dbPTM

NINL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NINL_HUMAN
UniProt AC	Q9Y2I6
Protein Name	Ninein-like protein
Gene Name	NINL
Organism	Homo sapiens (Human).
Sequence Length	1382
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex (PubMed:16254247). During centrosome maturation, PLK1 directly phosphory
Protein Description	Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis..
Protein Sequence	MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFARVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCDAATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAALSV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Ubiquitination	ARVNFEEFKEGFVAV CCCCHHHHHHCEEEE	7.41	22817900
87	Phosphorylation	VRPSDEDSSSLESAA CCCCCCCCCHHHHHH	21.56	12852856
88	Phosphorylation	RPSDEDSSSLESAAS CCCCCCCCHHHHHHH	51.79	12852856
128	Ubiquitination	ATEARRVPEQQTQAS HHHHHCCCHHHHHHH	31.69	22817900
148	Phosphorylation	WRSASLESVESPKSD HHHCCCCCCCCCCCH	36.16	-
161	Phosphorylation	SDEEAESTKEAQNEL CHHHHHHHHHHHHHH	25.14	12852856
185	Phosphorylation	WDSEDFGSPQKSCSP CCCCCCCCCCCCCCC	24.93	20890132
189	Phosphorylation	DFGSPQKSCSPSFDT CCCCCCCCCCCCCCC	17.99	28857561
191	Phosphorylation	GSPQKSCSPSFDTPE CCCCCCCCCCCCCCH	30.57	25850435
193	Phosphorylation	PQKSCSPSFDTPESQ CCCCCCCCCCCCHHH	21.33	28857561
244	Ubiquitination	ELEDLFNKLDQDGDG HHHHHHHHHCCCCCC	46.21	29967540
336	Ubiquitination	AMWTQEGIQNGREIL HHHHHHHHHCHHHHH	2.57	22817900
341	Ubiquitination	EGIQNGREILQSLDF HHHHCHHHHHHHCCC	49.83	22817900
426	Phosphorylation	KEMDDCHSTLEQLTE HHHHHHHHHHHHHHH	40.81	30576142
427	Phosphorylation	EMDDCHSTLEQLTEK HHHHHHHHHHHHHHH	15.62	30576142
448	Phosphorylation	QGYRERLSLLRSEVE HHHHHHHHHHHHHHH	31.42	22817900
495	Ubiquitination	EKLTLALKENSRLQK HHHHHHHHHCHHHHH	49.60	PubMed
500	Ubiquitination	ALKENSRLQKEIVEV HHHHCHHHHHHHHHH	9.53	22817900
510	Acetylation	EIVEVVEKLSDSERL HHHHHHHHCCHHHHH	41.50	19413330
511	Ubiquitination	IVEVVEKLSDSERLA HHHHHHHCCHHHHHH	4.32	22817900
516	Ubiquitination	EKLSDSERLALKLQK HHCCHHHHHHHHHHH	29.25	22817900
520	Ubiquitination	DSERLALKLQKDLEF HHHHHHHHHHHHHHH	43.17	29967540
585	Phosphorylation	RLPKNRHSPSWSPDG CCCCCCCCCCCCCCC	19.86	22817900
587	Phosphorylation	PKNRHSPSWSPDGRR CCCCCCCCCCCCCCC	43.11	27251275
589	Phosphorylation	NRHSPSWSPDGRRRQ CCCCCCCCCCCCCCC	19.90	20890132
606	Phosphorylation	GLGPAGISFLGNSAP CCCCCCEECCCCCCC	17.32	29888752
611	Phosphorylation	GISFLGNSAPVSIET CEECCCCCCCCCHHH	31.95	29888752
615	Phosphorylation	LGNSAPVSIETELMM CCCCCCCCHHHHHHH	17.41	29888752
618	Phosphorylation	SAPVSIETELMMEQV CCCCCHHHHHHHHHH	32.52	29888752
639	Ubiquitination	LRTQLETKVNYYERE HHHHHHHHHHHHHHH	21.07	29967540
686	Phosphorylation	LEELHEKSQEVIWGL HHHHHHHHHHHHHHH	28.70	12852856
758	Phosphorylation	LPARRDLTLELEEPP CCCCCCCEEEECCCC	23.60	-
