dbPTM

PRC2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRC2B_HUMAN
UniProt AC	Q5JSZ5
Protein Name	Protein PRRC2B
Gene Name	PRRC2B
Organism	Homo sapiens (Human).
Sequence Length	2229
Subcellular Localization
Protein Description
Protein Sequence	MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPPANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLNGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKGVLDLSYGPGPSLRPQNVTSWREGGGRHIISATSLSTSPTELGSRNSSTGDGAPSSACTSDSKDPSLRPAQPVRKGASQFMGNVYHPPTYHDMLPAFMCSPKSSENQGTVERGSFPLPQLRLEPRVPFRQFQMNDQDGKENRLGLSRPLRPLRQLVERAPRPTIINAENLKGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNSWDPRRQRQLSMSSADSADAKRTREEGKDWAEAVGASRVVRKAPDPQPPPRKLHGWAPGPDYQKSSMGSMFRQQSIEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPSAEKASPQENGPAVHKGSPEFPAQETPTTFPEEAPTVSPAVAQSNSSEEEAREAGSPAQEFKYQKSLPPRFQRQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLNGTGCRSEDQNCVPPLQERKVTPIDSPPVWSPEGYMALQSKGYPLPHPKSSDTLAMDMRVRNESSFSASLGRAGGVSAQRDLFEERGEEYLSAFDKKAQADFDSCISSQRIGQELLFPPQENVQDAGAPGGHTQNLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVERETPREGTAFNISSWDKNGSPNKQPSSEPEWTPEPRSSSSQHPEQTGRTRRSGPIKKPVLKALKVEDKEKELEKIKQELGEESTRLAKEKEQSPTAEKDEDEENDASLANSSTTTLEDKGPGHATFGREATKFEEEEKPDKAWEARPPRESSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRGRPAGGNGSGLCGGGVLGARSIYCSSQRSGRGRGLREFARPEDCPRAKPRRRVASETHSEGSEYEELPKRRRQRGSENGNEGSLLEREESTLKKGDCRDSWRSNKGCSEDHSGLDAKSRGPRAFGRALPPRLSNCGYGRRTFVSKESPHWQSKSPGSSWQEYGPSDTCGSRRPTDRDYVPDSYRHPDAFGGRGFEDSRAEDKRSFFQDEHVADSENAENRPFRRRRPPRQDKPPRFRRLRQERESLGLWGPEEEPHLLAGQWPGRPKLCSGDKSGTVGRRSPELSYQNSSDHANEEWETASESSDFSERRERREGPGSEPDSQVDGGLSGASLGEKKELAKRSFSSQRPVVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGGLSGCSSGSGHSPYALERAAHASADLPEASSKKAEKEAKLAAPRAGEQGEAMKQFDLNYGSAIIENCGSSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVKGRGLSSRIPPRFAKKQNNLCLEQGDVTVPGSSLGTEIWESSSQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLAEPKADSHKEQAPKPSEQKDSEQGSGQSKEHRPGPIGNERSLKNRKGSEGAERLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSASGPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGMQPLEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRRIPPPGSQPPVLNTSREPSQMEMKGFHFADSKQNVPSGGPVPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKQRVDEKPSLGAVKLQEAPSAASQMKRTGAIKPRAVKVEESKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	GKDGKSKYSTLSLFD CCCCCCCCCCHHHHH	17.61	27642862
19	Phosphorylation	KDGKSKYSTLSLFDK CCCCCCCCCHHHHHH	26.97	-
20	Phosphorylation	DGKSKYSTLSLFDKY CCCCCCCCHHHHHHH	19.78	28555341
22	Phosphorylation	KSKYSTLSLFDKYKG CCCCCCHHHHHHHCC	27.38	28857561
27	Phosphorylation	TLSLFDKYKGKSVDA CHHHHHHHCCCCHHH	27.15	-
31	Phosphorylation	FDKYKGKSVDAIRSS HHHHCCCCHHHHHHH	33.62	-
37	Phosphorylation	KSVDAIRSSVIPRHG CCHHHHHHHCCCHHH	23.89	-
47	Phosphorylation	IPRHGLQSLGKVAAA CCHHHHHHHHHHHHH	44.10	25159151
