LRRK1_HUMAN - dbPTM
LRRK1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRRK1_HUMAN
UniProt AC Q38SD2
Protein Name Leucine-rich repeat serine/threonine-protein kinase 1
Gene Name LRRK1 {ECO:0000312|EMBL:AAY67799.1}
Organism Homo sapiens (Human).
Sequence Length 2015
Subcellular Localization Cytoplasm .
Protein Description
Protein Sequence MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRAAYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTGRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30PhosphorylationCPERAMETLNGAGDT
CCHHHHHHHCCCCCC		16.6722322096
37PhosphorylationTLNGAGDTGGKPSTR
HHCCCCCCCCCCCCC		47.0922210691
175PhosphorylationVVKLLVLTHGADPES
HEEEEEHHCCCCHHH		15.70-
182PhosphorylationTHGADPESYAVRKNE
HCCCCHHHHCCCCCC		24.63-
183PhosphorylationHGADPESYAVRKNEF
CCCCHHHHCCCCCCC		13.88-
233UbiquitinationLDSPDPSKHLLRKYF
ECCCCHHHHHHHHHH		43.5927667366
248PhosphorylationIEASPLPSSYPGKTA
HCCCCCCCCCCCCEE		50.6230108239
249PhosphorylationEASPLPSSYPGKTAL
CCCCCCCCCCCCEEE		33.1530108239
337PhosphorylationRLLEIDISSNKLSHL
HEEEEECCCCCHHCC		24.90-
358PhosphorylationLSKLQKLTASKNCLE
HHHHHHHHCCCHHHH		35.60-
360PhosphorylationKLQKLTASKNCLEKL
HHHHHHCCCHHHHHH		21.11-
381UbiquitinationTNWIGLRKLQELDIS
CCCCCHHHCEECCCC		60.6129967540
393PhosphorylationDISDNKLTELPALFL
CCCCCCCCCCHHHHH		36.7728842319
405PhosphorylationLFLHSFKSLNSLNVS
HHHHHHCCCCCCCCC		30.67-
408PhosphorylationHSFKSLNSLNVSRNN
HHHCCCCCCCCCCCC		26.9822964224
447UbiquitinationLPDKMAVFWKNHLKD
CCHHHHHHHHHHHCC		5.8127667366
453UbiquitinationVFWKNHLKDVDFSEN
HHHHHHHCCCCCCHH		48.4329967540
532UbiquitinationTTRGRQRSGTEAASV
EECCCCCCCCCCHHH		41.5521963094
690UbiquitinationPAGSRAKVESVEFNV
CCCCCCEEEEEEEEE		6.9127667366
746UbiquitinationWLLNIEAKAPNAVVL
HHHHHHCCCCCEEEE		52.1421963094
784PhosphorylationYVLALCRSPSGSRAT
HHHHHHCCCCCCCCC		23.5624300666
786PhosphorylationLALCRSPSGSRATGF
HHHHCCCCCCCCCCC		51.1224300666
788PhosphorylationLCRSPSGSRATGFPD
HHCCCCCCCCCCCCC		24.0724300666
837UbiquitinationGSTIGCQRLAGRLIP
CCCCCHHHHHCCCCC		30.4927667366
938UbiquitinationLQRIFNIKGSRSVAK
HHHHHCCCCCCHHHH		52.5227667366
971PhosphorylationTQQTEEQYFQFLAKF
CCCCHHHHHHHHHHC		11.57-
989UbiquitinationLPVANDSYLLPHLLP
ECCCCCCCCHHHCCC		18.3421963094
997PhosphorylationLLPHLLPSKPGLDTH
CHHHCCCCCCCCCCC		51.9924719451
1054MethylationFENKKNTKSRNRKVT
HHCCCCCCCCCCEEE		57.7316214643
1061PhosphorylationKSRNRKVTIYSFTGN
CCCCCEEEEEEECCC		19.7521945579
1063PhosphorylationRNRKVTIYSFTGNQR
CCCEEEEEEECCCCC		6.5921945579
1064PhosphorylationNRKVTIYSFTGNQRN
CCEEEEEEECCCCCC		16.6921945579
1098PhosphorylationLVTFDGGYLSVESSD
EEEECCCEEEEECCC		11.00-
1100PhosphorylationTFDGGYLSVESSDVN
EECCCEEEEECCCCC		18.50-
1103PhosphorylationGGYLSVESSDVNWKK
CCEEEEECCCCCCEE		29.68-
1104PhosphorylationGYLSVESSDVNWKKK
CEEEEECCCCCCEEC		31.88-
1136UbiquitinationAMAFITDHVNSLIDQ
HHHHHHHHHHHHHHH		16.4121963094
1237UbiquitinationRLFLENSKLEHSEDE
