dbPTM

CKAP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CKAP2_HUMAN
UniProt AC	Q8WWK9
Protein Name	Cytoskeleton-associated protein 2
Gene Name	CKAP2 {ECO:0000312\|HGNC:HGNC:1990}
Organism	Homo sapiens (Human).
Sequence Length	683
Subcellular Localization	Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase aft
Protein Description	Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity)..
Protein Sequence	MSTPAVPQDLQLPPSQRAQSAFKEQRRQKLKEHLLRRKTLFAYKQENEMLSSSRDQRVVTSEDQVQEGTKVLKLKTKMADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDSNQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQDANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPKATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPPIRSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSSSQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRHTAGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHEPAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINEGCPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIYEKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCASKEEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPTHDVKTPNTETRTSCLIKYNVSTTPYLQSVKKKVQFDGTNSAFKELKFLTPVRRSRRLQEKTSKLPDMLKDHYPCVSSLEQLTELGRETDAFVCRPNAALCRVYYEADTT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTPAVPQD ------CCCCCCCCC	43.00	20068231
3	Phosphorylation	-----MSTPAVPQDL -----CCCCCCCCCC	17.61	20068231
8	Ubiquitination	MSTPAVPQDLQLPPS CCCCCCCCCCCCCHH	58.40	22817900
12 (in isoform 6)	Phosphorylation	-	9.77	19691289
15	Phosphorylation	QDLQLPPSQRAQSAF CCCCCCHHHHHHHHH	30.29	20068231
20	Phosphorylation	PPSQRAQSAFKEQRR CHHHHHHHHHHHHHH	34.39	24719451
21	Ubiquitination	PSQRAQSAFKEQRRQ HHHHHHHHHHHHHHH	13.88	21890473
21	Ubiquitination	PSQRAQSAFKEQRRQ HHHHHHHHHHHHHHH	13.88	33845483
22	Ubiquitination	SQRAQSAFKEQRRQK HHHHHHHHHHHHHHH	12.39	21890473
23	Acetylation	QRAQSAFKEQRRQKL HHHHHHHHHHHHHHH	53.29	25953088
24	Ubiquitination	RAQSAFKEQRRQKLK HHHHHHHHHHHHHHH	42.75	22817900
25	Ubiquitination	AQSAFKEQRRQKLKE HHHHHHHHHHHHHHH	46.58	22817900
26	Ubiquitination	QSAFKEQRRQKLKEH HHHHHHHHHHHHHHH	44.05	22817900
27	Ubiquitination	SAFKEQRRQKLKEHL HHHHHHHHHHHHHHH	37.37	22817900
31	Ubiquitination	EQRRQKLKEHLLRRK HHHHHHHHHHHHHHH	50.56	33845483
38	Ubiquitination	KEHLLRRKTLFAYKQ HHHHHHHHHHHHHHH	43.05	21890473
38 (in isoform 1)	Ubiquitination	-	43.05	21890473
