dbPTM

PKHG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKHG1_HUMAN
UniProt AC	Q9ULL1
Protein Name	Pleckstrin homology domain-containing family G member 1
Gene Name	PLEKHG1
Organism	Homo sapiens (Human).
Sequence Length	1385
Subcellular Localization
Protein Description
Protein Sequence	MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPENPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGSGDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPGSVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPSDVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQIATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNTLHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	LIPARPFSSSELQRD EEECCCCCCHHHCCC	35.32	24719451
65	Phosphorylation	PARPFSSSELQRDNP ECCCCCCHHHCCCCC	40.92	18491316
101	Phosphorylation	DSNGAPKTIADSATS CCCCCCCCHHHCCCC	21.97	23403867
105	Phosphorylation	APKTIADSATSPKLL CCCCHHHCCCCCCEE	25.15	23403867
107	Phosphorylation	KTIADSATSPKLLYV CCHHHCCCCCCEEHH	49.90	23403867
108	Phosphorylation	TIADSATSPKLLYVD CHHHCCCCCCEEHHH	21.54	23403867
234	Phosphorylation	FFRERQETLKHSLPL HHHHHHHHHHHCCCC	32.54	22210691
243	Phosphorylation	KHSLPLGSYLLKPVQ HHCCCCCHHHHHHHH	21.93	24719451
244	Phosphorylation	HSLPLGSYLLKPVQR HCCCCCHHHHHHHHH	17.79	24719451
445	Phosphorylation	HHPGFCYSPEGGTKA CCCCEEECCCCCCEE	20.04	25159151
469	Phosphorylation	PYRLRRKSEPSSRSH CCCCCCCCCCCHHCC	53.59	-
492	Phosphorylation	AQDIQKVSREEGSPQ HHHHHHHHHHCCCCC	40.80	23312004
497	Phosphorylation	KVSREEGSPQLSSAR HHHHHCCCCCCCCCC	16.86	26657352
501	Phosphorylation	EEGSPQLSSARPSPA HCCCCCCCCCCCCHH	19.39	22210691
502	Phosphorylation	EGSPQLSSARPSPAQ CCCCCCCCCCCCHHH	36.57	22210691
506	Phosphorylation	QLSSARPSPAQRNSQ CCCCCCCCHHHCCCC	27.58	23312004
512	Phosphorylation	PSPAQRNSQPSSSTM CCHHHCCCCCCHHHH	45.73	28450419
515	Phosphorylation	AQRNSQPSSSTMISV HHCCCCCCHHHHHHH	29.32	28450419
516	Phosphorylation	QRNSQPSSSTMISVL HCCCCCCHHHHHHHH	36.19	24114839
517	Phosphorylation	RNSQPSSSTMISVLR CCCCCCHHHHHHHHH	26.74	22210691
518	Phosphorylation	NSQPSSSTMISVLRA CCCCCHHHHHHHHHH	22.07	28450419
521	Phosphorylation	PSSSTMISVLRAGGA CCHHHHHHHHHHCCH	12.32	28450419
548	Phosphorylation	ALFPSRRSPQENEDD HHCCCCCCCCCCCCC	29.80	28348404
559	Phosphorylation	NEDDEDDYQMFVPSF CCCCCCHHHHHCCCC	17.75	27259358
580	Phosphorylation	STRLCEDSTSSRPCS CCCCCCCCCCCCCCC	14.11	27251275
581	Phosphorylation	TRLCEDSTSSRPCSW CCCCCCCCCCCCCCE	42.94	22210691
582	Phosphorylation	RLCEDSTSSRPCSWH CCCCCCCCCCCCCEE	28.44	28857561
583	Phosphorylation	LCEDSTSSRPCSWHM CCCCCCCCCCCCEEE	40.09	28857561
600	Phosphorylation	MESTETSSSGHRIVR CCCCCCCCCCCCEEE	48.00	22210691
601	Phosphorylation	ESTETSSSGHRIVRR CCCCCCCCCCCEEEE	38.08	22210691
610	Phosphorylation	HRIVRRASSAGESNT CCEEEEHHCCCCCCC	20.93	30266825
611	Phosphorylation	RIVRRASSAGESNTC CEEEEHHCCCCCCCC	39.03	26657352
