CEP85_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CEP85_HUMAN
• UniProt AC: Q6P2H3
• Protein Name: Centrosomal protein of 85 kDa
• Gene Name: CEP85
• Organism: Homo sapiens (Human).
• Sequence Length: 762
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Nucleus, nucleolus . Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates
• Protein Description: Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity. [PubMed: 26220856]
• Protein Sequence: MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAIGTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPLSGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFDIPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGPHSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAMQEKYPTEGISH -CCCCCCCCCCCCCC	18.03	26074081
9	Phosphorylation	AMQEKYPTEGISHVT CCCCCCCCCCCCCCC	43.69	30108239
13	Phosphorylation	KYPTEGISHVTSPSS CCCCCCCCCCCCCCC	23.82	30108239
16	Phosphorylation	TEGISHVTSPSSDVI CCCCCCCCCCCCCCH	29.51	25159151
17	Phosphorylation	EGISHVTSPSSDVIQ CCCCCCCCCCCCCHH	22.99	25159151
19	Phosphorylation	ISHVTSPSSDVIQKG CCCCCCCCCCCHHCC	38.65	25159151
20	Phosphorylation	SHVTSPSSDVIQKGS CCCCCCCCCCHHCCC	39.00	25159151
25	Ubiquitination	PSSDVIQKGSSLGTE CCCCCHHCCCCCCCC	50.03	29967540
27	Phosphorylation	SDVIQKGSSLGTEWQ CCCHHCCCCCCCCCC	29.44	26074081
28	Phosphorylation	DVIQKGSSLGTEWQT CCHHCCCCCCCCCCC	39.21	29396449
31	Phosphorylation	QKGSSLGTEWQTPVI HCCCCCCCCCCCCCC	39.07	27050516
35	Phosphorylation	SLGTEWQTPVISEPF CCCCCCCCCCCCCCC	22.16	25850435
39	Phosphorylation	EWQTPVISEPFRSRF CCCCCCCCCCCHHCC	39.18	27174698
44	Phosphorylation	VISEPFRSRFSRCSS CCCCCCHHCCCCCCC	37.75	-
50	Phosphorylation	RSRFSRCSSVADSGD HHCCCCCCCCCCCCC	27.08	29449344
51	Phosphorylation	SRFSRCSSVADSGDT HCCCCCCCCCCCCCC	25.58	30576142
55	Phosphorylation	RCSSVADSGDTAIGT CCCCCCCCCCCCCCC	28.91	30576142
58	Phosphorylation	SVADSGDTAIGTSCS CCCCCCCCCCCCCHH	24.57	27251275
62	Phosphorylation	SGDTAIGTSCSDIAE CCCCCCCCCHHHHHH	22.05	27251275
63	Phosphorylation	GDTAIGTSCSDIAED CCCCCCCCHHHHHHH	13.35	27251275
65	Phosphorylation	TAIGTSCSDIAEDFC CCCCCCHHHHHHHHH	31.64	27251275
65	Ubiquitination	TAIGTSCSDIAEDFC CCCCCCHHHHHHHHH	31.64	29967540
66	Ubiquitination	AIGTSCSDIAEDFCS CCCCCHHHHHHHHHH	48.74	29967540
73	Phosphorylation	DIAEDFCSSSGSPPF HHHHHHHHCCCCCCC	27.77	27690223
74	Phosphorylation	IAEDFCSSSGSPPFQ HHHHHHHCCCCCCCC	39.64	29449344
