SAMD9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAMD9_HUMAN
• UniProt AC: Q5K651
• Protein Name: Sterile alpha motif domain-containing protein 9
• Gene Name: SAMD9
• Organism: Homo sapiens (Human).
• Sequence Length: 1589
• Subcellular Localization: Cytoplasm .
• Protein Description: May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion..
• Protein Sequence: MAKQLNLPENTDDWTKEDVNQWLESHKIDQKHREILTEQDVNGAVLKWLKKEHLVDMGITHGPAIQIEELFKELRKTAIEDSIQTSKMGKPSKNAPKDQTVSQKERRETSKQKQKGKENPDMANPSAMSTTAKGSKSLKVELIEDKIDYTKERQPSIDLTCVSYPFDEFSNPYRYKLDFSLQPETGPGNLIDPIHEFKAFTNTATATEEDVKMKFSNEVFRFASACMNSRTNGTIHFGVKDKPHGKIVGIKVTNDTKEALINHFNLMINKYFEDHQVQQAKKCIREPRFVEVLLPNSTLSDRFVIEVDIIPQFSECQYDYFQIKMQNYNNKIWEQSKKFSLFVRDGTSSKDITKNKVDFRAFKADFKTLAESRKAAEEKFRAKTNKKEREGPKLVKLLTGNQDLLDNSYYEQYILVTNKCHPDQTKHLDFLKEIKWFAVLEFDPESNINGVVKAYKESRVANLHFPSVYVEQKTTPNETISTLNLYHQPSWIFCNGRLDLDSEKYKPFDPSSWQRERASDVRKLISFLTHEDIMPRGKFLVVFLLLSSVDDPRDPLIETFCAFYQDLKGMENILCICVHPHIFQGWKDLLEARLIKHQDEISSQCISALSLEEINGTILKLKSVTQSSKRLLPSIGLSTVLLKKEEDIMTALEIICENECEGTLLEKDKNKFLEFKASKEEDFYRGGKVSWWNFYFSSESYSSPFVKRDKYERLEAMIQNCADSSKPTSTKIIHLYHHPGCGGTTLAMHILWELRKKFRCAVLKNKTVDFSEIGEQVTSLITYGAMNRQEYVPVLLLVDDFEEQDNVYLLQYSIQTAIAKKYIRYEKPLVIILNCMRSQNPEKSARIPDSIAVIQQLSPKEQRAFELKLKEIKEQHKNFEDFYSFMIMKTNFNKEYIENVVRNILKGQNIFTKEAKLFSFLALLNSYVPDTTISLSQCEKFLGIGNKKAFWGTEKFEDKMGTYSTILIKTEVIECGNYCGVRIIHSLIAEFSLEELKKSYHLNKSQIMLDMLTENLFFDTGMGKSKFLQDMHTLLLTRHRDEHEGETGNWFSPFIEALHKDEGNEAVEAVLLESIHRFNPNAFICQALARHFYIKKKDFGNALNWAKQAKIIEPDNSYISDTLGQVYKSKIRWWIEENGGNGNISVDDLIALLDLAEHASSAFKESQQQSEDREYEVKERLYPKSKRRYDTYNIAGYQGEIEVGLYTIQILQLIPFFDNKNELSKRYMVNFVSGSSDIPGDPNNEYKLALKNYIPYLTKLKFSLKKSFDFFDEYFVLLKPRNNIKQNEEAKTRRKVAGYFKKYVDIFCLLEESQNNTGLGSKFSEPLQVERCRRNLVALKADKFSGLLEYLIKSQEDAISTMKCIVNEYTFLLEQCTVKIQSKEKLNFILANIILSCIQPTSRLVKPVEKLKDQLREVLQPIGLTYQFSEPYFLASLLFWPENQQLDQHSEQMKEYAQALKNSFKGQYKHMHRTKQPIAYFFLGKGKRLERLVHKGKIDQCFKKTPDINSLWQSGDVWKEEKVQELLLRLQGRAENNCLYIEYGINEKITIPITPAFLGQLRSGRSIEKVSFYLGFSIGGPLAYDIEIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	ENTDDWTKEDVNQWL CCCCCCCHHHHHHHH	47.89	29967540
27	Ubiquitination	NQWLESHKIDQKHRE HHHHHHCCCCHHHHH	58.20	29967540
37	Phosphorylation	QKHREILTEQDVNGA HHHHHHHCCCCCCHH	36.94	-
100	Phosphorylation	KNAPKDQTVSQKERR CCCCCCCCCCHHHHH	32.05	18452278
