EOGT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EOGT_HUMAN
• UniProt AC: Q5NDL2
• Protein Name: EGF domain-specific O-linked N-acetylglucosamine transferase
• Gene Name: EOGT
• Organism: Homo sapiens (Human).
• Sequence Length: 527
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains..
• Protein Sequence: MLMLFVFGVLLHEVSLSGQNEAPPNTHSIPGEPLYNYASIRLPEEHIPFFLHNNRHIATVCRKDSLCPYKKHLEKLKYCWGYEKSCKPEFRFGYPVCSYVDMGWTDTLESAEDIFWKQADFGYARERLEEMHVLCQPKETSDSSLVCSRYLQYCRATNLYLDLRNIKRNHDRFKEDFFQSGEIGGHCKLDIRTLTSEGQRKSPLQSWFAELQSYTQLNFRPIEDAKCDIVIEKPTYFMKLDAGVNMYHHFCDFINLYITQHVNNSFSTDVYIVMWDTSSYGYGDLFSDTWNAFTDYDVIHLKTYDSKRVCFKEAVFSLLPRMRYGLFYNTPLISGCQNTGLFRAFAQHVLHRLNITQEGPKDGKIRVTILARSTEYRKILNQNELVNALKTVSTFEVQIVDYKYRELGFLDQLRITHNTDIFIGMHGAGLTHLLFLPDWAAVFELYNCEDERCYLDLARLRGVHYITWRRQNKVFPQDKGHHPTLGEHPKFTNYSFDVEEFMYLVLQAADHVLQHPKWPFKKKHDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	ATVCRKDSLCPYKKH EEEECCCCCCCHHHH	34.60	46159981
94	Phosphorylation	KPEFRFGYPVCSYVD CCCCCCCCCEEEEEE	6.98	22210691
98	Phosphorylation	RFGYPVCSYVDMGWT CCCCCEEEEEECCCC	28.55	22210691
105	Phosphorylation	SYVDMGWTDTLESAE EEEECCCCCCHHHHH	17.24	22210691
157	Phosphorylation	YLQYCRATNLYLDLR HHHHHHHHCCEEEHH	13.35	30622161
160	Phosphorylation	YCRATNLYLDLRNIK HHHHHCCEEEHHHHH	10.55	30622161
354	N-linked_Glycosylation	QHVLHRLNITQEGPK HHHHHHCCCCCCCCC	34.91	UniProtKB CARBOHYD
368	Phosphorylation	KDGKIRVTILARSTE CCCCEEEEEEECCHH	10.63	28509920
376	Phosphorylation	ILARSTEYRKILNQN EEECCHHHHHHCCHH	19.79	28509920
378	Methylation	ARSTEYRKILNQNEL ECCHHHHHHCCHHHH	51.12	-
404	Phosphorylation	VQIVDYKYRELGFLD EEEEEEECCCCCCCE	11.77	7179013

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EOGT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EOGT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EOGT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NOTCH_DROME	N	physical	25488668

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.