SOS2_HUMAN - dbPTM
SOS2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SOS2_HUMAN
UniProt AC Q07890
Protein Name Son of sevenless homolog 2
Gene Name SOS2
Organism Homo sapiens (Human).
Sequence Length 1332
Subcellular Localization
Protein Description Promotes the exchange of Ras-bound GDP by GTP..
Protein Sequence MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAETPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
76UbiquitinationDVEERVQKTFPHPID
HHHHHHHHHCCCCCH		49.6429967540
96UbiquitinationDAQSAIEKRKRRNPL
HHHHHHHHHHHCCCC		58.0429967540
346PhosphorylationRLMLVPVYHCWHYFE
HHHHHHHHHHHHHHH		5.79-
351PhosphorylationPVYHCWHYFELLKQL
HHHHHHHHHHHHHHH		3.69-
362PhosphorylationLKQLKACSEEQEDRE
HHHHHHCCHHHHHHH		49.37-
384PhosphorylationALMNLQGSMDRIYKQ
HHHHHHHHHHHHHHH		12.4424247654
389PhosphorylationQGSMDRIYKQYSPRR
HHHHHHHHHHHCCCC		7.91-
392PhosphorylationMDRIYKQYSPRRRPG
HHHHHHHHCCCCCCC		19.25-
393PhosphorylationDRIYKQYSPRRRPGD
HHHHHHHCCCCCCCC		14.9426091039
419UbiquitinationSKHLAIKKMNEIQKN
HHHHHHHHHHHHHHC		40.62-
470AcetylationDGLMISCKPNHGQTR
CCEEEECCCCCCCCC		41.907712287
527UbiquitinationNSIIFAAKSAEEKNN
CCEEEEECCHHHHCC		46.9329967540
578UbiquitinationEVYRFVVKDSEENIV
HHEEEEECCCCCCEE		50.6829967540
613PhosphorylationKLIERLTYHMYADPN
HHHHHHHHHHHCCCH		6.8127811184
616PhosphorylationERLTYHMYADPNFVR
HHHHHHHHCCCHHHH		8.4423917254
658AcetylationPEPTDADKLAIEKGE
CCCCCHHHHHHHCCC		41.3519823589
663UbiquitinationADKLAIEKGEQPISA
HHHHHHHCCCCCCCC		62.7329967540
679PhosphorylationLKRFRKEYVQPVQLR
HHHHHHHHCCHHHHH		13.8622817900
717PhosphorylationERLESFISSVRGKAM
HHHHHHHHHHHHHHH		22.2924719451
718PhosphorylationRLESFISSVRGKAMK
HHHHHHHHHHHHHHH		15.8323403867
791PhosphorylationRQLTLLESDLYRKVQ
HHHHHHHHHHHHHCC		32.6521060948
794PhosphorylationTLLESDLYRKVQPSE
HHHHHHHHHHCCHHH		17.2421060948
800PhosphorylationLYRKVQPSELVGSVW
HHHHCCHHHHCCCEE		26.86-
809UbiquitinationLVGSVWTKEDKEINS
HCCCEECCCCCCCCC		48.4829967540
816PhosphorylationKEDKEINSPNLLKMI
CCCCCCCCHHHHHHH		22.3324719451
821UbiquitinationINSPNLLKMIRHTTN
CCCHHHHHHHHHCCC		35.1332015554
846MethylationEAENFEERVAVLSRI
HCCCHHHHHHHHHHH		17.94115386233
852MethylationERVAVLSRIIEILQV
HHHHHHHHHHHHHHH		29.73115386239
949UbiquitinationNNDFLKKKGKDLINF
CCHHHHHHCHHHCHH		70.39-
949MethylationNNDFLKKKGKDLINF
CCHHHHHHCHHHCHH		70.39-
958UbiquitinationKDLINFSKRRKVAEI
HHHCHHHHHCHHHHH		52.68-
958MethylationKDLINFSKRRKVAEI
HHHCHHHHHCHHHHH		52.68-
1006PhosphorylationSEKEFTDYLFNKSLE
CHHHHHHHHHCCCCC		15.33-
1010UbiquitinationFTDYLFNKSLEIEPR
HHHHHHCCCCCCCCC		49.43-