75	Phosphorylation	AEDFCSSSGSPPFQP HHHHHHCCCCCCCCC	27.31	30576142
77	Phosphorylation	DFCSSSGSPPFQPIK HHHHCCCCCCCCCCC	31.20	30576142
85	Phosphorylation	PPFQPIKSHVTIPTA CCCCCCCCCCEEECC	24.74	25002506
88	Ubiquitination	QPIKSHVTIPTAHVM CCCCCCCEEECCCCC	18.80	-
88	Phosphorylation	QPIKSHVTIPTAHVM CCCCCCCEEECCCCC	18.80	25002506
88	Ubiquitination	QPIKSHVTIPTAHVM CCCCCCCEEECCCCC	18.80	29967540
91	Phosphorylation	KSHVTIPTAHVMPST CCCCEEECCCCCCCC	26.08	25002506
97	Phosphorylation	PTAHVMPSTLGTSPA ECCCCCCCCCCCCCC	20.40	30576142
98	Phosphorylation	TAHVMPSTLGTSPAK CCCCCCCCCCCCCCC	24.28	28464451
101	Phosphorylation	VMPSTLGTSPAKPNS CCCCCCCCCCCCCCC	34.35	30576142
102	Phosphorylation	MPSTLGTSPAKPNST CCCCCCCCCCCCCCC	22.51	30576142
108	Phosphorylation	TSPAKPNSTPVGPSS CCCCCCCCCCCCCCC	42.49	25159151
109	Phosphorylation	SPAKPNSTPVGPSSS CCCCCCCCCCCCCCC	28.74	30576142
114	Phosphorylation	NSTPVGPSSSKLPLS CCCCCCCCCCCCCCC	41.12	21712546
115	Phosphorylation	STPVGPSSSKLPLSG CCCCCCCCCCCCCCH	34.33	28122231
116	Phosphorylation	TPVGPSSSKLPLSGL CCCCCCCCCCCCCHH	42.42	28122231
117	Ubiquitination	PVGPSSSKLPLSGLA CCCCCCCCCCCCHHH	56.95	29967540
126	Phosphorylation	PLSGLAESVGMTRNG CCCHHHHHHCCCCCC	20.54	23186163
127	Ubiquitination	LSGLAESVGMTRNGD CCHHHHHHCCCCCCC	4.59	-
129	Sulfoxidation	GLAESVGMTRNGDLG HHHHHHCCCCCCCCC	2.74	21406390
139	Ubiquitination	NGDLGAMKHSPGLSR CCCCCCCCCCCCCCC	40.16	29967540
141	Phosphorylation	DLGAMKHSPGLSRDL CCCCCCCCCCCCCCC	18.36	22617229
145	Phosphorylation	MKHSPGLSRDLMYFS CCCCCCCCCCCHHCC	29.66	28450419
150	Phosphorylation	GLSRDLMYFSGATGE CCCCCCHHCCCCCCC	11.24	27642862
165	Ubiquitination	NGIEQSWFPAVGHER CCCCCCCCCCCCCHH	3.18	-
165	Ubiquitination	NGIEQSWFPAVGHER CCCCCCCCCCCCCHH	3.18	29967540
175	Ubiquitination	VGHERQEEARKFDIP CCCHHHHHHHCCCCC	45.49	27667366
176	Ubiquitination	GHERQEEARKFDIPS CCHHHHHHHCCCCCC	21.14	-
176	Ubiquitination	GHERQEEARKFDIPS CCHHHHHHHCCCCCC	21.14	24816145
178	Ubiquitination	ERQEEARKFDIPSME HHHHHHHCCCCCCHH	55.20	-
191	Phosphorylation	MESTLNQSAMMETLY HHHHHCHHHHHHHHH	19.63	-
196	Phosphorylation	NQSAMMETLYSDPHH CHHHHHHHHHCCCCC	17.07	29978859
198	Phosphorylation	SAMMETLYSDPHHRV HHHHHHHHCCCCCCC	20.60	29978859
199	Phosphorylation	AMMETLYSDPHHRVR HHHHHHHCCCCCCCC	48.02	29978859
206	Dimethylation	SDPHHRVRFHNPRTS CCCCCCCCCCCCCCC	27.36	-
206	Methylation	SDPHHRVRFHNPRTS CCCCCCCCCCCCCCC	27.36	-
209	Ubiquitination	HHRVRFHNPRTSTSK CCCCCCCCCCCCCCH	25.66	-
212	Phosphorylation	VRFHNPRTSTSKELY CCCCCCCCCCCHHHH	37.30	24719451
