dbPTM

PPIG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PPIG_HUMAN
UniProt AC	Q13427
Protein Name	Peptidyl-prolyl cis-trans isomerase G
Gene Name	PPIG
Organism	Homo sapiens (Human).
Sequence Length	754
Subcellular Localization	Nucleus matrix . Nucleus speckle . Colocalizes with RNA splicing factors at nuclear speckles.
Protein Description	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. [PubMed: 20676357 May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.]
Protein Sequence	MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDKSG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Glutathionylation	IKVQRPRCFFDIAIN CCCCCCCEEEEEEEC	4.40	22555962
33	Glutathionylation	FELFSDVCPKTCENF HHHHCCCCCHHCCCC	3.25	22555962
35	Acetylation	LFSDVCPKTCENFRC HHCCCCCHHCCCCEE	61.76	26051181
48	Acetylation	RCLCTGEKGTGKSTQ EEEEECCCCCCCCCC	64.22	26051181
70	Acetylation	CLFHRVVKDFMVQGG HHHHHHHHHHEEECC	42.25	26051181
158	Acetylation	VREIENQKTDAASKP HHHHHHCCCCCCCCC	61.01	25953088
158	Ubiquitination	VREIENQKTDAASKP HHHHHHCCCCCCCCC	61.01	32015554
159	Phosphorylation	REIENQKTDAASKPF HHHHHCCCCCCCCCC	22.55	21406692
163	O-linked_Glycosylation	NQKTDAASKPFAEVR HCCCCCCCCCCCEEE	42.45	30379171
163	Phosphorylation	NQKTDAASKPFAEVR HCCCCCCCCCCCEEE	42.45	21406692
164	2-Hydroxyisobutyrylation	QKTDAASKPFAEVRI CCCCCCCCCCCEEEE	39.15	-
164	Acetylation	QKTDAASKPFAEVRI CCCCCCCCCCCEEEE	39.15	26051181
173	Phosphorylation	FAEVRILSCGELIPK CCEEEEEECCCCCCH	20.08	25159151
174	Glutathionylation	AEVRILSCGELIPKS CEEEEEECCCCCCHH	4.38	22555962
182	Ubiquitination	GELIPKSKVKKEEKK CCCCCHHHCCHHHHH	65.29	-
193	Phosphorylation	EEKKRHKSSSSSSSS HHHHHCCCCCCCCCC	29.36	-
195	Phosphorylation	KKRHKSSSSSSSSSS HHHCCCCCCCCCCCC	41.13	-
196	Phosphorylation	KRHKSSSSSSSSSSD HHCCCCCCCCCCCCC	35.87	-
197	Phosphorylation	RHKSSSSSSSSSSDS HCCCCCCCCCCCCCC	35.87	-
198	Phosphorylation	HKSSSSSSSSSSDSD CCCCCCCCCCCCCCC	35.87	-
199	Phosphorylation	KSSSSSSSSSSDSDS CCCCCCCCCCCCCCC	35.87	-
200	Phosphorylation	SSSSSSSSSSDSDSS CCCCCCCCCCCCCCC	35.49	-
201	Phosphorylation	SSSSSSSSSDSDSSS CCCCCCCCCCCCCCC	39.86	-
202	Phosphorylation	SSSSSSSSDSDSSSD CCCCCCCCCCCCCCC	42.98	-
204	Phosphorylation	SSSSSSDSDSSSDSQ CCCCCCCCCCCCCCC	41.14	-
206	Phosphorylation	SSSSDSDSSSDSQSS CCCCCCCCCCCCCCC	35.38	-
207	Phosphorylation	SSSDSDSSSDSQSSS CCCCCCCCCCCCCCC	43.06	-
208	Phosphorylation	SSDSDSSSDSQSSSD CCCCCCCCCCCCCCC	45.28	-
212	Phosphorylation	DSSSDSQSSSDSSDS CCCCCCCCCCCCCCC	35.44	30576142
213	Phosphorylation	SSSDSQSSSDSSDSE CCCCCCCCCCCCCCH	30.44	28985074
214	Phosphorylation	SSDSQSSSDSSDSES CCCCCCCCCCCCCHH	46.92	-
216	Phosphorylation	DSQSSSDSSDSESAT CCCCCCCCCCCHHHH	37.68	28985074
217	Phosphorylation	SQSSSDSSDSESATE CCCCCCCCCCHHHHH	50.58	-