39	Phosphorylation	EHLLRRKTLFAYKQE HHHHHHHHHHHHHHH	25.87	23312004
42	Ubiquitination	LRRKTLFAYKQENEM HHHHHHHHHHHHHHH	17.46	21906983
42	Ubiquitination	LRRKTLFAYKQENEM HHHHHHHHHHHHHHH	17.46	22817900
43	Ubiquitination	RRKTLFAYKQENEML HHHHHHHHHHHHHHH	13.08	22817900
44	Acetylation	RKTLFAYKQENEMLS HHHHHHHHHHHHHHC	47.94	26051181
44	Ubiquitination	RKTLFAYKQENEMLS HHHHHHHHHHHHHHC	47.94	29967540
60	Phosphorylation	SRDQRVVTSEDQVQE CCCCCCCCCHHHHHH	24.44	19691289
60 (in isoform 4)	Phosphorylation	-	24.44	19691289
60 (in isoform 5)	Phosphorylation	-	24.44	19691289
61	Phosphorylation	RDQRVVTSEDQVQEG CCCCCCCCHHHHHHH	27.80	19691289
69	Phosphorylation	EDQVQEGTKVLKLKT HHHHHHHHEEEEHHH	19.75	19060867
69	Ubiquitination	EDQVQEGTKVLKLKT HHHHHHHHEEEEHHH	19.75	33845483
70	Acetylation	DQVQEGTKVLKLKTK HHHHHHHEEEEHHHH	57.33	25953088
70	Ubiquitination	DQVQEGTKVLKLKTK HHHHHHHEEEEHHHH	57.33	22817900
70 (in isoform 1)	Ubiquitination	-	57.33	21890473
71	Ubiquitination	QVQEGTKVLKLKTKM HHHHHHEEEEHHHHH	5.98	33845483
72	Ubiquitination	VQEGTKVLKLKTKMA HHHHHEEEEHHHHHC	5.99	22817900
73	Ubiquitination	QEGTKVLKLKTKMAD HHHHEEEEHHHHHCC	51.42	22817900
74	Ubiquitination	EGTKVLKLKTKMADK HHHEEEEHHHHHCCH	8.13	22817900
75	Ubiquitination	GTKVLKLKTKMADKE HHEEEEHHHHHCCHH	44.50	22817900
77	Acetylation	KVLKLKTKMADKENM EEEEHHHHHCCHHHC	30.42	25953088
90	Ubiquitination	NMKRPAESKNNTVVG HCCCCCHHCCCCCCC	42.67	22817900
91	Ubiquitination	MKRPAESKNNTVVGK CCCCCHHCCCCCCCC	45.80	21906983
91 (in isoform 1)	Ubiquitination	-	45.80	21890473
119	Ubiquitination	STVVIDTHKPKDSNQ CEEEEECCCCCCCCC	40.44	33845483
120	Acetylation	TVVIDTHKPKDSNQT EEEEECCCCCCCCCC	56.72	26051181
120	Ubiquitination	TVVIDTHKPKDSNQT EEEEECCCCCCCCCC	56.72	33845483
124	Phosphorylation	DTHKPKDSNQTPHLL ECCCCCCCCCCCCEE	36.64	21712546
127	Phosphorylation	KPKDSNQTPHLLLTE CCCCCCCCCCEEEEC	19.54	25159151
138	Ubiquitination	LLTEDDPQSQHMTLS EEECCCCCCCCCCHH	63.82	32015554
139	Phosphorylation	LTEDDPQSQHMTLSQ EECCCCCCCCCCHHH	27.69	29214152
145	Phosphorylation	QSQHMTLSQAFHLKN CCCCCCHHHHHHCCC	15.42	28555341
160	Phosphorylation	NSKKKQMTTEKQKQD CCCHHCCCHHHHHHH	29.34	-
161	Phosphorylation	SKKKQMTTEKQKQDA CCHHCCCHHHHHHHC	35.52	-
168	Ubiquitination	TEKQKQDANMPKKPV HHHHHHHCCCCCCCC	16.24	29967540
178	Phosphorylation	PKKPVLGSYRGQIVQ CCCCCCCHHHHHHHH	13.90	23186163
179	Phosphorylation	KKPVLGSYRGQIVQS CCCCCCHHHHHHHHH	19.57	23186163