821	Phosphorylation	GKRVDGPSLEAEMQA CCCCCCCCHHHHHHH	44.35	29083192
946	Phosphorylation	RELPLLGTERDASQT CCCCCCCCCCCHHHC	28.02	24719451
1015	Ubiquitination	GCHKHSVEVARRGSL CCHHHHHHHHHCCCC	33.21	29967540
1021	Phosphorylation	VEVARRGSLPSHLQL HHHHHCCCCCCCCEE	34.98	28348404
1094	Phosphorylation	HRLSEENTLLKNDLG EHHHHHCCHHHCCHH	36.43	23312004
1097	Ubiquitination	SEENTLLKNDLGRVR HHHCCHHHCCHHHHH	52.07	29967540
1267	Phosphorylation	AELHRLLSLQGEQAR HHHHHHHHHCHHHHH	24.20	28857561
1364	Ubiquitination	QSRLLEEKVRALNKL HHHHHHHHHHHHHHH	27.87	29967540
1373	Phosphorylation	RALNKLVSRIAPAAL HHHHHHHHHHHHHHH	28.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
87	S	Phosphorylation	Kinase	PLK1	P53350	PSP
88	S	Phosphorylation	Kinase	PLK1	P53350	PSP
161	T	Phosphorylation	Kinase	PLK1	P53350	PSP
185	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
185	S	Phosphorylation	Kinase	CDK1	P06493	PSP
448	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
585	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
589	S	Phosphorylation	Kinase	CDK1	P06493	PSP
686	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NINL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NINL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPERT_HUMAN	SPERT	physical	16189514
CCD33_HUMAN	CCDC33	physical	16189514
GPKOW_HUMAN	GPKOW	physical	16189514
LZTS2_HUMAN	LZTS2	physical	16189514
ZC3H1_HUMAN	ZFC3H1	physical	16189514
KANL1_HUMAN	KANSL1	physical	16189514
DCTN5_HUMAN	DCTN5	physical	16189514
3BP5L_HUMAN	SH3BP5L	physical	16189514
TSYL4_HUMAN	TSPYL4	physical	16189514
ZN426_HUMAN	ZNF426	physical	16189514
CLC1B_HUMAN	CLEC1B	physical	16189514
SYT17_HUMAN	SYT17	physical	16189514
RIBC2_HUMAN	RIBC2	physical	16189514
GCC1_HUMAN	GCC1	physical	16189514
CC130_HUMAN	CCDC130	physical	16189514
APEX2_HUMAN	APEX2	physical	16189514
MCM10_HUMAN	MCM10	physical	16189514
ZN250_HUMAN	ZNF250	physical	16189514
TEANC_HUMAN	TCEANC	physical	16189514
RCOR3_HUMAN	RCOR3	physical	16189514
MBIP1_HUMAN	MBIP	physical	16189514
ANC2_HUMAN	ANAPC2	physical	17403670
CDC27_HUMAN	CDC27	physical	17403670
CDC20_HUMAN	CDC20	physical	17403670
FZR1_HUMAN	FZR1	physical	17403670
BRCA1_HUMAN	BRCA1	physical	19509300
TBG1_HUMAN	TUBG1	physical	12852856
GCP4_HUMAN	TUBGCP4	physical	12852856
PLK1_HUMAN	PLK1	physical	12852856
CCHCR_HUMAN	CCHCR1	physical	25416956
RBM41_HUMAN	RBM41	physical	25416956
RCOR3_HUMAN	RCOR3	physical	25416956
CC146_HUMAN	CCDC146	physical	25416956
SH24A_HUMAN	SH2D4A	physical	25416956
F161A_HUMAN	FAM161A	physical	25416956
LMBL4_HUMAN	L3MBTL4	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
ABLM1_HUMAN	ABLIM1	physical	26638075
AL3A2_HUMAN	ALDH3A2	physical	26638075
RHG21_HUMAN	ARHGAP21	physical	26638075
ARRB2_HUMAN	ARRB2	physical	26638075
CP131_HUMAN	CEP131	physical	26638075
CA198_HUMAN	C1orf198	physical	26638075