50	Acetylation	HGLQSLGKVAAARRM HHHHHHHHHHHHHCC	33.71	25953088
56	Methylation	GKVAAARRMPPPANL HHHHHHHCCCCCCCC	36.91	-
65	Phosphorylation	PPPANLPSLKSENKG CCCCCCCCCCCCCCC	52.15	26503514
68	Phosphorylation	ANLPSLKSENKGNDP CCCCCCCCCCCCCCC	52.25	26503514
102	Phosphorylation	DPKSSSATASQPPES CCCCCCCCCCCCCHH	28.87	28555341
104	Phosphorylation	KSSSATASQPPESLP CCCCCCCCCCCHHCC	38.57	28555341
109	Phosphorylation	TASQPPESLPQPGLQ CCCCCCHHCCCCCHH	51.64	28555341
118	Phosphorylation	PQPGLQKSVSNLQKP CCCCHHHHHHCCCCC	20.16	28857561
120	Phosphorylation	PGLQKSVSNLQKPTQ CCHHHHHHCCCCCCC	38.62	28555341
124	Acetylation	KSVSNLQKPTQSISQ HHHHCCCCCCCCCCC	53.88	26051181
128	Phosphorylation	NLQKPTQSISQENTN CCCCCCCCCCCCCCC	27.04	28555341
130	Phosphorylation	QKPTQSISQENTNSV CCCCCCCCCCCCCCC	36.37	28555341
150	Acetylation	SWAQLNGKPVGHEGG CHHHHCCCCCCCCCC	35.14	26051181
163	Methylation	GGLRGSSRLLSFSPE CCCCCCCCCCCCCHH	41.15	-
166	Phosphorylation	RGSSRLLSFSPEEFP CCCCCCCCCCHHHCC	28.41	27273156
168	Phosphorylation	SSRLLSFSPEEFPTL CCCCCCCCHHHCCCH	28.20	29255136
174	Phosphorylation	FSPEEFPTLKAAGGQ CCHHHCCCHHHCCCC	46.33	24732914
194	Phosphorylation	EKGVLDLSYGPGPSL CCCCEECCCCCCCCC	27.92	25159151
195	Phosphorylation	KGVLDLSYGPGPSLR CCCEECCCCCCCCCC	34.34	27642862
219	Phosphorylation	GGGRHIISATSLSTS CCCEEEEEEEECCCC	25.54	23927012
221	Phosphorylation	GRHIISATSLSTSPT CEEEEEEEECCCCCC	24.34	22167270
222	Phosphorylation	RHIISATSLSTSPTE EEEEEEEECCCCCCC	21.75	22167270
224	Phosphorylation	IISATSLSTSPTELG EEEEEECCCCCCCCC	26.97	29255136
225	Phosphorylation	ISATSLSTSPTELGS EEEEECCCCCCCCCC	43.98	29255136
226	Phosphorylation	SATSLSTSPTELGSR EEEECCCCCCCCCCC	26.84	29255136
228	Phosphorylation	TSLSTSPTELGSRNS EECCCCCCCCCCCCC	43.54	29255136
232	Phosphorylation	TSPTELGSRNSSTGD CCCCCCCCCCCCCCC	40.70	29255136
235	Phosphorylation	TELGSRNSSTGDGAP CCCCCCCCCCCCCCC	28.32	23312004
236	Phosphorylation	ELGSRNSSTGDGAPS CCCCCCCCCCCCCCC	39.70	21815630
237	Phosphorylation	LGSRNSSTGDGAPSS CCCCCCCCCCCCCCC	38.83	28102081
243	Phosphorylation	STGDGAPSSACTSDS CCCCCCCCCCCCCCC	29.99	23312004
244	Phosphorylation	TGDGAPSSACTSDSK CCCCCCCCCCCCCCC	26.72	21815630
247	Phosphorylation	GAPSSACTSDSKDPS CCCCCCCCCCCCCCC	34.97	23312004
248	Phosphorylation	APSSACTSDSKDPSL CCCCCCCCCCCCCCC	39.51	21815630
250	Phosphorylation	SSACTSDSKDPSLRP CCCCCCCCCCCCCCC	38.43	23312004
250 (in isoform 4)	Phosphorylation	-	38.43	25627689
251	Sumoylation	SACTSDSKDPSLRPA CCCCCCCCCCCCCCC	77.86	28112733
254	Phosphorylation	TSDSKDPSLRPAQPV CCCCCCCCCCCCCCC	47.33	23312004
266	Phosphorylation	QPVRKGASQFMGNVY CCCCCCHHHHCCCCC	32.40	26552605
273	Phosphorylation	SQFMGNVYHPPTYHD HHHCCCCCCCCCHHH	16.77	23403867
277	Phosphorylation	GNVYHPPTYHDMLPA CCCCCCCCHHHCCCH	37.63	26552605
278	Phosphorylation	NVYHPPTYHDMLPAF CCCCCCCHHHCCCHH	11.12	26552605
288	Phosphorylation	MLPAFMCSPKSSENQ CCCHHHCCCCCCCCC	24.47	23403867
291	Phosphorylation	AFMCSPKSSENQGTV HHHCCCCCCCCCCCC	46.39	23403867
