	22817900
1021	Phosphorylation	DKVMSTSSLEKIVPI HHHCCHHHHHHHCCE	40.41	23532336
1024	Ubiquitination	MSTSSLEKIVPIIAV CCHHHHHHHCCEEEC	55.06	-
1033	Phosphorylation	VPIIAVPSSEQEIMH CCEEECCCCHHHHHH	39.65	20860994
1034	Phosphorylation	PIIAVPSSEQEIMHM CEEECCCCHHHHHHH	36.91	20860994
1059	Acetylation	NYMKFKAKFSLIQFH HHHHHHHHCHHHHHH	35.76	25953088
1078	Phosphorylation	SAILSFTSLIKHLNL HHHHHHHHHHHHCCH	26.53	24719451
1091	Phosphorylation	NLHKISKSVTTLQKN CHHHHCCHHHHHHHH	20.22	-
1106	Ubiquitination	LCDIIESKLKQVKKN HHHHHHHHHHHHHHC	47.08	29967540
1156	Phosphorylation	ILVCDSKSFGRDSDE EEEECCHHCCCCCCC	36.56	23186163
1161	Phosphorylation	SKSFGRDSDEGKLEK CHHCCCCCCCCCCCH	35.88	28985074
1165	Acetylation	GRDSDEGKLEKTSKQ CCCCCCCCCCHHHHH	51.96	23749302
1168	Acetylation	SDEGKLEKTSKQNAQ CCCCCCCHHHHHHHC	69.41	25953088
1176	Phosphorylation	TSKQNAQYSNSQKRS HHHHHHCCCHHHCCC	13.86	23403867
1177	Phosphorylation	SKQNAQYSNSQKRSV HHHHHCCCHHHCCCC	20.23	23403867
1179	Phosphorylation	QNAQYSNSQKRSVDN HHHCCCHHHCCCCCC	31.01	23403867
1206	Acetylation	SEDPVHYKSLVGCKK CCCCCHHHHHHCCCC	23.57	25953088
1212	Acetylation	YKSLVGCKKSEENYQ HHHHHCCCCCHHHCC	54.10	25953088
1213	Sumoylation	KSLVGCKKSEENYQD HHHHCCCCCHHHCCC	68.15	-
1213	Sumoylation	KSLVGCKKSEENYQD HHHHCCCCCHHHCCC	68.15	-
1245	Ubiquitination	NICFDNIKNSQSEER EEEECCCCCCCCHHH	57.72	29967540
1247	Phosphorylation	CFDNIKNSQSEERSL EECCCCCCCCHHHEE	30.04	29449344
1249	Phosphorylation	DNIKNSQSEERSLEV CCCCCCCCHHHEEEE	41.04	20873877
1253	Phosphorylation	NSQSEERSLEVHCPS CCCCHHHEEEEECCC	31.96	25159151
1260	Phosphorylation	SLEVHCPSTPKSEKN EEEEECCCCCCCCCC	63.84	30266825
1261	Phosphorylation	LEVHCPSTPKSEKNE EEEECCCCCCCCCCC	21.63	30266825
1264	Phosphorylation	HCPSTPKSEKNEGSS ECCCCCCCCCCCCCC	55.81	25002506
1266	Acetylation	PSTPKSEKNEGSSIE CCCCCCCCCCCCCHH	68.35	25953088
1270	Phosphorylation	KSEKNEGSSIEDAQT CCCCCCCCCHHHHCH	23.20	25850435
1271	Phosphorylation	SEKNEGSSIEDAQTS CCCCCCCCHHHHCHH	40.63	28450419
1277	Phosphorylation	SSIEDAQTSQHATLK CCHHHHCHHHCCCCC	31.88	29255136
1278	Phosphorylation	SIEDAQTSQHATLKP CHHHHCHHHCCCCCC	14.11	23401153
1282	Phosphorylation	AQTSQHATLKPERSF HCHHHCCCCCCCHHE	32.94	21082442
1284	Acetylation	TSQHATLKPERSFEI HHHCCCCCCCHHEEC	40.24	23236377
1284	Ubiquitination	TSQHATLKPERSFEI HHHCCCCCCCHHEEC	40.24	21906983
1288	Phosphorylation	ATLKPERSFEILTEQ CCCCCCHHEECCCHH	26.10	26074081
1293	Phosphorylation	ERSFEILTEQQASSL CHHEECCCHHHHHCC	37.09	26074081
1326	Phosphorylation	QGSDLLDSSVNCTEK CCCCCCCCCCCCCCC	35.83	30576142
1327	Phosphorylation	GSDLLDSSVNCTEKS CCCCCCCCCCCCCCC	19.60	30576142
1331	Phosphorylation	LDSSVNCTEKSEWEL CCCCCCCCCCCCCCC	41.04	26074081
1339	Ubiquitination	EKSEWELKTPEKQLL CCCCCCCCCCHHHHH	50.98	29967540
