PDZ11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDZ11_HUMAN
• UniProt AC: Q5EBL8
• Protein Name: PDZ domain-containing protein 11
• Gene Name: PDZD11
• Organism: Homo sapiens (Human).
• Sequence Length: 140
• Subcellular Localization: Isoform 2: Secreted .; Isoform 1: Cytoplasm .
• Protein Sequence: MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MDSRIPYDDYPVVF -CCCCCCCCCCCEEE	21.05	21082442
10	Phosphorylation	SRIPYDDYPVVFLPA CCCCCCCCCEEEEEC	8.60	20007894
18	Phosphorylation	PVVFLPAYENPPAWI CEEEEECCCCCCCCC	17.82	25106551
36	Phosphorylation	ERVHHPDYNNELTQF CCCCCCCCCCHHHHH	25.08	28796482
49	Phosphorylation	QFLPRTITLKKPPGA HHCCCEEECCCCCCC	31.73	28857561
68	Phosphorylation	NIRGGKASQLGIFIS EEECCCHHHEEEEEE	29.44	-
109	Ubiquitination	FQDIEHSKAVEILKT HHHCCHHHHHHHHHH	59.36	29967540
115	Ubiquitination	SKAVEILKTAREISM HHHHHHHHHHHHHHH	45.88	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDZ11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDZ11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDZ11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGMR1_HUMAN	SIGMAR1	physical	21988832
PKHA5_HUMAN	PLEKHA5	physical	25416956
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-7 AND TYR-10, AND MASSSPECTROMETRY.
PubMed: 19534553

"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks.";
Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.;
Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-7, AND MASSSPECTROMETRY.
PubMed: 17389395