292	Phosphorylation	FMCSPKSSENQGTVE HHCCCCCCCCCCCCC	46.85	23403867
297	Phosphorylation	KSSENQGTVERGSFP CCCCCCCCCCCCCCC	14.94	23403867
300	Methylation	ENQGTVERGSFPLPQ CCCCCCCCCCCCCCC	41.54	-
302	Phosphorylation	QGTVERGSFPLPQLR CCCCCCCCCCCCCCE	29.88	28555341
313	Methylation	PQLRLEPRVPFRQFQ CCCEECCCCCCCCEE	39.09	-
381	Phosphorylation	GLHEEVDYSEKLKFS HHHHCCCHHHCCCCC	24.73	29978859
382	Phosphorylation	LHEEVDYSEKLKFSD HHHCCCHHHCCCCCC	24.64	29978859
386	Phosphoglycerylation	VDYSEKLKFSDDEEE CCHHHCCCCCCCHHH	54.62	-
388	Phosphorylation	YSEKLKFSDDEEEEE HHHCCCCCCCHHHHH	42.43	29255136
398	Phosphoglycerylation	EEEEEVVKDGRPKWN HHHHHHHHCCCCCCC	60.69	-
406	Phosphorylation	DGRPKWNSWDPRRQR CCCCCCCCCCHHHHH	31.57	-
416	Phosphorylation	PRRQRQLSMSSADSA HHHHHHHCCCCCCHH	14.31	29255136
418	Phosphorylation	RQRQLSMSSADSADA HHHHHCCCCCCHHHH	20.99	27273156
419	Phosphorylation	QRQLSMSSADSADAK HHHHCCCCCCHHHHH	27.70	29255136
422	Phosphorylation	LSMSSADSADAKRTR HCCCCCCHHHHHHHH	27.97	29255136
442	Phosphorylation	WAEAVGASRVVRKAP HHHHHCCHHHHCCCC	21.49	-
467	Phosphorylation	GWAPGPDYQKSSMGS CCCCCCCCCCCCHHH	22.45	25159151
474	Phosphorylation	YQKSSMGSMFRQQSI CCCCCHHHHHHHHCC	13.20	29514088
480	Phosphorylation	GSMFRQQSIEDKEDK HHHHHHHCCCCCCCC	21.43	29255136
499	Sulfoxidation	QKFIQSEMSEAVERA HHHHHHHHHHHHHHH	5.48	21406390
500	Phosphorylation	KFIQSEMSEAVERAR HHHHHHHHHHHHHHH	20.53	30576142
528	Acetylation	RLAACAAKLKQLDQK HHHHHHHHHHHHHHH	37.38	25953088
528	Ubiquitination	RLAACAAKLKQLDQK HHHHHHHHHHHHHHH	37.38	-
556	O-linked_Glycosylation	AEKEVPWSPSAEKAS HHHCCCCCCCHHHCC	11.69	30059200
556	Phosphorylation	AEKEVPWSPSAEKAS HHHCCCCCCCHHHCC	11.69	25159151
558	Phosphorylation	KEVPWSPSAEKASPQ HCCCCCCCHHHCCCC	43.47	30266825
563	Phosphorylation	SPSAEKASPQENGPA CCCHHHCCCCCCCCC	37.88	30266825
575	Phosphorylation	GPAVHKGSPEFPAQE CCCCCCCCCCCCCCC	26.51	25159151
585	Phosphorylation	FPAQETPTTFPEEAP CCCCCCCCCCCCCCC	48.79	28348404
586	Phosphorylation	PAQETPTTFPEEAPT CCCCCCCCCCCCCCC	38.09	28348404
593	Phosphorylation	TFPEEAPTVSPAVAQ CCCCCCCCCCHHHHC	40.44	25850435
595	Phosphorylation	PEEAPTVSPAVAQSN CCCCCCCCHHHHCCC	15.04	25850435
601	Phosphorylation	VSPAVAQSNSSEEEA CCHHHHCCCCCHHHH	29.01	25850435
603	Phosphorylation	PAVAQSNSSEEEARE HHHHCCCCCHHHHHH	44.36	26471730
604	Phosphorylation	AVAQSNSSEEEAREA HHHCCCCCHHHHHHC	53.96	30576142
613	Phosphorylation	EEAREAGSPAQEFKY HHHHHCCCHHHHHHH	24.90	29255136
623	Phosphorylation	QEFKYQKSLPPRFQR HHHHHHHCCCHHHHH	30.50	24719451
641	Phosphorylation	QQQQEQLYKMQHWQP HHHHHHHHHHHCCCC	12.24	22817900
673	Methylation	QMLGFDPRWMMMPSY HHCCCCCCCCCCCCC	35.45	-
684	Methylation	MPSYMDPRITPTRTP CCCCCCCCCCCCCCC	40.94	-
686	Phosphorylation	SYMDPRITPTRTPVD CCCCCCCCCCCCCCC	21.64	22199227
688	Phosphorylation	MDPRITPTRTPVDFY CCCCCCCCCCCCCCC	38.23	22199227
690	Phosphorylation	PRITPTRTPVDFYPS CCCCCCCCCCCCCCC	30.09	22199227
