dbPTM

TNNT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TNNT1_HUMAN
UniProt AC	P13805
Protein Name	Troponin T, slow skeletal muscle
Gene Name	TNNT1
Organism	Homo sapiens (Human).
Sequence Length	278
Subcellular Localization
Protein Description	Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity..
Protein Sequence	MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLRARSAWLPPSQPSCPAREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDTEEQEY ------CCHHHHHHH	53.92	-
2	Phosphorylation	------MSDTEEQEY ------CCHHHHHHH	53.92	22673903
2 (in isoform 2)	Phosphorylation	-	53.92	22673903
4	Phosphorylation	----MSDTEEQEYEE ----CCHHHHHHHHH	33.83	22673903
4 (in isoform 2)	Phosphorylation	-	33.83	22673903
155	Phosphorylation	AKKKKVLSNMGAHFG HHHHHHHHHHCHHHH	27.97	22210691
164	Phosphorylation	MGAHFGGYLVKAEQK HCHHHHHHHHHHHHH	14.54	17053785
186 (in isoform 2)	Phosphorylation	-	2.81	26437602
197	Phosphorylation	KKPLDIDYMGEEQLR CCCCCCCCCCHHHHH	13.83	-
197 (in isoform 3)	Phosphorylation	-	13.83	26437602
249	Phosphorylation	AKLKQQKYEINVLYN HHHHHHHHHHHHHHH	20.08	26437602
255	Phosphorylation	KYEINVLYNRISHAQ HHHHHHHHHHHHHHH	9.71	22673903
259	Phosphorylation	NVLYNRISHAQKFRK HHHHHHHHHHHHHHC	14.99	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TNNT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TNNT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CC85B_HUMAN	CCDC85B	physical	16189514
PKHF1_HUMAN	PLEKHF1	physical	16189514
LIPA1_HUMAN	PPFIA1	physical	16189514
TNNT1_HUMAN	TNNT1	physical	16189514
ZMY19_HUMAN	ZMYND19	physical	16189514
NINL_HUMAN	NINL	physical	16189514
FXR2_HUMAN	FXR2	physical	16189514
TPM1_HUMAN	TPM1	physical	6822572
KGP1_HUMAN	PRKG1	physical	10601315
MIC60_HUMAN	IMMT	physical	21900206
SH3G3_HUMAN	SH3GL3	physical	21900206
ZN768_HUMAN	ZNF768	physical	21900206
KAT5_HUMAN	KAT5	physical	21900206
NACAD_HUMAN	NACAD	physical	21900206
EF1G_HUMAN	EEF1G	physical	21900206
HMGX4_HUMAN	HMGXB4	physical	21900206
BL1S2_HUMAN	BLOC1S2	physical	21900206
SNW1_HUMAN	SNW1	physical	21900206
ZC3HF_HUMAN	ZC3H15	physical	21900206
NSG2_HUMAN	HMP19	physical	21900206
KAIN_HUMAN	SERPINA4	physical	21900206
UB2D1_HUMAN	UBE2D1	physical	21900206
ZN250_HUMAN	ZNF250	physical	21900206
ZKSC5_HUMAN	ZKSCAN5	physical	21900206
NAGK_HUMAN	NAGK	physical	21900206
ONCM_HUMAN	OSM	physical	21900206
OSBP2_HUMAN	OSBP2	physical	21900206
HS90B_HUMAN	HSP90AB1	physical	21900206
TRA2A_HUMAN	TRA2A	physical	21900206
TMM98_HUMAN	TMEM98	physical	21900206
SYMC_HUMAN	MARS	physical	21900206
VIME_HUMAN	VIM	physical	21900206
HAP1_HUMAN	HAP1	physical	21900206
ARMC8_HUMAN	ARMC8	physical	21900206
SC31A_HUMAN	SEC31A	physical	21900206
FYN_HUMAN	FYN	physical	21900206
WDCP_HUMAN	C2orf44	physical	21900206
CHD3_HUMAN	CHD3	physical	21900206
DDX5_HUMAN	DDX5	physical	21900206
FAF1_HUMAN	FAF1	physical	21900206
LARP1_HUMAN	LARP1	physical	21900206
TNNT1_HUMAN	TNNT1	physical	25416956
TPM1_HUMAN	TPM1	physical	25416956
TPM3_HUMAN	TPM3	physical	25416956
TBPL1_HUMAN	TBPL1	physical	25416956
MO4L1_HUMAN	MORF4L1	physical	25416956
LDOC1_HUMAN	LDOC1	physical	25416956
TFP11_HUMAN	TFIP11	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
TPM1_HUMAN	TPM1	physical	21516116

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
605355	Nemaline myopathy 5 (NEM5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TNNT1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-164, AND MASSSPECTROMETRY.	17053785 [Abstract]