219	Phosphorylation	SSSDSSDSESATEEK CCCCCCCCHHHHHHH	35.08	-
221	Phosphorylation	SDSSDSESATEEKSK CCCCCCHHHHHHHHH	44.43	30576142
223	Phosphorylation	SSDSESATEEKSKKR CCCCHHHHHHHHHHH	54.69	-
251	Phosphorylation	EKKKRKKSKKSASSE HHHHHHHHHHCCCCH	48.64	29116813
254	Phosphorylation	KRKKSKKSASSESEA HHHHHHHCCCCHHHH	36.80	26503892
256	Phosphorylation	KKSKKSASSESEAEN HHHHHCCCCHHHHHH	41.55	26503892
257	Phosphorylation	KSKKSASSESEAENL HHHHCCCCHHHHHHH	44.87	26503892
259	Phosphorylation	KKSASSESEAENLEA HHCCCCHHHHHHHHC	44.01	29255136
270	Phosphorylation	NLEAQPQSTVRPEEI HHHCCCCCCCCHHHC	35.24	28450419
271	Phosphorylation	LEAQPQSTVRPEEIP HHCCCCCCCCHHHCC	18.45	28450419
290	Phosphorylation	NRFLMRKSPPKADEK CCCCCCCCCCCCCHH	35.75	30266825
315	Phosphorylation	RECNPPNSQPASYQR HHCCCCCCCCCHHHH	43.23	17525332
319	Phosphorylation	PPNSQPASYQRRLLV CCCCCCCHHHHHEEE	28.60	28674419
320	Phosphorylation	PNSQPASYQRRLLVT CCCCCCHHHHHEEEE	14.24	-
329	Phosphorylation	RRLLVTRSGRKIKGR HHEEEECCCCCCCCC	33.32	24732914
341	Phosphorylation	KGRGPRRYRTPSRSR CCCCCCCCCCCCCCC	21.81	30242111
343	Phosphorylation	RGPRRYRTPSRSRSR CCCCCCCCCCCCCCH	19.38	30242111
345	Phosphorylation	PRRYRTPSRSRSRDR CCCCCCCCCCCCHHH	42.13	30242111
347	Phosphorylation	RYRTPSRSRSRDRFR CCCCCCCCCCHHHHH	38.66	20068231
349	Phosphorylation	RTPSRSRSRDRFRRS CCCCCCCCHHHHHCC	39.52	20068231
356	Phosphorylation	SRDRFRRSETPPHWR CHHHHHCCCCCHHHH	41.38	18388127
358	Phosphorylation	DRFRRSETPPHWRQE HHHHCCCCCHHHHHH	43.28	18388127
375	Phosphorylation	RAQRMRVSSGERWIK HHHHHHCCCCCHHHC	23.43	30266825
376	Phosphorylation	AQRMRVSSGERWIKG HHHHHCCCCCHHHCC	41.64	30266825
386	Phosphorylation	RWIKGDKSELNEIKE HHHCCCHHHHHHHHH	52.64	23927012
392	Sumoylation	KSELNEIKENQRSPV HHHHHHHHHHCCCCC	44.42	28112733
392	Ubiquitination	KSELNEIKENQRSPV HHHHHHHHHHCCCCC	44.42	32015554
397	Phosphorylation	EIKENQRSPVRVKER HHHHHCCCCCCCCEE	20.27	22167270
407	Phosphorylation	RVKERKITDHRNVSE CCCEECCCCCCCCCC	28.87	23403867
413	Phosphorylation	ITDHRNVSESPNRKN CCCCCCCCCCCCCCC	35.59	29255136
415	Phosphorylation	DHRNVSESPNRKNEK CCCCCCCCCCCCCHH	21.70	29255136
431	Phosphorylation	KKVKDHKSNSKERDI HHHHHHHCCHHHHHH	42.80	30576142
433	Phosphorylation	VKDHKSNSKERDIRR HHHHHCCHHHHHHHH	42.88	27422710
442	Phosphorylation	ERDIRRNSEKDDKYK HHHHHHHHHHHHHHH	44.18	24719451
447	Acetylation	RNSEKDDKYKNKVKK HHHHHHHHHHHHHHH	69.16	7491897
449	Acetylation	SEKDDKYKNKVKKRA HHHHHHHHHHHHHHH	56.91	7491909
458	Phosphorylation	KVKKRAKSKSRSKSK HHHHHHHHHHHHHHH	34.57	26074081
459	Ubiquitination	VKKRAKSKSRSKSKE HHHHHHHHHHHHHHH	49.54	-
460	Phosphorylation	KKRAKSKSRSKSKEK HHHHHHHHHHHHHHH	49.21	26074081
462	Phosphorylation	RAKSKSRSKSKEKSK HHHHHHHHHHHHHHH	48.66	26074081
463	Ubiquitination	AKSKSRSKSKEKSKS HHHHHHHHHHHHHHH	65.52	-
464	Phosphorylation	KSKSRSKSKEKSKSK HHHHHHHHHHHHHHH	47.49	26074081
468	Phosphorylation	RSKSKEKSKSKERDS HHHHHHHHHHHHHHH	43.16	26074081
487	Phosphorylation	NEEKRMRSRSKGRDH HHHHHHHHHHCCCCH	31.40	26074081
489	Phosphorylation	EKRMRSRSKGRDHEN HHHHHHHHCCCCHHH	40.48	25849741
509	Ubiquitination	KQSDSKGKDQERSRS HHHCCCCHHHHHHHH	61.03	24816145
525	O-linked_Glycosylation	EKSKQLESKSNEHDH HHHHHHHHHCCCCCC	50.40	30379171
525	Phosphorylation	EKSKQLESKSNEHDH HHHHHHHHHCCCCCC	50.40	24719451
527	Phosphorylation	SKQLESKSNEHDHSK HHHHHHHCCCCCCHH	57.65	20068231
533	Phosphorylation	KSNEHDHSKSKEKDR HCCCCCCHHHHHHHH	44.69	29743597
535	Phosphorylation	NEHDHSKSKEKDRRA CCCCCHHHHHHHHHH	49.41	23312004
544	Phosphorylation	EKDRRAQSRSRECDI HHHHHHHHHHCCCCC	31.10	23401153
546	Phosphorylation	DRRAQSRSRECDITK HHHHHHHHCCCCCCC	37.36	23401153
552	Phosphorylation	RSRECDITKGKHSYN HHCCCCCCCCCCCCC	22.09	26552605
557	Phosphorylation	DITKGKHSYNSRTRE CCCCCCCCCCCHHHH	29.51	24719451
558	Phosphorylation	ITKGKHSYNSRTRER CCCCCCCCCCHHHHH	19.51	24719451
560	Phosphorylation	KGKHSYNSRTRERSR CCCCCCCCHHHHHHH	27.13	30576142
562	Phosphorylation	KHSYNSRTRERSRSR CCCCCCHHHHHHHHH	36.38	30576142
566	Phosphorylation	NSRTRERSRSRDRSR CCHHHHHHHHHHHHH	29.83	20068231
568	Phosphorylation	RTRERSRSRDRSRRV HHHHHHHHHHHHHHH	39.52	20068231
572	Phosphorylation	RSRSRDRSRRVRSRT HHHHHHHHHHHHHHC	28.82	20068231
585	Phosphorylation	RTHDRDRSRSKEYHR HCCCCCHHHHHHHHH	45.24	25849741
587	Phosphorylation	HDRDRSRSKEYHRYR CCCCHHHHHHHHHHH	30.96	25849741
590	Phosphorylation	DRSRSKEYHRYREQE CHHHHHHHHHHHHHH	8.71	24144214
598	Phosphorylation	HRYREQEYRRRGRSR HHHHHHHHHHHCCCC	14.76	30242111
604	Phosphorylation	EYRRRGRSRSRERRT HHHHHCCCCCCCCCC	37.11	20068231
606	Phosphorylation	RRRGRSRSRERRTPP HHHCCCCCCCCCCCC	39.48	20068231
611	Phosphorylation	SRSRERRTPPGRSRS CCCCCCCCCCCCCCH	39.80	28355574
616	Phosphorylation	RRTPPGRSRSKDRRR CCCCCCCCCHHHHHH	46.98	28348404
618	Phosphorylation	TPPGRSRSKDRRRRR CCCCCCCHHHHHHHH	39.91	20068231
628	Phosphorylation	RRRRRRDSRSSEREE HHHHHHHHHHHHHHH	32.05	27794612
630	Phosphorylation	RRRRDSRSSEREESQ HHHHHHHHHHHHHHH	40.27	25849741
631	Phosphorylation	RRRDSRSSEREESQS HHHHHHHHHHHHHHH	39.29	25849741
636	Phosphorylation	RSSEREESQSRNKDK HHHHHHHHHHHHHHH	28.80	27794612
638	Phosphorylation	SEREESQSRNKDKYR HHHHHHHHHHHHHHH	47.29	24144214
649	Phosphorylation	DKYRNQESKSSHRKE HHHHCHHHHHHHHHH	28.24	30576142
658	O-linked_Glycosylation	SSHRKENSESEKRMY HHHHHHCCHHHHHHH	43.52	30379171
658	Phosphorylation	SSHRKENSESEKRMY HHHHHHCCHHHHHHH	43.52	24275748
660	Phosphorylation	HRKENSESEKRMYSK HHHHCCHHHHHHHHH	48.52	29052541
666	Phosphorylation	ESEKRMYSKSRDHNS HHHHHHHHHHCCCCC	18.14	24719451
673	Phosphorylation	SKSRDHNSSNNSREK HHHCCCCCCCCHHHH	30.90	-
674	Phosphorylation	KSRDHNSSNNSREKK HHCCCCCCCCHHHHH	45.40	-
677	Phosphorylation	DHNSSNNSREKKADR CCCCCCCHHHHHCCC	46.17	-
687	Phosphorylation	KKADRDQSPFSKIKQ HHCCCCCCHHHHHHH	32.00	29255136
690	Phosphorylation	DRDQSPFSKIKQSSQ CCCCCHHHHHHHHHH	36.53	22167270
693	Sumoylation	QSPFSKIKQSSQDNE CCHHHHHHHHHHCHH	48.11	28112733
695	Phosphorylation	PFSKIKQSSQDNELK HHHHHHHHHHCHHHH	25.60	29255136
696	Phosphorylation	FSKIKQSSQDNELKS HHHHHHHHHCHHHHH	38.77	23401153
703	Phosphorylation	SQDNELKSSMLKNKE HHCHHHHHHHHCCHH	33.34	28555341
716	Phosphorylation	KEDEKIRSSVEKENQ HHHHHHHHHHHHHHH	42.06	22167270
717	Phosphorylation	EDEKIRSSVEKENQK HHHHHHHHHHHHHHH	25.17	22167270
720	Acetylation	KIRSSVEKENQKSKG HHHHHHHHHHHHCCC	60.86	20167786
724	Acetylation	SVEKENQKSKGQEND HHHHHHHHCCCCCCH	66.76	20167786
725	Phosphorylation	VEKENQKSKGQENDH HHHHHHHCCCCCCHH	32.05	26074081
744	Phosphorylation	NKKFDHESSPGTDED CCCCCCCCCCCCCCC	38.11	29255136
745	Phosphorylation	KKFDHESSPGTDEDK CCCCCCCCCCCCCCC	25.10	29255136
748	Phosphorylation	DHESSPGTDEDKSG- CCCCCCCCCCCCCC-	39.33	29255136
753	Phosphorylation	PGTDEDKSG------ CCCCCCCCC------	63.16	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PPIG_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PPIG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PPIG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PININ_HUMAN	PNN	physical	15358154
RPB1_MOUSE	Polr2a	physical	9153302
PR40A_HUMAN	PRPF40A	physical	22365833
PR38A_HUMAN	PRPF38A	physical	22365833
SLU7_HUMAN	SLU7	physical	22365833
PCBP1_HUMAN	PCBP1	physical	22365833
NKAP_HUMAN	NKAP	physical	22365833
ZCH10_HUMAN	ZCCHC10	physical	22365833
RBM39_HUMAN	RBM39	physical	25416956
PNMA2_HUMAN	PNMA2	physical	25416956
THAP1_HUMAN	THAP1	physical	25416956
COAC_HUMAN	PPCDC	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
KCTD6_HUMAN	KCTD6	physical	25416956
BEND7_HUMAN	BEND7	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00172	L-Proline

Regulatory Network of PPIG_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-397, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254; SER-256; SER-257;SER-259; SER-356; THR-358; SER-397; SER-687; SER-744; SER-745; THR-748AND SER-753, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315 AND SER-696, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413 AND SER-415, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254; SER-256; SER-257;SER-259; SER-290; SER-356; THR-358; SER-397; SER-413; SER-415;SER-568; SER-572; THR-611 AND SER-687, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356; THR-358 ANDSER-415, AND MASS SPECTROMETRY.	15302935 [Abstract]