615	Phosphorylation	RASSAGESNTCPPEI EHHCCCCCCCCCCCC	36.20	30266825
617	Phosphorylation	SSAGESNTCPPEIGT HCCCCCCCCCCCCCC	35.35	23403867
634	Phosphorylation	RTRELQNSPKTEGQE HHHHHHCCCCCCCCC	18.14	23312004
637	Phosphorylation	ELQNSPKTEGQEEMT HHHCCCCCCCCCCCC	49.05	25072903
644	Phosphorylation	TEGQEEMTPFGSSIE CCCCCCCCCCCCEEE	20.81	25072903
648	Phosphorylation	EEMTPFGSSIELTID CCCCCCCCEEEEEEC	28.64	25072903
649	Phosphorylation	EMTPFGSSIELTIDD CCCCCCCEEEEEECC	22.06	25072903
653	Phosphorylation	FGSSIELTIDDIDHV CCCEEEEEECCCCHH	15.01	25072903
661	Phosphorylation	IDDIDHVYDNISYED ECCCCHHCCCCCHHH	10.39	25072903
665	Phosphorylation	DHVYDNISYEDLKLM CHHCCCCCHHHHHHH	28.82	25072903
666	Phosphorylation	HVYDNISYEDLKLMV HHCCCCCHHHHHHHH	15.07	25072903
681	Phosphorylation	AKREEAESTPSKSAR HCHHHHCCCCCCCHH	53.30	-
682	Phosphorylation	KREEAESTPSKSARD CHHHHCCCCCCCHHH	24.08	28985074
690	Phosphorylation	PSKSARDSVRPKSTP CCCCHHHCCCCCCCH	17.93	24719451
695	Phosphorylation	RDSVRPKSTPELAFT HHCCCCCCCHHHCEE	52.45	28985074
696	Phosphorylation	DSVRPKSTPELAFTK HCCCCCCCHHHCEEC	27.23	23403867
864	Phosphorylation	LLAAFPVSKDDVPDR HHHHCCCCCCCCCCC	30.52	22468782
876	Phosphorylation	PDRLHAESTPELSRD CCCCCCCCCHHHHHH	50.47	28857561
877	Phosphorylation	DRLHAESTPELSRDV CCCCCCCCHHHHHHC	16.58	28348404
881	Phosphorylation	AESTPELSRDVGRSV CCCCHHHHHHCCCCC	25.44	27251275
887	Phosphorylation	LSRDVGRSVSTLSLP HHHHCCCCCCCCCCC	17.94	28857561
889	Phosphorylation	RDVGRSVSTLSLPES HHCCCCCCCCCCCHH	25.52	24719451
890	Phosphorylation	DVGRSVSTLSLPESQ HCCCCCCCCCCCHHH	20.43	28857561
892	Phosphorylation	GRSVSTLSLPESQAL CCCCCCCCCCHHHHH	41.80	26657352
896	Phosphorylation	STLSLPESQALLTPV CCCCCCHHHHHCCCH	20.86	30087585
901	Phosphorylation	PESQALLTPVKSRAG CHHHHHCCCHHHHCC	27.21	27050516
923	Phosphorylation	PFEEDLISKEGSFMS CCHHHCCCCCCCCHH	31.77	27251275
927	Phosphorylation	DLISKEGSFMSLNRL HCCCCCCCCHHHHCH	20.90	23312004
930	Phosphorylation	SKEGSFMSLNRLSLA CCCCCCHHHHCHHHC	22.08	23312004
938	Phosphorylation	LNRLSLASEMPLMDN HHCHHHCCCCCCCCC	39.46	-
947	Phosphorylation	MPLMDNPYDLANSGL CCCCCCHHHHHHCCC	29.82	27642862
984	Phosphorylation	FMMARQYSQKIKKAN HHHHHHHHHHHHHHH	19.36	24719451
998	Phosphorylation	NQLLKVKSLELEQPP HHHHCCEEEECCCCC	30.02	23403867
1007	Phosphorylation	ELEQPPASQHQKSMH ECCCCCHHHHHHHHH	33.69	23403867
1042	Phosphorylation	IAEYSQLYDQIVFRE HHHHHHHHHEECCCC	9.73	27273156
1050	Phosphorylation	DQIVFRESPLKIQKD HEECCCCCCCCCCCC	31.14	24719451
1061	Phosphorylation	IQKDGWASPQESSLL CCCCCCCCHHHHHCC	22.17	28355574
1066	Phosphorylation	WASPQESSLLRSVSP CCCHHHHHCCCCCCH	30.58	24719451
1109	Phosphorylation	EQDLRSRYPTFEINT HHHHHHHCCEEEECC	14.10	20090780
1124	Phosphorylation	KSTPRQLSAACSVPS CCCHHHHHHHHCCCC	12.89	28348404
1128	Phosphorylation	RQLSAACSVPSLQTS HHHHHHHCCCCCCCC	32.13	27050516
1146	Phosphorylation	PGSVQRCSVVVSQPN CCCEEEEEEEEECCC	21.82	27251275
