TF2H4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2H4_HUMAN
• UniProt AC: Q92759
• Protein Name: General transcription factor IIH subunit 4
• Gene Name: GTF2H4
• Organism: Homo sapiens (Human).
• Sequence Length: 462
• Subcellular Localization: Nucleus.
• Protein Description: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription..
• Protein Sequence: MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRMLFLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRIALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLSQAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQLSFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGTVHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	QEFLGGLSPGVLDRL HHHHCCCCHHHHHHH	23.92	21712546
71	Ubiquitination	QPLPQAAVALWVKKE CCCCHHHHHHHHHHH	5.15	-
81	Ubiquitination	WVKKEFSKAQEESTG HHHHHHHHHHHHHHC	60.45	21906983
84	Ubiquitination	KEFSKAQEESTGLLS HHHHHHHHHHHCHHC	59.79	-
91	Phosphorylation	EESTGLLSGLRIWHT HHHHCHHCHHHHEEE	40.60	18669648
127	Ubiquitination	IALLGGGKAWSDDTS EEECCCCCCCCCCCH	50.38	21906983
127	Acetylation	IALLGGGKAWSDDTS EEECCCCCCCCCCCH	50.38	26051181
133	Phosphorylation	GKAWSDDTSQLGPDK CCCCCCCCHHCCCCC	24.30	20873877
134	Phosphorylation	KAWSDDTSQLGPDKH CCCCCCCHHCCCCCC	30.33	20873877
140	Ubiquitination	TSQLGPDKHARDVPS CHHCCCCCCCCCCCC	42.15	21906983
140	Acetylation	TSQLGPDKHARDVPS CHHCCCCCCCCCCCC	42.15	25953088
151	Phosphorylation	DVPSLDKYAEERWEV CCCCHHHHHHHHHHE	20.93	25690035
284	Phosphorylation	KSRRYYPTRLAINLS CCCCCCCCEEEEECC	23.38	25072903
316	Phosphorylation	VETNYRLYAYTESEL EEECCEEEEECHHHH	6.64	24043423
318	Phosphorylation	TNYRLYAYTESELQI ECCEEEEECHHHHHH	9.48	24043423
319	Phosphorylation	NYRLYAYTESELQIA CCEEEEECHHHHHHH	25.51	24043423
321	Phosphorylation	RLYAYTESELQIALI EEEEECHHHHHHHHH	35.49	24043423
332	Phosphorylation	IALIALFSEMLYRFP HHHHHHHHHHHHHCC	23.97	24043423
336	Phosphorylation	ALFSEMLYRFPNMVV HHHHHHHHHCCCCCE	14.64	24043423
378	Ubiquitination	RAHPVMLKQTPVLPP CCCCCCCCCCCCCCC	33.75	-
414	Phosphorylation	VLYNQFLSQVDFELL HHHHHHHHHCCHHHH	29.46	22210691
438	Ubiquitination	LVFENSAKRLMVVTP EEEECCCCEEEEECC	45.98	21906983
452	Ubiquitination	PAGHSDVKRFWKRQK CCCHHHHHHHHHHHC	47.04	-
452	Malonylation	PAGHSDVKRFWKRQK CCCHHHHHHHHHHHC	47.04	26320211
452	Acetylation	PAGHSDVKRFWKRQK CCCHHHHHHHHHHHC	47.04	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TF2H4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2H4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2H4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBP_HUMAN	TBP	physical	9159119
TF2H5_HUMAN	GTF2H5	physical	26340423
ERCC3_HUMAN	ERCC3	physical	26340423
TF2H2_HUMAN	GTF2H2	physical	26340423
TF2H3_HUMAN	GTF2H3	physical	26340423

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.