EURL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EURL_HUMAN
• UniProt AC: Q9NYK6
• Protein Name: Protein EURL homolog {ECO:0000305}
• Gene Name: EURL {ECO:0000250|UniProtKB:Q9I8W6}
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Protein Description: Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway..
• Protein Sequence: MNEEEQFVNIDLNDDNICSVCKLGTDKETLSFCHICFELNIEGVPKSDLLHTKSLRGHKDCFEKYHLIANQGCPRSKLSKSTYEEVKTILSKKINWIVQYAQNKDLDSDSECSKNPQHHLFNFRHKPEEKLLPQFDSQVPKYSAKWIDGSAGGISNCTQRILEQRENTDFGLSMLQDSGATLCRNSVLWPHSHNQAQKKEETISSPEANVQTQHPHYSREELNSMTLGEVEQLNAKLLQQIQEVFEELTHQVQEKDSLASQLHVRHVAIEQLLKNCSKLPCLQVGRTGMKSHLPINN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Ubiquitination	KSDLLHTKSLRGHKD HHHHCCCCCCCCCHH	36.42	-
54	Phosphorylation	SDLLHTKSLRGHKDC HHHCCCCCCCCCHHH	25.18	-
64	Ubiquitination	GHKDCFEKYHLIANQ CCHHHHHHHHHHHCC	20.09	-
76	Phosphorylation	ANQGCPRSKLSKSTY HCCCCCHHHCCCHHH	24.08	29396449
79	Phosphorylation	GCPRSKLSKSTYEEV CCCHHHCCCHHHHHH	28.44	29396449
80	Ubiquitination	CPRSKLSKSTYEEVK CCHHHCCCHHHHHHH	58.20	-
81	Phosphorylation	PRSKLSKSTYEEVKT CHHHCCCHHHHHHHH	32.61	29396449
82	Phosphorylation	RSKLSKSTYEEVKTI HHHCCCHHHHHHHHH	38.39	29396449
83	Phosphorylation	SKLSKSTYEEVKTIL HHCCCHHHHHHHHHH	19.72	28796482
88	Phosphorylation	STYEEVKTILSKKIN HHHHHHHHHHHHHHH	32.12	22817900
108	Phosphorylation	AQNKDLDSDSECSKN HHCCCCCCCCHHHCC	50.78	28985074
114	Ubiquitination	DSDSECSKNPQHHLF CCCCHHHCCCCHHCC	81.79	-
141	Ubiquitination	QFDSQVPKYSAKWID CCCCCCCCCCEEECC	53.64	-
198	Ubiquitination	HSHNQAQKKEETISS CCCCCHHHHHHCCCC	66.23	-
199	Ubiquitination	SHNQAQKKEETISSP CCCCHHHHHHCCCCC	49.02	-
202	Phosphorylation	QAQKKEETISSPEAN CHHHHHHCCCCCCHH	27.53	21955146
204	Phosphorylation	QKKEETISSPEANVQ HHHHHCCCCCCHHHC	47.46	25159151
205	Phosphorylation	KKEETISSPEANVQT HHHHCCCCCCHHHCC	23.94	25159151
212	Phosphorylation	SPEANVQTQHPHYSR CCCHHHCCCCCCCCH	25.27	21955146
217	Phosphorylation	VQTQHPHYSREELNS HCCCCCCCCHHHHHC	17.55	21955146
218	Phosphorylation	QTQHPHYSREELNSM CCCCCCCCHHHHHCC	30.13	21955146
290	Ubiquitination	QVGRTGMKSHLPINN EECCCCCCCCCCCCC	35.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EURL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EURL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EURL_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EURL_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.