LZTS3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LZTS3_HUMAN
• UniProt AC: O60299
• Protein Name: Leucine zipper putative tumor suppressor 3 {ECO:0000305}
• Gene Name: LZTS3 {ECO:0000312|HGNC:HGNC:30139}
• Organism: Homo sapiens (Human).
• Sequence Length: 673
• Subcellular Localization: Cell junction, synapse . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cytoplasm, cytoskeleton . Detected at synapses, postsynaptic density, synaptic spines and dendrites. Rather found at excitatory than inhibitory synaps
• Protein Description: May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses..
• Protein Sequence: MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSGEGGGGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAWTPSRLERIESTEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MAKLETLPVR -----CCCCCCCCCC		25953088
6	Phosphorylation	--MAKLETLPVRADP --CCCCCCCCCCCCC		-
86	Phosphorylation	SRERPGRYPSEDKGL CCCCCCCCCCCCCCC		29514088
88	Phosphorylation	ERPGRYPSEDKGLAN CCCCCCCCCCCCCCC		29514088
135	Phosphorylation	SDKAPPQYREPSHPP CCCCCCCCCCCCCCC		20873877
139	Phosphorylation	PPQYREPSHPPKLLA CCCCCCCCCCCCCEE		20873877
147	Phosphorylation	HPPKLLATSGKLDQC CCCCCEECCCCCCCC		20873877
148	Phosphorylation	PPKLLATSGKLDQCS CCCCEECCCCCCCCC		20873877
174	Phosphorylation	VVPKNFHSMQNLCPP CCCCCHHHHHCCCCC		28348404
212	Phosphorylation	TMTPAGGSGSGLSDS EECCCCCCCCCCCCC		27251275
217	Phosphorylation	GGSGSGLSDSGRNSL CCCCCCCCCCCCCCC		24275569
229	Phosphorylation	NSLTSLPTYSSSYSQ CCCCCCCCCCCCCCH		28348404
230	Phosphorylation	SLTSLPTYSSSYSQH CCCCCCCCCCCCCHH		28348404
231	Phosphorylation	LTSLPTYSSSYSQHL CCCCCCCCCCCCHHC		28348404
232	Phosphorylation	TSLPTYSSSYSQHLA CCCCCCCCCCCHHCC		28348404
233	Phosphorylation	SLPTYSSSYSQHLAP CCCCCCCCCCHHCCC		28348404
235	Phosphorylation	PTYSSSYSQHLAPLS CCCCCCCCHHCCCCC		28348404
242	Phosphorylation	SQHLAPLSASTSHIN CHHCCCCCCCCCCCC		28348404
244	Phosphorylation	HLAPLSASTSHINRI HCCCCCCCCCCCCCE		28348404
245	Phosphorylation	LAPLSASTSHINRIG CCCCCCCCCCCCCEE		28348404
246	Phosphorylation	APLSASTSHINRIGT CCCCCCCCCCCCEEE		28348404
260	Phosphorylation	TASYGSGSGGSSGGG ECCCCCCCCCCCCCC		-
270	Phosphorylation	SSGGGSGYQDLGTSD CCCCCCCCCCCCCCC		-
275	Phosphorylation	SGYQDLGTSDSGRAS CCCCCCCCCCCCCCC		-
278	Phosphorylation	QDLGTSDSGRASSKS CCCCCCCCCCCCCCC		-
287	Phosphorylation	RASSKSGSSSSMGRP CCCCCCCCCCCCCCC		-
316	Phosphorylation	FAACSPPSPSALIQE CCCCCCCCHHHHHHH		26657352
318	Phosphorylation	ACSPPSPSALIQELE CCCCCCHHHHHHHHH		24173317
401	Acetylation	LRLQQDKKQLQEEAA HHHHHHHHHHHHHHH		156215
411	Ubiquitination	QEEAARLMRQREELE HHHHHHHHHHHHHHH		30230243
438	Phosphorylation	FLPRIEETKWEVCQK CHHHHHHHHHHHHHH		26074081
450	Phosphorylation	CQKAGEISLLKQQLK HHHHHHHHHHHHHHH		24719451
457	Ubiquitination	SLLKQQLKDSQADVS HHHHHHHHHCCCHHH		30230243
487	Ubiquitination	GRASLREKEEQLLSL HHHHHHHHHHHHHHH		30230243
497	Phosphorylation	QLLSLRDSFSSKQAS HHHHHHHHHCCCHHH		27251275
504	Phosphorylation	SFSSKQASLELGEGE HHCCCHHHHHCCCCC		30108239
557	Phosphorylation	AAAASLVSVDGEAEA HHHHHEEEECCCHHH		28348404
602	Phosphorylation	GASFAEERRVWLEEK CCCHHHHHHHHHHHH		33259812
615	Phosphorylation	EKEKVIEYQKQLQLS HHHHHHHHHHHHCHH		18083107
622	O-linked_Glycosylation	YQKQLQLSYVEMYQR HHHHHCHHHHHHHHH		30379171
627	Phosphorylation	QLSYVEMYQRNQQLE CHHHHHHHHHHHHHH		18083107
647	Phosphorylation	RGAAGGASTPTPQHG CCCCCCCCCCCCCCC		25850435
648	Phosphorylation	GAAGGASTPTPQHGE CCCCCCCCCCCCCCC		25850435
650	Phosphorylation	AGGASTPTPQHGEEK CCCCCCCCCCCCCHH		25850435
661	Phosphorylation	GEEKKAWTPSRLERI CCHHCCCCHHHHHHH		22210691
663	Phosphorylation	EKKAWTPSRLERIES HHCCCCHHHHHHHHC		22210691
670	Phosphorylation	SRLERIESTEI---- HHHHHHHCCCC----		28857561
671	Phosphorylation	RLERIESTEI----- HHHHHHCCCC-----		22210691
678	Phosphorylation	TEI------------ CCC------------		33259812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LZTS3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LZTS3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LZTS3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LZTS3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.