PFKAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PFKAP_HUMAN
• UniProt AC: Q01813
• Protein Name: ATP-dependent 6-phosphofructokinase, platelet type {ECO:0000255|HAMAP-Rule:MF_03184}
• Gene Name: PFKP
• Organism: Homo sapiens (Human).
• Sequence Length: 784
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis..
• Protein Sequence: MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDADDSRA -------CCCCCCCC		19413330
6	Phosphorylation	--MDADDSRAPKGSL --CCCCCCCCCCHHH		26074081
10	Ubiquitination	ADDSRAPKGSLRKFL CCCCCCCCHHHHHHH		-
12	Phosphorylation	DSRAPKGSLRKFLEH CCCCCCHHHHHHHHH		26074081
15	Acetylation	APKGSLRKFLEHLSG CCCHHHHHHHHHHCC		25953088
15	Malonylation	APKGSLRKFLEHLSG CCCHHHHHHHHHHCC		26320211
15	Ubiquitination	APKGSLRKFLEHLSG CCCHHHHHHHHHHCC		21890473
15	Ubiquitination	APKGSLRKFLEHLSG CCCHHHHHHHHHHCC		21890473
21	Phosphorylation	RKFLEHLSGAGKAIG HHHHHHHCCCCCEEE		29514088
25	Ubiquitination	EHLSGAGKAIGVLTS HHHCCCCCEEEEEEC		21890473
31	Phosphorylation	GKAIGVLTSGGDAQG CCEEEEEECCCCHHH		21406692
32	Phosphorylation	KAIGVLTSGGDAQGM CEEEEEECCCCHHHH		21406692
39	Sulfoxidation	SGGDAQGMNAAVRAV CCCCHHHHHHHHHHH		28183972
52	Phosphorylation	AVVRMGIYVGAKVYF HHHHCCCEECCEEEE		20860994
64	Phosphorylation	VYFIYEGYQGMVDGG EEEEEECCCCEECCC		-
95	Phosphorylation	VGGTIIGSARCQAFR CCCEEEEHHHHHHHH		25332170
109	"N6,N6-dimethyllysine"	RTREGRLKAACNLLQ HCCHHHHHHHHHHHH		-
109	Acetylation	RTREGRLKAACNLLQ HCCHHHHHHHHHHHH		23749302
109	Methylation	RTREGRLKAACNLLQ HCCHHHHHHHHHHHH		23644510
109	Ubiquitination	RTREGRLKAACNLLQ HCCHHHHHHHHHHHH		-
112	S-nitrosylation	EGRLKAACNLLQRGI HHHHHHHHHHHHCCC		2212679
123	S-palmitoylation	QRGITNLCVIGGDGS HCCCCCEEEECCCCC		29575903
130	Phosphorylation	CVIGGDGSLTGANLF EEECCCCCCCHHHHH		25693802
131	Ubiquitination	VIGGDGSLTGANLFR EECCCCCCCHHHHHH		21890473
131	Ubiquitination	VIGGDGSLTGANLFR EECCCCCCCHHHHHH		21890473
132	Phosphorylation	IGGDGSLTGANLFRK ECCCCCCCHHHHHHH		25693802
139	2-Hydroxyisobutyrylation	TGANLFRKEWSGLLE CHHHHHHHHHHHHHH		-
139	Acetylation	TGANLFRKEWSGLLE CHHHHHHHHHHHHHH		26051181
139	Ubiquitination	TGANLFRKEWSGLLE CHHHHHHHHHHHHHH		21890473
139	Ubiquitination	TGANLFRKEWSGLLE CHHHHHHHHHHHHHH		21890473
142	Phosphorylation	NLFRKEWSGLLEELA HHHHHHHHHHHHHHH		22777824
