DCTN5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCTN5_HUMAN
• UniProt AC: Q9BTE1
• Protein Name: Dynactin subunit 5
• Gene Name: DCTN5
• Organism: Homo sapiens (Human).
• Sequence Length: 182
• Subcellular Localization: Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore .
• Protein Sequence: MELGELLYNKSEYIETASGNKVSRQSVLCGSQNIVLNGKTIVMNDCIIRGDLANVRVGRHCVVKSRSVIRPPFKKFSKGVAFFPLHIGDHVFIEEDCVVNAAQIGSYVHVGKNCVIGRRCVLKDCCKILDNTVLPPETVVPPFTVFSGCPGLFSGELPECTQELMIDVTKSYYQKFLPLTQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MELGELLY -------CCHHHHHC	9.65	22223895
8	Phosphorylation	MELGELLYNKSEYIE CCHHHHHCCHHHEEE	32.92	29496907
10	Ubiquitination	LGELLYNKSEYIETA HHHHHCCHHHEEEEC	30.98	29967540
13	Phosphorylation	LLYNKSEYIETASGN HHCCHHHEEEECCCC	15.91	29496907
21	Acetylation	IETASGNKVSRQSVL EEECCCCCEECCEEE	45.15	20167786
21	Ubiquitination	IETASGNKVSRQSVL EEECCCCCEECCEEE	45.15	21906983
31	Phosphorylation	RQSVLCGSQNIVLNG CCEEECCCCEEEECC	21.03	24719451
48 (in isoform 3)	Phosphorylation	-	5.18	30257219
65	Phosphorylation	GRHCVVKSRSVIRPP CCEEEEECCCEECCC	20.41	20068231
67	Phosphorylation	HCVVKSRSVIRPPFK EEEEECCCEECCCCC	29.05	20068231
74	Malonylation	SVIRPPFKKFSKGVA CEECCCCCCCCCCEE	59.70	32601280
74	Ubiquitination	SVIRPPFKKFSKGVA CEECCCCCCCCCCEE	59.70	-
75	Ubiquitination	VIRPPFKKFSKGVAF EECCCCCCCCCCEEE	56.07	-
123	Acetylation	IGRRCVLKDCCKILD ECCCHHHHHHHHHCC	28.46	25953088
123	Ubiquitination	IGRRCVLKDCCKILD ECCCHHHHHHHHHCC	28.46	-
170	Ubiquitination	ELMIDVTKSYYQKFL HHHHHHHHHHHHHHC	35.99	22817900
175	Ubiquitination	VTKSYYQKFLPLTQV HHHHHHHHHCCCCCC	32.52	21890473
175	Ubiquitination	VTKSYYQKFLPLTQV HHHHHHHHHCCCCCC	32.52	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCTN5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCTN5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCTN5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FATE1_HUMAN	FATE1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.