HHHHCCCCCCCCCCC		70.2721963094
1241PhosphorylationENSKLEHSEDEGSVL
CCCCCCCCCCCCCCC		37.05-
1246PhosphorylationEHSEDEGSVLGQGGS
CCCCCCCCCCCCCCC		16.48-
1276AcetylationVKRFHIKKFKNFANV
EEEEECHHCCCCCCC		62.057706995
1278AcetylationRFHIKKFKNFANVPA
EEECHHCCCCCCCCH		61.107707005
1287PhosphorylationFANVPADTMLRHLRA
CCCCCHHHHHHHHHH		21.8830108239
1295PhosphorylationMLRHLRATDAMKNFS
HHHHHHHHHHHHCHH		20.1829083192
1302PhosphorylationTDAMKNFSEFRQEAS
HHHHHCHHHHHHHHH		45.2629083192
1427PhosphorylationGALGVEGTPGYQAPE
CCCCCCCCCCCCCCC		10.47-
1430PhosphorylationGVEGTPGYQAPEIRP
CCCCCCCCCCCCCCC		11.6027642862
1449PhosphorylationDEKVDMFSYGMVLYE
CCCCCEEHHHHHHHH		17.7123663014
1450PhosphorylationEKVDMFSYGMVLYEL
CCCCEEHHHHHHHHH		9.6623663014
1455PhosphorylationFSYGMVLYELLSGQR
EHHHHHHHHHHHCCC		7.9723663014
1459PhosphorylationMVLYELLSGQRPALG
HHHHHHHHCCCCCCC		45.5723663014
1567PhosphorylationRNYTVVNTEKGLMEV
CCEEEEECCCCHHHH		27.7128387310
1628PhosphorylationLDTPAVVTCFLAVPV
CCCCHHHHEEEECHH		7.31-
1678UbiquitinationSHTANRSKFSIADED
CCCCCCCCCCCCCHH		39.6329967540
1817PhosphorylationGDSIADVSIMYSEEL
CCCCEEEEEEEEHHH		11.37-
1855PhosphorylationPPRQAARSPSSLPSS
CHHHCCCCCCCCCCC		25.14-
1858PhosphorylationQAARSPSSLPSSPAS
HCCCCCCCCCCCCCC		47.92-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
971YPhosphorylationKinaseEGFRP00533
PSP
1427TPhosphorylationKinaseCDK1P06493
PSP
1817SPhosphorylationKinasePLK1P53350
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LRRK1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRRK1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PAK4_HUMANPAK4physical
17353931
S10A8_HUMANS100A8physical
17353931
RIMS1_HUMANRIMS1physical
17353931
CI163_HUMANC9orf163physical
17353931
YI001_HUMANC9orf163physical
17353931
LYSC_HUMANLYZphysical
17353931
LRRK1_HUMANLRRK1physical
22952686
GRB2_HUMANGRB2physical
20697350
BCR_HUMANBCRphysical
20697350
ABL1_HUMANABL1physical
20697350
SHC1_HUMANSHC1physical
20697350
TCPB_HUMANCCT2physical
20697350
FKBP5_HUMANFKBP5physical
20697350
CDC37_HUMANCDC37physical
20697350
DNJA1_HUMANDNAJA1physical
20697350
NEDD4_HUMANNEDD4physical
20697350
NP1L1_HUMANNAP1L1physical
20697350
VAPA_HUMANVAPAphysical
20697350
SHIP1_HUMANINPP5Dphysical
20697350
DOK3_HUMANDOK3physical
20697350
GAB2_HUMANGAB2physical
20697350
SHIP2_HUMANINPPL1physical
20697350
PTN11_HUMANPTPN11physical
20697350
M4K1_HUMANMAP4K1physical
20697350
ASAP1_HUMANASAP1physical
20697350
SOS2_HUMANSOS2physical
20697350
SOS1_HUMANSOS1physical
20697350
HNRPK_HUMANHNRNPKphysical
20697350
RSU1_HUMANRSU1physical
20697350
LRRK1_HUMANLRRK1physical
19712061
DAPK1_HUMANDAPK1physical
19712061
LRRK2_HUMANLRRK2physical
20144646
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRRK1_HUMAN

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Related Literatures of Post-Translational Modification

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