dbPTM

RFIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RFIP1_HUMAN
UniProt AC	Q6WKZ4
Protein Name	Rab11 family-interacting protein 1
Gene Name	RAB11FIP1
Organism	Homo sapiens (Human).
Sequence Length	1283
Subcellular Localization	Recycling endosome . Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC). Isoform 2: Cytoplasmic vesicle, phagosome membrane. Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).
Protein Description	A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis..
Protein Sequence	MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPLLPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSEASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQVGKKAGKM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSLMVSAGRGLGA --CCCCCCCCCCCCC	15.84	30108239
6 (in isoform 2)	Phosphorylation	-	15.84	29507054
8 (in isoform 2)	Phosphorylation	-	19.38	30153514
9	Methylation	SLMVSAGRGLGAVWS CCCCCCCCCCCCCCC	36.56	115387261
13 (in isoform 1)	Phosphorylation	-	12.49	-
13 (in isoform 2)	Phosphorylation	-	12.49	29507054
14 (in isoform 1)	Phosphorylation	-	5.02	-
15 (in isoform 1)	Phosphorylation	-	9.69	-
21 (in isoform 1)	Phosphorylation	-	19.98	-
51	2-Hydroxyisobutyrylation	VIQVGKEKYATSVSE EEEECCCEEEECCCH	43.61	-
83 (in isoform 1)	Phosphorylation	-	17.17	-
87 (in isoform 1)	Phosphorylation	-	15.43	-
129	Acetylation	KTQWYKLKSKPGKKD CCCEEECCCCCCCCC	52.89	18525541
131	Acetylation	QWYKLKSKPGKKDKE CEEECCCCCCCCCCC	57.09	18525549
154	Phosphorylation	QFMRNNMTASMFDLS HHHHHCCCHHHHCCC	20.08	30266825
156	Phosphorylation	MRNNMTASMFDLSMK HHHCCCHHHHCCCCC	15.71	29255136
161	Phosphorylation	TASMFDLSMKDKSRN CHHHHCCCCCCCCCC	26.15	30266825
184	Phosphorylation	IKGKNKDSGSDTASA HCCCCCCCCCCCCCC	41.63	30266825
186	Phosphorylation	GKNKDSGSDTASAII CCCCCCCCCCCCCCC	35.42	30266825
188	Phosphorylation	NKDSGSDTASAIIPS CCCCCCCCCCCCCCC	24.98	30266825
190	Phosphorylation	DSGSDTASAIIPSTT CCCCCCCCCCCCCCC	23.30	30266825
195	Phosphorylation	TASAIIPSTTPSVDS CCCCCCCCCCCCCCC	34.21	30266825
196	Phosphorylation	ASAIIPSTTPSVDSD CCCCCCCCCCCCCCC	37.05	30266825
197	Phosphorylation	SAIIPSTTPSVDSDD CCCCCCCCCCCCCCC	20.22	30266825
199	Phosphorylation	IIPSTTPSVDSDDES CCCCCCCCCCCCCCH	36.14	29255136
202	Phosphorylation	STTPSVDSDDESVVK CCCCCCCCCCCHHHC	44.82	29255136
206	Phosphorylation	SVDSDDESVVKDKKK CCCCCCCHHHCCHHH	38.92	29255136
