HTR5A_HUMAN - dbPTM
HTR5A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HTR5A_HUMAN
UniProt AC Q86XA9
Protein Name HEAT repeat-containing protein 5A
Gene Name HEATR5A
Organism Homo sapiens (Human).
Sequence Length 2040
Subcellular Localization
Protein Description
Protein Sequence MELAHSLLLNEEAYNQLGEVQKAEFIFEWLRYLEKLLLATSRNDVREKQKTLVEQLLSLLNSSPGPPTRKLLAKNLAILYSIGDTFSVHEAIDKCNDLIRSKDDSPSYLPTKLAAVVCLGSLYKKLGRILGNTFTDTVGNILKAMKSAESQGRYEIMLSLQNILNGLGAAAAPCHRDVYKAARSCLTDRSMAVRCAAAKNEAIFMWSTDLDSVATLCFKSFEGSNYDVRISVSKLLGIILAKAVISKHPGTAASRQSIRRVSLEEVLELLGTGFLRGSSGFLRASGDMLKGTSSVSRDVRVGVTQAYVVFVSTLGGAWLEKNFAAFFSHILSLASPSHPKATQTQIDAVCCRRCVSFILRTTIGGLLGEKAQLAAVKDICQAIWKLKKVMDAVMSDGNLETRLGSTDVAASQHMLVCALQELGNLIHNLGTTAAPLLQDSSTGLLDSILSVILHPSISVRLAAAWCLHCIAVALPSYLTPLLDRCLERLTGHKSSPEAVTGFSFAVAALLGAVKHCPLGIPHGKGKIIMTLAEDLLCSAAQNSRLSAQRTQAGWLLISALMTLGPAVVSHHLARVLLLWKCVFPASPKDLETEKSRGDSFTWQVTLEGRAGALCAIKSFVSHCGDLLTEEVTQRLLPPLPCAVDLLTQLSSILKMYGSPLKTPSVVYRQRLYELLILLPPETYEGNLCAILRELAADLTAPDIQVAASTFLLPPLCHQDDLLILSPFLQETDHRFIEEQLLLGNGVACGSLEYDPYSIYEKDVEGDSVPKPLPPALSVISSASKLFGVVCAHVGETQRLLILEQLLDSIKHTKGARQQVVQLHVVSSVSSFLKYVAGSKGCLGPEEMKRFALTLVMGALESPNPLLRCAAAESWARLAQVVDDGAFTAGLAQVSFDKLKSARDVVTRTGHSLALGSLHRYLGGISSSQHLNSCIGILYTLAQDSTSPDVQTWALHSLSLIIDSAGPLYYVHVEPTLSLIIMLLLNVPPTHAEVHQSLGRCLNALITTLGPELQGNSTSISTLRTSCLLGCAVMQDNPDCLVQAQAISCLQQLHMFAPRHVNLSSLVSCLCVNLCSPYLLLRRAVLACLRQLVQREAAEVSEHAVMLAKDSREELTPDANIREVGLEGALLILLDKETDERLCHDIKETLNYMLTSMAVEKLSLWLKLCKDVLAASADFTAVTCVDTMQEEEGDKGDDASVLTTRRDEKSHPFTNPRWATRVFAAECVCRIINQCENANSAHFDIALAQEMKKRDSRNDFLVLHLADLIRMAFMAATDHSDQLRLSGLEMLLVVIRRFATVPEPEFPGHVILEQYQANVGAALRPAFTSETPPDVTAKACQVCSAWIASGVVSDLNDLRRVHQLLVSSLTKIQAGKEALSHLYNESASTMEILAVLKAWAEVYIIAVQRHKNHRQPLKTTTCLEDGIRNGSCSSDGLLDLVYADLGTLSRLWLAALQDFALLTLPSEFASQLPAEGGAFYTAETSENAKLHYYNSWALILHATALWLTSTGFVVADPDEGASNLSRPVTPTSMCQGSSSGATIKSPEDVYTDRFHLILGISVEFLCSLRSDATMESITACLHALQALLDVPWPRSKIGSDQDLGIELLNVLHRVILTRESPSIQLASLEVVRQIICAAQEHVKEKRRSAEVDDGAAEKETLPEFGEGKDTGGLVPGKSLVFATLELCVCILVRQLPELNPKLTGSPGVKATKPQILLEDGSRLVSAALVILSELPAVCSPEGSISILPTILYLTIGVLRETAVKLPGGQLSSTVAASLQALKGILSSPMARAEKSRTAWTDLLRSALTTILDCWDPVDETHQELDEVSLLTAITVFILSTSPEVTTIPCLQKRCIDKFKATLEIKDPVVQIKTYQLLHSIFQYPNPAVSYPYIYSLASCIMEKLQEIDKRKPENTAELEIFQEGIKVLETLVTVAEEHHRAQLVACLLPILISFLLDENSLGSATSIMRNLHDFALQNLMQIGPQYSSVFKSLVASSPALKARLEAAIKGNQESVKVKIPTSKYTKSPGKNSSIQLKTSFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
