DACH1_HUMAN - dbPTM
DACH1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DACH1_HUMAN
UniProt AC Q9UI36
Protein Name Dachshund homolog 1
Gene Name DACH1
Organism Homo sapiens (Human).
Sequence Length 760
Subcellular Localization Nucleus .
Protein Description Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity)..
Protein Sequence MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVGSSDGSWDKETLPSSPSQGPQASITHPRMPGARSLPLSHPLNHLQQSHLLPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRMHIEKDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASTDSLRVLNDSLTPEIEADRSGGRTDAERTIQDGRLYLKTTVMY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
84PhosphorylationGGGGGGGSGGGGGSS
CCCCCCCCCCCCCCC		33.0228985074
144PhosphorylationNASTGSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
145PhosphorylationASTGSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
146PhosphorylationSTGSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
147PhosphorylationTGSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
148PhosphorylationGSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
149PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
150PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
151PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
152PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.8719664994
153PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.8719664994
154PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.8719664994
155PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.8719664994
156PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
157PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
158PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
159PhosphorylationSSSSSSSSSSSSSSC
CCCCCCCCCCCCCCC		35.87-
204PhosphorylationGAKVASFTVEGCELI
CCEEEEEEEECCEEE		55.88-
230PhosphorylationHLVGGLHTVYTKLKR
HHHCCHHHHHHHHHH		10.1820049867
232PhosphorylationVGGLHTVYTKLKRLE
HCCHHHHHHHHHHCC		34.0320049867
233PhosphorylationGGLHTVYTKLKRLEI
CCHHHHHHHHHHCCC		2.7720049867
254UbiquitinationVEQVRILRGLGAIQP
HHHHHHHHHCCCCCC		3.1922817900
258UbiquitinationRILRGLGAIQPGVNR
HHHHHCCCCCCCCCH		28.3221890473
273UbiquitinationCKLISRKDFETLYND
HEEEEHHHHHHHHHH		48.3021890473
285PhosphorylationYNDCTNASSRPGRPP
HHHHCCCCCCCCCCC		34.89-
286PhosphorylationNDCTNASSRPGRPPK
HHHCCCCCCCCCCCC		45.13-
297PhosphorylationRPPKRTQSVTSPENS
CCCCCCCCCCCCCCC		43.7622210691
300PhosphorylationKRTQSVTSPENSHIM
CCCCCCCCCCCCCCC		71.7422210691
306UbiquitinationTSPENSHIMPHSVPG
CCCCCCCCCCCCCCC		18.9222817900
310UbiquitinationNSHIMPHSVPGLMSP
CCCCCCCCCCCCCCC		32.9621890473
325UbiquitinationGIIPPTGLTAAAAAA
CCCCCCCHHHHHHHH		10.5121890473
357PhosphorylationKLEAMSNYHASNNQH
EHHHHHHCCCCCCCC		12.00-
357 (in isoform 3)Phosphorylation-12.00-
360 (in isoform 3)Phosphorylation-32.5022210691
376 (in isoform 3)Phosphorylation-24.3122210691
384 (in isoform 3)Phosphorylation-46.4722210691
388PhosphorylationDGSWDKETLPSSPSQ
CCCCCCCCCCCCCCC		39.9327732954
391PhosphorylationWDKETLPSSPSQGPQ
CCCCCCCCCCCCCCC		34.7027732954
392PhosphorylationDKETLPSSPSQGPQA