C2D1A_HUMAN	CC2D1A	physical	26638075
CC138_HUMAN	CCDC138	physical	26638075
CCD14_HUMAN	CCDC14	physical	26638075
CCD66_HUMAN	CCDC66	physical	26638075
CC85C_HUMAN	CCDC85C	physical	26638075
CCHCR_HUMAN	CCHCR1	physical	26638075
CP110_HUMAN	CCP110	physical	26638075
CE162_HUMAN	CEP162	physical	26638075
CE350_HUMAN	CEP350	physical	26638075
CEP55_HUMAN	CEP55	physical	26638075
CEP85_HUMAN	CEP85	physical	26638075
CEP97_HUMAN	CEP97	physical	26638075
CKAP2_HUMAN	CKAP2	physical	26638075
CNOT1_HUMAN	CNOT1	physical	26638075
CSPP1_HUMAN	CSPP1	physical	26638075
DYHC1_HUMAN	DYNC1H1	physical	26638075
DC1L2_HUMAN	DYNC1LI2	physical	26638075
FR1OP_HUMAN	FGFR1OP	physical	26638075
GPTC1_HUMAN	GPATCH1	physical	26638075
GPS2_HUMAN	GPS2	physical	26638075
IFT74_HUMAN	IFT74	physical	26638075
IFT81_HUMAN	IFT81	physical	26638075
KANK2_HUMAN	KANK2	physical	26638075
GSE1_HUMAN	GSE1	physical	26638075
K1671_HUMAN	KIAA1671	physical	26638075
KIF14_HUMAN	KIF14	physical	26638075
KIF1B_HUMAN	KIF1B	physical	26638075
LPP_HUMAN	LPP	physical	26638075
LUZP1_HUMAN	LUZP1	physical	26638075
MA7D3_HUMAN	MAP7D3	physical	26638075
MPP9_HUMAN	MPHOSPH9	physical	26638075
MZT2A_HUMAN	MZT2A	physical	26638075
NCK5L_HUMAN	NCKAP5L	physical	26638075
NCOR1_HUMAN	NCOR1	physical	26638075
NEDD1_HUMAN	NEDD1	physical	26638075
NDK7_HUMAN	NME7	physical	26638075
OFD1_HUMAN	OFD1	physical	26638075
PALLD_HUMAN	PALLD	physical	26638075
PDLI7_HUMAN	PDLIM7	physical	26638075
PLK1_HUMAN	PLK1	physical	26638075
ASPP1_HUMAN	PPP1R13B	physical	26638075
PRC2B_HUMAN	PRRC2B	physical	26638075
SCYL2_HUMAN	SCYL2	physical	26638075
SDCG3_HUMAN	SDCCAG3	physical	26638075
SI1L3_HUMAN	SIPA1L3	physical	26638075
SVIL_HUMAN	SVIL	physical	26638075
TCHP_HUMAN	TCHP	physical	26638075
TNR6A_HUMAN	TNRC6A	physical	26638075
TNR6B_HUMAN	TNRC6B	physical	26638075
P53_HUMAN	TP53	physical	26638075
ASPP2_HUMAN	TP53BP2	physical	26638075
TROAP_HUMAN	TROAP	physical	26638075
TTK_HUMAN	TTK	physical	26638075
TXLNA_HUMAN	TXLNA	physical	26638075
TXLNG_HUMAN	TXLNG	physical	26638075
WDR83_HUMAN	WDR83	physical	26638075
ZN598_HUMAN	ZNF598	physical	26638075
BCR_HUMAN	BCR	physical	26638075
PRSR3_HUMAN	PROSER3	physical	26638075
KCC2B_HUMAN	CAMK2B	physical	26638075
CAMP1_HUMAN	CAMSAP1	physical	26638075
CAMP2_HUMAN	CAMSAP2	physical	26638075
CAMP3_HUMAN	CAMSAP3	physical	26638075
CC112_HUMAN	CCDC112	physical	26638075
CCD22_HUMAN	CCDC22	physical	26638075
CCD77_HUMAN	CCDC77	physical	26638075
CE170_HUMAN	CEP170	physical	26638075
CEP89_HUMAN	CEP89	physical	26638075
CEP95_HUMAN	CEP95	physical	26638075
CKAP5_HUMAN	CKAP5	physical	26638075
CNO10_HUMAN	CNOT10	physical	26638075
CNOT3_HUMAN	CNOT3	physical	26638075
COMD2_HUMAN	COMMD2	physical	26638075
CRKL_HUMAN	CRKL	physical	26638075
CYLD_HUMAN	CYLD	physical	26638075
DAPK3_HUMAN	DAPK3	physical	26638075