32PhosphorylationFIFEWLRYLEKLLLA
HHHHHHHHHHHHHHH		19.62-
102UbiquitinationCNDLIRSKDDSPSYL
HHHHHHCCCCCCCCC		56.56-
105PhosphorylationLIRSKDDSPSYLPTK
HHHCCCCCCCCCCHH		26.3621815630
112UbiquitinationSPSYLPTKLAAVVCL
CCCCCCHHHHHHHHH		33.90-
124UbiquitinationVCLGSLYKKLGRILG
HHHHHHHHHHHHHHC		46.98-
143UbiquitinationDTVGNILKAMKSAES
HHHHHHHHHHHHHHH		42.51-
231PhosphorylationSNYDVRISVSKLLGI
CCCEEEEEHHHHHHH		15.1324719451
237PhosphorylationISVSKLLGIILAKAV
EEHHHHHHHHHHHHH		18.4824719451
262PhosphorylationRQSIRRVSLEEVLEL
HHHHHHCCHHHHHHH		28.4022210691
268PhosphorylationVSLEEVLELLGTGFL
CCHHHHHHHHCCCCH		47.31-
272PhosphorylationEVLELLGTGFLRGSS
HHHHHHCCCCHHCCC		25.4022210691
290UbiquitinationRASGDMLKGTSSVSR
HHCCCCCCCCCCCCC		54.212190698
290 (in isoform 2)Ubiquitination-54.2121906983
293PhosphorylationGDMLKGTSSVSRDVR
CCCCCCCCCCCCCCC		37.0930576142
295 (in isoform 1)Ubiquitination-5.6521906983
296PhosphorylationLKGTSSVSRDVRVGV
CCCCCCCCCCCCCCC		25.3930576142
296UbiquitinationLKGTSSVSRDVRVGV
CCCCCCCCCCCCCCC		25.39-
313PhosphorylationAYVVFVSTLGGAWLE
EEEEEEEECCHHHHH		24.91-
370UbiquitinationIGGLLGEKAQLAAVK
HHHHHHHHHHHHHHH		39.37-
370AcetylationIGGLLGEKAQLAAVK
HHHHHHHHHHHHHHH		39.3711588353
377AcetylationKAQLAAVKDICQAIW
HHHHHHHHHHHHHHH		36.3311588363
385UbiquitinationDICQAIWKLKKVMDA
HHHHHHHHHHHHHHH		44.29-
530UbiquitinationGKGKIIMTLAEDLLC
CCCCEEEHHHHHHHH		16.65-
550PhosphorylationSRLSAQRTQAGWLLI
CCCCCHHHHHHHHHH		15.6425332170
562PhosphorylationLLISALMTLGPAVVS
HHHHHHHHHCHHHHH		29.4325332170
592PhosphorylationASPKDLETEKSRGDS
CCHHHHHCCHHCCCC		56.8824706070
594UbiquitinationPKDLETEKSRGDSFT
HHHHHCCHHCCCCEE		53.53-
595PhosphorylationKDLETEKSRGDSFTW
HHHHCCHHCCCCEEE		34.9524706070
623UbiquitinationIKSFVSHCGDLLTEE
HHHHHHHHHHHCCHH		3.36-
651PhosphorylationDLLTQLSSILKMYGS
HHHHHHHHHHHHHCC		40.3024719451
776UbiquitinationPKPLPPALSVISSAS
CCCCCHHHHHHHHHH		5.32-
777PhosphorylationKPLPPALSVISSASK