180	Ubiquitination	KPVLGSYRGQIVQSK CCCCCHHHHHHHHHH	32.03	-
180	Ubiquitination	KPVLGSYRGQIVQSK CCCCCHHHHHHHHHH	32.03	29967540
186	Ubiquitination	YRGQIVQSKINSFRK HHHHHHHHHHHHCCC	25.30	32015554
187	Acetylation	RGQIVQSKINSFRKP HHHHHHHHHHHCCCC	28.90	25953088
187	Ubiquitination	RGQIVQSKINSFRKP HHHHHHHHHHHCCCC	28.90	32015554
190	Phosphorylation	IVQSKINSFRKPLQV HHHHHHHHCCCCCCC	29.87	26074081
198	Sumoylation	FRKPLQVKDESSAAT CCCCCCCCCCCCHHH	42.70	-
198	Sumoylation	FRKPLQVKDESSAAT CCCCCCCCCCCCHHH	42.70	-
201	Phosphorylation	PLQVKDESSAATKKL CCCCCCCCCHHHHHH	35.10	29083192
202	Phosphorylation	LQVKDESSAATKKLS CCCCCCCCHHHHHHH	21.63	24825855
205	Phosphorylation	KDESSAATKKLSATI CCCCCHHHHHHHCCC	28.55	24825855
206	Acetylation	DESSAATKKLSATIP CCCCHHHHHHHCCCC	47.17	11924467
209	Phosphorylation	SAATKKLSATIPKAT CHHHHHHHCCCCCCC	32.04	25159151
211	Phosphorylation	ATKKLSATIPKATKP HHHHHHCCCCCCCCC	34.14	19691289
216	Ubiquitination	SATIPKATKPQPVNT HCCCCCCCCCCCCCC	49.75	29967540
217	Ubiquitination	ATIPKATKPQPVNTS CCCCCCCCCCCCCCC	46.65	29967540
220	Ubiquitination	PKATKPQPVNTSSVT CCCCCCCCCCCCCEE	29.83	29967540
223	Phosphorylation	TKPQPVNTSSVTVKS CCCCCCCCCCEEEEE	23.71	28555341
224	Phosphorylation	KPQPVNTSSVTVKSN CCCCCCCCCEEEEEC	20.01	28555341
225	Phosphorylation	PQPVNTSSVTVKSNR CCCCCCCCEEEEECC	21.55	25627689
227	Phosphorylation	PVNTSSVTVKSNRSS CCCCCCEEEEECCCC	24.94	-
228	Ubiquitination	VNTSSVTVKSNRSSN CCCCCEEEEECCCCC	6.32	29967540
229	Acetylation	NTSSVTVKSNRSSNM CCCCEEEEECCCCCC	32.42	25953088
229	Ubiquitination	NTSSVTVKSNRSSNM CCCCEEEEECCCCCC	32.42	29967540
233	O-linked_Glycosylation	VTVKSNRSSNMTATT EEEEECCCCCCEEEE	30.25	23301498
234	O-linked_Glycosylation	TVKSNRSSNMTATTK EEEECCCCCCEEEEE	27.64	23301498
239	Ubiquitination	RSSNMTATTKFVSTT CCCCCEEEEEEEECC	22.73	29967540
241	Acetylation	SNMTATTKFVSTTSQ CCCEEEEEEEECCCC	39.14	25953088
245	Ubiquitination	ATTKFVSTTSQNTQL EEEEEEECCCCCCEE	25.76	-
245	Phosphorylation	ATTKFVSTTSQNTQL EEEEEEECCCCCCEE	25.76	29214152
247	Phosphorylation	TKFVSTTSQNTQLVR EEEEECCCCCCEEEC	22.86	29214152
254	Ubiquitination	SQNTQLVRPPIRSHH CCCCEEECCCCCCCC	39.61	24816145
262	O-linked_Glycosylation	PPIRSHHSNTRDTVK CCCCCCCCCCHHHHH	34.18	23301498
268	Ubiquitination	HSNTRDTVKQGISRT CCCCHHHHHHCCCCC	5.23	29967540
269	Acetylation	SNTRDTVKQGISRTS CCCHHHHHHCCCCCC	44.92	25953088
269	Ubiquitination	SNTRDTVKQGISRTS CCCHHHHHHCCCCCC	44.92	29967540
