OSBP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OSBP2_HUMAN
• UniProt AC: Q969R2
• Protein Name: Oxysterol-binding protein 2
• Gene Name: OSBP2
• Organism: Homo sapiens (Human).
• Sequence Length: 916
• Subcellular Localization: Membrane; Peripheral membrane protein.
• Protein Description: Binds 7-ketocholesterol..
• Protein Sequence: MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGKAAAPSRGGGCGG CCCCCCCCCCCCCCC	38.54	-
9	Methylation	GKAAAPSRGGGCGGR CCCCCCCCCCCCCCC	46.87	115388007
46	Ubiquitination	MSASTSGSGPEPKPQ CCCCCCCCCCCCCCC	51.44	29967540
108	Phosphorylation	LQGSRPGSESSSGVG HCCCCCCCCCCCCCC	36.67	-
110	Phosphorylation	GSRPGSESSSGVGAG CCCCCCCCCCCCCCC	31.34	-
120	Phosphorylation	GVGAGPFTKAASEPL CCCCCCCHHHCCCCH	23.94	-
122	Phosphorylation	GAGPFTKAASEPLSR CCCCCHHHCCCCHHH	17.11	33259812
124	Phosphorylation	GPFTKAASEPLSRAV CCCHHHCCCCHHHHC	44.60	25072903
128	Phosphorylation	KAASEPLSRAVGSAT HHCCCCHHHHCCCCE	28.98	25072903
135	Ubiquitination	SRAVGSATFLRPESG HHHCCCCEEECCCCC	25.54	29967540
197	Malonylation	LKWTNYLKGYQRRWF HHHHHHCCCCCEEEE	45.25	26320211
223	Phosphorylation	NQGEMAHTCRGTINL CCCCCCCEECCEEEC	8.38	-
244	Ubiquitination	TEDSCGILLTSGARS CCCCCEEEECCCCCC	2.31	29967540
269	Ubiquitination	RQQWITALELAKAKA HHHHHHHHHHHHHHE	4.08	32015554
274	Ubiquitination	TALELAKAKAVRVMN HHHHHHHHHEEEEEC	10.22	29967540
282	Phosphorylation	KAVRVMNTHSDDSGD HEEEEECCCCCCCCC	12.50	22617229
284	Phosphorylation	VRVMNTHSDDSGDDD EEEECCCCCCCCCCC	40.86	28102081
287	Phosphorylation	MNTHSDDSGDDDEAT ECCCCCCCCCCCCCC	49.46	22617229
294	Phosphorylation	SGDDDEATTPADKSE CCCCCCCCCCCCHHH	31.12	30576142
295	Phosphorylation	GDDDEATTPADKSEL CCCCCCCCCCCHHHH	24.43	23607784
310	Phosphorylation	HHTLKNLSLKLDDLS HHHHHHHCCCHHCHH	32.62	24719451
317	Phosphorylation	SLKLDDLSTCNDLIA CCCHHCHHHHHHHHH	37.60	21815630
336	Ubiquitination	ALQRSLTELDGLKIP HHHHHHHHHCCCCCC	50.59	29967540
358	Ubiquitination	KVVNERATLFRITSN EEEECCCHHHHHHHH	32.42	32015554
363	Ubiquitination	RATLFRITSNAMINA CCHHHHHHHHHHHHH	16.21	29967540
364	Phosphorylation	ATLFRITSNAMINAC CHHHHHHHHHHHHHH	21.88	23917254
385	Ubiquitination	AEIHSRKWQRALQYE HHHHCHHHHHHHHHH	7.56	29967540
419	Phosphorylation	SLERAFHSAPGRPAN HHHHHHHCCCCCCCC	29.70	28555341
427	Ubiquitination	APGRPANPSKSFIEG CCCCCCCCCCCCEEC	45.28	29967540
428	Phosphorylation	PGRPANPSKSFIEGS CCCCCCCCCCCEECC	40.51	27251275
430	Phosphorylation	RPANPSKSFIEGSLL CCCCCCCCCEECCCC	35.48	28348404