1150	Phosphorylation	QRCSVVVSQPNKENW EEEEEEEECCCCCCH	28.45	22817900
1163	Phosphorylation	NWCQDHLYNSLGRKG CHHHHHHHHHHCCCC	10.17	23403867
1165	Phosphorylation	CQDHLYNSLGRKGIS HHHHHHHHHCCCCCC	20.74	23403867
1172	Phosphorylation	SLGRKGISAKSQPYH HHCCCCCCCCCCCCC	38.01	-
1175	Phosphorylation	RKGISAKSQPYHRSQ CCCCCCCCCCCCCCC	35.78	18077418
1178	Phosphorylation	ISAKSQPYHRSQSSS CCCCCCCCCCCCCCC	11.39	-
1181	Phosphorylation	KSQPYHRSQSSSSVL CCCCCCCCCCCCCEE	22.54	23403867
1183	Phosphorylation	QPYHRSQSSSSVLIN CCCCCCCCCCCEEEE	33.17	25159151
1184	Phosphorylation	PYHRSQSSSSVLINK CCCCCCCCCCEEEEC	20.99	23403867
1185	Phosphorylation	YHRSQSSSSVLINKS CCCCCCCCCEEEECC	29.70	23403867
1186	Phosphorylation	HRSQSSSSVLINKSM CCCCCCCCEEEECCC	23.92	28857561
1192	Phosphorylation	SSVLINKSMDSINYP CCEEEECCCCCCCCC	24.27	25159151
1195	Phosphorylation	LINKSMDSINYPSDV EEECCCCCCCCCCCC	12.23	23312004
1198	Phosphorylation	KSMDSINYPSDVGKQ CCCCCCCCCCCCCHH	11.48	28122231
1200	Phosphorylation	MDSINYPSDVGKQQL CCCCCCCCCCCHHHH	34.27	28122231
1209	Phosphorylation	VGKQQLLSLHRSSRC CCHHHHHHHHHHCCC	30.62	30576142
1218	Phosphorylation	HRSSRCESHQDLLPD HHHCCCHHHHHHHHH	30.03	27251275
1245	Phosphorylation	SDLTLQDSQKVVVVN HCCCCCCCCEEEEEE	20.95	17525332
1247	Acetylation	LTLQDSQKVVVVNRN CCCCCCCEEEEEECC	40.73	20167786
1263	Phosphorylation	PLNAQIATQNYFSNF CCCCEECCCCHHHCC	20.98	29978859
1266	Phosphorylation	AQIATQNYFSNFKET CEECCCCHHHCCCCC	9.89	27642862
1273	Phosphorylation	YFSNFKETDGDEDDY HHHCCCCCCCCCCCC	45.96	26471730
1280	Phosphorylation	TDGDEDDYVEIKSEE CCCCCCCCEEEECCC	16.59	27642862
1285	Phosphorylation	DDYVEIKSEEDESEL CCCEEEECCCCCCHH	52.45	26657352
1290	Phosphorylation	IKSEEDESELELSHN EECCCCCCHHHHCCC	60.86	27642862
1295	Phosphorylation	DESELELSHNRRRKS CCCHHHHCCCCCCCC	14.89	22985185
1317	Phosphorylation	DFSDNVCSGNTLHSL CCCCCCCCCCCHHHC	30.69	27251275
1320	Phosphorylation	DNVCSGNTLHSLNSP CCCCCCCCHHHCCCC	29.40	27251275
1323	Phosphorylation	CSGNTLHSLNSPRTP CCCCCHHHCCCCCCC	32.15	25159151
1326	Phosphorylation	NTLHSLNSPRTPKKP CCHHHCCCCCCCCCC	22.50	25159151
1341	Phosphorylation	VNSKLGLSPYLTPYN CCCCCCCCCCCCCCC	15.08	25159151
1345	Phosphorylation	LGLSPYLTPYNDSDK CCCCCCCCCCCCHHH	20.20	25159151
1362	Phosphorylation	DYLWRGPSPNQQNIV HCCCCCCCCCHHHHH	39.03	25159151
1371	Phosphorylation	NQQNIVQSLREKFQC CHHHHHHHHHHHHHH	20.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PKHG1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKHG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKHG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PKHG1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKHG1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1192, AND MASSSPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1245, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1150, AND MASSSPECTROMETRY.	17081983 [Abstract]