213	Phosphorylation	RFHNPRTSTSKELYR CCCCCCCCCCHHHHH	31.78	24719451
215	Phosphorylation	HNPRTSTSKELYRVL CCCCCCCCHHHHHHC	24.73	-
216	Ubiquitination	NPRTSTSKELYRVLP CCCCCCCHHHHHHCH	52.40	29967540
219	Phosphorylation	TSTSKELYRVLPEAK CCCCHHHHHHCHHHH	10.36	25159151
226	Acetylation	YRVLPEAKKAPGSGA HHHCHHHHCCCCCCC	48.05	25953088
226	Ubiquitination	YRVLPEAKKAPGSGA HHHCHHHHCCCCCCC	48.05	27667366
227	Ubiquitination	RVLPEAKKAPGSGAV HHCHHHHCCCCCCCC	67.85	24816145
259	Phosphorylation	LQPAPGLSKPLPSQV CCCCCCCCCCCCCCC	37.84	24719451
260	Ubiquitination	QPAPGLSKPLPSQVW CCCCCCCCCCCCCCC	56.46	-
264	Phosphorylation	GLSKPLPSQVWQPSP CCCCCCCCCCCCCCC	45.08	-
270	Phosphorylation	PSQVWQPSPDTWHPR CCCCCCCCCCCCCCC	21.95	25159151
289	Ubiquitination	ELSTCRQQLELIRLQ CHHHHHHHHHHHHHH	19.97	-
289	Ubiquitination	ELSTCRQQLELIRLQ CHHHHHHHHHHHHHH	19.97	29967540
295	Ubiquitination	QQLELIRLQMEQMQL HHHHHHHHHHHHHHH	4.51	-
295	Ubiquitination	QQLELIRLQMEQMQL HHHHHHHHHHHHHHH	4.51	27667366
298	Ubiquitination	ELIRLQMEQMQLQNG HHHHHHHHHHHHHCC	29.91	-
298	Ubiquitination	ELIRLQMEQMQLQNG HHHHHHHHHHHHHCC	29.91	29967540
306	Ubiquitination	QMQLQNGAICHHPAA HHHHHCCCCCCCCCH	14.58	-
306	Ubiquitination	QMQLQNGAICHHPAA HHHHHCCCCCCCCCH	14.58	22817900
340	Ubiquitination	NEHLLKEKELLIDKQ CHHHHHHHHHHHHHH	52.66	29967540
346	Ubiquitination	EKELLIDKQRKHISQ HHHHHHHHHHHHHHH	45.04	27667366
349	Ubiquitination	LLIDKQRKHISQLEQ HHHHHHHHHHHHHHH	42.68	29967540
350	Ubiquitination	LIDKQRKHISQLEQK HHHHHHHHHHHHHHH	27.41	-
350	Ubiquitination	LIDKQRKHISQLEQK HHHHHHHHHHHHHHH	27.41	27667366
352	Phosphorylation	DKQRKHISQLEQKVR HHHHHHHHHHHHHHH	28.56	-
357	Ubiquitination	HISQLEQKVRESELQ HHHHHHHHHHHHHHH	33.61	22817900
357 (in isoform 1)	Ubiquitination	-	33.61	21906983
357 (in isoform 2)	Ubiquitination	-	33.61	21906983
380	Ubiquitination	PAPFGDVCLLRLQEL CCCCHHHHHHHHHHH	3.35	-
380	Ubiquitination	PAPFGDVCLLRLQEL CCCCHHHHHHHHHHH	3.35	29967540
385	Ubiquitination	DVCLLRLQELQRENT HHHHHHHHHHHHCCH	42.81	29967540
401	Ubiquitination	LRAQFAQKTEALSRE HHHHHHHHHHHHHHH	44.92	27667366
408	Ubiquitination	KTEALSREKIDLEKK HHHHHHHHHCCHHHH	51.49	29967540
415	Acetylation	EKIDLEKKLSASEVE HHCCHHHHCCHHHHH	38.00	18585897
417	Phosphorylation	IDLEKKLSASEVEVQ CCHHHHCCHHHHHHH	38.33	29978859
419	Phosphorylation	LEKKLSASEVEVQLI HHHHCCHHHHHHHHH	38.51	29978859
431	Ubiquitination	QLIRESLKVALQKHS HHHHHHHHHHHHHCH	34.44	29967540