435	Phosphorylation	SKSFIEGSLLTPKGE CCCCEECCCCCCCCC	13.86	28555341
438	Phosphorylation	FIEGSLLTPKGEDSE CEECCCCCCCCCCCC	28.40	21815630
444	Phosphorylation	LTPKGEDSEEDEDTE CCCCCCCCCCCCCCC	38.29	27251275
467	Ubiquitination	TSFITVITEAKEDSR CCEEEEEECHHHHHH	26.08	32015554
472	Ubiquitination	VITEAKEDSRKAEGS EEECHHHHHHCCCCC	53.70	29967540
473	Phosphorylation	ITEAKEDSRKAEGST EECHHHHHHCCCCCC	36.45	-
474	Ubiquitination	TEAKEDSRKAEGSTG ECHHHHHHCCCCCCC	55.30	29967540
488	Phosphorylation	GTSSVDWSSADNVLD CCCCCCHHHCCCCCC	15.93	-
498	Phosphorylation	DNVLDGASLVPKGSS CCCCCCCCCCCCCCC	35.11	-
501	Ubiquitination	LDGASLVPKGSSKVK CCCCCCCCCCCCCCE	40.35	29967540
502	Ubiquitination	DGASLVPKGSSKVKR CCCCCCCCCCCCCEE	65.04	29967540
516	Ubiquitination	RRVRIPNKPNYSLNL EEEECCCCCCCCCCH	29.32	29967540
559	Ubiquitination	QRLTEDLEYHHLLDK HHHHHHHHHHHHHHH	55.96	32015554
564	Ubiquitination	DLEYHHLLDKAVHCT HHHHHHHHHHHHCCC	5.73	29967540
583	Ubiquitination	QMCLVAAFSVSSYST HHHHHHHHHCCCCCC	5.52	29967540
619	Phosphorylation	LDDMGLRSLCEQVSH CCHHHHHHHHHHHHC	42.27	-
625	Phosphorylation	RSLCEQVSHHPPSAA HHHHHHHHCCCCCHH	18.77	-
675	Ubiquitination	LEFQASGNHYVWRKS EEEECCCCEEEEEEC	22.33	29967540
682	Phosphorylation	NHYVWRKSTSTVHNI CEEEEEECCCCCCEE	21.01	-
683	Phosphorylation	HYVWRKSTSTVHNII EEEEEECCCCCCEEE	31.30	-
684	Phosphorylation	YVWRKSTSTVHNIIV EEEEECCCCCCEEEE	35.21	-
685	Phosphorylation	VWRKSTSTVHNIIVG EEEECCCCCCEEEEE	26.35	-
717	Ubiquitination	NDRCQLKFLPYSYFS CCCCEEEECCHHHCC	12.97	29967540
720	Phosphorylation	CQLKFLPYSYFSKEA CEEEECCHHHCCHHH	20.39	20068231
721	Phosphorylation	QLKFLPYSYFSKEAA EEEECCHHHCCHHHH	20.12	20068231
722	Phosphorylation	LKFLPYSYFSKEAAR EEECCHHHCCHHHHH	13.16	20068231
724	Phosphorylation	FLPYSYFSKEAARKV ECCHHHCCHHHHHHH	22.73	20068231
724	Ubiquitination	FLPYSYFSKEAARKV ECCHHHCCHHHHHHH	22.73	32015554
725	Ubiquitination	LPYSYFSKEAARKVT CCHHHCCHHHHHHHC	41.28	32015554
729	Ubiquitination	YFSKEAARKVTGVVS HCCHHHHHHHCCEEE	40.81	29967540
730	Ubiquitination	FSKEAARKVTGVVSD CCHHHHHHHCCEEEC	39.15	29967540
762	Phosphorylation	ECSKVMHSSPSSPSS HHHHCCCCCCCCCCC	26.33	21955146
763	Phosphorylation	CSKVMHSSPSSPSSD HHHCCCCCCCCCCCC	17.70	26055452
765	Phosphorylation	KVMHSSPSSPSSDGK HCCCCCCCCCCCCCC	57.75	25159151
766	Phosphorylation	VMHSSPSSPSSDGKQ CCCCCCCCCCCCCCC	31.99	25159151
768	Phosphorylation	HSSPSSPSSDGKQKT CCCCCCCCCCCCCCH	42.90	22199227
769	Phosphorylation	SSPSSPSSDGKQKTV CCCCCCCCCCCCCHH	54.49	22199227
777	Phosphorylation	DGKQKTVYQTLSAKL CCCCCHHHHHHHHHH	10.87	27642862