156	2-Hydroxyisobutyrylation	ARNGQIDKEAVQKYA HHCCCCCHHHHHHHH		-
156	Acetylation	ARNGQIDKEAVQKYA HHCCCCCHHHHHHHH		23749302
156	Ubiquitination	ARNGQIDKEAVQKYA HHCCCCCHHHHHHHH		21890473
202	Sulfoxidation	IEVVDAIMTTAQSHQ HHHHHHHHHHCHHHH		30846556
203	Phosphorylation	EVVDAIMTTAQSHQR HHHHHHHHHCHHHHH		28348404
204	Phosphorylation	VVDAIMTTAQSHQRT HHHHHHHHCHHHHHH		28348404
207	Phosphorylation	AIMTTAQSHQRTFVL HHHHHCHHHHHHHHH		28348404
211	Phosphorylation	TAQSHQRTFVLEVMG HCHHHHHHHHHHHCC		21406692
287	Ubiquitination	NKPITSEKIKELVVT CCCCCHHHHHHHHHH		21890473
289	Acetylation	PITSEKIKELVVTQL CCCHHHHHHHHHHCC		26051181
289	Ubiquitination	PITSEKIKELVVTQL CCCHHHHHHHHHHCC		21890473
310	Methylation	TILGHVQRGGTPSAF EEEEEHHHCCCCCHH		115487171
313	Phosphorylation	GHVQRGGTPSAFDRI EEHHHCCCCCHHHHH		28857561
315	Phosphorylation	VQRGGTPSAFDRILA HHHCCCCCHHHHHHH		22673903
319	Methylation	GTPSAFDRILASRMG CCCCHHHHHHHHHHC		115487161
358	Sulfoxidation	HAVRLPLMECVQMTQ CEEEEEHHHHHHHHH		21406390
363	Sulfoxidation	PLMECVQMTQDVQKA EHHHHHHHHHHHHHH		30846556
386	Phosphorylation	AVRLRGRSFAGNLNT HHHHCCCCCCCCCCH		19664994
387	Ubiquitination	VRLRGRSFAGNLNTY HHHCCCCCCCCCCHH		21890473
387	Acetylation	VRLRGRSFAGNLNTY HHHCCCCCCCCCCHH		19608861
387	Ubiquitination	VRLRGRSFAGNLNTY HHHCCCCCCCCCCHH		19608861
387	Ubiquitination	VRLRGRSFAGNLNTY HHHCCCCCCCCCCHH		21890473
392	Ubiquitination	RSFAGNLNTYKRLAI CCCCCCCCHHHEEEE		21890473
392	Ubiquitination	RSFAGNLNTYKRLAI CCCCCCCCHHHEEEE		21890473
393	Phosphorylation	SFAGNLNTYKRLAIK CCCCCCCHHHEEEEE		23927012
394	Phosphorylation	FAGNLNTYKRLAIKL CCCCCCHHHEEEEEC		23403867
395	2-Hydroxyisobutyrylation	AGNLNTYKRLAIKLP CCCCCHHHEEEEECC		-
395	Acetylation	AGNLNTYKRLAIKLP CCCCCHHHEEEEECC		19608861
395	Malonylation	AGNLNTYKRLAIKLP CCCCCHHHEEEEECC		26320211
395	Ubiquitination	AGNLNTYKRLAIKLP CCCCCHHHEEEEECC		21890473
395	Ubiquitination	AGNLNTYKRLAIKLP CCCCCHHHEEEEECC		21890473
400	Acetylation	TYKRLAIKLPDDQIP HHHEEEEECCCCCCC		25953088
400	Ubiquitination	TYKRLAIKLPDDQIP HHHEEEEECCCCCCC		21890473
400	Ubiquitination	TYKRLAIKLPDDQIP HHHEEEEECCCCCCC		21890473
408	Acetylation	LPDDQIPKTNCNVAV CCCCCCCCCCCEEEE		26051181
411	S-nitrosylation	DQIPKTNCNVAVINV CCCCCCCCEEEEEEE		2212679
443	Sulfoxidation	GIADGHRMLAIYDGF CCCCCCCEEEEECCC		30846556