122	Sulfoxidation	KGKENPDMANPSAMS CCCCCCCCCCHHHHC	4.02	21406390
126	Phosphorylation	NPDMANPSAMSTTAK CCCCCCHHHHCCCCC	36.09	-
135	Phosphorylation	MSTTAKGSKSLKVEL HCCCCCCCCCCEEEE	20.54	29759185
137	Phosphorylation	TTAKGSKSLKVELIE CCCCCCCCCEEEEEE	34.81	29759185
156	Phosphorylation	YTKERQPSIDLTCVS CCCCCCCCCEEEEEE	22.01	25159151
160	Phosphorylation	RQPSIDLTCVSYPFD CCCCCEEEEEECCCC	13.71	28450419
163	Phosphorylation	SIDLTCVSYPFDEFS CCEEEEEECCCCCCC	29.27	28464451
164	Phosphorylation	IDLTCVSYPFDEFSN CEEEEEECCCCCCCC	6.37	29978859
170	Phosphorylation	SYPFDEFSNPYRYKL ECCCCCCCCCCEEEE	34.54	26552605
173	Phosphorylation	FDEFSNPYRYKLDFS CCCCCCCCEEEEEEE	30.72	26552605
175	Phosphorylation	EFSNPYRYKLDFSLQ CCCCCCEEEEEEEEC	15.28	23090842
176	Ubiquitination	FSNPYRYKLDFSLQP CCCCCEEEEEEEECC	32.36	29967540
180	Phosphorylation	YRYKLDFSLQPETGP CEEEEEEEECCCCCC	26.26	-
198	Ubiquitination	IDPIHEFKAFTNTAT CCCHHHHHHHCCCCC	39.34	29967540
201	Phosphorylation	IHEFKAFTNTATATE HHHHHHHCCCCCCCH	36.20	-
203	Phosphorylation	EFKAFTNTATATEED HHHHHCCCCCCCHHH	23.48	-
205	Phosphorylation	KAFTNTATATEEDVK HHHCCCCCCCHHHHH	31.88	-
214	Acetylation	TEEDVKMKFSNEVFR CHHHHHHHCCHHHHH	39.67	25953088
214	Malonylation	TEEDVKMKFSNEVFR CHHHHHHHCCHHHHH	39.67	26320211
214	Ubiquitination	TEEDVKMKFSNEVFR CHHHHHHHCCHHHHH	39.67	-
224	Phosphorylation	NEVFRFASACMNSRT HHHHHHHHHHHCCCC	21.20	20068231
229	Phosphorylation	FASACMNSRTNGTIH HHHHHHCCCCCCEEE	17.38	20068231
231	Phosphorylation	SACMNSRTNGTIHFG HHHHCCCCCCEEEEE	37.51	20068231
234	Phosphorylation	MNSRTNGTIHFGVKD HCCCCCCEEEEEECC	17.22	20068231
242	Ubiquitination	IHFGVKDKPHGKIVG EEEEECCCCCCEEEE	32.94	29967540
246	Ubiquitination	VKDKPHGKIVGIKVT ECCCCCCEEEEEEEC	31.05	29967540
251	Ubiquitination	HGKIVGIKVTNDTKE CCEEEEEEECCCHHH	36.76	29967540
257	Ubiquitination	IKVTNDTKEALINHF EEECCCHHHHHHHHH	43.80	29967540
281	Ubiquitination	DHQVQQAKKCIREPR HHHHHHHHHHHCCCC	43.79	29967540
282	Ubiquitination	HQVQQAKKCIREPRF HHHHHHHHHHCCCCE	37.60	-
328	Phosphorylation	FQIKMQNYNNKIWEQ EEEEEECCCCHHHHH	11.83	-
338	Malonylation	KIWEQSKKFSLFVRD HHHHHHHCEEEEEEC	45.49	32601280
350	Ubiquitination	VRDGTSSKDITKNKV EECCCCCCCCCCCCC	53.57	-
367	Ubiquitination	RAFKADFKTLAESRK HHHHHHHHHHHHHHH	43.08	29967540
374	Ubiquitination	KTLAESRKAAEEKFR HHHHHHHHHHHHHHH	62.32	24816145