CCCCHHHHHHHHHHH		21.36-
780PhosphorylationPPALSVISSASKLFG
CHHHHHHHHHHHHHC		20.07-
783PhosphorylationLSVISSASKLFGVVC
HHHHHHHHHHHCCHH		31.66-
830PhosphorylationHVVSSVSSFLKYVAG
HHHHHHHHHHHHHHC		32.2324719451
838PhosphorylationFLKYVAGSKGCLGPE
HHHHHHCCCCCCCHH		19.01-
845UbiquitinationSKGCLGPEEMKRFAL
CCCCCCHHHHHHHHH		69.77-
916PhosphorylationGHSLALGSLHRYLGG
CCHHHHHHHHHHHCC		23.11-
1021PhosphorylationGNSTSISTLRTSCLL
CCCCCHHHHHHHHHH		20.70-
1110PhosphorylationAVMLAKDSREELTPD
HHHHHCCCHHHCCCC		40.6717192257
1115PhosphorylationKDSREELTPDANIRE
CCCHHHCCCCCCHHH		23.5425159151
1116PhosphorylationDSREELTPDANIREV
CCHHHCCCCCCHHHH		51.8718691976
1121PhosphorylationLTPDANIREVGLEGA
CCCCCCHHHHCHHHE		32.1518691976
1141UbiquitinationDKETDERLCHDIKET
CCCCCHHHHHHHHHH		2.60-
1148PhosphorylationLCHDIKETLNYMLTS
HHHHHHHHHHHHHHH		18.46-
1214UbiquitinationEKSHPFTNPRWATRV
CCCCCCCCCHHHHHH		25.23-
1327PhosphorylationAALRPAFTSETPPDV
HHHCCCCCCCCCCCC		27.9729255136
1328PhosphorylationALRPAFTSETPPDVT
HHCCCCCCCCCCCCC		32.7829255136
1330PhosphorylationRPAFTSETPPDVTAK
CCCCCCCCCCCCCHH		39.6329255136
1334PhosphorylationTSETPPDVTAKACQV
CCCCCCCCCHHHHHH		7.46-
1528PhosphorylationSNLSRPVTPTSMCQG
CCCCCCCCCCCCCCC		24.4329255136
1530PhosphorylationLSRPVTPTSMCQGSS
CCCCCCCCCCCCCCC		21.5229255136
1531PhosphorylationSRPVTPTSMCQGSSS
CCCCCCCCCCCCCCC		20.8229978859
1534PhosphorylationVTPTSMCQGSSSGAT
CCCCCCCCCCCCCCC		46.27-
1536PhosphorylationPTSMCQGSSSGATIK
CCCCCCCCCCCCCCC		8.7529978859
1537PhosphorylationTSMCQGSSSGATIKS
CCCCCCCCCCCCCCC		39.3529978859
1538PhosphorylationSMCQGSSSGATIKSP
CCCCCCCCCCCCCCH		33.8629978859
1601UbiquitinationSKIGSDQDLGIELLN
HHCCCCHHHHHHHHH		52.43-
1619PhosphorylationRVILTRESPSIQLAS
HHHHCCCCCCHHHHH		22.21-
1621PhosphorylationILTRESPSIQLASLE
HHCCCCCCHHHHHHH		32.04-
1626PhosphorylationSPSIQLASLEVVRQI
CCCHHHHHHHHHHHH		33.39-
1647PhosphorylationHVKEKRRSAEVDDGA
HHHHHHHHCCCCCCH		32.5825159151
1653PhosphorylationRSAEVDDGAAEKETL
HHCCCCCCHHHHCCC		23.4024719451
1663UbiquitinationEKETLPEFGEGKDTG
HHCCCCCCCCCCCCC		11.58-
1673UbiquitinationGKDTGGLVPGKSLVF
CCCCCCCCCCCHHHH		7.12-
1702PhosphorylationPELNPKLTGSPGVKA
