dbPTM

RASF8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RASF8_HUMAN
UniProt AC	Q8NHQ8
Protein Name	Ras association domain-containing protein 8
Gene Name	RASSF8
Organism	Homo sapiens (Human).
Sequence Length	419
Subcellular Localization
Protein Description
Protein Sequence	MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIEKWRDTERHLAPHENPIISLNKWGQYASDVQLILRRTGPSLSERPTSDSVARIPERTLYRQSLPPLAKLRPQIDKSIKRREPKRKSLTFTGGAKGLMDIFGKGKETEFKQKVLNNCKTTADELKKLIRLQTEKLQSIEKQLESNEIEIRFWEQKYNSNLEEEIVRLEQKIKRNDVEIEEEEFWENELQIEQENEKQLKDQLQEIRQKITECENKLKDYLAQIRTMESGLEAEKLQREVQEAQVNEEEVKGKIGKVKGEIDIQGQQSLRLENGIKAVERSLGQATKRLQDKEQELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPIEIEASHADIEREAPFQSGSLKRPGSSRQLPSNLRILQNPISSGFNPEGIYV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	AIGRTGRYTLIEKWR HHCCCCCEEHHHHHH	13.77	25072903
41	Phosphorylation	IGRTGRYTLIEKWRD HCCCCCEEHHHHHHC	21.65	25072903
49	Phosphorylation	LIEKWRDTERHLAPH HHHHHHCCCHHCCCC	26.75	25072903
80	Phosphorylation	VQLILRRTGPSLSER HHHHHHHHCCCCCCC	47.19	23186163
83	Phosphorylation	ILRRTGPSLSERPTS HHHHHCCCCCCCCCC	45.96	27732954
85	Phosphorylation	RRTGPSLSERPTSDS HHHCCCCCCCCCCCC	35.58	27732954
89	Phosphorylation	PSLSERPTSDSVARI CCCCCCCCCCCCCCC	51.92	25849741
90	Phosphorylation	SLSERPTSDSVARIP CCCCCCCCCCCCCCC	30.48	25849741
92	Phosphorylation	SERPTSDSVARIPER CCCCCCCCCCCCCHH	19.90	28857561
100	Phosphorylation	VARIPERTLYRQSLP CCCCCHHHHHHCCCC	26.86	23403867
102	Phosphorylation	RIPERTLYRQSLPPL CCCHHHHHHCCCCCH	13.14	23403867
105	Phosphorylation	ERTLYRQSLPPLAKL HHHHHHCCCCCHHHH	33.57	22617229
119	Phosphorylation	LRPQIDKSIKRREPK HHHHHCHHHHCCCCC	29.60	29514088
129	Phosphorylation	RREPKRKSLTFTGGA CCCCCCCCCEECCCC	36.35	23927012
131	Phosphorylation	EPKRKSLTFTGGAKG CCCCCCCEECCCCHH	26.66	30266825
133	Phosphorylation	KRKSLTFTGGAKGLM CCCCCEECCCCHHHH	29.48	30266825
270	Phosphorylation	AQIRTMESGLEAEKL HHHHHHHHHHHHHHH	37.54	25690035
294	Acetylation	NEEEVKGKIGKVKGE CHHHHCCCCEEEEEE	42.44	22368439
297	Acetylation	EVKGKIGKVKGEIDI HHCCCCEEEEEEEEE	44.22	22368447
322	Phosphorylation	GIKAVERSLGQATKR HHHHHHHHHHHHHHH	24.28	-
327	Phosphorylation	ERSLGQATKRLQDKE HHHHHHHHHHHHHHH	14.60	-
385	Phosphorylation	EREAPFQSGSLKRPG CCCCCCCCCCCCCCC	30.63	29255136
387	Phosphorylation	EAPFQSGSLKRPGSS CCCCCCCCCCCCCCC	35.64	29255136
389	Ubiquitination	PFQSGSLKRPGSSRQ CCCCCCCCCCCCCCC	59.24	-
393	Phosphorylation	GSLKRPGSSRQLPSN CCCCCCCCCCCCCCC	25.65	23186163
394	Phosphorylation	SLKRPGSSRQLPSNL CCCCCCCCCCCCCCE	29.93	23403867
418	Phosphorylation	GFNPEGIYV------ CCCCCCCCC------	15.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RASF8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RASF8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RASF8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FRMD6_HUMAN	FRMD6	physical	16189514
A4_HUMAN	APP	physical	21832049
KLC1_HUMAN	KLC1	physical	21915095
KDM1A_HUMAN	KDM1A	physical	23455924
ASPP1_HUMAN	PPP1R13B	physical	26186194
ASPP2_HUMAN	TP53BP2	physical	26186194
PARD3_HUMAN	PARD3	physical	26186194
GOGA2_HUMAN	GOLGA2	physical	26186194
KPCI_HUMAN	PRKCI	physical	26186194
ZBTB2_HUMAN	ZBTB2	physical	26186194
PCM1_HUMAN	PCM1	physical	26186194
ZN639_HUMAN	ZNF639	physical	26186194
POC1A_HUMAN	POC1A	physical	26186194
FP100_HUMAN	C17orf70	physical	26186194
GOLP3_HUMAN	GOLPH3	physical	26186194
ASPP1_HUMAN	PPP1R13B	physical	24366813
ASPP2_HUMAN	TP53BP2	physical	24366813
PP1A_HUMAN	PPP1CA	physical	24366813
PP1B_HUMAN	PPP1CB	physical	24366813
PP1G_HUMAN	PPP1CC	physical	24366813
RPAB3_HUMAN	POLR2H	physical	26496610
TCOF_HUMAN	TCOF1	physical	26496610
ASPP2_HUMAN	TP53BP2	physical	26496610
TRIB1_HUMAN	TRIB1	physical	26496610
APBP2_HUMAN	APPBP2	physical	26496610
SETD2_HUMAN	SETD2	physical	26496610
PARD3_HUMAN	PARD3	physical	26496610
TBC24_HUMAN	TBC1D24	physical	26496610
NEUL_HUMAN	NLN	physical	26496610
RFIP1_HUMAN	RAB11FIP1	physical	26496610
PAR10_HUMAN	PARP10	physical	26496610
PARD3_HUMAN	PARD3	physical	28514442
ASPP2_HUMAN	TP53BP2	physical	28514442
ASPP1_HUMAN	PPP1R13B	physical	28514442
ZN639_HUMAN	ZNF639	physical	28514442
ZBTB2_HUMAN	ZBTB2	physical	28514442
POC1A_HUMAN	POC1A	physical	28514442
PCM1_HUMAN	PCM1	physical	28514442
GOLP3_HUMAN	GOLPH3	physical	28514442
FP100_HUMAN	C17orf70	physical	28514442
CEP44_HUMAN	CEP44	physical	28514442
GOGA2_HUMAN	GOLGA2	physical	28514442
KPCI_HUMAN	PRKCI	physical	28514442
COR1A_HUMAN	CORO1A	physical	28514442
RAB3I_HUMAN	RAB3IP	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RASF8_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.	18669648 [Abstract]