695	Phosphorylation	TRTPVDFYPSALHPS CCCCCCCCCCCCCCC	7.57	22199227
717	Phosphorylation	PQESLNGTGCRSEDQ CHHHHCCCCCCCCCC	31.84	25332170
721	Phosphorylation	LNGTGCRSEDQNCVP HCCCCCCCCCCCCCC	49.99	28674419
734	Sumoylation	VPPLQERKVTPIDSP CCCCCCCCCCCCCCC	50.11	28112733
736	Phosphorylation	PLQERKVTPIDSPPV CCCCCCCCCCCCCCC	19.98	21712546
740	Phosphorylation	RKVTPIDSPPVWSPE CCCCCCCCCCCCCCC	31.64	25159151
745	Phosphorylation	IDSPPVWSPEGYMAL CCCCCCCCCCCCCHH	17.20	25159151
749	Phosphorylation	PVWSPEGYMALQSKG CCCCCCCCCHHHCCC	4.23	28450419
754	Phosphorylation	EGYMALQSKGYPLPH CCCCHHHCCCCCCCC	28.97	25850435
755	Ubiquitination	GYMALQSKGYPLPHP CCCHHHCCCCCCCCC	49.88	-
757	Phosphorylation	MALQSKGYPLPHPKS CHHHCCCCCCCCCCC	12.82	20068231
764	Phosphorylation	YPLPHPKSSDTLAMD CCCCCCCCCCCEEEE	37.59	23401153
764 (in isoform 5)	Phosphorylation	-	37.59	25159151
765	Phosphorylation	PLPHPKSSDTLAMDM CCCCCCCCCCEEEEE	40.52	25159151
765 (in isoform 5)	Phosphorylation	-	40.52	25159151
767	Phosphorylation	PHPKSSDTLAMDMRV CCCCCCCCEEEEEEC	20.54	28985074
776	Phosphorylation	AMDMRVRNESSFSAS EEEEECCCHHHHHHH	51.12	18669648
776 (in isoform 5)	Phosphorylation	-	51.12	25159151
778	Phosphorylation	DMRVRNESSFSASLG EEECCCHHHHHHHHH	39.99	25159151
779	Phosphorylation	MRVRNESSFSASLGR EECCCHHHHHHHHHC	19.62	25159151
781	Phosphorylation	VRNESSFSASLGRAG CCCHHHHHHHHHCCC	20.92	26462736
783	Phosphorylation	NESSFSASLGRAGGV CHHHHHHHHHCCCCC	30.11	21815630
786	Methylation	SFSASLGRAGGVSAQ HHHHHHHCCCCCHHH	35.04	-
786	Phosphorylation	SFSASLGRAGGVSAQ HHHHHHHCCCCCHHH	35.04	18669648
786 (in isoform 5)	Phosphorylation	-	35.04	28450419
789 (in isoform 5)	Phosphorylation	-	14.82	25850435
790	Phosphorylation	SLGRAGGVSAQRDLF HHHCCCCCHHHHHHH	4.13	18220336
790 (in isoform 5)	Phosphorylation	-	4.13	25850435
792 (in isoform 5)	Phosphorylation	-	13.16	27732954
795	Phosphorylation	GGVSAQRDLFEERGE CCCHHHHHHHHHHHH	43.56	18220336
795 (in isoform 5)	Phosphorylation	-	43.56	25850435
797	Phosphorylation	VSAQRDLFEERGEEY CHHHHHHHHHHHHHH	12.26	18669648
797 (in isoform 5)	Phosphorylation	-	12.26	27732954
804	Phosphorylation	FEERGEEYLSAFDKK HHHHHHHHHHHHHHH	11.14	28674151
810	Ubiquitination	EYLSAFDKKAQADFD HHHHHHHHHHHCCHH	43.48	-
847	Phosphorylation	AGAPGGHTQNLRCSP CCCCCCCCCCCCCCC	23.56	25159151
853	Phosphorylation	HTQNLRCSPLEPDFV CCCCCCCCCCCCCCC	26.53	29255136
870	Phosphorylation	EKKPECGSWDVSHQP CCCCCCCCCCCCCCC	31.59	-
874	Phosphorylation	ECGSWDVSHQPETAD CCCCCCCCCCCCCCC	17.58	-
890	Phosphorylation	AHGVERETPREGTAF CCCCCCCCCCCCCCE	33.59	28555341
895	Phosphorylation	RETPREGTAFNISSW CCCCCCCCCEECCCC	24.27	23401153
900	Phosphorylation	EGTAFNISSWDKNGS CCCCEECCCCCCCCC	26.87	22210691
901	Phosphorylation	GTAFNISSWDKNGSP CCCEECCCCCCCCCC	35.18	28464451
907	Phosphorylation	SSWDKNGSPNKQPSS CCCCCCCCCCCCCCC	34.39	23401153
913	Phosphorylation	GSPNKQPSSEPEWTP CCCCCCCCCCCCCCC	44.85	30266825