HHCCCCCCCCCCCCC		41.5630266825
1704PhosphorylationLNPKLTGSPGVKATK
CCCCCCCCCCCCCCC		17.1630266825
1710PhosphorylationGSPGVKATKPQILLE
CCCCCCCCCCEEECC		37.2224719451
1785PhosphorylationQALKGILSSPMARAE
HHHHHHHHCHHHHHH		30.40-
1786PhosphorylationALKGILSSPMARAEK
HHHHHHHCHHHHHHH		18.43-
1794PhosphorylationPMARAEKSRTAWTDL
HHHHHHHHHHHHHHH		26.77-
1870UbiquitinationIKDPVVQIKTYQLLH
ECCCEEEEEHHHHHH		2.14-
1878PhosphorylationKTYQLLHSIFQYPNP
EHHHHHHHHHCCCCC		25.68-
1882PhosphorylationLLHSIFQYPNPAVSY
HHHHHHCCCCCCCCH		8.33-
1914UbiquitinationDKRKPENTAELEIFQ
HHCCCCCCHHHHHHH		21.61-
1995PhosphorylationVFKSLVASSPALKAR
HHHHHHHCCHHHHHH		29.4029396449
1996PhosphorylationFKSLVASSPALKARL
HHHHHHCCHHHHHHH		12.4017192257
2001PhosphorylationASSPALKARLEAAIK
HCCHHHHHHHHHHHH		23.34-
2002PhosphorylationSSPALKARLEAAIKG
CCHHHHHHHHHHHHC		31.3218691976
2006UbiquitinationLKARLEAAIKGNQES
HHHHHHHHHHCCCCC		8.47-
2014UbiquitinationIKGNQESVKVKIPTS
HHCCCCCEEEECCCC		8.99-
2023PhosphorylationVKIPTSKYTKSPGKN
EECCCCCCCCCCCCC		21.11-
2026PhosphorylationPTSKYTKSPGKNSSI
CCCCCCCCCCCCCCE		30.9622617229
2028UbiquitinationSKYTKSPGKNSSIQL
CCCCCCCCCCCCEEE		49.20-
2031PhosphorylationTKSPGKNSSIQLKTS
CCCCCCCCCEEEECC		32.1021712546
2032PhosphorylationKSPGKNSSIQLKTSF
CCCCCCCCEEEECCC		24.6124719451
2035UbiquitinationGKNSSIQLKTSFL--
CCCCCEEEECCCC--		6.61-
2036MethylationKNSSIQLKTSFL---
CCCCEEEECCCC---		26.25115970585
2037PhosphorylationNSSIQLKTSFL----
CCCEEEECCCC----		33.05-
2038PhosphorylationSSIQLKTSFL-----
CCEEEECCCC-----		23.9821712546
2042MethylationLKTSFL---------
EECCCC---------		-
2044PhosphorylationTSFL-----------
CCCC-----------		-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HTR5A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HTR5A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HTR5A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TF2H3_HUMANGTF2H3physical
22939629
NUP62_HUMANNUP62physical
22939629
PPIA_HUMANPPIAphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HTR5A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1110; THR-1115; SER-1647AND SER-1996, AND MASS SPECTROMETRY.

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