1340	Phosphorylation	KSEWELKTPEKQLLE CCCCCCCCCHHHHHH	49.67	23401153
1343	Acetylation	WELKTPEKQLLETLK CCCCCCHHHHHHHHC	47.66	23954790
1343	Ubiquitination	WELKTPEKQLLETLK CCCCCCHHHHHHHHC	47.66	29967540
1348	Phosphorylation	PEKQLLETLKCESIP CHHHHHHHHCCCCCC	31.33	26074081
1353	Phosphorylation	LETLKCESIPACTTE HHHHCCCCCCCCCHH	43.26	29978859
1358	Phosphorylation	CESIPACTTEELVSG CCCCCCCCHHHHHCC	39.07	29978859
1359	Phosphorylation	ESIPACTTEELVSGV CCCCCCCHHHHHCCC	27.61	29978859
1364	Phosphorylation	CTTEELVSGVASPCP CCHHHHHCCCCCCCC	39.93	29255136
1368	Phosphorylation	ELVSGVASPCPKMIS HHHCCCCCCCCCCCC	25.32	29255136
1375	Phosphorylation	SPCPKMISDDNWSLL CCCCCCCCCCCCHHH	35.10	26074081
1380	Phosphorylation	MISDDNWSLLSSEKG CCCCCCCHHHCCCCC	26.20	25159151
1383	Phosphorylation	DDNWSLLSSEKGPSL CCCCHHHCCCCCCCC	41.57	25159151
1384	Phosphorylation	DNWSLLSSEKGPSLS CCCHHHCCCCCCCCC	43.21	21815630
1418	Phosphorylation	VSTNLPLSKDNVCSV ECCCCCCCCCCCCCC	35.70	-
1424	Phosphorylation	LSKDNVCSVEKSKPC CCCCCCCCCCCCCCC	29.09	25159151
1443	Phosphorylation	LLEDLAVSLTVPSPL HHHHHHHEEECCCCC	16.83	28122231
1445	Phosphorylation	EDLAVSLTVPSPLKS HHHHHEEECCCCCCC	23.90	26074081
1448	Phosphorylation	AVSLTVPSPLKSDGH HHEEECCCCCCCCCC	38.23	26074081
1452	Phosphorylation	TVPSPLKSDGHLSFL ECCCCCCCCCCCCCC	57.41	26074081
1457	Phosphorylation	LKSDGHLSFLKPDMS CCCCCCCCCCCCCCC	23.90	24719451
1537	Phosphorylation	HAVIMEKSNDHFIVK EEEEEECCCCEEEEE	33.90	30266825
1544	Acetylation	SNDHFIVKIRRATPS CCCEEEEEEEECCCC	26.19	25953088
1549	Phosphorylation	IVKIRRATPSTSSGL EEEEEECCCCCCCCC	18.89	20860994
1551	Phosphorylation	KIRRATPSTSSGLKQ EEEECCCCCCCCCCH	36.24	-
1552	Phosphorylation	IRRATPSTSSGLKQS EEECCCCCCCCCCHH	28.28	28348404
1553	Phosphorylation	RRATPSTSSGLKQSM EECCCCCCCCCCHHC	27.09	27251275
1554	Phosphorylation	RATPSTSSGLKQSMM ECCCCCCCCCCHHCC	48.51	27251275
1557	Ubiquitination	PSTSSGLKQSMMPDE CCCCCCCCHHCCCHH	43.80	21906983
1559	Phosphorylation	TSSGLKQSMMPDELL CCCCCCHHCCCHHHH	18.56	20860994
1567	Phosphorylation	MMPDELLTSLPRHGK CCCHHHHHCCCCCCC	40.62	20860994
1568	Phosphorylation	MPDELLTSLPRHGKE CCHHHHHCCCCCCCC	36.02	20860994
1582	Ubiquitination	EADEGPEKEYISCQN CCCCCCCHHHEECCC	59.97	29967540
1593	Ubiquitination	SCQNTVFKSVEELEN ECCCCEECCHHHHHH	49.62	29967540
1601	Phosphorylation	SVEELENSNKNVDGS CHHHHHHCCCCCCCC	39.54	25159151
1603	Acetylation	EELENSNKNVDGSKS HHHHHCCCCCCCCCC	59.16	26051181
1603	Ubiquitination	EELENSNKNVDGSKS HHHHHCCCCCCCCCC	59.16	21906983
1627	Phosphorylation	QTQVPDIYEFLKDAS HHHCCCHHHHHHHHH	14.17	27642862
1631	Ubiquitination	PDIYEFLKDASDKMG CCHHHHHHHHHHHCC	57.48	21906983
1636	Acetylation	FLKDASDKMGHSDEV HHHHHHHHCCCCHHH	44.26	25953088
1636	Ubiquitination	FLKDASDKMGHSDEV HHHHHHHHCCCCHHH	44.26	22817900