914	Phosphorylation	SPNKQPSSEPEWTPE CCCCCCCCCCCCCCC	64.95	30266825
919	Phosphorylation	PSSEPEWTPEPRSSS CCCCCCCCCCCCCCC	18.99	21815630
925	Phosphorylation	WTPEPRSSSSQHPEQ CCCCCCCCCCCCHHH	34.98	-
936	Phosphorylation	HPEQTGRTRRSGPIK CHHHCCCCCCCCCCC	31.60	-
939	Phosphorylation	QTGRTRRSGPIKKPV HCCCCCCCCCCCHHH	45.70	26055452
963	Sumoylation	EKELEKIKQELGEES HHHHHHHHHHHHHHH	49.11	-
963	Sumoylation	EKELEKIKQELGEES HHHHHHHHHHHHHHH	49.11	28112733
980	Phosphorylation	LAKEKEQSPTAEKDE HHHHHHCCCCCCCCC	25.88	30576142
982	Phosphorylation	KEKEQSPTAEKDEDE HHHHCCCCCCCCCCC	53.33	30576142
994	Phosphorylation	EDEENDASLANSSTT CCCCCCHHHCCCCCC	30.77	20873877
997	Phosphorylation	ENDASLANSSTTTLE CCCHHHCCCCCCCCC	41.61	18669648
998	Phosphorylation	NDASLANSSTTTLED CCHHHCCCCCCCCCC	35.80	25159151
999	Phosphorylation	DASLANSSTTTLEDK CHHHCCCCCCCCCCC	29.58	25159151
1000	Phosphorylation	ASLANSSTTTLEDKG HHHCCCCCCCCCCCC	24.50	23090842
1001	Phosphorylation	SLANSSTTTLEDKGP HHCCCCCCCCCCCCC	31.19	23090842
1002	Phosphorylation	LANSSTTTLEDKGPG HCCCCCCCCCCCCCC	28.39	23090842
1006	Ubiquitination	STTTLEDKGPGHATF CCCCCCCCCCCCCCC	58.59	-
1086	Phosphorylation	RPAGGNGSGLCGGGV CCCCCCCCCCCCCCC	32.37	28555341
1097	Methylation	GGGVLGARSIYCSSQ CCCCCCCCEEEECCC	23.07	-
1100	Phosphorylation	VLGARSIYCSSQRSG CCCCCEEEECCCCCC	6.37	-
1106	Phosphorylation	IYCSSQRSGRGRGLR EEECCCCCCCCCCHH	25.79	28387310
1108	Methylation	CSSQRSGRGRGLREF ECCCCCCCCCCHHHH	32.64	-
1110	Methylation	SQRSGRGRGLREFAR CCCCCCCCCHHHHCC	39.34	-
1113	Methylation	SGRGRGLREFARPED CCCCCCHHHHCCCCC	39.55	-
1132	Phosphorylation	KPRRRVASETHSEGS CCCCCCCCCCCCCCC	39.92	29255136
1134	Phosphorylation	RRRVASETHSEGSEY CCCCCCCCCCCCCCH	28.36	23401153
1136	Phosphorylation	RVASETHSEGSEYEE CCCCCCCCCCCCHHH	51.58	29255136
1139	Phosphorylation	SETHSEGSEYEELPK CCCCCCCCCHHHHCH	32.71	23401153
1141	Phosphorylation	THSEGSEYEELPKRR CCCCCCCHHHHCHHH	19.19	27273156
1149	Phosphorylation	EELPKRRRQRGSENG HHHCHHHHHHCCCCC	34.28	18669648
1153	Phosphorylation	KRRRQRGSENGNEGS HHHHHHCCCCCCCCC	30.03	28985074
1160	Phosphorylation	SENGNEGSLLEREES CCCCCCCCHHHHHHH	24.49	21815630
1167	Phosphorylation	SLLEREESTLKKGDC CHHHHHHHHCCCCCC	34.00	29449344
1168	Phosphorylation	LLEREESTLKKGDCR HHHHHHHHCCCCCCH	45.97	29449344
1185	Phosphorylation	WRSNKGCSEDHSGLD HHCCCCCCCCCCCCC	55.52	25849741
1189	Phosphorylation	KGCSEDHSGLDAKSR CCCCCCCCCCCHHHC	54.06	29396449
1210	Phosphorylation	RALPPRLSNCGYGRR CCCCCCHHCCCCCCC	31.21	28555341
1221	Phosphorylation	YGRRTFVSKESPHWQ CCCCEECCCCCCCCC	26.89	29978859
1224	Phosphorylation	RTFVSKESPHWQSKS CEECCCCCCCCCCCC	26.29	29978859
1229	Phosphorylation	KESPHWQSKSPGSSW CCCCCCCCCCCCCCH	29.88	27251275
1230	Ubiquitination	ESPHWQSKSPGSSWQ CCCCCCCCCCCCCHH	45.64	-
1231	Phosphorylation	SPHWQSKSPGSSWQE CCCCCCCCCCCCHHH	39.48	25159151
1234	Phosphorylation	WQSKSPGSSWQEYGP CCCCCCCCCHHHHCC	31.61	25159151
1235	Phosphorylation	QSKSPGSSWQEYGPS CCCCCCCCHHHHCCC	38.40	25262027