275	Phosphorylation	VKQGISRTSANVTIR HHHCCCCCCCCEEEE	25.96	27134283
276	Phosphorylation	KQGISRTSANVTIRK HHCCCCCCCCEEEEC	19.41	30576142
280	Phosphorylation	SRTSANVTIRKGPHE CCCCCCEEEECCHHH	18.18	30576142
284	Ubiquitination	ANVTIRKGPHEKELL CCEEEECCHHHHHHH	20.96	29967540
287	Ubiquitination	TIRKGPHEKELLQSK EEECCHHHHHHHHCH	51.89	29967540
288	Ubiquitination	IRKGPHEKELLQSKT EECCHHHHHHHHCHH	51.10	24816145
289	Ubiquitination	RKGPHEKELLQSKTA ECCHHHHHHHHCHHH	52.29	24816145
294	Acetylation	EKELLQSKTALSSVK HHHHHHCHHHHHCCC	25.51	25953088
294	Ubiquitination	EKELLQSKTALSSVK HHHHHHCHHHHHCCC	25.51	-
298	Phosphorylation	LQSKTALSSVKTSSS HHCHHHHHCCCCCCC	30.53	23312004
299	Phosphorylation	QSKTALSSVKTSSSQ HCHHHHHCCCCCCCC	28.60	30576142
301	Acetylation	KTALSSVKTSSSQGI HHHHHCCCCCCCCCC	44.64	25953088
301	Ubiquitination	KTALSSVKTSSSQGI HHHHHCCCCCCCCCC	44.64	29967540
302	Phosphorylation	TALSSVKTSSSQGII HHHHCCCCCCCCCCC	31.52	30576142
303	Phosphorylation	ALSSVKTSSSQGIIR HHHCCCCCCCCCCCC	23.44	30576142
304	Phosphorylation	LSSVKTSSSQGIIRN HHCCCCCCCCCCCCC	31.73	22199227
305	Phosphorylation	SSVKTSSSQGIIRNK HCCCCCCCCCCCCCC	31.99	22199227
317	Phosphorylation	RNKTLSRSIASEVIA CCCCCCHHHHHHHHH	21.09	29083192
320	Phosphorylation	TLSRSIASEVIARPA CCCHHHHHHHHHCCH	30.63	20068231
328	Phosphorylation	EVIARPASLSNDKLM HHHHCCHHCCCCHHH	34.71	19691289
330	Phosphorylation	IARPASLSNDKLMEK HHCCHHCCCCHHHCC	40.25	28122231
332	Ubiquitination	RPASLSNDKLMEKSE CCHHCCCCHHHCCCC	41.93	29967540
333	Acetylation	PASLSNDKLMEKSEP CHHCCCCHHHCCCCC	54.72	25953088
333	Ubiquitination	PASLSNDKLMEKSEP CHHCCCCHHHCCCCC	54.72	29967540
336	Ubiquitination	LSNDKLMEKSEPVDQ CCCCHHHCCCCCCHH	64.96	24816145
337	Ubiquitination	SNDKLMEKSEPVDQR CCCHHHCCCCCCHHH	46.27	24816145
349	Ubiquitination	DQRRHTAGKAIVDSR HHHHHHCCHHHHCCC	22.53	29967540
350	Acetylation	QRRHTAGKAIVDSRS HHHHHCCHHHHCCCC	32.26	25953088
350	Ubiquitination	QRRHTAGKAIVDSRS HHHHHCCHHHHCCCC	32.26	29967540
352	Ubiquitination	RHTAGKAIVDSRSAQ HHHCCHHHHCCCCCC	3.94	29967540
355	Phosphorylation	AGKAIVDSRSAQPKE CCHHHHCCCCCCCCC	19.76	26074081
357	Phosphorylation	KAIVDSRSAQPKETS HHHHCCCCCCCCCCH	34.90	25262027
363	Phosphorylation	RSAQPKETSEERKAR CCCCCCCCHHHHHHH	47.79	26074081
364	Phosphorylation	SAQPKETSEERKARL CCCCCCCHHHHHHHH	38.25	26074081
372	Phosphorylation	EERKARLSEWKAGKG HHHHHHHHHHHCCCC	35.54	28555341
