CCD66_HUMAN - dbPTM
CCD66_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CCD66_HUMAN
UniProt AC A2RUB6
Protein Name Coiled-coil domain-containing protein 66 {ECO:0000305}
Gene Name CCDC66 {ECO:0000312|HGNC:HGNC:27709}
Organism Homo sapiens (Human).
Sequence Length 948
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Photoreceptor inner segm
Protein Description Microtubule-binding protein required for ciliogenesis. [PubMed: 28235840 May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites]
Protein Sequence MNLGDGLKLETELLDGKTKLILSPYEHKSKISVKMGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLLPLAENQEESFGSSF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationGDGLKLETELLDGKT
CCCCEEEEEECCCCC		42.2324719451
18PhosphorylationTELLDGKTKLILSPY
EEECCCCCEEEECCC		36.2924719451
23PhosphorylationGKTKLILSPYEHKSK
CCCEEEECCCCCCCC		20.6028674419
25PhosphorylationTKLILSPYEHKSKIS
CEEEECCCCCCCCCE		27.5627642862
48PhosphorylationIAKCPLRTKTGHILK
EEECCCCCCCCCCCC		40.4127251275
49UbiquitinationAKCPLRTKTGHILKS
EECCCCCCCCCCCCC		46.1822505724
50UbiquitinationKCPLRTKTGHILKST
ECCCCCCCCCCCCCC		33.1222505724
50PhosphorylationKCPLRTKTGHILKST
ECCCCCCCCCCCCCC		33.1227251275
57PhosphorylationTGHILKSTQDTCIGS
CCCCCCCCCCCCCCC		28.95-
60PhosphorylationILKSTQDTCIGSEKL
CCCCCCCCCCCCHHH		9.01-
64PhosphorylationTQDTCIGSEKLLQKK
CCCCCCCCHHHHCCC		16.2024719451
115PhosphorylationQKEISPATPNMQKTR
HHCCCCCCCCCHHHC		20.6918669648
117UbiquitinationEISPATPNMQKTRNT
CCCCCCCCCHHHCCC		40.9622505724
118UbiquitinationISPATPNMQKTRNTV
CCCCCCCCHHHCCCC		4.5622505724
120AcetylationPATPNMQKTRNTVNT
CCCCCCHHHCCCCCH		38.3911789725
121PhosphorylationATPNMQKTRNTVNTS
CCCCCHHHCCCCCHH		16.5618669648
132AcetylationVNTSLVGKQKPHKKH
CCHHHCCCCCCCCCC		47.9011789733
139UbiquitinationKQKPHKKHITAENMK
CCCCCCCCCCHHHHH		27.6922505724
140UbiquitinationQKPHKKHITAENMKS
CCCCCCCCCHHHHHH		5.5422505724
141PhosphorylationKPHKKHITAENMKSS
CCCCCCCCHHHHHHH		27.86-
178UbiquitinationLSLTENGKEAKSQYS
EEECCCCHHHHHHHH		67.11-
182UbiquitinationENGKEAKSQYSLYLN
CCCHHHHHHHHHHHH		41.2022505724
183UbiquitinationNGKEAKSQYSLYLNS
CCHHHHHHHHHHHHH		31.0022505724
185PhosphorylationKEAKSQYSLYLNSIS
HHHHHHHHHHHHHHC		11.6924114839
190PhosphorylationQYSLYLNSISNQPKD
HHHHHHHHHCCCCCC		25.4624114839
206UbiquitinationNIMGLFKKTEMVSSV
CCCHHHHCCCCHHCC		42.24-
229UbiquitinationNEHQETSKQCEQKIA
HHHHHHHHHHHHHHH		67.40-
242UbiquitinationIAIENEWKPADIFST
HHHCCCCCHHHHHHH		24.93-
269AcetylationAKKAQWRKELDEQVA
HHHHHHHHHHHHHHH		60.7223749302
270UbiquitinationKKAQWRKELDEQVAL
HHHHHHHHHHHHHHH		53.5329967540
281UbiquitinationQVALKKKEKEVSEKW
HHHHHHHHHHHHHHH		64.4322505724
282UbiquitinationVALKKKEKEVSEKWN
HHHHHHHHHHHHHHC		72.7522505724
291UbiquitinationVSEKWNDPWKKSESD
HHHHHCCCCCCCHHC		41.3929967540
304UbiquitinationSDKIIWEKHQILDQS
HCCHHHHHHHHHHCC		26.3029967540
317UbiquitinationQSRETVLLEHPFSAV
CCCCHHHHHCCHHHH		5.0229967540
325UbiquitinationEHPFSAVKQELQRKW
HCCHHHHHHHHHHHH		37.4629967540
351UbiquitinationRQRKIEEKIIYSKGE
HHHHHHHHHEECCCC		22.9329967540
356UbiquitinationEEKIIYSKGEEHDRW
HHHHEECCCCCCCCE		54.06-
369PhosphorylationRWAMHFDSLKSYPGS
CEEECHHHHHCCCCC		36.43-
391PhosphorylationSTHKQPEYFCVSPDT
CCCCCCCEEEECCCH		14.6827642862
431UbiquitinationIAKPIKDVVMANSKK
CCCCHHHHHHHCCCC		2.4222505724
432UbiquitinationAKPIKDVVMANSKKT
CCCHHHHHHHCCCCC		4.2622505724
438UbiquitinationVVMANSKKTNFLRSM
HHHHCCCCCCHHHHH		48.8222505724
439UbiquitinationVMANSKKTNFLRSMT
HHHCCCCCCHHHHHH		34.6322505724
447UbiquitinationNFLRSMTALLDPAQI
CHHHHHHHHCCHHHH		9.4822505724
