TF2H3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2H3_HUMAN
• UniProt AC: Q13889
• Protein Name: General transcription factor IIH subunit 3
• Gene Name: GTF2H3
• Organism: Homo sapiens (Human).
• Sequence Length: 308
• Subcellular Localization: Nucleus .
• Protein Description: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription..
• Protein Sequence: MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVIASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKLKVSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Ubiquitination	LNLLVIVVDANPIWW CCEEEEEEECCCCCC	3.85	-
28	Ubiquitination	WWGKQALKESQFTLS CCHHHHHHHCCCCHH	59.33	-
33	Ubiquitination	ALKESQFTLSKCIDA HHHHCCCCHHHHHHH	23.61	-
56	Ubiquitination	LFMNRSNKLAVIASH EECCCCCCHHHHHHH	38.78	21906983
56	Ubiquitination	LFMNRSNKLAVIASH EECCCCCCHHHHHHH	38.78	-
59	Ubiquitination	NRSNKLAVIASHIQE CCCCCHHHHHHHHHH	5.64	21906983
74	Ubiquitination	SRFLYPGKNGRLGDF CCCCCCCCCCCCCCC	52.29	-
80	Ubiquitination	GKNGRLGDFFGDPGN CCCCCCCCCCCCCCC	40.05	21906983
84	Ubiquitination	RLGDFFGDPGNPPEF CCCCCCCCCCCCCCC	42.66	21906983
94	Phosphorylation	NPPEFNPSGSKDGKY CCCCCCCCCCCCCCE	57.72	30242111
96	Phosphorylation	PEFNPSGSKDGKYEL CCCCCCCCCCCCEEE	31.73	30242111
97	Ubiquitination	EFNPSGSKDGKYELL CCCCCCCCCCCEEEE	74.21	21906983
98	Ubiquitination	FNPSGSKDGKYELLT CCCCCCCCCCEEEEC	61.59	-
100	Ubiquitination	PSGSKDGKYELLTSA CCCCCCCCEEEECCC	45.76	21906983
111	Ubiquitination	LTSANEVIVEEIKDL ECCCCHHHHHHHHHH	2.35	21906983
116	Ubiquitination	EVIVEEIKDLMTKSD HHHHHHHHHHCCHHH	48.35	-
120	Phosphorylation	EEIKDLMTKSDIKGQ HHHHHHCCHHHCCCC	34.39	25278378
121	Ubiquitination	EIKDLMTKSDIKGQH HHHHHCCHHHCCCCC	31.97	21906983
122	Phosphorylation	IKDLMTKSDIKGQHT HHHHCCHHHCCCCCH	35.09	25278378
125	Sumoylation	LMTKSDIKGQHTETL HCCHHHCCCCCHHHH	58.47	-
125	Ubiquitination	LMTKSDIKGQHTETL HCCHHHCCCCCHHHH	58.47	21906983
125	Sumoylation	LMTKSDIKGQHTETL HCCHHHCCCCCHHHH	58.47	-
129	Phosphorylation	SDIKGQHTETLLAGS HHCCCCCHHHHHHHH	23.83	20068231
131	Phosphorylation	IKGQHTETLLAGSLA CCCCCHHHHHHHHHH	28.38	25278378
136	Phosphorylation	TETLLAGSLAKALCY HHHHHHHHHHHHHHH	21.39	20068231
143	Phosphorylation	SLAKALCYIHRMNKE HHHHHHHHHHHHCHH	10.70	20068231
152	Ubiquitination	HRMNKEVKDNQEMKS HHHCHHCCCCHHHHH	52.64	2190698
158	Ubiquitination	VKDNQEMKSRILVIK CCCCHHHHHEEEEEE	35.51	-
257	Ubiquitination	DYRAACFCHRNLIEI CHHHHHHHCCCHHHH	2.72	-
298	Ubiquitination	ISLPPVLKAKKKKLK CCCCHHHHHCHHCCC	59.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TF2H3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2H3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2H3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANDR_HUMAN	AR	physical	21157430
ERCC2_HUMAN	ERCC2	physical	21157430
CDK7_HUMAN	CDK7	physical	21157430
TF2H1_HUMAN	GTF2H1	physical	21157430
TF2H2_HUMAN	GTF2H2	physical	21157430
TF2H1_HUMAN	GTF2H1	physical	8194529
ERCC3_HUMAN	ERCC3	physical	8194529
TF2H2_HUMAN	GTF2H2	physical	15790571
TF2H4_HUMAN	GTF2H4	physical	12080057
TF2H1_HUMAN	GTF2H1	physical	12080057
TF2H2_HUMAN	GTF2H2	physical	12080057
TF2H4_HUMAN	GTF2H4	physical	22939629
TF2H1_HUMAN	GTF2H1	physical	26344197
T2H2L_HUMAN	GTF2H2C	physical	26344197
TF2H2_HUMAN	GTF2H2	physical	26344197
TF2H4_HUMAN	GTF2H4	physical	26344197
TF2H5_HUMAN	GTF2H5	physical	28514442
TF2H1_HUMAN	GTF2H1	physical	28514442
TF2H4_HUMAN	GTF2H4	physical	28514442
TF2H2_HUMAN	GTF2H2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.