373	Ubiquitination	ERKARLSEWKAGKGR HHHHHHHHHHCCCCC	58.55	29967540
400	Ubiquitination	HEPAGQNEKPVGSFW CCCCCCCCCCCCCCC	51.34	29967540
401	Ubiquitination	EPAGQNEKPVGSFWT CCCCCCCCCCCCCCC	53.18	29967540
403	Ubiquitination	AGQNEKPVGSFWTTM CCCCCCCCCCCCCCC	17.35	29967540
421	Ubiquitination	DEQRLFTEKVNNTFS HHHHHHHHHHHHHHH	47.90	29967540
422	Ubiquitination	EQRLFTEKVNNTFSE HHHHHHHHHHHHHHH	47.40	29967540
426	Ubiquitination	FTEKVNNTFSECLNL HHHHHHHHHHHHHHH	24.27	22817900
430	Ubiquitination	VNNTFSECLNLINEG HHHHHHHHHHHHHCC	2.71	22817900
446	Phosphorylation	PKEDILVTLNDLIKN CHHHHEEHHHHHHHC	19.19	22985185
451	Ubiquitination	LVTLNDLIKNIPDAK EEHHHHHHHCCCCHH	3.42	29967540
452	Ubiquitination	VTLNDLIKNIPDAKK EHHHHHHHCCCCHHH	57.00	29967540
460	Ubiquitination	NIPDAKKLVKYWICL CCCCHHHHHHHHHHH	3.86	-
460	Ubiquitination	NIPDAKKLVKYWICL CCCCHHHHHHHHHHH	3.86	22817900
461	Ubiquitination	IPDAKKLVKYWICLA CCCHHHHHHHHHHHH	6.49	22817900
464	Ubiquitination	AKKLVKYWICLALIE HHHHHHHHHHHHHHH	2.97	-
464	Ubiquitination	AKKLVKYWICLALIE HHHHHHHHHHHHHHH	2.97	22817900
465	Ubiquitination	KKLVKYWICLALIEP HHHHHHHHHHHHHHC	0.94	22817900
473	Ubiquitination	CLALIEPITSPIENI HHHHHHCCCCCHHHH	3.75	29967540
503	Ubiquitination	EEMRHTIVDILTMKS HHHHHHHHHHHCHHH	3.83	29967540
507	Phosphorylation	HTIVDILTMKSQEKA HHHHHHHCHHHHHHH	23.92	21712546
508	Ubiquitination	TIVDILTMKSQEKAN HHHHHHCHHHHHHHC	3.35	22817900
509	Ubiquitination	IVDILTMKSQEKANL HHHHHCHHHHHHHCC	43.69	22817900
510	Phosphorylation	VDILTMKSQEKANLG HHHHCHHHHHHHCCC	32.52	21712546
512	Ubiquitination	ILTMKSQEKANLGEN HHCHHHHHHHCCCHH	62.32	22817900
513	Ubiquitination	LTMKSQEKANLGENM HCHHHHHHHCCCHHH	34.63	22817900
513 (in isoform 1)	Ubiquitination	-	34.63	21890473
515	Ubiquitination	MKSQEKANLGENMEK HHHHHHHCCCHHHHH	60.70	29967540
521	Ubiquitination	ANLGENMEKSCASKE HCCCHHHHHHHCCHH	54.09	29967540
522	Ubiquitination	NLGENMEKSCASKEE CCCHHHHHHHCCHHH	39.81	29967540
529	Ubiquitination	KSCASKEEVKEVSIE HHHCCHHHHEEEEHH	63.73	29967540
534	Phosphorylation	KEEVKEVSIEDTGVD HHHHEEEEHHHCCCC	22.73	30266825
534	Ubiquitination	KEEVKEVSIEDTGVD HHHHEEEEHHHCCCC	22.73	21890473
537	Ubiquitination	VKEVSIEDTGVDVDP HEEEEHHHCCCCCCH	47.28	21890473
538	Phosphorylation	KEVSIEDTGVDVDPE EEEEHHHCCCCCCHH	26.72	30266825
551	Ubiquitination	PEKLEMESKLHRNLL HHHHHHHHHHHHHHH	38.93	29967540
552	Ubiquitination	EKLEMESKLHRNLLF HHHHHHHHHHHHHHH	34.70	29967540