1239	Phosphorylation	PGSSWQEYGPSDTCG CCCCHHHHCCCCCCC	21.16	27251275
1242	Phosphorylation	SWQEYGPSDTCGSRR CHHHHCCCCCCCCCC	40.98	27251275
1244	Phosphorylation	QEYGPSDTCGSRRPT HHHCCCCCCCCCCCC	24.09	27251275
1247	Phosphorylation	GPSDTCGSRRPTDRD CCCCCCCCCCCCCCC	27.54	27251275
1251	Phosphorylation	TCGSRRPTDRDYVPD CCCCCCCCCCCCCCH	41.68	28555341
1281	Phosphorylation	SRAEDKRSFFQDEHV CCCCHHHHHCCCHHH	35.83	28555341
1291	Phosphorylation	QDEHVADSENAENRP CCHHHCCCCCCCCCC	24.02	28555341
1297	Methylation	DSENAENRPFRRRRP CCCCCCCCCCCCCCC	24.20	-
1351	Phosphorylation	KLCSGDKSGTVGRRS CCCCCCCCCCCCCCC	44.42	21406692
1353	Phosphorylation	CSGDKSGTVGRRSPE CCCCCCCCCCCCCCC	27.21	21406692
1358	Phosphorylation	SGTVGRRSPELSYQN CCCCCCCCCCCCCCC	22.74	28450419
1362	Phosphorylation	GRRSPELSYQNSSDH CCCCCCCCCCCCCCC	24.02	28450419
1363	Phosphorylation	RRSPELSYQNSSDHA CCCCCCCCCCCCCCC	25.08	28450419
1366	Phosphorylation	PELSYQNSSDHANEE CCCCCCCCCCCCCHH	22.93	21406692
1367	Phosphorylation	ELSYQNSSDHANEEW CCCCCCCCCCCCHHH	40.75	21406692
1376	Phosphorylation	HANEEWETASESSDF CCCHHHHHHHHCCCH	36.23	21406692
1378	Phosphorylation	NEEWETASESSDFSE CHHHHHHHHCCCHHH	45.49	21406692
1380	Phosphorylation	EWETASESSDFSERR HHHHHHHCCCHHHHH	32.48	21406692
1381	Phosphorylation	WETASESSDFSERRE HHHHHHCCCHHHHHH	38.33	21406692
1384	Phosphorylation	ASESSDFSERRERRE HHHCCCHHHHHHHHC	34.87	21406692
1395	Phosphorylation	ERREGPGSEPDSQVD HHHCCCCCCCCHHCC	49.44	23401153
1399	Phosphorylation	GPGSEPDSQVDGGLS CCCCCCCHHCCCCCC	42.70	30266825
1406	Phosphorylation	SQVDGGLSGASLGEK HHCCCCCCCCCHHHH	35.27	30266825
1409	Phosphorylation	DGGLSGASLGEKKEL CCCCCCCCHHHHHHH	40.19	25850435
1420	Phosphorylation	KKELAKRSFSSQRPV HHHHHHHHCCCCCCC	28.86	30266825
1422	Phosphorylation	ELAKRSFSSQRPVVD HHHHHHCCCCCCCCC	27.14	23401153
1423	Phosphorylation	LAKRSFSSQRPVVDR HHHHHCCCCCCCCCC	28.35	30266825
1432	Phosphorylation	RPVVDRQSRKLEPGG CCCCCCCCCCCCCCC	32.07	21406692
1452	Phosphorylation	VRPGGGDTSPRYESQ CCCCCCCCCCCCCCC	43.86	29255136
1453	Phosphorylation	RPGGGDTSPRYESQQ CCCCCCCCCCCCCCC	16.48	29255136
1456	Phosphorylation	GGDTSPRYESQQNGT CCCCCCCCCCCCCCC	24.26	29496907
1458	Phosphorylation	DTSPRYESQQNGTPL CCCCCCCCCCCCCCC	28.29	22199227
1463	Phosphorylation	YESQQNGTPLKVKRS CCCCCCCCCCEEECC	32.75	21815630
1470	Phosphorylation	TPLKVKRSPDEALPG CCCEEECCCCCCCCC	30.87	23401153
1480	Phosphorylation	EALPGGLSGCSSGSG CCCCCCCCCCCCCCC	40.82	22167270
1483	Phosphorylation	PGGLSGCSSGSGHSP CCCCCCCCCCCCCCH	41.06	22167270
1484	Phosphorylation	GGLSGCSSGSGHSPY CCCCCCCCCCCCCHH	40.84	22167270
1486	Phosphorylation	LSGCSSGSGHSPYAL CCCCCCCCCCCHHHH	34.97	23401153
1489	Phosphorylation	CSSGSGHSPYALERA CCCCCCCCHHHHHHH	24.11	22167270
1491	Phosphorylation	SGSGHSPYALERAAH CCCCCCHHHHHHHHH	27.17	22167270
1500	Phosphorylation	LERAAHASADLPEAS HHHHHHHCCCCCHHH	16.67	28985074
1507	Phosphorylation	SADLPEASSKKAEKE CCCCCHHHHHHHHHH	40.82	20068231