DCAF7_HUMAN	DCAF7	physical	26638075
DCP1B_HUMAN	DCP1B	physical	26638075
DHX35_HUMAN	DHX35	physical	26638075
DIAP3_HUMAN	DIAPH3	physical	26638075
DLG5_HUMAN	DLG5	physical	26638075
DNMBP_HUMAN	DNMBP	physical	26638075
DESP_HUMAN	DSP	physical	26638075
DC1L1_HUMAN	DYNC1LI1	physical	26638075
4ET_HUMAN	EIF4ENIF1	physical	26638075
RB6I2_HUMAN	ERC1	physical	26638075
FA83H_HUMAN	FAM83H	physical	26638075
GGYF1_HUMAN	GIGYF1	physical	26638075
GGYF2_HUMAN	GIGYF2	physical	26638075
GTSE1_HUMAN	GTSE1	physical	26638075
HAUS2_HUMAN	HAUS2	physical	26638075
HAUS5_HUMAN	HAUS5	physical	26638075
HAUS6_HUMAN	HAUS6	physical	26638075
HAUS7_HUMAN	HAUS7	physical	26638075
HDAC3_HUMAN	HDAC3	physical	26638075
HS71L_HUMAN	HSPA1L	physical	26638075
ITSN2_HUMAN	ITSN2	physical	26638075
C170B_HUMAN	CEP170B	physical	26638075
MOONR_HUMAN	KIAA0753	physical	26638075
SKT_HUMAN	KIAA1217	physical	26638075
CE295_HUMAN	CEP295	physical	26638075
KIF7_HUMAN	KIF7	physical	26638075
LATS1_HUMAN	LATS1	physical	26638075
LMO7_HUMAN	LMO7	physical	26638075
LZTS2_HUMAN	LZTS2	physical	26638075
MCM10_HUMAN	MCM10	physical	26638075
MICA3_HUMAN	MICAL3	physical	26638075
MS18A_HUMAN	MIS18A	physical	26638075
M18BP_HUMAN	MIS18BP1	physical	26638075
MPP5_HUMAN	MPP5	physical	26638075
MTUS1_HUMAN	MTUS1	physical	26638075
NDEL1_HUMAN	NDEL1	physical	26638075
PCM1_HUMAN	PCM1	physical	26638075
PDZ11_HUMAN	PDZD11	physical	26638075
P3C2A_HUMAN	PIK3C2A	physical	26638075
PKHA7_HUMAN	PLEKHA7	physical	26638075
PKHG1_HUMAN	PLEKHG1	physical	26638075
PP1A_HUMAN	PPP1CA	physical	26638075
PTN13_HUMAN	PTPN13	physical	26638075
RASF8_HUMAN	RASSF8	physical	26638075
RAVR1_HUMAN	RAVER1	physical	26638075
RCOR1_HUMAN	RCOR1	physical	26638075
FTM_HUMAN	RPGRIP1L	physical	26638075
CNOT9_HUMAN	RQCD1	physical	26638075
SAS6_HUMAN	SASS6	physical	26638075
SH3R1_HUMAN	SH3RF1	physical	26638075
SHKB1_HUMAN	SHKBP1	physical	26638075
SI1L1_HUMAN	SIPA1L1	physical	26638075
SI1L2_HUMAN	SIPA1L2	physical	26638075
SMG7_HUMAN	SMG7	physical	26638075
TANC1_HUMAN	TANC1	physical	26638075
TBK1_HUMAN	TBK1	physical	26638075
TBL1R_HUMAN	TBL1XR1	physical	26638075
TDRD3_HUMAN	TDRD3	physical	26638075
TNIP1_HUMAN	TNIP1	physical	26638075
TTC28_HUMAN	TTC28	physical	26638075
TTF2_HUMAN	TTF2	physical	26638075
GCP2_HUMAN	TUBGCP2	physical	26638075
UBP54_HUMAN	USP54	physical	26638075
VPS45_HUMAN	VPS45	physical	26638075
XRN1_HUMAN	XRN1	physical	26638075
RBNS5_HUMAN	RBSN	physical	26638075
CENPJ_HUMAN	CENPJ	physical	26638075
LZTS3_HUMAN	LZTS3	physical	26638075
TPM2_HUMAN	TPM2	physical	28514442
KCC2A_HUMAN	CAMK2A	physical	27173435
DCTN2_HUMAN	DCTN2	physical	27173435
AHI1_HUMAN	AHI1	physical	27173435
DCTN1_HUMAN	DCTN1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NINL_HUMAN

Related Literatures of Post-Translational Modification