555	Ubiquitination	EMESKLHRNLLFQDC HHHHHHHHHHHHHHH	46.02	-
555	Ubiquitination	EMESKLHRNLLFQDC HHHHHHHHHHHHHHH	46.02	29967540
557	Ubiquitination	ESKLHRNLLFQDCEK HHHHHHHHHHHHHHH	5.23	29967540
563	Ubiquitination	NLLFQDCEKEQDNKT HHHHHHHHHHCCCCC	68.84	29967540
564	Ubiquitination	LLFQDCEKEQDNKTK HHHHHHHHHCCCCCC	67.99	29967540
568	Ubiquitination	DCEKEQDNKTKDPTH HHHHHCCCCCCCCCC	54.30	21890473
568	Ubiquitination	DCEKEQDNKTKDPTH HHHHHCCCCCCCCCC	54.30	-
568	Ubiquitination	DCEKEQDNKTKDPTH HHHHHCCCCCCCCCC	54.30	21890473
569	Ubiquitination	CEKEQDNKTKDPTHD HHHHCCCCCCCCCCC	66.30	21890473
570	Phosphorylation	EKEQDNKTKDPTHDV HHHCCCCCCCCCCCC	47.11	19691289
571	Ubiquitination	KEQDNKTKDPTHDVK HHCCCCCCCCCCCCC	64.42	21890473
571	Ubiquitination	KEQDNKTKDPTHDVK HHCCCCCCCCCCCCC	64.42	-
571	Ubiquitination	KEQDNKTKDPTHDVK HHCCCCCCCCCCCCC	64.42	21890473
572	Ubiquitination	EQDNKTKDPTHDVKT HCCCCCCCCCCCCCC	59.57	21890473
574	Phosphorylation	DNKTKDPTHDVKTPN CCCCCCCCCCCCCCC	40.62	19691289
577	Ubiquitination	TKDPTHDVKTPNTET CCCCCCCCCCCCCCC	6.04	29967540
578	Ubiquitination	KDPTHDVKTPNTETR CCCCCCCCCCCCCCC	65.41	29967540
579	Phosphorylation	DPTHDVKTPNTETRT CCCCCCCCCCCCCCC	22.94	25159151
582	Phosphorylation	HDVKTPNTETRTSCL CCCCCCCCCCCCEEE	39.68	25159151
584	Phosphorylation	VKTPNTETRTSCLIK CCCCCCCCCCEEEEE	36.89	19691289
586	Phosphorylation	TPNTETRTSCLIKYN CCCCCCCCEEEEEEC	31.08	22199227
587	Phosphorylation	PNTETRTSCLIKYNV CCCCCCCEEEEEECC	12.02	20860994
588	Ubiquitination	NTETRTSCLIKYNVS CCCCCCEEEEEECCC	4.50	29967540
592	Phosphorylation	RTSCLIKYNVSTTPY CCEEEEEECCCCCHH	17.50	20068231
595	Phosphorylation	CLIKYNVSTTPYLQS EEEEECCCCCHHHHH	23.95	25159151
596	Phosphorylation	LIKYNVSTTPYLQSV EEEECCCCCHHHHHH	27.75	25159151
597	Phosphorylation	IKYNVSTTPYLQSVK EEECCCCCHHHHHHH	11.48	25159151
599	Phosphorylation	YNVSTTPYLQSVKKK ECCCCCHHHHHHHHH	18.45	21712546
602	Phosphorylation	STTPYLQSVKKKVQF CCCHHHHHHHHHEEC	33.05	25159151
603	Ubiquitination	TTPYLQSVKKKVQFD CCHHHHHHHHHEECC	7.31	29967540
604	Acetylation	TPYLQSVKKKVQFDG CHHHHHHHHHEECCC	52.72	25953088
604	Methylation	TPYLQSVKKKVQFDG CHHHHHHHHHEECCC	52.72	-
604	Ubiquitination	TPYLQSVKKKVQFDG CHHHHHHHHHEECCC	52.72	29967540
605	Methylation	PYLQSVKKKVQFDGT HHHHHHHHHEECCCC	56.89	-
605	Ubiquitination	PYLQSVKKKVQFDGT HHHHHHHHHEECCCC	56.89	29967540
606	Methylation	YLQSVKKKVQFDGTN HHHHHHHHEECCCCC	35.23	-
606	Ubiquitination	YLQSVKKKVQFDGTN HHHHHHHHEECCCCC	35.23	29967540