781	Phosphorylation	KTVYQTLSAKLLWKK CHHHHHHHHHHHHHC	27.09	28674419
840	Ubiquitination	RWDEANTEKQRLEEK CCCHHHHHHHHHHHH	47.18	29967540
841	Ubiquitination	WDEANTEKQRLEEKQ CCHHHHHHHHHHHHH	38.38	29967540
851	Phosphorylation	LEEKQRLSRRRRLEA HHHHHHHHHHHHHHH	26.40	-
863	Phosphorylation	LEACGPGSSCSSEEE HHHHCCCCCCCCHHH	31.16	28060719
864	Phosphorylation	EACGPGSSCSSEEEK HHHCCCCCCCCHHHH	24.75	28060719
866	Phosphorylation	CGPGSSCSSEEEKEA HCCCCCCCCHHHHHC	42.61	28060719
867	Phosphorylation	GPGSSCSSEEEKEAD CCCCCCCCHHHHHCC	54.04	28060719
876	Phosphorylation	EEKEADAYTPLWFEK HHHHCCCCCCCHHHH	14.94	28060719
877	Phosphorylation	EKEADAYTPLWFEKR HHHCCCCCCCHHHHC	17.39	28060719
882	Ubiquitination	AYTPLWFEKRLDPLT CCCCCHHHHCCCCCC	26.19	29967540
883	Ubiquitination	YTPLWFEKRLDPLTG CCCCHHHHCCCCCCC	49.11	29967540
900	Phosphorylation	ACVYKGGYWEAKEKQ EEEEECCCEEHHHCC	14.56	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
762	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
762	S	Phosphorylation	Kinase	ERK1	P27361	PSP
762	S	Phosphorylation	Kinase	JNK1	P45983	PSP
762	S	Phosphorylation	Kinase	CK1A	P48729	PSP
762	S	Phosphorylation	Kinase	JNK3	P53779	PSP
762	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
762	S	Phosphorylation	Kinase	CDK1	P06493	PSP
763	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
763	S	Phosphorylation	Kinase	JNK1	P45983	PSP
763	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
763	S	Phosphorylation	Kinase	CDK1	P06493	PSP
763	S	Phosphorylation	Kinase	JNK3	P53779	PSP
763	S	Phosphorylation	Kinase	ERK1	P27361	PSP
763	S	Phosphorylation	Kinase	CK1A	P48729	PSP
766	S	Phosphorylation	Kinase	JNK3	P53779	PSP
766	S	Phosphorylation	Kinase	CDK1	P06493	PSP
766	S	Phosphorylation	Kinase	JNK1	P45983	PSP
766	S	Phosphorylation	Kinase	ERK1	P27361	PSP
766	S	Phosphorylation	Kinase	CK1A	P48729	PSP
766	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
766	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
768	S	Phosphorylation	Kinase	ERK1	P27361	PSP
768	S	Phosphorylation	Kinase	CK1A	P48729	PSP
768	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
768	S	Phosphorylation	Kinase	JNK1	P45983	PSP
768	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
768	S	Phosphorylation	Kinase	JNK3	P53779	PSP
768	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OSBP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OSBP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.