432	Methylation	TKHLDFLKEIKWFAV CCCHHHHHHCCEEEE	58.34	-
432	Ubiquitination	TKHLDFLKEIKWFAV CCCHHHHHHCCEEEE	58.34	-
467	Phosphorylation	VANLHFPSVYVEQKT CCCCCCCEEEEEECC	25.74	29396449
469	Phosphorylation	NLHFPSVYVEQKTTP CCCCCEEEEEECCCC	11.56	29396449
502	Phosphorylation	NGRLDLDSEKYKPFD CCCCCCCCCCCCCCC	43.20	-
526	Phosphorylation	SDVRKLISFLTHEDI HHHHHHHHHHCCCHH	25.33	24719451
620	Ubiquitination	EINGTILKLKSVTQS HHCCEEEEEHHHCHH	50.44	29967540
622	Acetylation	NGTILKLKSVTQSSK CCEEEEEHHHCHHHC	41.09	7339581
622	Ubiquitination	NGTILKLKSVTQSSK CCEEEEEHHHCHHHC	41.09	29967540
625	O-linked_Glycosylation	ILKLKSVTQSSKRLL EEEEHHHCHHHCHHH	29.80	28510447
634	Phosphorylation	SSKRLLPSIGLSTVL HHCHHHHCCCHHHEE	29.29	29978859
638	Phosphorylation	LLPSIGLSTVLLKKE HHHCCCHHHEEECCH	15.97	29978859
639	Phosphorylation	LPSIGLSTVLLKKEE HHCCCHHHEEECCHH	21.88	29978859
676	Methylation	KNKFLEFKASKEEDF CCCCEEEEECCCCCC	42.23	115977527
695	Phosphorylation	KVSWWNFYFSSESYS EEEEEEEECCCCCCC	10.19	-
711	Phosphorylation	PFVKRDKYERLEAMI CCCCHHHHHHHHHHH	15.57	-
726	Ubiquitination	QNCADSSKPTSTKII HHHCCCCCCCCCEEE	57.16	29901268
767	Phosphorylation	CAVLKNKTVDFSEIG EEEECCCEECHHHHH	34.40	-
858	Phosphorylation	IAVIQQLSPKEQRAF HHHHHHCCHHHHHHH	29.59	29255136
860	Ubiquitination	VIQQLSPKEQRAFEL HHHHCCHHHHHHHHH	64.20	29967540
913	Ubiquitination	KGQNIFTKEAKLFSF CCCCCCCHHHHHHHH	44.95	29967540
919	Phosphorylation	TKEAKLFSFLALLNS CHHHHHHHHHHHHHH	29.77	26074081
926	Phosphorylation	SFLALLNSYVPDTTI HHHHHHHHCCCCCEE	27.72	26074081
927	Phosphorylation	FLALLNSYVPDTTIS HHHHHHHCCCCCEEE	18.22	26074081
931	Phosphorylation	LNSYVPDTTISLSQC HHHCCCCCEEEHHHH	21.69	26074081
932	Phosphorylation	NSYVPDTTISLSQCE HHCCCCCEEEHHHHH	18.89	26074081
934	Phosphorylation	YVPDTTISLSQCEKF CCCCCEEEHHHHHHH	21.63	26074081
936	Phosphorylation	PDTTISLSQCEKFLG CCCEEEHHHHHHHHC	26.45	26074081
947	Ubiquitination	KFLGIGNKKAFWGTE HHHCCCCCCCCCCCH	40.02	29967540
955	Ubiquitination	KAFWGTEKFEDKMGT CCCCCCHHHHHHCCC	54.62	29967540
1013	Phosphorylation	QIMLDMLTENLFFDT HHHHHHHHHCCCCCC	19.05	-
1026	Acetylation	DTGMGKSKFLQDMHT CCCCCHHHHHHHHHH	54.29	25953088
1033	Phosphorylation	KFLQDMHTLLLTRHR HHHHHHHHHHHHCCC	16.68	-
1037	Phosphorylation	DMHTLLLTRHRDEHE HHHHHHHHCCCCCCC	25.13	-
1107	Ubiquitination	GNALNWAKQAKIIEP HHHCHHHHHCCCCCC	42.26	29967540
