T2H2L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T2H2L_HUMAN
• UniProt AC: Q6P1K8
• Protein Name: General transcription factor IIH subunit 2-like protein
• Gene Name: GTF2H2C
• Organism: Homo sapiens (Human).
• Sequence Length: 395
• Subcellular Localization: Nucleus.
• Protein Description: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II..
• Protein Sequence: MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKEAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHLSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	TKRWEGGYERTWEIL HHCCCCCHHHHHHHH	17.07	-
20	Ubiquitination	GGYERTWEILKEDES CCHHHHHHHHEECCC	37.52	21963094
21	Ubiquitination	GYERTWEILKEDESG CHHHHHHHHEECCCC	5.13	21963094
23	Ubiquitination	ERTWEILKEDESGSL HHHHHHHEECCCCCC	69.64	21906983
31	Ubiquitination	EDESGSLKATIEDIL ECCCCCCEEEHHHHH	45.22	32015554
40	Methylation	TIEDILFKAKRKRVF EHHHHHHHHHHHHHH	49.94	-
40	Ubiquitination	TIEDILFKAKRKRVF EHHHHHHHHHHHHHH	49.94	21963094
42	Ubiquitination	EDILFKAKRKRVFEH HHHHHHHHHHHHHHH	60.07	22817900
44	Ubiquitination	ILFKAKRKRVFEHHG HHHHHHHHHHHHHHC	52.81	22817900
55	Ubiquitination	EHHGQVRLGMMRHLY HHHCCCEEECCEEEE	5.60	22817900
56	Ubiquitination	HHGQVRLGMMRHLYV HHCCCEEECCEEEEE	9.40	22817900
59	Ubiquitination	QVRLGMMRHLYVVVD CCEEECCEEEEEEEE	14.04	22817900
60	Ubiquitination	VRLGMMRHLYVVVDG CEEECCEEEEEEEEC	12.01	22817900
62	Phosphorylation	LGMMRHLYVVVDGSR EECCEEEEEEEECCC	5.76	29496907
70	Phosphorylation	VVVDGSRTMEDQDLK EEEECCCCCCCCCCC	26.98	22210691
77	Ubiquitination	TMEDQDLKPNRLTCT CCCCCCCCCCHHHHH	48.84	21906983
90	Phosphorylation	CTLKLLEYFVEEYFD HHHHHHHHHHHHHCC	16.94	-
95	Phosphorylation	LEYFVEEYFDQNPIS HHHHHHHHCCCCCCH	10.03	-
112	Ubiquitination	GIIVTKSKRAEKLTE EEEEECCHHHHHHHH	58.12	22817900
116	Ubiquitination	TKSKRAEKLTELSGN ECCHHHHHHHHHCCC	60.78	22817900
126	Ubiquitination	ELSGNPRKHITSLKE HHCCCCCHHCCHHHH	40.39	-
138	Phosphorylation	LKEAVDMTCHGEPSL HHHHHHCCCCCCHHH	9.26	21406692
144	Phosphorylation	MTCHGEPSLYNSLSM CCCCCCHHHHHHHHH	38.90	21406692
146	Phosphorylation	CHGEPSLYNSLSMAM CCCCHHHHHHHHHHH	13.67	21406692
148	Phosphorylation	GEPSLYNSLSMAMQT CCHHHHHHHHHHHHH	14.31	21406692
150	Phosphorylation	PSLYNSLSMAMQTLK HHHHHHHHHHHHHHH	12.33	21406692
155	Phosphorylation	SLSMAMQTLKHMPGH HHHHHHHHHHCCCCC	25.37	21406692
163	Phosphorylation	LKHMPGHTSREVLII HHCCCCCCCCCEEEE	35.08	21406692
163	Ubiquitination	LKHMPGHTSREVLII HHCCCCCCCCCEEEE	35.08	33845483
164	Phosphorylation	KHMPGHTSREVLIIF HCCCCCCCCCEEEEE	22.29	21406692
202	Phosphorylation	RVSVIGLSAEVRVCT EEEEEECCEEEEEEE	19.71	20068231
229	Ubiquitination	ILDESHYKELLTHHL EECHHHHHHHHHHCC	36.14	-
237	Phosphorylation	ELLTHHLSPPPASSS HHHHHCCCCCCCCCC	30.88	-
249	Ubiquitination	SSSSECSLIRMGFPQ CCCCCCCEEECCCCC	4.32	21963094
250	Ubiquitination	SSSECSLIRMGFPQH CCCCCCEEECCCCCC	1.31	21963094
261	Ubiquitination	FPQHTIASLSDQDAK CCCCHHCCCCCCCCC	25.26	33845483
280	Ubiquitination	MAHLDGNTEPGLTLG EEECCCCCCCCCCCC	49.43	33845483
297	Ubiquitination	FCPQCRAKYCELPVE ECHHHCCCCCCCCCE	30.95	33845483
306	Ubiquitination	CELPVECKICGLTLV CCCCCEEEECCCEEE	27.76	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T2H2L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T2H2L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T2H2L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF2H4_HUMAN	GTF2H4	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.