448UbiquitinationFLRSMTALLDPAQIE
HHHHHHHHCCHHHHH		4.0222505724
449UbiquitinationLRSMTALLDPAQIEE
HHHHHHHCCHHHHHH		7.4122505724
472PhosphorylationLEHQKAITAQVEEKR
HHHHHHHHHHHHHHH		18.8525278378
474UbiquitinationHQKAITAQVEEKRRK
HHHHHHHHHHHHHHH		34.2122505724
475UbiquitinationQKAITAQVEEKRRKK
HHHHHHHHHHHHHHH		10.7322505724
481UbiquitinationQVEEKRRKKQLEEEQ
HHHHHHHHHHHHHHH		49.2422505724
482UbiquitinationVEEKRRKKQLEEEQR
HHHHHHHHHHHHHHH		59.3022505724
487UbiquitinationRKKQLEEEQRKKEEQ
HHHHHHHHHHHHHHH		46.4321890473
549UbiquitinationLAQRLKQEQRIRELA
HHHHHHHHHHHHHHH		39.9921890473
562PhosphorylationLAQKGHDTSRLIKNL
HHHCCCCHHHHHHHH		15.2923403867
563PhosphorylationAQKGHDTSRLIKNLG
HHCCCCHHHHHHHHC		31.0223403867
571UbiquitinationRLIKNLGVDTIQMEY
HHHHHHCCCEEEEEE		7.0821890473
594PhosphorylationRHDSDEISGKMNTYM
CCCHHHCCCHHHHHC		30.25-
599PhosphorylationEISGKMNTYMNSTTS
HCCCHHHHHCCCCCC		22.20-
603PhosphorylationKMNTYMNSTTSKKDT
HHHHHCCCCCCCCCC		19.28-
606PhosphorylationTYMNSTTSKKDTGVQ
HHCCCCCCCCCCCCC		37.48-
614UbiquitinationKKDTGVQTDDLNIGI
CCCCCCCCCCCCEEE		29.1321890473
620UbiquitinationQTDDLNIGIFTNAES
CCCCCCEEEECCCHH		14.1021890473
666AcetylationKQELTQDKGASLEKE
HHHHHHCCCCCHHHH		46.7012433211
669PhosphorylationLTQDKGASLEKENNR
HHHCCCCCHHHHCHH		45.8130576142
672AcetylationDKGASLEKENNRCND
CCCCCHHHHCHHCHH		71.6612433221
691PhosphorylationFTRIEKQTKHMKKYP
HHHHHHHHHHHHHCC		33.70-
719UbiquitinationYIPASEKYPKQLQKQ
CCCCCHHCCHHHHHH		16.1721890473
719PhosphorylationYIPASEKYPKQLQKQ
CCCCCHHCCHHHHHH		16.17-
751PhosphorylationKNNPGHLSQNRGISP
HCCCCCCCCCCCCCH		21.53-
757UbiquitinationLSQNRGISPEIFHSS
CCCCCCCCHHHHCCC		21.2129967540
757PhosphorylationLSQNRGISPEIFHSS
CCCCCCCCHHHHCCC		21.2127050516
763PhosphorylationISPEIFHSSHQETES
CCHHHHCCCCCHHHH		20.83-
764PhosphorylationSPEIFHSSHQETESK
CHHHHCCCCCHHHHH		22.18-
788PhosphorylationEEPLNIHSFSKERSP
CCCCCCCCCCCCCCC		27.6724719451
791UbiquitinationLNIHSFSKERSPSSP
CCCCCCCCCCCCCCC		55.9529967540
794PhosphorylationHSFSKERSPSSPVPV
CCCCCCCCCCCCCCC		30.1726055452
796PhosphorylationFSKERSPSSPVPVVK
CCCCCCCCCCCCCCC		48.8225159151
797PhosphorylationSKERSPSSPVPVVKN
CCCCCCCCCCCCCCC		33.0430576142
812PhosphorylationRTQQTQNTLHLPLKN
CCCCCCCEEECCCCC		13.02-
863UbiquitinationYYLDPDAPLSGPSTQ
EEECCCCCCCCCCCC		34.1421890473
870UbiquitinationPLSGPSTQDPQYQNS
CCCCCCCCCCCCCCC		65.8021890473
876UbiquitinationTQDPQYQNSQDCGQK
CCCCCCCCCCCCCHH		36.3821890473
879UbiquitinationPQYQNSQDCGQKRQL
CCCCCCCCCCHHHHC		38.0321890473
880UbiquitinationQYQNSQDCGQKRQLF
CCCCCCCCCHHHHCC		4.8921890473
885UbiquitinationQDCGQKRQLFDSDCV
CCCCHHHHCCCCCHH		54.2221890473
886UbiquitinationDCGQKRQLFDSDCVR
CCCHHHHCCCCCHHC		6.3021890473
906UbiquitinationPNMVKNRDRQQAILK
HHHCCCHHHHHHHHH		63.2321890473
912UbiquitinationRDRQQAILKGLSELR
HHHHHHHHHHHHHHH		3.9521890473
913UbiquitinationDRQQAILKGLSELRQ
HHHHHHHHHHHHHHH		52.2521890473
919UbiquitinationLKGLSELRQGLLQKQ
HHHHHHHHHHHHHHH		25.1921890473
943PhosphorylationLAENQEESFGSSF--
HHHCCHHHHCCCC--		33.8727251275
946PhosphorylationNQEESFGSSF-----
CCHHHHCCCC-----		26.9327251275
947PhosphorylationQEESFGSSF------
CHHHHCCCC------		35.0427251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CCD66_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CCD66_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CCD66_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CCD66_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CCD66_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-115 AND THR-121, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory