PAXX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAXX_HUMAN
• UniProt AC: Q9BUH6
• Protein Name: Protein PAXX {ECO:0000305}
• Gene Name: PAXX {ECO:0000303|PubMed:25574025, ECO:0000312|HGNC:HGNC:27849}
• Organism: Homo sapiens (Human).
• Sequence Length: 204
• Subcellular Localization: Nucleus . Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation.
• Protein Description: Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery..
• Protein Sequence: MDPLSPPLCTLPPGPEPPRFVCYCEGEESGEGDRGGFNLYVTDAAELWSTCFTPDSLAALKARFGLSAAEDITPRFRAACEQQAVALTLQEDRASLTLSGGPSALAFDLSKVPGPEAAPRLRALTLGLAKRVWSLERRLAAAEETAVSPRKSPRPAGPQLFLPDPDPQRGGPGPGVRRRCPGESLINPGFKSKKPAGGVDFDET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	O-linked_Glycosylation	---MDPLSPPLCTLP ---CCCCCCCCCCCC		23301498
5	Phosphorylation	---MDPLSPPLCTLP ---CCCCCCCCCCCC		28188228
10	Phosphorylation	PLSPPLCTLPPGPEP CCCCCCCCCCCCCCC		27732954
56	Phosphorylation	STCFTPDSLAALKAR HHCCCHHHHHHHHHH		24719451
67	Phosphorylation	LKARFGLSAAEDITP HHHHHCCCHHHHCCH		20068231
73	Phosphorylation	LSAAEDITPRFRAAC CCHHHHCCHHHHHHH		20068231
95	Phosphorylation	TLQEDRASLTLSGGP EEECCCCCEEECCCC		-
99	Phosphorylation	DRASLTLSGGPSALA CCCCEEECCCCEEEE		-
103	Phosphorylation	LTLSGGPSALAFDLS EEECCCCEEEEEEHH		-
130	Acetylation	ALTLGLAKRVWSLER HHHHHHHHHHHHHHH		25953088
134	Phosphorylation	GLAKRVWSLERRLAA HHHHHHHHHHHHHHH		28857561
145	Phosphorylation	RLAAAEETAVSPRKS HHHHHHHHCCCCCCC		22167270
148	Phosphorylation	AAEETAVSPRKSPRP HHHHHCCCCCCCCCC		19664994
152	Phosphorylation	TAVSPRKSPRPAGPQ HCCCCCCCCCCCCCC		22167270
169	Methylation	LPDPDPQRGGPGPGV CCCCCCCCCCCCCCC		115486555
184	Phosphorylation	RRRCPGESLINPGFK HHCCCCCCCCCCCCC		20068231
191	Acetylation	SLINPGFKSKKPAGG CCCCCCCCCCCCCCC		25953088
192	Phosphorylation	LINPGFKSKKPAGGV CCCCCCCCCCCCCCC		17192257
192	O-linked_Glycosylation	LINPGFKSKKPAGGV CCCCCCCCCCCCCCC		23301498

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAXX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAXX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAXX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.