| UniProt ID | PEPL1_HUMAN | |
|---|---|---|
| UniProt AC | Q8NDH3 | |
| Protein Name | Probable aminopeptidase NPEPL1 | |
| Gene Name | NPEPL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 523 | |
| Subcellular Localization | ||
| Protein Description | Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.. | |
| Protein Sequence | MANVGLQFQASAGDSDPQSRPLLLLGQLHHLHRVPWSHVRGKLQPRVTEELWQAALSTLNPNPTDSCPLYLNYATVAALPCRVSRHNSPSAAHFITRLVRTCLPPGAHRCIVMVCEQPEVFASACALARAFPLFTHRSGASRRLEKKTVTVEFFLVGQDNGPVEVSTLQCLANATDGVRLAARIVDTPCNEMNTDTFLEEINKVGKELGIIPTIIRDEELKTRGFGGIYGVGKAALHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAAVLGAFRAAIKQGFKDNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIILDMATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGRKCGDLVHPLVYCPELHFSEFTSAVADMKNSVADRDNSPSSCAGLFIASHIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGRASEDPLLNLVSPLGCEVDVEEGDLGRDSKRRRLV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 88 | Phosphorylation | CRVSRHNSPSAAHFI CCHHCCCCHHHHHHH | 17.69 | 28348404 | |
| 90 | Phosphorylation | VSRHNSPSAAHFITR HHCCCCHHHHHHHHH | 37.60 | 20068231 | |
| 96 | Phosphorylation | PSAAHFITRLVRTCL HHHHHHHHHHHHHHC | 19.60 | 20068231 | |
| 158 | Ubiquitination | VEFFLVGQDNGPVEV EEEEEECCCCCCEEE | 33.25 | 33845483 | |
| 173 | Ubiquitination | STLQCLANATDGVRL EEEHHHHHCCCHHHH | 30.35 | 29967540 | |
| 178 | Ubiquitination | LANATDGVRLAARIV HHHCCCHHHHHEEEE | 5.15 | 33845483 | |
| 193 | Ubiquitination | DTPCNEMNTDTFLEE CCCCCCCCHHHHHHH | 28.73 | 29967540 | |
| 206 | Ubiquitination | EEINKVGKELGIIPT HHHHHHHHHHCCCEE | 53.40 | 33845483 | |
| 221 | Ubiquitination | IIRDEELKTRGFGGI EECCHHHCCCCCCCC | 39.18 | 29967540 | |
| 224 | Ubiquitination | DEELKTRGFGGIYGV CHHHCCCCCCCCCCC | 30.68 | 29967540 | |
| 229 | Phosphorylation | TRGFGGIYGVGKAAL CCCCCCCCCCCHHHC | 14.72 | - | |
| 244 | Ubiquitination | HPPALAVLSHTPDGA CCCEEEEEECCCCCC | 2.30 | 29967540 | |
| 264 | Phosphorylation | WVGKGIVYDTGGLSI EEECCEEEECCCCEE | 13.08 | 29759185 | |
| 270 | Phosphorylation | VYDTGGLSIKGKTTM EEECCCCEECCCCCC | 26.06 | - | |
| 272 | Ubiquitination | DTGGLSIKGKTTMPG ECCCCEECCCCCCCC | 51.48 | 29967540 | |
| 274 | Malonylation | GGLSIKGKTTMPGMK CCCEECCCCCCCCCC | 35.50 | 26320211 | |
| 331 | Phosphorylation | PDDIHLLYSGKTVEI CCCEEEEEECCEEEE | 23.03 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PEPL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PEPL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PEPL1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HEM3_HUMAN | HMBS | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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