1649	Ubiquitination	EVADECFKLHQVWET HHHHHHHHHHHHHHC	57.63	32015554
1667	Phosphorylation	ESIEELPSMEEISHS CCHHHCCCHHHHHHH	51.99	25159151
1672	Phosphorylation	LPSMEEISHSVGEHL CCCHHHHHHHHHCCC	17.00	25627689
1674	Phosphorylation	SMEEISHSVGEHLPN CHHHHHHHHHCCCCC	25.65	25159151
1688	Ubiquitination	NTYVDLTKDPVTETK CCEEECCCCCCCCCC	68.29	29967540
1745	Phosphorylation	IDLTQDASSEAKSEG EECCCCCCHHHHHCC	36.68	26074081
1746	Phosphorylation	DLTQDASSEAKSEGN ECCCCCCHHHHHCCC	43.21	26074081
1778	Sumoylation	EDNCKEEKAQVANRP CCCCHHHHHHHHCCC	45.25	-
1778	Sumoylation	EDNCKEEKAQVANRP CCCCHHHHHHHHCCC	45.25	-
1798	Phosphorylation	EETYIDLTTESPSSC EEEEEECCCCCCCCC	25.44	28348404
1799	Phosphorylation	ETYIDLTTESPSSCE EEEEECCCCCCCCCE	41.59	28348404
1801	Phosphorylation	YIDLTTESPSSCEVK EEECCCCCCCCCEEC	28.17	28348404
1813	Sumoylation	EVKKDELKSEPGSNC EECHHHHCCCCCCCC	51.21	-
1813	Sumoylation	EVKKDELKSEPGSNC EECHHHHCCCCCCCC	51.21	-
1814	Phosphorylation	VKKDELKSEPGSNCD ECHHHHCCCCCCCCC	62.74	20873877
1818	Phosphorylation	ELKSEPGSNCDNSEL HHCCCCCCCCCCCCC	45.03	20873877
1823	Phosphorylation	PGSNCDNSELPGTLH CCCCCCCCCCCCCCC	27.53	20873877
1832	Phosphorylation	LPGTLHNSHKKRRNI CCCCCCCCHHHCCCH	26.40	28985074
1847	Acetylation	SDLNHPHKKQRKETD HHCCCCCHHHHHHCC	55.86	25953088
1877	Ubiquitination	ENTEAHQKKASKKKA CCHHHHHHHHHHCCC	40.20	-
1883	Ubiquitination	QKKASKKKAPPVTKD HHHHHHCCCCCCCCC	70.62	-
1895	Acetylation	TKDPSSLKATPGIKD CCCHHHCCCCCCCCC	52.76	25953088
1895	Ubiquitination	TKDPSSLKATPGIKD CCCHHHCCCCCCCCC	52.76	21906983
1916	Acetylation	TSTSLSAKNVIKKKG HCCCCCHHHHHHCCC	48.66	30587467
1947	Phosphorylation	ECQKRGPSFKTFAYL HHHHHCCCHHHHHHH	42.05	29083192
1950	Phosphorylation	KRGPSFKTFAYLAAK HHCCCHHHHHHHHHH	16.10	29083192
1953	Phosphorylation	PSFKTFAYLAAKLDK CCHHHHHHHHHHCCC	7.84	29083192
1960	Ubiquitination	YLAAKLDKNPNQVSE HHHHHCCCCHHHHHH	82.07	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of C8AP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of C8AP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of C8AP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF2_HUMAN	TRAF2	physical	11340079
C8AP2_HUMAN	CASP8AP2	physical	10235259
FADD_HUMAN	FADD	physical	10235259
TNR6_HUMAN	FAS	physical	10235259
CASP8_HUMAN	CASP8	physical	10235259
PIAS1_HUMAN	PIAS1	physical	21338522
SUMO2_HUMAN	SUMO2	physical	23086935
SUMO1_HUMAN	SUMO1	physical	23086935
CTBP2_HUMAN	CTBP2	physical	21988832
CREM_HUMAN	CREM	physical	21988832
PML_HUMAN	PML	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of C8AP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1278, AND MASSSPECTROMETRY.	17525332 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-92 AND LYS-93, AND MASSSPECTROMETRY.	17370265 [Abstract]