447	Phosphorylation	GHRMLAIYDGFDGFA CCCEEEEECCCCCCC		27259358
451	Ubiquitination	LAIYDGFDGFAKGQI EEEECCCCCCCCCCC		21890473
451	Ubiquitination	LAIYDGFDGFAKGQI EEEECCCCCCCCCCC		21890473
455	Ubiquitination	DGFDGFAKGQIKEIG CCCCCCCCCCCEEEE		21906983
459	Ubiquitination	GFAKGQIKEIGWTDV CCCCCCCEEEECEEC		21890473
459	Ubiquitination	GFAKGQIKEIGWTDV CCCCCCCEEEECEEC		21890473
478	Ubiquitination	GQGGSILGTKRVLPG CCCCCCCCCCCCCCH		21890473
478	Acetylation	GQGGSILGTKRVLPG CCCCCCCCCCCCCCH		19608861
478	Ubiquitination	GQGGSILGTKRVLPG CCCCCCCCCCCCCCH		19608861
478	Ubiquitination	GQGGSILGTKRVLPG CCCCCCCCCCCCCCH		21890473
480	Acetylation	GGSILGTKRVLPGKY CCCCCCCCCCCCHHH		25953088
480	Ubiquitination	GGSILGTKRVLPGKY CCCCCCCCCCCCHHH		21890473
486	2-Hydroxyisobutyrylation	TKRVLPGKYLEEIAT CCCCCCHHHHHHHHH		-
486	Acetylation	TKRVLPGKYLEEIAT CCCCCCHHHHHHHHH		19608861
486	Malonylation	TKRVLPGKYLEEIAT CCCCCCHHHHHHHHH		26320211
486	Ubiquitination	TKRVLPGKYLEEIAT CCCCCCHHHHHHHHH		21890473
486	Ubiquitination	TKRVLPGKYLEEIAT CCCCCCHHHHHHHHH		21890473
487	Phosphorylation	KRVLPGKYLEEIATQ CCCCCHHHHHHHHHH		-
495	Sulfoxidation	LEEIATQMRTHSINA HHHHHHHHHHCCCCE		30846556
538	O-linked_Glycosylation	PMVMVPATVSNNVPG EEEEEECEECCCCCC		22923583
540	O-linked_Glycosylation	VMVPATVSNNVPGSD EEEECEECCCCCCCC		UniProtKB CARBOHYD
567	Ubiquitination	TDTCDRIKQSASGTK HHHHHHHHHCCCCCC		21890473
569	Phosphorylation	TCDRIKQSASGTKRR HHHHHHHCCCCCCCE		28555341
571	Phosphorylation	DRIKQSASGTKRRVF HHHHHCCCCCCCEEE		24719451
574	2-Hydroxyisobutyrylation	KQSASGTKRRVFIIE HHCCCCCCCEEEEEE		-
574	Acetylation	KQSASGTKRRVFIIE HHCCCCCCCEEEEEE		24847231
586	Phosphorylation	IIETMGGYCGYLANM EEEECCHHHHHHHHH		-
617	Phosphorylation	FDIRDLQSNVEHLTE CCHHHHHHHHHHHHH		20873877
623	Phosphorylation	QSNVEHLTEKMKTTI HHHHHHHHHHHHHHH		28857561
625	Acetylation	NVEHLTEKMKTTIQR HHHHHHHHHHHHHHH		27452117
625	Ubiquitination	NVEHLTEKMKTTIQR HHHHHHHHHHHHHHH		21890473
627	Ubiquitination	EHLTEKMKTTIQRGL HHHHHHHHHHHHHCC		-
640	Phosphorylation	GLVLRNESCSENYTT CCEECCCCCCCCCCH		20873877
642	Phosphorylation	VLRNESCSENYTTDF EECCCCCCCCCCHHH		20873877
645	Phosphorylation	NESCSENYTTDFIYQ CCCCCCCCCHHHHHH		20873877
646	Phosphorylation	ESCSENYTTDFIYQL CCCCCCCCHHHHHHH		20873877
647	Phosphorylation	SCSENYTTDFIYQLY CCCCCCCHHHHHHHH		20873877