1508	Phosphorylation	ADLPEASSKKAEKEA CCCCHHHHHHHHHHH	45.27	20068231
1510	Ubiquitination	LPEASSKKAEKEAKL CCHHHHHHHHHHHHH	64.82	17203973
1595	Phosphorylation	PVKGRGLSSRIPPRF CCCCCCHHHCCCHHH	22.01	21406692
1596	Phosphorylation	VKGRGLSSRIPPRFA CCCCCHHHCCCHHHH	38.99	21406692
1647	Ubiquitination	PANDSWRKAVTAFSS CCCCHHHHHHHHHCC	40.73	-
1654	Phosphorylation	KAVTAFSSTETGSAE HHHHHHCCCCCCCHH	24.65	30576142
1666	Phosphorylation	SAEQGFKSSQGDSGV CHHHCCCCCCCCCCC	26.15	30576142
1667	Phosphorylation	AEQGFKSSQGDSGVD HHHCCCCCCCCCCCC	38.48	21815630
1671	Phosphorylation	FKSSQGDSGVDLSAE CCCCCCCCCCCCCHH	47.76	25159151
1676	Phosphorylation	GDSGVDLSAESRESS CCCCCCCCHHHHCCC	26.06	21815630
1679	Phosphorylation	GVDLSAESRESSATS CCCCCHHHHCCCCCC	40.85	21815630
1682	Phosphorylation	LSAESRESSATSSQR CCHHHHCCCCCCCCC	24.94	30576142
1683	Phosphorylation	SAESRESSATSSQRS CHHHHCCCCCCCCCC	30.71	30576142
1685	Phosphorylation	ESRESSATSSQRSSP HHHCCCCCCCCCCCC	30.75	30278072
1686	Phosphorylation	SRESSATSSQRSSPY HHCCCCCCCCCCCCC	24.96	30278072
1687	Phosphorylation	RESSATSSQRSSPYG HCCCCCCCCCCCCCC	25.84	30576142
1690	Phosphorylation	SATSSQRSSPYGTLK CCCCCCCCCCCCCCC	28.20	23401153
1691	Phosphorylation	ATSSQRSSPYGTLKP CCCCCCCCCCCCCCH	25.08	30278072
1693	Phosphorylation	SSQRSSPYGTLKPEE CCCCCCCCCCCCHHH	25.37	30278072
1695	Phosphorylation	QRSSPYGTLKPEEMS CCCCCCCCCCHHHHC	26.26	30278072
1702	Phosphorylation	TLKPEEMSGPGLAEP CCCHHHHCCCCCCCC	45.15	28985074
1747	Phosphorylation	GPIGNERSLKNRKGS CCCCCHHHHCCCCCC	37.20	-
1754	Phosphorylation	SLKNRKGSEGAERLQ HHCCCCCCHHHHHHC	35.57	26699800
1789	Phosphorylation	PPIEFGVSPKDSDFS CCEECCCCCCCCCCC	26.98	25159151
1793	O-linked_Glycosylation	FGVSPKDSDFSLPPG CCCCCCCCCCCCCCC	46.83	30059200
1796	O-linked_Glycosylation	SPKDSDFSLPPGSAS CCCCCCCCCCCCCCC	44.98	30059200
1801	O-linked_Glycosylation	DFSLPPGSASGPTGS CCCCCCCCCCCCCCC	25.65	30059200
1801	Phosphorylation	DFSLPPGSASGPTGS CCCCCCCCCCCCCCC	25.65	25850435
1803	Phosphorylation	SLPPGSASGPTGSPV CCCCCCCCCCCCCCC	47.18	25850435
1806	Phosphorylation	PGSASGPTGSPVVKL CCCCCCCCCCCCEEH	54.54	21815630
1808	Phosphorylation	SASGPTGSPVVKLQD CCCCCCCCCCEEHHH	19.59	26462736
1819	Phosphorylation	KLQDALASNAGLTQS EHHHHHHHCCCCCCC	28.23	28555341
1826	Phosphorylation	SNAGLTQSIPILRRD HCCCCCCCCHHHCCC	25.70	25159151
1843	Phosphorylation	IQRAIGLSPMSFPTA HHHHHCCCCCCCCCC	17.22	21712546
1846	Phosphorylation	AIGLSPMSFPTADLT HHCCCCCCCCCCCEE	31.30	22199227
1849	Phosphorylation	LSPMSFPTADLTLKM CCCCCCCCCCEECCH	30.69	27251275
1853	Phosphorylation	SFPTADLTLKMESAR CCCCCCEECCHHHHH	25.53	27251275
1858	Phosphorylation	DLTLKMESARKAWEN CEECCHHHHHHHHHC	29.85	17081983
1976	Methylation	AQAQLGLRGGLPVSQ HHHHHCCCCCCCCCH	35.02	-
1982	O-linked_Glycosylation	LRGGLPVSQSQEIFS CCCCCCCCHHHHHHH	23.36	30059200
1984	O-linked_Glycosylation	GGLPVSQSQEIFSSL CCCCCCHHHHHHHHC	23.44	30059200
1984	Phosphorylation	GGLPVSQSQEIFSSL CCCCCCHHHHHHHHC	23.44	28348404
