SYT17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT17_HUMAN
• UniProt AC: Q9BSW7
• Protein Name: Synaptotagmin-17
• Gene Name: SYT17
• Organism: Homo sapiens (Human).
• Sequence Length: 474
• Subcellular Localization: Membrane; Peripheral membrane protein.
• Protein Description: Plays a role in dendrite formation by melanocytes. [PubMed: 23999003]
• Protein Sequence: MAYIQLEPLNEGFLSRISGLLLCRWTCRHCCQKCYESSCCQSSEDEVEILGPFPAQTPPWLMASRSSDKDGDSVHTASEVPLTPRTNSPDGRRSSSDTSKSTYSLTRRISSLESRRPSSPLIDIKPIEFGVLSAKKEPIQPSVLRRTYNPDDYFRKFEPHLYSLDSNSDDVDSLTDEEILSKYQLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLLTVVDFDKFSRHCVIGKVSVPLCEVDLVKGGHWWKALIPSSQNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSETNHWRRMLNTHRTAVEQWHSLRSRAECDRVSPASLEVT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MAYIQLEPLN -----CCCEEEEECC	6.47	27642862
15	Phosphorylation	PLNEGFLSRISGLLL ECCHHHHHHHHHHHH	25.88	24043423
18	Phosphorylation	EGFLSRISGLLLCRW HHHHHHHHHHHHHHH	23.44	24043423
26	Phosphorylation	GLLLCRWTCRHCCQK HHHHHHHHHHHHHHH	4.74	-
73	Phosphorylation	SSDKDGDSVHTASEV CCCCCCCCCCCCCCC	22.71	28348404
83	Phosphorylation	TASEVPLTPRTNSPD CCCCCCCCCCCCCCC	12.49	27050516
86	Phosphorylation	EVPLTPRTNSPDGRR CCCCCCCCCCCCCCC	41.05	28102081
88	Phosphorylation	PLTPRTNSPDGRRSS CCCCCCCCCCCCCCC	24.61	28102081
94	Phosphorylation	NSPDGRRSSSDTSKS CCCCCCCCCCCCCHH	32.60	28102081
95	Phosphorylation	SPDGRRSSSDTSKST CCCCCCCCCCCCHHH	30.35	28102081
96	Phosphorylation	PDGRRSSSDTSKSTY CCCCCCCCCCCHHHH	46.27	28102081
98	Phosphorylation	GRRSSSDTSKSTYSL CCCCCCCCCHHHHHH	39.75	26657352
99	Phosphorylation	RRSSSDTSKSTYSLT CCCCCCCCHHHHHHH	29.60	28102081
102	Phosphorylation	SSDTSKSTYSLTRRI CCCCCHHHHHHHHHH	22.36	26657352
103	Phosphorylation	SDTSKSTYSLTRRIS CCCCHHHHHHHHHHH	14.58	26657352
110	Phosphorylation	YSLTRRISSLESRRP HHHHHHHHHHHHCCC	27.36	25884760
111	Phosphorylation	SLTRRISSLESRRPS HHHHHHHHHHHCCCC	33.51	27273156
114	Phosphorylation	RRISSLESRRPSSPL HHHHHHHHCCCCCCC	38.59	23312004
118	Phosphorylation	SLESRRPSSPLIDIK HHHHCCCCCCCEECC	42.66	28152594
119	Phosphorylation	LESRRPSSPLIDIKP HHHCCCCCCCEECCC	26.80	27273156
133	Phosphorylation	PIEFGVLSAKKEPIQ CEEEEEEECCCCCCC	35.32	26074081
142	Phosphorylation	KKEPIQPSVLRRTYN CCCCCCHHHHHCCCC	19.87	26074081
153	Phosphorylation	RTYNPDDYFRKFEPH CCCCCCHHHHHCCCC	16.80	27642862
173	Phosphorylation	SNSDDVDSLTDEEIL CCCCCHHHCCHHHHH	32.77	28348404
351	Phosphorylation	RAKQLLQTDVSQGSD HHHHHHHCCHHCCCC	38.03	-
354	Phosphorylation	QLLQTDVSQGSDPFV HHHHCCHHCCCCCCE	31.47	-
357	Phosphorylation	QTDVSQGSDPFVKIQ HCCHHCCCCCCEEEE	34.18	-
393	Phosphorylation	PFYNESFSFKVPQEE CCCCCCCCEECCHHH	33.18	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
T22D4_HUMAN	TSC22D4	physical	16189514
A4_HUMAN	APP	physical	21832049
NIF3L_HUMAN	NIF3L1	physical	25416956
GMCL1_HUMAN	GMCL1	physical	25416956
CEP63_HUMAN	CEP63	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
TRFE_HUMAN	TF	physical	26186194
TRIM1_HUMAN	MID2	physical	26186194
TRFE_HUMAN	TF	physical	28514442
TRIM1_HUMAN	MID2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.