436	Ubiquitination	SLKVALQKHSEEVKK HHHHHHHHCHHHHHH	50.37	29967540
443	Ubiquitination	KHSEEVKKQEERVKG HCHHHHHHHHHHHHH	69.03	29967540
459	Ubiquitination	DKHINNLKKKCQKES HHHHHHHHHHHHHHH	52.92	29967540
461	Ubiquitination	HINNLKKKCQKESEQ HHHHHHHHHHHHHHH	40.07	29967540
479	Ubiquitination	KQQRIETLERYLADL HHHHHHHHHHHHHCC	1.98	-
479	Ubiquitination	KQQRIETLERYLADL HHHHHHHHHHHHHCC	1.98	24816145
494	Ubiquitination	PTLEDHQKQSQQLKD CCHHHHHHHHHHHCH	48.80	29967540
512	Ubiquitination	KSTELQEKVTELESL HHHHHHHHHHHHHHH	41.31	29967540
530	Acetylation	TQAICREKEIQLESL HHHHHHHHHHHHHHH	40.54	25953088
530	Ubiquitination	TQAICREKEIQLESL HHHHHHHHHHHHHHH	40.54	24816145
545	Phosphorylation	RQREAEFSSAGHSLQ HHHHHHHHHCCCCHH	15.70	23312004
546	Phosphorylation	QREAEFSSAGHSLQD HHHHHHHHCCCCHHC	43.52	23312004
550	Phosphorylation	EFSSAGHSLQDKQSV HHHHCCCCHHCCCCH	27.15	23312004
574	Ubiquitination	VEMESWQKRYDSLQK HHHHHHHHHHHHHHH	46.82	-
576	Phosphorylation	MESWQKRYDSLQKIV HHHHHHHHHHHHHHH	19.54	19664994
578	Phosphorylation	SWQKRYDSLQKIVEK HHHHHHHHHHHHHHH	24.62	19664994
582	Ubiquitination	RYDSLQKIVEKQQQK HHHHHHHHHHHHHHH	2.89	29967540
610	Phosphorylation	EVAQEEGTSQALREE HHHHHHHHHHHHHHH	22.42	27174698
611	Phosphorylation	VAQEEGTSQALREEA HHHHHHHHHHHHHHH	25.06	27174698
623	Phosphorylation	EEAQRRDSALQQLRT HHHHHHHHHHHHHHH	29.12	30266825
633	Ubiquitination	QQLRTAVKELSVQNQ HHHHHHHHHHHHCCH	50.93	29967540
660	Phosphorylation	LRQAQPGSPPSPDTA HHHCCCCCCCCCHHH	40.08	28464451
679	Phosphorylation	ELHQELASCLQDLQA HHHHHHHHHHHHHHH	28.16	28464451
692	Phosphorylation	QAVCSIVTQRAQGHD HHHHHHHHHHHCCCC	15.63	24719451
745	Phosphorylation	RDIEDLRTTMSDRYA HHHHHHHHHHHHHHH	33.86	-
746	Phosphorylation	DIEDLRTTMSDRYAQ HHHHHHHHHHHHHHH	14.29	-
748	Phosphorylation	EDLRTTMSDRYAQDM HHHHHHHHHHHHHHH	19.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CEP85_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CEP85_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CEP85_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOX13_HUMAN	SOX13	physical	26186194
SOX5_HUMAN	SOX5	physical	26186194
CEP44_HUMAN	CEP44	physical	26186194
CEP85_HUMAN	CEP85	physical	26472760
PSA7_HUMAN	PSMA7	physical	26472760
PSB5_HUMAN	PSMB5	physical	26472760
PRS7_HUMAN	PSMC2	physical	26472760
PSA6_HUMAN	PSMA6	physical	26472760
SOX13_HUMAN	SOX13	physical	28514442
SOX5_HUMAN	SOX5	physical	28514442
CEP44_HUMAN	CEP44	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.
PubMed: 18669648