CCCCCCCCCCCCCCC		50.1227732954
393UbiquitinationKETLPSSPSQGPQAS
CCCCCCCCCCCCCCC		71.6022817900
394PhosphorylationETLPSSPSQGPQASI
CCCCCCCCCCCCCCC		22.1827732954
397UbiquitinationPSSPSQGPQASITHP
CCCCCCCCCCCCCCC		13.1621890473
397 (in isoform 4)Ubiquitination-13.1621890473
399UbiquitinationSPSQGPQASITHPRM
CCCCCCCCCCCCCCC		4.6221890473
400PhosphorylationPSQGPQASITHPRMP
CCCCCCCCCCCCCCC		24.2727732954
402PhosphorylationQGPQASITHPRMPGA
CCCCCCCCCCCCCCC		26.1427732954
412UbiquitinationRMPGARSLPLSHPLN
CCCCCCCCCCCCCCH		9.9721890473
412 (in isoform 4)Ubiquitination-9.9721890473
414UbiquitinationPGARSLPLSHPLNHL
CCCCCCCCCCCCHHH		38.2521890473
441PhosphorylationPFMMMPHPLIPVSLP
CEEECCCCCCCCCCC		3.5932142685
441 (in isoform 2)Phosphorylation-3.5924719451
443PhosphorylationMMMPHPLIPVSLPPA
EECCCCCCCCCCCHH		7.9118452278
447PhosphorylationHPLIPVSLPPASVTM
CCCCCCCCCHHHHHH		42.3218452278
447UbiquitinationHPLIPVSLPPASVTM
CCCCCCCCCHHHHHH		42.3222817900
451UbiquitinationPVSLPPASVTMAMSQ
CCCCCHHHHHHHHHH		9.1921890473
451 (in isoform 3)Ubiquitination-9.1921890473
453UbiquitinationSLPPASVTMAMSQMN
CCCHHHHHHHHHHHH		5.7721890473
466UbiquitinationMNHLSTIANMAAAAQ
HHHHHHHHHHHHHHH		1.6621890473
466 (in isoform 3)Ubiquitination-1.6621890473
467PhosphorylationNHLSTIANMAAAAQV
HHHHHHHHHHHHHHC		8.1833259812
468UbiquitinationHLSTIANMAAAAQVQ
HHHHHHHHHHHHHCC		7.8021890473
491PhosphorylationSVIKERVPDSPSPAP
EEEEECCCCCCCCCC		22.62-
493PhosphorylationIKERVPDSPSPAPSL
EEECCCCCCCCCCCH		37.3323401153
495PhosphorylationERVPDSPSPAPSLEE
ECCCCCCCCCCCHHC		15.6222617229
497PhosphorylationVPDSPSPAPSLEEGR
CCCCCCCCCCHHCCC		50.9832142685
499PhosphorylationDSPSPAPSLEEGRRP
CCCCCCCCHHCCCCC		63.8422617229
508PhosphorylationEEGRRPGSHPSSHRS
HCCCCCCCCCCCCCC		38.9429523821
511PhosphorylationRRPGSHPSSHRSSSV
CCCCCCCCCCCCCCC		37.6729523821
512PhosphorylationRPGSHPSSHRSSSVS
CCCCCCCCCCCCCCC		39.9329523821
515PhosphorylationSHPSSHRSSSVSSSP
CCCCCCCCCCCCCCC		27.5429052541
516PhosphorylationHPSSHRSSSVSSSPA
CCCCCCCCCCCCCCC		7.5129052541
517PhosphorylationPSSHRSSSVSSSPAR
CCCCCCCCCCCCCCC		27.3529052541
519PhosphorylationSHRSSSVSSSPARTE
CCCCCCCCCCCCCCC		18.3130377224
520PhosphorylationHRSSSVSSSPARTES
CCCCCCCCCCCCCCC		27.9230177828
521PhosphorylationRSSSVSSSPARTESS
CCCCCCCCCCCCCCC		32.7325849741
525PhosphorylationVSSSPARTESSSDRI
CCCCCCCCCCCCCCC		34.2330377224
527PhosphorylationSSPARTESSSDRIPV
CCCCCCCCCCCCCCC		39.9420068231
528PhosphorylationSPARTESSSDRIPVH
CCCCCCCCCCCCCCC		55.2530377224
528 (in isoform 2)Phosphorylation-55.2524719451
529PhosphorylationPARTESSSDRIPVHQ
CCCCCCCCCCCCCCC		36.7430377224
531PhosphorylationRTESSSDRIPVHQNG
CCCCCCCCCCCCCCC		20.5917287340
531 (in isoform 2)Phosphorylation-20.5924719451
532 (in isoform 2)Phosphorylation-7.2524719451
534PhosphorylationSSSDRIPVHQNGLSM
CCCCCCCCCCCCCCH		46.0117287340
540PhosphorylationPVHQNGLSMNQMLMG
CCCCCCCCHHHHHHC		22.2730377224
549PhosphorylationNQMLMGLSPNVLPGP
HHHHHCCCCCCCCCC		44.5828348404
578PhosphorylationKRMHIEKDETPLSTP
HCCCCCCCCCCCCCC		39.4017287340
580PhosphorylationMHIEKDETPLSTPTA
CCCCCCCCCCCCCCH		13.3825159151