651	Phosphorylation	NYTTDFIYQLYSEEG CCCHHHHHHHHCCCC		21082442
654	Phosphorylation	TDFIYQLYSEEGKGV HHHHHHHHCCCCCCC		-
658	Ubiquitination	YQLYSEEGKGVFDCR HHHHCCCCCCCEECC		21890473
658	Ubiquitination	YQLYSEEGKGVFDCR HHHHCCCCCCCEECC		21890473
666	Malonylation	KGVFDCRKNVLGHMQ CCCEECCHHHHHHCC		26320211
666	Ubiquitination	KGVFDCRKNVLGHMQ CCCEECCHHHHHHCC		21890473
666	Ubiquitination	KGVFDCRKNVLGHMQ CCCEECCHHHHHHCC		21890473
672	Sulfoxidation	RKNVLGHMQQGGAPS CHHHHHHCCCCCCCC		30846556
679	Phosphorylation	MQQGGAPSPFDRNFG CCCCCCCCCCCCCCC		27067055
680	Acetylation	QQGGAPSPFDRNFGT CCCCCCCCCCCCCCC		19608861
680	Ubiquitination	QQGGAPSPFDRNFGT CCCCCCCCCCCCCCC		19608861
688	Acetylation	FDRNFGTKISARAME CCCCCCCHHHHHHHH		19608861
688	Malonylation	FDRNFGTKISARAME CCCCCCCHHHHHHHH		26320211
688	Ubiquitination	FDRNFGTKISARAME CCCCCCCHHHHHHHH		21906983
694	Sulfoxidation	TKISARAMEWITAKL CHHHHHHHHHHHHHH		30846556
700	Acetylation	AMEWITAKLKEARGR HHHHHHHHHHHHCCC		20167786
700	Malonylation	AMEWITAKLKEARGR HHHHHHHHHHHHCCC		26320211
700	Ubiquitination	AMEWITAKLKEARGR HHHHHHHHHHHHCCC		-
710	Acetylation	EARGRGKKFTTDDSI HHCCCCCCCCCCCCE		25953088
712	Phosphorylation	RGRGKKFTTDDSICV CCCCCCCCCCCCEEE		25693802
713	Phosphorylation	GRGKKFTTDDSICVL CCCCCCCCCCCEEEE		25693802
716	Phosphorylation	KKFTTDDSICVLGIS CCCCCCCCEEEEEEC		25693802
724	2-Hydroxyisobutyrylation	ICVLGISKRNVIFQP EEEEEECCCCEEEEE		-
724	Acetylation	ICVLGISKRNVIFQP EEEEEECCCCEEEEE		25953088
724	Ubiquitination	ICVLGISKRNVIFQP EEEEEECCCCEEEEE		-
736	2-Hydroxyisobutyrylation	FQPVAELKKQTDFEH EEEHHHHHHCCCCCC		-
736	Acetylation	FQPVAELKKQTDFEH EEEHHHHHHCCCCCC		23749302
736	Malonylation	FQPVAELKKQTDFEH EEEHHHHHHCCCCCC		26320211
736	Methylation	FQPVAELKKQTDFEH EEEHHHHHHCCCCCC		30584247
736	Ubiquitination	FQPVAELKKQTDFEH EEEHHHHHHCCCCCC		-
737	Methylation	QPVAELKKQTDFEHR EEHHHHHHCCCCCCC		115974847
737	Ubiquitination	QPVAELKKQTDFEHR EEHHHHHHCCCCCCC		-
739	Ubiquitination	VAELKKQTDFEHRIP HHHHHHCCCCCCCCC		21890473
739	Phosphorylation	VAELKKQTDFEHRIP HHHHHHCCCCCCCCC		23663014
739	Ubiquitination	VAELKKQTDFEHRIP HHHHHHCCCCCCCCC		21890473
745	Acetylation	QTDFEHRIPKEQWWL CCCCCCCCCHHHHHH		19608861
747	2-Hydroxyisobutyrylation	DFEHRIPKEQWWLKL CCCCCCCHHHHHHHH		-
747	Acetylation	DFEHRIPKEQWWLKL CCCCCCCHHHHHHHH		28639649