1989	O-linked_Glycosylation	SQSQEIFSSLQPFRS CHHHHHHHHCCCCCC	35.48	30059200
1990	O-linked_Glycosylation	QSQEIFSSLQPFRSQ HHHHHHHHCCCCCCC	21.92	30059200
2003	Phosphorylation	SQVYMHPSLSPPSTM CCCCCCCCCCCCCEE	27.14	26074081
2005	Phosphorylation	VYMHPSLSPPSTMIL CCCCCCCCCCCEEEE	38.82	26074081
2083	Phosphorylation	LTMPLPRYGSGQQPL CCCCCCCCCCCCCCE	17.44	24043423
2085	Phosphorylation	MPLPRYGSGQQPLIL CCCCCCCCCCCCEEC	25.21	24043423
2095	Phosphorylation	QPLILPQSIQLPPGQ CCEECCCCCCCCCCC	15.46	24043423
2103	Phosphorylation	IQLPPGQSLSVGAPR CCCCCCCCCCCCCCC	28.64	24043423
2105	Phosphorylation	LPPGQSLSVGAPRRI CCCCCCCCCCCCCCC	24.61	24043423
2110	Methylation	SLSVGAPRRIPPPGS CCCCCCCCCCCCCCC	48.94	-
2153	Phosphorylation	PSGGPVPSPQTYRPS CCCCCCCCCCCCCCC	29.85	21815630
2156	Phosphorylation	GPVPSPQTYRPSSAS CCCCCCCCCCCCCCC	25.53	29978859
2160	Phosphorylation	SPQTYRPSSASPSGK CCCCCCCCCCCCCCC	29.54	25627689
2161	Phosphorylation	PQTYRPSSASPSGKP CCCCCCCCCCCCCCC	35.13	25627689
2163	Phosphorylation	TYRPSSASPSGKPSG CCCCCCCCCCCCCCC	22.88	25627689
2169	Phosphorylation	ASPSGKPSGSAVNMG CCCCCCCCCCCCCHH	49.19	20068231
2171	Phosphorylation	PSGKPSGSAVNMGSV CCCCCCCCCCCHHHC	33.12	20068231
2177	Phosphorylation	GSAVNMGSVQGHYVQ CCCCCHHHCCHHHHH	10.66	20068231
2182	Phosphorylation	MGSVQGHYVQQAKQR HHHCCHHHHHHHHHH	13.53	20068231
2195	Phosphorylation	QRVDEKPSLGAVKLQ HHCCCCCCCCCEEHH	50.97	25841592
2211	Sulfoxidation	APSAASQMKRTGAIK CCCHHHHHHHHCCCC	2.69	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
166	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRC2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRC2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KLH15_HUMAN	KLHL15	physical	26186194
ZER1_HUMAN	ZER1	physical	26186194
PLOD1_HUMAN	PLOD1	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRC2B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND SER-388, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388, AND MASSSPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-168; SER-226;SER-388; SER-416; THR-736; SER-740; SER-745; SER-1470; TYR-1491 ANDSER-1843, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226; SER-1470; SER-1484AND SER-1489, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613, AND MASSSPECTROMETRY.	19007248 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND SER-168, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-388 ANDSER-613, AND MASS SPECTROMETRY.	17081983 [Abstract]
Ubiquitylation
Reference	PubMed
"The proteomic reactor facilitates the analysis of affinity-purifiedproteins by mass spectrometry: application for identifyingubiquitinated proteins in human cells."; Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M.,Haines D.S., Figeys D.; J. Proteome Res. 6:298-305(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1510, AND MASSSPECTROMETRY.	17203973 [Abstract]