581PhosphorylationHIEKDETPLSTPTAR
CCCCCCCCCCCCCHH		33.2817287340
582PhosphorylationIEKDETPLSTPTARD
CCCCCCCCCCCCHHH		32.1317287340
583PhosphorylationEKDETPLSTPTARDS
CCCCCCCCCCCHHHH		22.2325159151
584PhosphorylationKDETPLSTPTARDSL
CCCCCCCCCCHHHHH		34.1225159151
586PhosphorylationETPLSTPTARDSLDK
CCCCCCCCHHHHHHH		36.2122617229
590PhosphorylationSTPTARDSLDKLSLT
CCCCHHHHHHHHHCC		54.5228450419
595UbiquitinationRDSLDKLSLTGHGQP
HHHHHHHHCCCCCCC		24.6122817900
599UbiquitinationDKLSLTGHGQPLPPG
HHHHCCCCCCCCCCC		30.5921890473
601 (in isoform 2)Ubiquitination-6.5021890473
614UbiquitinationFPSPFLFPDGLSSIE
CCCCCCCCCCCHHHH		27.9121890473
616 (in isoform 2)Ubiquitination-34.5021890473
647UbiquitinationAQEKQVQLEKTELKM
HHHHHHHHHHHHHHH		56.7622817900
651UbiquitinationQVQLEKTELKMDFLR
HHHHHHHHHHHHHHH		30.1421890473
651 (in isoform 1)Ubiquitination-30.1421890473
653UbiquitinationQLEKTELKMDFLRER
HHHHHHHHHHHHHHH		37.53-
666UbiquitinationERELRETLEKQLAME
HHHHHHHHHHHHHHH		54.4421890473
666 (in isoform 1)Ubiquitination-54.4421890473
668UbiquitinationELRETLEKQLAMEQK
HHHHHHHHHHHHHHH		7.89-
675PhosphorylationKQLAMEQKNRAIVQK
HHHHHHHHHHHHHHH		32.5020068231
677PhosphorylationLAMEQKNRAIVQKRL
HHHHHHHHHHHHHHH		2.8120068231
682AcetylationKNRAIVQKRLKKEKK
HHHHHHHHHHHHHHH		13.8157399015
713UbiquitinationEQAEQTLKQAASTDS
HHHHHHHHHHHCCCC		11.20-
717PhosphorylationQTLKQAASTDSLRVL
HHHHHHHCCCCHHHH		43.0824247654
720PhosphorylationKQAASTDSLRVLNDS
HHHHCCCCHHHHHCC		34.5224247654
727PhosphorylationSLRVLNDSLTPEIEA
CHHHHHCCCCCCEEC		23.8720068231
729PhosphorylationRVLNDSLTPEIEADR
HHHHCCCCCCEECCC		48.5020068231
737PhosphorylationPEIEADRSGGRTDAE
CCEECCCCCCCCCHH		30.4820068231
741PhosphorylationADRSGGRTDAERTIQ
CCCCCCCCCHHHHCC		13.9323312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DACH1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DACH1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DACH1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC9_HUMANUBE2Iphysical
16189514
NAGK_HUMANNAGKphysical
16189514
UBC9_HUMANUBE2Iphysical
11025202
HDAC1_HUMANHDAC1physical
17182846
HDAC3_HUMANHDAC3physical
17182846
NCOR1_HUMANNCOR1physical
17182846
JUN_HUMANJUNphysical
17182846
JUN_HUMANJUNphysical
16980615
CREB1_HUMANCREB1physical
16980615
NCOR1_HUMANNCOR1physical
14525983
SIN3A_HUMANSIN3Aphysical
14525983
SMAD4_HUMANSMAD4physical
14525983
SMAD3_HUMANSMAD3physical
14525983
DACH1_HUMANDACH1physical
25416956
FGF12_HUMANFGF12physical
25416956
PPIG_HUMANPPIGphysical
25416956
RNF14_HUMANRNF14physical
25416956
SAHH2_HUMANAHCYL1physical
25416956
U2AF2_HUMANU2AF2physical
25416956
ZCH10_HUMANZCCHC10physical
25416956
NAGK_HUMANNAGKphysical
25416956
MMTA2_HUMANC1orf35physical
25416956
HBB_HUMANHBBphysical
26186194
NAGK_HUMANNAGKphysical
21516116
MMTA2_HUMANC1orf35physical
21516116
HBB_HUMANHBBphysical
28514442
P53_HUMANTP53physical
23798621
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DACH1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-578; SER-581; THR-582AND THR-584, AND MASS SPECTROMETRY.

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