1030PhosphorylationPRFPRKSTFSLKSPG
CCCCCCCCCCCCCCC		21.93-
1032PhosphorylationFPRKSTFSLKSPGIR
CCCCCCCCCCCCCCC		34.6729214152
1035PhosphorylationKSTFSLKSPGIRPNT
CCCCCCCCCCCCCCC		33.3828555341
1042PhosphorylationSPGIRPNTGRHGSTS
CCCCCCCCCCCCCCC		37.9730576142
1047PhosphorylationPNTGRHGSTSGTLRG
CCCCCCCCCCCCCCC		17.1828857561
1048PhosphorylationNTGRHGSTSGTLRGH
CCCCCCCCCCCCCCC		35.45-
1051PhosphorylationRHGSTSGTLRGHPTP
CCCCCCCCCCCCCCC		17.04-
1057PhosphorylationGTLRGHPTPLEREPC
CCCCCCCCCCCCCCC		34.53-
1128PhosphorylationVLLPHSKSFFSSCGS
HCCCCCHHHHHCCCC		34.2428060719
1131PhosphorylationPHSKSFFSSCGSLHK
CCCHHHHHCCCCHHC		23.7828450419
1132PhosphorylationHSKSFFSSCGSLHKL
CCHHHHHCCCCHHCC		19.8325849741
1135PhosphorylationSFFSSCGSLHKLSEE
HHHHCCCCHHCCCCC		31.4628060719
1168PhosphorylationNSKGNMKSDDDPPAI
CCCCCCCCCCCCCCC		35.19-
1193PhosphorylationKPRVPVPTGAFDGPL
CCCCCCCCCCCCCCC		41.1826657352
1202PhosphorylationAFDGPLHSPPPPPPR
CCCCCCCCCCCCCCC		46.9525849741
1253PhosphorylationSDWLRDISTCPNSPS
CCHHHCCCCCCCCCC		28.3927080861
1254PhosphorylationDWLRDISTCPNSPST
CHHHCCCCCCCCCCC		32.1127080861
1258PhosphorylationDISTCPNSPSTPPST
CCCCCCCCCCCCCCC		12.8425850435
1260PhosphorylationSTCPNSPSTPPSTPS
CCCCCCCCCCCCCCC		54.0625850435
1261PhosphorylationTCPNSPSTPPSTPSP
CCCCCCCCCCCCCCC		42.4725850435
1264PhosphorylationNSPSTPPSTPSPRVP
CCCCCCCCCCCCCCC		54.9029255136
1265PhosphorylationSPSTPPSTPSPRVPR
CCCCCCCCCCCCCCC		33.2929255136
1267PhosphorylationSTPPSTPSPRVPRRC
CCCCCCCCCCCCCCE		25.9829255136
1275PhosphorylationPRVPRRCYVLSSSQN
CCCCCCEEEEECCCC		11.5622817900
1298PhosphorylationPVPPRQNSSPHLPKL
CCCCCCCCCCCCCCC		36.5926437602
1299PhosphorylationVPPRQNSSPHLPKLP
CCCCCCCCCCCCCCC		24.7228348404
1315PhosphorylationKTYKRELSHPPLYRL
CCCCCCCCCCCCCCC		29.2426657352
1320PhosphorylationELSHPPLYRLPLLEN
CCCCCCCCCCCCCCC		18.84-
1321Asymmetric dimethylarginineLSHPPLYRLPLLENA
CCCCCCCCCCCCCCC		37.20-
1321MethylationLSHPPLYRLPLLENA
CCCCCCCCCCCCCCC		37.20-
1330PhosphorylationPLLENAETPQ-----
CCCCCCCCCC-----		25.2829978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SOS2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SOS2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SOS2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHC1_HUMANSHC1physical
10675333
EGFR_HUMANEGFRphysical
10675333
PLCG1_HUMANPLCG1physical
10940929
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SOS2_HUMAN

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Related Literatures of Post-Translational Modification

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