RSU1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RSU1_HUMAN
• UniProt AC: Q15404
• Protein Name: Ras suppressor protein 1
• Gene Name: RSU1
• Organism: Homo sapiens (Human).
• Sequence Length: 277
• Protein Description: Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro..
• Protein Sequence: MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSKSLKKLV ------CCHHHHHHH	30.83	22814378
6	Ubiquitination	--MSKSLKKLVEESR --CCHHHHHHHHHHH	51.67	-
7	Ubiquitination	-MSKSLKKLVEESRE -CCHHHHHHHHHHHH	64.16	24816145
12	Phosphorylation	LKKLVEESREKNQPE HHHHHHHHHHHCCCC	32.03	20068231
34	Ubiquitination	ISNMLDVNGLFTLSH HHHHCCCCCCCHHHH	40.91	29967540
54	Sulfoxidation	LSHNKLTMVPPNIAE HHCCCCCCCCCCHHH	6.54	21406390
87	Ubiquitination	TQISSLQKLKHLNLG HHHHHHHHHHHCCCC	65.87	29967540
89	Ubiquitination	ISSLQKLKHLNLGMN HHHHHHHHHCCCCCH	53.75	-
100	Phosphorylation	LGMNRLNTLPRGFGS CCCHHHCCCCCCCCC	42.61	27535140
102	Ubiquitination	MNRLNTLPRGFGSLP CHHHCCCCCCCCCCC	32.10	23000965
105	Ubiquitination	LNTLPRGFGSLPALE HCCCCCCCCCCCHHH	6.75	21890473
105	Ubiquitination	LNTLPRGFGSLPALE HCCCCCCCCCCCHHH	6.75	23000965
121	Ubiquitination	LDLTYNNLSENSLPG HHCCCCCCCCCCCCC	6.39	29967540
130	Ubiquitination	ENSLPGNFFYLTTLR CCCCCCCEEHHHHHH	5.44	23000965
142	Phosphorylation	TLRALYLSDNDFEIL HHHHHHCCCCCCCCC	22.32	-
155	Ubiquitination	ILPPDIGKLTKLQIL CCCCCHHHCCEEEEE	54.00	23000965
158	Ubiquitination	PDIGKLTKLQILSLR CCHHHCCEEEEEECC	49.16	23000965
158	Acetylation	PDIGKLTKLQILSLR CCHHHCCEEEEEECC	49.16	25953088
158	Malonylation	PDIGKLTKLQILSLR CCHHHCCEEEEEECC	49.16	26320211
159	Ubiquitination	DIGKLTKLQILSLRD CHHHCCEEEEEECCC	3.01	23503661
171	Phosphorylation	LRDNDLISLPKEIGE CCCCCCCCCCHHHHH	46.01	20873877
174	Ubiquitination	NDLISLPKEIGELTQ CCCCCCCHHHHHHHC	68.22	29967540
180	Phosphorylation	PKEIGELTQLKELHI CHHHHHHHCCEEEEE	27.79	20068231
183	Ubiquitination	IGELTQLKELHIQGN HHHHHCCEEEEECCC	48.70	23000965
190	Ubiquitination	KELHIQGNRLTVLPP EEEEECCCEEEECCC	21.29	23000965
206	Ubiquitination	LGNLDLTGQKQVFKA CCCCCCCCCEEEEEC	39.73	24816145
208	Ubiquitination	NLDLTGQKQVFKAEN CCCCCCCEEEEECCC	50.18	33845483
212	Ubiquitination	TGQKQVFKAENNPWV CCCEEEEECCCCCCC	56.80	23503661
217	Ubiquitination	VFKAENNPWVTPIAD EEECCCCCCCCCCHH	38.20	24816145
220	Phosphorylation	AENNPWVTPIADQFQ CCCCCCCCCCHHHHH	12.71	25159151
243	Ubiquitination	YIRSETYKYLYGRHM HHHHHHHHHHHHHHC	35.88	23000965
243	Malonylation	YIRSETYKYLYGRHM HHHHHHHHHHHHHHC	35.88	26320211
244	Phosphorylation	IRSETYKYLYGRHMQ HHHHHHHHHHHHHCC	8.51	-
259	Ubiquitination	ANPEPPKKNNDKSKK CCCCCCCCCCCCCCC	67.75	24816145
268	Phosphorylation	NDKSKKISRKPLAAK CCCCCCCCCCCHHHC	43.03	-
270	Ubiquitination	KSKKISRKPLAAKNR CCCCCCCCCHHHCCC	37.28	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RSU1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RSU1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RSU1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
PARVA_HUMAN	PARVA	physical	26186194
PARVB_HUMAN	PARVB	physical	26186194
ILK_HUMAN	ILK	physical	26186194
LIMS1_HUMAN	LIMS1	physical	26186194
CBS_HUMAN	CBS	physical	26344197
ROA3_HUMAN	HNRNPA3	physical	26344197
ILK_HUMAN	ILK	physical	26344197
LIMS1_HUMAN	LIMS1	physical	26344197
NDUA8_HUMAN	NDUFA8	physical	26344197
NTM1A_HUMAN	NTMT1	physical	26344197
PARVA_HUMAN	PARVA	physical	26344197
PFKAP_HUMAN	PFKP	physical	26344197
TIAR_HUMAN	TIAL1	physical	26344197
TKT_HUMAN	TKT	physical	26344197
PARVA_HUMAN	PARVA	physical	28514442
PARVB_HUMAN	PARVB	physical	28514442
ILK_HUMAN	ILK	physical	28514442
LIMS1_HUMAN	LIMS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.