218	Ubiquitination	KKKKSKIKTLLSKSN HHHHHHHHHHHCCCC	36.54	29967540
219	Phosphorylation	KKKSKIKTLLSKSNL HHHHHHHHHHCCCCC	36.08	21712546
222	Phosphorylation	SKIKTLLSKSNLQKT HHHHHHHCCCCCCCC	36.83	29978859
224	Phosphorylation	IKTLLSKSNLQKTPL HHHHHCCCCCCCCCC	39.12	29978859
229	Phosphorylation	SKSNLQKTPLSQSMS CCCCCCCCCCHHHCC	19.26	30266825
232	Phosphorylation	NLQKTPLSQSMSVLP CCCCCCCHHHCCCCC	22.78	23401153
234	Phosphorylation	QKTPLSQSMSVLPTS CCCCCHHHCCCCCCC	15.06	25159151
236	Phosphorylation	TPLSQSMSVLPTSKP CCCHHHCCCCCCCCC	26.25	30266825
240	Phosphorylation	QSMSVLPTSKPEKVL HHCCCCCCCCCCEEE	45.26	21955146
241	Phosphorylation	SMSVLPTSKPEKVLL HCCCCCCCCCCEEEE	44.25	25159151
266	Phosphorylation	EDDNEDESSSASDVM CCCCCCCCCCHHHHH	41.75	26471730
267	Phosphorylation	DDNEDESSSASDVMS CCCCCCCCCHHHHHH	28.07	30576142
268	Phosphorylation	DNEDESSSASDVMSH CCCCCCCCHHHHHHC	40.86	26471730
270	Phosphorylation	EDESSSASDVMSHKR CCCCCCHHHHHHCCC	32.46	26471730
274	Phosphorylation	SSASDVMSHKRTAST CCHHHHHHCCCCCCC	26.21	26471730
278	Phosphorylation	DVMSHKRTASTDLKQ HHHHCCCCCCCCHHH	29.75	27794612
280	Phosphorylation	MSHKRTASTDLKQLN HHCCCCCCCCHHHHH	23.11	23401153
281	Phosphorylation	SHKRTASTDLKQLNQ HCCCCCCCCHHHHHC	42.77	30266825
292	Phosphorylation	QLNQVNFTLPKKEGL HHHCCCCCCCHHHCH	36.63	25159151
296	2-Hydroxyisobutyrylation	VNFTLPKKEGLSFLG CCCCCCHHHCHHHHC	55.89	-
296	Ubiquitination	VNFTLPKKEGLSFLG CCCCCCHHHCHHHHC	55.89	29967540
296 (in isoform 1)	Phosphorylation	-	55.89	-
300	Phosphorylation	LPKKEGLSFLGGLRS CCHHHCHHHHCCCCC	29.31	25159151
307	Phosphorylation	SFLGGLRSKNDVLSR HHHCCCCCCCCCCCC	40.63	23312004
313	Phosphorylation	RSKNDVLSRSNVCIN CCCCCCCCCCCEEEC	33.25	22496350
315	Phosphorylation	KNDVLSRSNVCINGN CCCCCCCCCEEECCC	30.18	21945579
325	Phosphorylation	CINGNHVYLEQPEAK EECCCEEEECCCCCC	9.29	21945579
338	Phosphorylation	AKGEIKDSSPSSSPS CCCCCCCCCCCCCCC	38.86	25159151
339	Phosphorylation	KGEIKDSSPSSSPSP CCCCCCCCCCCCCCC	38.65	29255136
341	Phosphorylation	EIKDSSPSSSPSPKG CCCCCCCCCCCCCCC	45.45	22617229
342	Phosphorylation	IKDSSPSSSPSPKGF CCCCCCCCCCCCCCC	50.05	29255136
343	Phosphorylation	KDSSPSSSPSPKGFR CCCCCCCCCCCCCCC	33.46	29255136
345	Phosphorylation	SSPSSSPSPKGFRKK CCCCCCCCCCCCCHH	40.99	29255136
352	Ubiquitination	SPKGFRKKHLFSSTE CCCCCCHHHCCCCCC	41.08	29967540
356	Phosphorylation	FRKKHLFSSTENLAA CCHHHCCCCCCCCCC	42.59	22167270
357	Phosphorylation	RKKHLFSSTENLAAG CHHHCCCCCCCCCCC	32.19	22167270