1110	Ubiquitination	LNWAKQAKIIEPDNS CHHHHHCCCCCCCCC	41.54	29967540
1128	Acetylation	DTLGQVYKSKIRWWI HHHHHHHHHHHEEEH	46.55	25953088
1128	Ubiquitination	DTLGQVYKSKIRWWI HHHHHHHHHHHEEEH	46.55	29967540
1130	Ubiquitination	LGQVYKSKIRWWIEE HHHHHHHHHEEEHHH	31.94	-
1175	Phosphorylation	QQSEDREYEVKERLY HHHHHCCHHHHHHHC	27.24	-
1259	Acetylation	NYIPYLTKLKFSLKK HHHHHHHHHCCEECC	47.27	25953088
1259	Malonylation	NYIPYLTKLKFSLKK HHHHHHHHHCCEECC	47.27	26320211
1259	Ubiquitination	NYIPYLTKLKFSLKK HHHHHHHHHCCEECC	47.27	19608861
1261	Acetylation	IPYLTKLKFSLKKSF HHHHHHHCCEECCCC	34.17	25953088
1263	Phosphorylation	YLTKLKFSLKKSFDF HHHHHCCEECCCCCC	37.38	27135362
1285	Ubiquitination	LKPRNNIKQNEEAKT EECCCCCCCCHHHHH	49.55	24816145
1299	Phosphorylation	TRRKVAGYFKKYVDI HHHHHHHHHHHHHHE	11.50	26657352
1345	Phosphorylation	ALKADKFSGLLEYLI HHHHHHHHHHHHHHH	33.98	-
1350	Phosphorylation	KFSGLLEYLIKSQED HHHHHHHHHHHCHHH	17.44	29759185
1360	Phosphorylation	KSQEDAISTMKCIVN HCHHHHHHHHHHHHH	24.95	29083192
1361	Phosphorylation	SQEDAISTMKCIVNE CHHHHHHHHHHHHHH	17.97	29083192
1369	Phosphorylation	MKCIVNEYTFLLEQC HHHHHHHHHHHHHHC	9.51	28787133
1370	Phosphorylation	KCIVNEYTFLLEQCT HHHHHHHHHHHHHCE	11.13	28787133
1377	Phosphorylation	TFLLEQCTVKIQSKE HHHHHHCEEEECCHH	25.24	28787133
1461	Acetylation	KEYAQALKNSFKGQY HHHHHHHHHHHHHHH	54.27	25953088
1461	Methylation	KEYAQALKNSFKGQY HHHHHHHHHHHHHHH	54.27	115977523
1465	Acetylation	QALKNSFKGQYKHMH HHHHHHHHHHHHCCC	44.95	25953088
1468	Phosphorylation	KNSFKGQYKHMHRTK HHHHHHHHHCCCCCC	16.13	22817900
1497	Ubiquitination	ERLVHKGKIDQCFKK HHHHHHCCHHHHHHC	48.16	29967540
1504	Ubiquitination	KIDQCFKKTPDINSL CHHHHHHCCCCHHHH	45.07	29967540
1505	Phosphorylation	IDQCFKKTPDINSLW HHHHHHCCCCHHHHH	27.12	-
1519	Ubiquitination	WQSGDVWKEEKVQEL HHCCCCCCHHHHHHH	56.71	22817900
1522	Ubiquitination	GDVWKEEKVQELLLR CCCCCHHHHHHHHHH	50.76	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAMD9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAMD9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAMD9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPC13_HUMAN	TRAPPC13	physical	26496610
EOGT_HUMAN	EOGT	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 610455: Tumoral calcinosis, normophosphatemic, familial (NFTC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.