747	Ubiquitination	DFEHRIPKEQWWLKL CCCCCCCHHHHHHHH		21890473
747	Ubiquitination	DFEHRIPKEQWWLKL CCCCCCCHHHHHHHH		21890473
753	Acetylation	PKEQWWLKLRPLMKI CHHHHHHHHHHHHHH		25953088
753	Ubiquitination	PKEQWWLKLRPLMKI CHHHHHHHHHHHHHH		19608861
757	Ubiquitination	WWLKLRPLMKILAKY HHHHHHHHHHHHHHH		21890473
757	Ubiquitination	WWLKLRPLMKILAKY HHHHHHHHHHHHHHH		21890473
759	Acetylation	LKLRPLMKILAKYKA HHHHHHHHHHHHHHC		25953088
759	Ubiquitination	LKLRPLMKILAKYKA HHHHHHHHHHHHHHC		-
763	Ubiquitination	PLMKILAKYKASYDV HHHHHHHHHHCCEEC		-
765	Ubiquitination	MKILAKYKASYDVSD HHHHHHHHCCEECCC		21890473
765	Ubiquitination	MKILAKYKASYDVSD HHHHHHHHCCEECCC		21890473
771	Phosphorylation	YKASYDVSDSGQLEH HHCCEECCCCCCCEE		20873877
773	Phosphorylation	ASYDVSDSGQLEHVQ CCEECCCCCCCEECC		20873877
783	Phosphorylation	LEHVQPWSV------ CEECCCCCC------		28355574

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
64	Y	Phosphorylation	Kinase	EGFR	P00533	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PFKAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PFKAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LAP2A_HUMAN	TMPO	physical	22939629
LAP2B_HUMAN	TMPO	physical	22939629
SYEP_HUMAN	EPRS	physical	22939629
WNK1_HUMAN	WNK1	physical	21988832
QOR_HUMAN	CRYZ	physical	22863883
PCBP1_HUMAN	PCBP1	physical	22863883
PPIB_HUMAN	PPIB	physical	22863883
TBB4B_HUMAN	TUBB4B	physical	22863883
VAT1_HUMAN	VAT1	physical	22863883
A16A1_HUMAN	ALDH16A1	physical	26344197
ARFP1_HUMAN	ARFIP1	physical	26344197
RHG01_HUMAN	ARHGAP1	physical	26344197
CCD22_HUMAN	CCDC22	physical	26344197
DNJC9_HUMAN	DNAJC9	physical	26344197
EF1A1_HUMAN	EEF1A1	physical	26344197
MCFD2_HUMAN	MCFD2	physical	26344197
MCMBP_HUMAN	MCMBP	physical	26344197
C1TC_HUMAN	MTHFD1	physical	26344197
NMD3_HUMAN	NMD3	physical	26344197
PEPL1_HUMAN	NPEPL1	physical	26344197
OXSR1_HUMAN	OXSR1	physical	26344197
KPYM_HUMAN	PKM	physical	26344197
PLCG1_HUMAN	PLCG1	physical	26344197
PSMG1_HUMAN	PSMG1	physical	26344197
PTN6_HUMAN	PTPN6	physical	26344197
SAMD9_HUMAN	SAMD9	physical	26344197
SNW1_HUMAN	SNW1	physical	26344197
LAP2A_HUMAN	TMPO	physical	26344197
LAP2B_HUMAN	TMPO	physical	26344197
TXLNA_HUMAN	TXLNA	physical	26344197
PFKAM_HUMAN	PFKM	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.