358	Phosphorylation	KKHLFSSTENLAAGS HHHCCCCCCCCCCCC	27.91	22167270
365	Phosphorylation	TENLAAGSWKEPAEG CCCCCCCCCCCCCCC	30.19	23927012
376	Phosphorylation	PAEGGGLSSDRQLSE CCCCCCCCCCHHHCC	33.20	23927012
377	Phosphorylation	AEGGGLSSDRQLSES CCCCCCCCCHHHCCC	41.68	23403867
380 (in isoform 2)	Phosphorylation	-	55.09	25159151
381 (in isoform 2)	Phosphorylation	-	6.81	25159151
382	Phosphorylation	LSSDRQLSESSTKDS CCCCHHHCCCCCHHH	27.39	21406692
384	Phosphorylation	SDRQLSESSTKDSLK CCHHHCCCCCHHHHH	39.67	28450419
385	Phosphorylation	DRQLSESSTKDSLKS CHHHCCCCCHHHHHH	35.11	26657352
386	Phosphorylation	RQLSESSTKDSLKSM HHHCCCCCHHHHHHC	48.42	28450419
387	Ubiquitination	QLSESSTKDSLKSMT HHCCCCCHHHHHHCC	47.47	27667366
389	Phosphorylation	SESSTKDSLKSMTLP CCCCCHHHHHHCCCC	38.97	25159151
391	Ubiquitination	SSTKDSLKSMTLPSY CCCHHHHHHCCCCCC	41.98	29967540
392	Phosphorylation	STKDSLKSMTLPSYR CCHHHHHHCCCCCCC	23.46	25159151
394	Phosphorylation	KDSLKSMTLPSYRPA HHHHHHCCCCCCCCC	42.48	25159151
397	Phosphorylation	LKSMTLPSYRPAPLV HHHCCCCCCCCCCCC	36.57	29978859
398	Phosphorylation	KSMTLPSYRPAPLVS HHCCCCCCCCCCCCC	20.76	29978859
405	Phosphorylation	YRPAPLVSGDLRENM CCCCCCCCCCHHHCC	33.98	23186163
424	Ubiquitination	SEATKEAKESKKPES HHHHHHHHHHCCCHH	64.71	24816145
426	Phosphorylation	ATKEAKESKKPESRR HHHHHHHHCCCHHHH	45.32	24719451
431	Phosphorylation	KESKKPESRRSSLLS HHHCCCHHHHHHHHH	41.33	24719451
434	Phosphorylation	KKPESRRSSLLSLMT CCCHHHHHHHHHHHH	24.99	29255136
435	Phosphorylation	KPESRRSSLLSLMTG CCHHHHHHHHHHHHC	31.36	29255136
438	Phosphorylation	SRRSSLLSLMTGKKD HHHHHHHHHHHCCCC	22.76	25159151
441	Phosphorylation	SSLLSLMTGKKDVAK HHHHHHHHCCCCHHC	51.66	23927012
443	2-Hydroxyisobutyrylation	LLSLMTGKKDVAKGS HHHHHHCCCCHHCCC	36.31	-
443	Acetylation	LLSLMTGKKDVAKGS HHHHHHCCCCHHCCC	36.31	30591741
448	Ubiquitination	TGKKDVAKGSEGENP HCCCCHHCCCCCCCC	63.92	27667366
450	Phosphorylation	KKDVAKGSEGENPLT CCCHHCCCCCCCCCC	41.54	28348404
463	2-Hydroxyisobutyrylation	LTVPGREKEGMLMGV CCCCCCCCCCCEECC	59.20	-
464 (in isoform 1)	Phosphorylation	-	45.11	-
466	Sulfoxidation	PGREKEGMLMGVKPG CCCCCCCCEECCCCC	2.15	21406390
471	Ubiquitination	EGMLMGVKPGEDASG CCCEECCCCCCCCCC	41.39	24816145
477	Phosphorylation	VKPGEDASGPAEDLV CCCCCCCCCCHHHHH	58.60	25159151
483 (in isoform 1)	Phosphorylation	-	2.13	-
487	Phosphorylation	AEDLVRRSEKDTAAV HHHHHHHCHHCHHEE	38.13	-