612	Phosphorylation	KKVQFDGTNSAFKEL HHEECCCCCHHHHHH	28.04	22617229
614	Phosphorylation	VQFDGTNSAFKELKF EECCCCCHHHHHHHH	34.61	29255136
616	Ubiquitination	FDGTNSAFKELKFLT CCCCCHHHHHHHHHC	6.75	21890473
617	Acetylation	DGTNSAFKELKFLTP CCCCHHHHHHHHHCH	62.95	26051181
617	Ubiquitination	DGTNSAFKELKFLTP CCCCHHHHHHHHHCH	62.95	21890473
617 (in isoform 1)	Ubiquitination	-	62.95	21890473
619	Ubiquitination	TNSAFKELKFLTPVR CCHHHHHHHHHCHHH	4.98	21890473
620	Ubiquitination	NSAFKELKFLTPVRR CHHHHHHHHHCHHHH	39.14	22817900
620 (in isoform 1)	Ubiquitination	-	39.14	21890473
623	Phosphorylation	FKELKFLTPVRRSRR HHHHHHHCHHHHHHH	23.91	30266825
628	Phosphorylation	FLTPVRRSRRLQEKT HHCHHHHHHHHHHHH	15.93	19369249
636	Ubiquitination	RRLQEKTSKLPDMLK HHHHHHHHCCCHHHH	43.17	29967540
637	Ubiquitination	RLQEKTSKLPDMLKD HHHHHHHCCCHHHHH	70.08	29967540
646	Phosphorylation	PDMLKDHYPCVSSLE CHHHHHHCCCCCCHH	14.41	23663014
650	Phosphorylation	KDHYPCVSSLEQLTE HHHCCCCCCHHHHHH	35.60	23663014
651	Phosphorylation	DHYPCVSSLEQLTEL HHCCCCCCHHHHHHH	18.61	25159151
656	Phosphorylation	VSSLEQLTELGRETD CCCHHHHHHHHCCCC	28.94	23663014
677	Phosphorylation	NAALCRVYYEADTT- CCEEEEEEEECCCC-	4.00	21552520
678	Phosphorylation	AALCRVYYEADTT-- CEEEEEEEECCCC--	11.20	29496907
682	Phosphorylation	RVYYEADTT------ EEEEECCCC------	41.26	29052541
683	Phosphorylation	VYYEADTT------- EEEECCCC-------	36.84	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
39	T	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
623	T	Phosphorylation	Kinase	CDK1	P06493	PSP
628	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:17339342

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CKAP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CKAP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
FZR1_HUMAN	FZR1	physical	17339342

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CKAP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-597 AND SER-602, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-579; THR-582; SER-595;THR-596; THR-597; TYR-599 AND SER-602, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69; SER-209; THR-211;SER-276; THR-280; SER-304; SER-305; SER-328; SER-534; THR-597 ANDSER-614, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534; THR-579; THR-582;THR-597; SER-602 AND THR-623, AND MASS SPECTROMETRY.	16565220 [Abstract]