489	2-Hydroxyisobutyrylation	DLVRRSEKDTAAVVS HHHHHCHHCHHEEEE	62.72	-
489	Ubiquitination	DLVRRSEKDTAAVVS HHHHHCHHCHHEEEE	62.72	24816145
491	Phosphorylation	VRRSEKDTAAVVSRQ HHHCHHCHHEEEECC	27.81	28450419
496	Phosphorylation	KDTAAVVSRQGSSLN HCHHEEEECCCCCCC	16.58	29255136
500	Phosphorylation	AVVSRQGSSLNLFED EEEECCCCCCCCEEC	24.26	22617229
501	Phosphorylation	VVSRQGSSLNLFEDV EEECCCCCCCCEECE	28.27	30278072
511	Phosphorylation	LFEDVQITEPEAEPE CEECEECCCCCCCCC	28.53	22115753
519	Phosphorylation	EPEAEPESKSEPRPP CCCCCCCCCCCCCCC	52.80	22817900
521	Phosphorylation	EAEPESKSEPRPPIS CCCCCCCCCCCCCCC	63.21	25159151
528	Phosphorylation	SEPRPPISSPRAPQT CCCCCCCCCCCCCCC	39.81	23401153
528 (in isoform 3)	Phosphorylation	-	39.81	25159151
529	Phosphorylation	EPRPPISSPRAPQTR CCCCCCCCCCCCCCC	21.08	30266825
529 (in isoform 3)	Phosphorylation	-	21.08	25159151
535	Phosphorylation	SSPRAPQTRAVKPRL CCCCCCCCCCCCCCE	21.38	30619164
541 (in isoform 1)	Ubiquitination	-	37.45	21906983
545	Phosphorylation	VKPRLEVSPEAQPTA CCCCEECCCCCCCCC	13.98	25159151
551	Phosphorylation	VSPEAQPTARLPSPT CCCCCCCCCCCCCCC	16.60	27050516
565 (in isoform 1)	Ubiquitination	-	30.26	-
577	Ubiquitination	SSGQASVPSELGHGA CCCCCCCCHHHCCCC	21.42	23503661
578	Ubiquitination	SGQASVPSELGHGAD CCCCCCCHHHCCCCC	43.21	23503661
578 (in isoform 3)	Ubiquitination	-	43.21	21906983
602	Ubiquitination	FSSLSSPIAAPISTS HHCCCCCCCCCCCCC	5.73	23503661
604	Ubiquitination	SLSSPIAAPISTSTP CCCCCCCCCCCCCCC	11.59	23503661
625	Phosphorylation	VDRGQAKSEGPPLLP CCCCCCCCCCCCCCC	53.28	25159151
638	Phosphorylation	LPKAELQTESLTPVP CCCHHEECCCCCCCC	39.92	21406692
642	Phosphorylation	ELQTESLTPVPNSGS HEECCCCCCCCCCCC	31.36	24719451
644	Ubiquitination	QTESLTPVPNSGSSA ECCCCCCCCCCCCHH	6.21	33845483
648	Ubiquitination	LTPVPNSGSSALGSL CCCCCCCCCHHHHHH	30.49	24816145
654	Phosphorylation	SGSSALGSLFKQPSF CCCHHHHHHHCCCCC	26.86	24719451
660	Phosphorylation	GSLFKQPSFPANKGT HHHHCCCCCCCCCCC	41.17	26657352
670	Phosphorylation	ANKGTEDSLMGRTRE CCCCCCCCCCCCCCC	17.64	21815630
684	Phosphorylation	ETGTEKNTSSLELEE CCCCCCCCCCCCCHH	30.66	17192257
685	Phosphorylation	TGTEKNTSSLELEES CCCCCCCCCCCCHHH	42.17	17192257
686	Phosphorylation	GTEKNTSSLELEESL CCCCCCCCCCCHHHC	24.67	17192257
692	Phosphorylation	SSLELEESLPEQPET CCCCCHHHCCCCCCC	39.59	17192257
717	Phosphorylation	PCKKQDYSPSSGEAQ CCCCCCCCCCCCCCC	26.96	25921289
719	Phosphorylation	KKQDYSPSSGEAQEV CCCCCCCCCCCCCCC	45.06	28348404
720	Phosphorylation	KQDYSPSSGEAQEVP CCCCCCCCCCCCCCC	44.00	28348404
731	Phosphorylation	QEVPFALSLSSDGAV CCCCEEEEECCCCCC	23.83	28122231
733	Phosphorylation	VPFALSLSSDGAVSP CCEEEEECCCCCCCC	24.02	28122231
734	Phosphorylation	PFALSLSSDGAVSPV CEEEEECCCCCCCCH	45.41	28122231
739	Phosphorylation	LSSDGAVSPVGELAA ECCCCCCCCHHHHHC	17.21	26657352
754	Phosphorylation	GGDRDLESQAGSLVE CCCCCHHHHHHHHHH	32.40	25159151
758	Phosphorylation	DLESQAGSLVESKAR CHHHHHHHHHHHHHH	32.05	25159151
762	Phosphorylation	QAGSLVESKARDAAE HHHHHHHHHHHHHHH	24.92	20873877
783	Phosphorylation	PMGASVPSIDSMMRK CCCCCCCCHHHHHHH	36.55	22210691
786	Phosphorylation	ASVPSIDSMMRKLEE CCCCCHHHHHHHHHH	16.89	22210691
800	Acetylation	EMGLNLRKDQKKTKK HHCCCCCCCHHHHHH	68.62	20167786
803	Acetylation	LNLRKDQKKTKKRVS CCCCCCHHHHHHCCC	72.97	20167786
880	Phosphorylation	ATCGAPASPADHLLL CCCCCCCCHHCCCCC	21.40	-
908	Phosphorylation	EASSAKDTPLFRMEG HHHCCCCCCCEEEEC	22.61	21815630
921	Phosphorylation	EGEDALVTQYQSKAS ECCCEEHHHHHHCCC	23.55	29978859
923	Phosphorylation	EDALVTQYQSKASDH CCEEHHHHHHCCCCC	12.85	29978859
925	Phosphorylation	ALVTQYQSKASDHEG EEHHHHHHCCCCCCC	25.84	21815630
928	Phosphorylation	TQYQSKASDHEGLLS HHHHHCCCCCCCCCC	43.14	25159151
935	Phosphorylation	SDHEGLLSDPLSDLQ CCCCCCCCCCHHHHH	42.07	25159151
939	Phosphorylation	GLLSDPLSDLQLVSD CCCCCCHHHHHHHHC	41.48	24626860
945	Phosphorylation	LSDLQLVSDFKSPIM HHHHHHHHCCCCCHH	46.02	24626860
958	Phosphorylation	IMADLNLSLPSIPEV HHHCCCCCCCCCHHC	36.84	20873877
961	Phosphorylation	DLNLSLPSIPEVASD CCCCCCCCCHHCCCC	56.95	30278072
967	Phosphorylation	PSIPEVASDDERIDQ CCCHHCCCCCHHCCC	51.26	30278072
1038	Phosphorylation	RLQAPQASVTAPSEQ EEECCCCCEECCCCC	18.11	28555341
1070	Phosphorylation	DKQLPGPSGGEEEKP CCCCCCCCCCCCCCC	66.40	27794612
1131	Phosphorylation	AESQKKATAEGSAGR HHHHHHHHHCCCCHH	33.84	28555341
1135	Phosphorylation	KKATAEGSAGRVENF HHHHHCCCCHHHHHC	21.03	25159151
1154	Phosphorylation	PLLQAWVSPSETHPV CCEEECCCCCCCCCC	16.41	18691976
1156	Phosphorylation	LQAWVSPSETHPVSA EEECCCCCCCCCCCC	47.85	28348404
1158	Phosphorylation	AWVSPSETHPVSAQP ECCCCCCCCCCCCCC	35.50	26434776
1162	Phosphorylation	PSETHPVSAQPGAGT CCCCCCCCCCCCCCC	26.15	26434776
1169	Phosphorylation	SAQPGAGTGSAKHRL CCCCCCCCCCCCCCC	27.68	26434776
1171	Phosphorylation	QPGAGTGSAKHRLHP CCCCCCCCCCCCCCC	33.70	26434776
1187	Phosphorylation	KPMNAMATKVANCSL CCCCHHHHHHHCCCC	16.99	-
1193	Phosphorylation	ATKVANCSLGTATII HHHHHCCCCCCEEEE	29.64	25159151
1196	Phosphorylation	VANCSLGTATIISEN HHCCCCCCEEEEECC	26.39	25159151
1198	Phosphorylation	NCSLGTATIISENLN CCCCCCEEEEECCCC	20.77	25627689
1211	Ubiquitination	LNNEVMMKKYSPSDP CCCHHHHHCCCCCCH	30.39	23503661
1212	Ubiquitination	NNEVMMKKYSPSDPA CCHHHHHCCCCCCHH	32.82	2190698
1212 (in isoform 4)	Ubiquitination	-	32.82	21906983
1214	Phosphorylation	EVMMKKYSPSDPAFA HHHHHCCCCCCHHHH	27.14	25159151
1216	Phosphorylation	MMKKYSPSDPAFAYA HHHCCCCCCHHHHHH	50.73	-
1226	Phosphorylation	AFAYAQLTHDELIQL HHHHHHCCHHHHHHH	18.39	-
1236	Ubiquitination	ELIQLVLKQKETISK HHHHHHHHCCCCCCH	52.42	23503661
1238	Ubiquitination	IQLVLKQKETISKKE HHHHHHCCCCCCHHH	56.06	23503661
1254	Phosphorylation	QVRELEDYIDNLLVR CHHHHHHHHHHHHHH	10.78	29978859
1274	Phosphorylation	PNILRIPTQVGKKAG CCCEECCCHHHHHCC	33.25	26657352
1278	2-Hydroxyisobutyrylation	RIPTQVGKKAGKM-- ECCCHHHHHCCCC--	40.36	-
1278	Ubiquitination	RIPTQVGKKAGKM-- ECCCHHHHHCCCC--	40.36	33845483
1282	Ubiquitination	QVGKKAGKM------ HHHHHCCCC------	46.42	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
234	S	Phosphorylation	Kinase	MARK2	Q7KZI7	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RFIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RFIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFIP1_HUMAN	RAB11FIP1	physical	12364336
RFIP2_HUMAN	RAB11FIP2	physical	12364336
RB11A_HUMAN	RAB11A	physical	11495908
RAB14_HUMAN	RAB14	physical	19702578
ASAP1_HUMAN	ASAP1	physical	18685082
NOLC1_HUMAN	NOLC1	physical	28514442
1433Z_HUMAN	YWHAZ	physical	28514442
1433G_HUMAN	YWHAG	physical	28514442
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RFIP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; SER-357 ANDSER-545, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199; SER-202; SER-338;SER-343; SER-345 AND SER-545, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202; SER-338; SER-339;SER-341; SER-342; SER-343; SER-345; SER-435; SER-477 AND SER-545, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300; SER-435; SER-477;SER-500; SER-501; SER-545; THR-684; SER-685; SER-686; SER-692;SER-754; SER-758 AND SER-1135, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, AND MASSSPECTROMETRY.	17287340 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496, AND MASSSPECTROMETRY.	16964243 [Abstract]
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